G13 signaling pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="G13 signaling pathway" Organism="Bos taurus"> <Comment Source="WikiPathways-description">The G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cells and is essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells. Source: [[wikipedia:G12/G13_alpha_subunits|Wikipedia]]</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP524_r95116 WP524 (r95116)] with a 92.0% conversion rate.</Comment> <BiopaxRef>cdf</BiopaxRef> <Graphics BoardWidth="992.2245540398743" BoardHeight="733.9999999999999"/> <DataNode TextLabel="RTKN" GraphId="a04" Type="GeneProduct" GroupRef="d445c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6242</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RTKN | rhotekin"/> <Graphics CenterX="316.591815320042" CenterY="222.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000490"/> </DataNode> <DataNode TextLabel="PKN1" GraphId="a11" Type="GeneProduct" GroupRef="d445c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5585</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PKN1 | protein kinase N1"/> <Graphics CenterX="316.591815320042" CenterY="182.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017037"/> </DataNode> <DataNode TextLabel="CFL2" GraphId="a28" Type="GeneProduct" GroupRef="a5b59"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1073</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CFL2 | cofilin 2 (muscle)"/> <Graphics CenterX="842.5918153200423" CenterY="582.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015053"/> </DataNode> <DataNode TextLabel="RHPN2" GraphId="a6c" Type="GeneProduct" GroupRef="d445c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:85415</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RHPN2 | rhophilin Rho GTPase binding protein 2..."/> <Graphics CenterX="316.591815320042" CenterY="202.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003089"/> </DataNode> <DataNode TextLabel="RHOA" GraphId="a73" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:387</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RHOA | ras homolog gene family member A"/> <Graphics CenterX="469.24439747966636" CenterY="219.00000000000006" Width="60.0" Height="21.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004279"/> </DataNode> <DataNode TextLabel="PFN1" GraphId="ae8" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5216</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PFN1 | profilin 1"/> <Graphics CenterX="864.4489581771854" CenterY="219.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018312"/> </DataNode> <DataNode TextLabel="ARHGEF1" GraphId="afa" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9138</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARHGEF1 | Rho guanine nucleotide exchange facto..."/> <Graphics CenterX="467.591815320042" CenterY="155.33333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018912"/> </DataNode> <DataNode TextLabel="CYFIP1" GraphId="b1f" Type="GeneProduct" GroupRef="d3b55"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23191</Comment> <Graphics CenterX="693.9251486533757" CenterY="363.3333333333333" Width="86.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016894"/> </DataNode> <DataNode TextLabel="GNA13" GraphId="b20" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10672</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNA13 | guanine nucleotide binding protein (G p..."/> <Graphics CenterX="467.591815320042" CenterY="88.33333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046174"/> </DataNode> <DataNode TextLabel="IQGAP2" GraphId="b87" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10788</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IQGAP2 | IQ motif containing GTPase activating ..."/> <Graphics CenterX="425.9251486533753" CenterY="564.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000897"/> </DataNode> <DataNode TextLabel="IQGAP1" GraphId="b88" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8826</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IQGAP1 | IQ motif containing GTPase activating ..."/> <Graphics CenterX="425.9251486533753" CenterY="544.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013060"/> </DataNode> <DataNode TextLabel="PIK3CD" GraphId="ba2" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="GenMAPP remarks">P42338</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5293</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3CD | phosphoinositide-3-kinase catalytic ..."/> <Graphics CenterX="534.2584819867088" CenterY="584.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018984"/> </DataNode> <DataNode TextLabel="ARHGDIB" GraphId="bf4" Type="GeneProduct" GroupRef="ed225"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:397</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARHGDIB | Rho GDP dissociation inhibitor (GDI) ..."/> <Graphics CenterX="471.25848198670866" CenterY="375.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006039"/> </DataNode> <DataNode TextLabel="PIK3CB" GraphId="c6f" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5291</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3CB | phosphoinositide-3-kinase catalytic ..."/> <Graphics CenterX="534.2584819867088" CenterY="564.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006909"/> </DataNode> <DataNode TextLabel="SH3RF1" GraphId="c82" Type="GeneProduct" GroupRef="d3b55"> <Comment Source="GenMAPP remarks">Posh</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57630</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SH3MD2 | SH3 multiple domains 2"/> <Graphics CenterX="693.9251486533757" CenterY="393.3333333333333" Width="86.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001508"/> </DataNode> <DataNode TextLabel="LIMK1" GraphId="c97" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3984</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LIMK1 | LIM domain kinase 1"/> <Graphics CenterX="842.5918153200423" CenterY="506.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000044083"/> </DataNode> <DataNode TextLabel="MYBPH" GraphId="cae" Type="GeneProduct" GroupRef="d445c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4608</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYBPH | myosin binding protein H"/> <Graphics CenterX="315.591815320042" CenterY="311.8333333333333" Width="60.0" Height="19.666666666666668" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011465"/> </DataNode> <DataNode TextLabel="RAC1" GraphId="d1c" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5879</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAC1 | ras-related C3 botulinum toxin substrate..."/> <Graphics CenterX="567.1598461000351" CenterY="463.33333333333326" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009233"/> </DataNode> <DataNode TextLabel="TNK2" GraphId="d39" Type="GeneProduct"> <Comment Source="GenMAPP remarks">S33596</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10188</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNK2 | tyrosine kinase non-receptor 2"/> <Graphics CenterX="145.92514865337532" CenterY="459.0" Width="68.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000021364"/> </DataNode> <DataNode TextLabel="PAK3" GraphId="d40" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5063</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK3 | p21 (CDKN1A)-activated kinase 3"/> <Graphics CenterX="640.9251486533756" CenterY="544.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015670"/> </DataNode> <DataNode TextLabel="PIP4K2A" GraphId="d49" Type="GeneProduct" GroupRef="d3b55"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5305</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIP5K2A | phosphatidylinositol-4-phosphate 5-ki..."/> <Graphics CenterX="693.9251486533757" CenterY="333.3333333333333" Width="86.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018033"/> </DataNode> <DataNode TextLabel="MAPK10" GraphId="da1" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5602</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10"/> <Graphics CenterX="848.2584819867088" CenterY="393.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020048"/> </DataNode> <DataNode TextLabel="CALM1" GraphId="dc3" Type="GeneProduct"> <Comment Source="HomologyMapper">No homologues found for original id L:801</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CALM1 | calmodulin 1 (phosphorylase kinase del..."/> <Graphics CenterX="179.25848198670863" CenterY="604.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="WASL" GraphId="e1d" Type="GeneProduct" GroupRef="f7775"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8976</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="WASL | Wiskott-Aldrich syndrome-like"/> <Graphics CenterX="182.59181532004197" CenterY="523.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004643"/> </DataNode> <DataNode TextLabel="PIK3R2" GraphId="e1f" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5296</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3R2 | phosphoinositide-3-kinase regulatory ..."/> <Graphics CenterX="541.5918153200423" CenterY="240.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002350"/> </DataNode> <DataNode TextLabel="PPP1CB" GraphId="e45" Type="GeneProduct" GroupRef="c8b0f"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5500</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPP1CB | protein phosphatase 1 catalytic subun..."/> <Graphics CenterX="268.25848198670866" CenterY="396.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012447"/> </DataNode> <DataNode TextLabel="WAS" GraphId="e4c" Type="GeneProduct" GroupRef="f7775"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7454</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="WAS | Wiskott-Aldrich syndrome (eczema-thromboc..."/> <Graphics CenterX="182.59181532004197" CenterY="543.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046555"/> </DataNode> <DataNode TextLabel="MAP3K4" GraphId="e6c" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4216</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K4 | mitogen-activated protein kinase kinas..."/> <Graphics CenterX="307.591815320042" CenterY="564.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020079"/> </DataNode> <DataNode TextLabel="MYL1" GraphId="e7a" Type="GeneProduct" GroupRef="c8b0f"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4632</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYL1 | myosin light polypeptide 1 alkali; ske..."/> <Graphics CenterX="268.25848198670866" CenterY="376.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009707"/> </DataNode> <DataNode TextLabel="CIT" GraphId="e8d" Type="GeneProduct" GroupRef="d445c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:11113</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CIT | citron (rho-interacting serine/threonine..."/> <Graphics CenterX="316.591815320042" CenterY="119.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008963"/> </DataNode> <DataNode TextLabel="ARHGDIG" GraphId="efa" Type="GeneProduct" GroupRef="ed225"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:398</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARHGDIG | Rho GDP dissociation inhibitor (GDI) ..."/> <Graphics CenterX="471.25848198670866" CenterY="394.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000027854"/> </DataNode> <DataNode TextLabel="ROCK1" GraphId="f0a" Type="GeneProduct" GroupRef="d445c"> <Comment Source="GenMAPP remarks">S69211</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6093</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ROCK1 | Rho-associated coiled-coil containing ..."/> <Graphics CenterX="315.591815320042" CenterY="271.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008403"/> </DataNode> <DataNode TextLabel="FCHSD1" GraphId="f2c" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1729</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DIAPH1 | diaphanous homolog 1 (Drosophila)"/> <Graphics CenterX="729.9251486533756" CenterY="219.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000030499"/> </DataNode> <DataNode TextLabel="PIK3CA" GraphId="f6f" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5290</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3CA | phosphoinositide-3-kinase catalytic ..."/> <Graphics CenterX="534.2584819867088" CenterY="544.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009232"/> </DataNode> <DataNode TextLabel="CDC42" GraphId="f7b" Type="GeneProduct"> <Comment Source="HomologyMapper">No homologues found for original id L:998</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDC42 | cell division cycle 42 (GTP binding pro..."/> <Graphics CenterX="375.591815320042" CenterY="459.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RPS6KB1" GraphId="f9e" Type="GeneProduct" GroupRef="e24cf"> <Comment Source="GenMAPP remarks">A41687</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6198</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPS6KB1 | ribosomal protein S6 kinase 70kDa p..."/> <Graphics CenterX="307.591815320042" CenterY="544.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016851"/> </DataNode> <DataNode TextLabel="ROCK2" GraphId="fa3" Type="GeneProduct" GroupRef="d445c"> <Comment Source="GenMAPP remarks">BAA31594</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9475</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ROCK2 | Rho-associated coiled-coil containing ..."/> <Graphics CenterX="315.591815320042" CenterY="291.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005847"/> </DataNode> <DataNode TextLabel="CFL1" GraphId="ffc" Type="GeneProduct" GroupRef="a5b59"> <Comment Source="HomologyMapper">No homologues found for original id L:1072</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CFL1 | cofilin 1 (non-muscle)"/> <Graphics CenterX="842.5918153200423" CenterY="562.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <Interaction GraphId="a0da4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="450.59181532004203" Y="412.3333333333333" GraphRef="affcf" RelX="-0.5" RelY="1.0"/> <Point X="375.591815320042" Y="449.0" GraphRef="f7b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a1d09"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="469.24439747966636" Y="229.50000000000006" GraphRef="a73" RelX="0.0" RelY="1.0"/> <Point X="471.25848198670866" Y="281.0" GraphRef="a99" RelX="-0.03664921465968586" 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