Eukaryotic transcription initiation (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Eukaryotic transcription initiation" Organism="Bos taurus" License="CC BY 2.0"> <Comment Source="GenMAPP notes">Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: [[wikipedia:Transcription_(genetics)|Wikipedia]]</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP405_r73594 WP405(73594)] with a 97.0% conversion rate.</Comment> <BiopaxRef>c7b</BiopaxRef> <BiopaxRef>fcc</BiopaxRef> <Graphics BoardWidth="1197.0" BoardHeight="719.5"/> <DataNode TextLabel="TBP" GraphId="c6f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6908</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TBP | TATA box binding protein"/> <Graphics CenterX="146.66666666666666" CenterY="296.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002545"/> </DataNode> <DataNode TextLabel="GTF2B" GraphId="b1a" Type="GeneProduct" GroupRef="a10fb"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2959</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2B | general transcription factor IIB"/> <Graphics CenterX="250.0" CenterY="116.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000504"/> </DataNode> <DataNode TextLabel="TAF5" GraphId="d9c" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6877</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF5 | TAF5 RNA polymerase II TATA box binding..."/> <Graphics CenterX="146.66666666666666" CenterY="116.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009709"/> </DataNode> <DataNode TextLabel="TAF6" GraphId="f18" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6878</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF6 | TAF6 RNA polymerase II TATA box binding..."/> <Graphics CenterX="146.66666666666666" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000030966"/> </DataNode> <DataNode TextLabel="TAF7" GraphId="fe2" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6879</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF7 | TAF7 RNA polymerase II TATA box binding..."/> <Graphics CenterX="146.66666666666666" CenterY="156.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011945"/> </DataNode> <DataNode TextLabel="AK6" GraphId="fad" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6880</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF9 | TAF9 RNA polymerase II TATA box binding..."/> <Graphics CenterX="146.66666666666666" CenterY="176.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046192"/> </DataNode> <DataNode TextLabel="ILK" GraphId="aa4" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ILK | integrin-linked kinase"/> <Graphics CenterX="146.66666666666666" CenterY="196.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000696"/> </DataNode> <DataNode TextLabel="TAF12" GraphId="be4" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6883</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF12 | TAF12 RNA polymerase II TATA box bindi..."/> <Graphics CenterX="146.66666666666666" CenterY="216.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000026660"/> </DataNode> <DataNode TextLabel="TAF13" GraphId="d35" Type="GeneProduct" GroupRef="d78a7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6884</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAF13 | TAF13 RNA polymerase II TATA box bindi..."/> <Graphics CenterX="146.66666666666666" CenterY="236.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000031656"/> </DataNode> <DataNode TextLabel="GTF2E1" GraphId="f36" Type="GeneProduct" GroupRef="e9f40"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2960</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2E1 | general transcription factor IIE poly..."/> <Graphics CenterX="250.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016848"/> </DataNode> <DataNode TextLabel="GTF2A2" GraphId="a94" Type="GeneProduct" GroupRef="b8629"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2958</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2A2 | general transcription factor IIA 2 1..."/> <Graphics CenterX="250.0" CenterY="230.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000010298"/> </DataNode> <DataNode TextLabel="GTF2F2" GraphId="ac8" Type="GeneProduct" GroupRef="c5866"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2963</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2F2 | general transcription factor IIF poly..."/> <Graphics CenterX="250.0" CenterY="276.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000034495"/> </DataNode> <DataNode TextLabel="GTF2E2" GraphId="fcb" Type="GeneProduct" GroupRef="e9f40"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2961</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2E2 | general transcription factor IIE poly..."/> <Graphics CenterX="250.0" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012691"/> </DataNode> <DataNode TextLabel="CDK7" GraphId="a8e" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1022</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK7 | cyclin-dependent kinase 7 (MO15 homolog..."/> <Graphics CenterX="346.6666666666667" CenterY="116.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011046"/> </DataNode> <DataNode TextLabel="GTF2H1" GraphId="eca" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2965</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2H1 | general transcription factor IIH poly..."/> <Graphics CenterX="346.6666666666667" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005160"/> </DataNode> <DataNode TextLabel="GTF2H2" GraphId="c4f" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2966</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2H2 | general transcription factor IIH poly..."/> <Graphics CenterX="346.6666666666667" CenterY="156.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000027983"/> </DataNode> <DataNode TextLabel="GTF2H4" GraphId="cf5" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2968</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2H4 | general transcription factor IIH poly..."/> <Graphics CenterX="346.6666666666667" CenterY="196.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046757"/> </DataNode> <DataNode TextLabel="ERCC3" GraphId="ccb" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2071</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ERCC3 | excision repair cross-complementing rod..."/> <Graphics CenterX="346.6666666666667" CenterY="216.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020777"/> </DataNode> <DataNode TextLabel="ERCC2" GraphId="eb1" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2068</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ERCC2 | excision repair cross-complementing rod..."/> <Graphics CenterX="346.6666666666667" CenterY="236.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002072"/> </DataNode> <DataNode TextLabel="POLR1B" GraphId="e6a" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84172</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR1B | polymerase (RNA) I polypeptide B 128k..."/> <Graphics CenterX="613.3333333333334" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014166"/> </DataNode> <DataNode TextLabel="POLR3B" GraphId="a16" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55703</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR3B | polymerase (RNA) III (DNA directed) po..."/> <Graphics CenterX="983.3333333333334" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004781"/> </DataNode> <DataNode TextLabel="POLR2A" GraphId="a06" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5430</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2A | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046765"/> </DataNode> <DataNode TextLabel="POLR2F" GraphId="fcf" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5435</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2F | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="240.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004820"/> </DataNode> <DataNode TextLabel="POLR2C" GraphId="cb0" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5432</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2C | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="200.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001856"/> </DataNode> <DataNode TextLabel="POLR2E" GraphId="c7c" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5434</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2E | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020776"/> </DataNode> <DataNode TextLabel="POLR2K" GraphId="b1b" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5440</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2K | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="853.3333333333334" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000022539"/> </DataNode> <DataNode TextLabel="POLR3D" GraphId="e75" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:661</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR3D | polymerase (RNA) III (DNA directed) po..."/> <Graphics CenterX="983.3333333333334" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000010036"/> </DataNode> <DataNode TextLabel="POLR3E" GraphId="f41" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55718</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR3E | polymerase (RNA) III (DNA directed) po..."/> <Graphics CenterX="983.3333333333334" CenterY="200.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018044"/> </DataNode> <DataNode TextLabel="POLR3H" GraphId="cd9" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:171568</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR3H | polymerase (RNA) III (DNA directed) po..."/> <Graphics CenterX="983.3333333333334" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005311"/> </DataNode> <DataNode TextLabel="POLR3K" GraphId="bb9" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51728</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR3K | polymerase (RNA) III (DNA directed) po..."/> <Graphics CenterX="983.3333333333334" CenterY="240.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019803"/> </DataNode> <DataNode TextLabel="POLR1A" GraphId="f29" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25885</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR1A | polymerase (RNA) I polypeptide A 194k..."/> <Graphics CenterX="613.3333333333334" CenterY="160.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006481"/> </DataNode> <DataNode TextLabel="POLR2I" GraphId="eb2" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5438</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2I | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="853.3333333333334" CenterY="200.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015002"/> </DataNode> <DataNode TextLabel="POLR2G" GraphId="dbe" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5436</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2G | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="260.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009483"/> </DataNode> <DataNode TextLabel="POLR2H" GraphId="f4a" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5437</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2H | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="853.3333333333334" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000040199"/> </DataNode> <DataNode TextLabel="POLR2J" GraphId="f15" Type="GeneProduct" GroupRef="e671e"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2J | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="853.3333333333334" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="POLR2B" GraphId="c74" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5431</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR2B | polymerase (RNA) II (DNA directed) pol..."/> <Graphics CenterX="760.0" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019366"/> </DataNode> <DataNode TextLabel="CCNH" GraphId="f38" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCNH | cyclin H"/> <Graphics CenterX="346.6666666666667" CenterY="256.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009566"/> </DataNode> <DataNode TextLabel="MNAT1" GraphId="fb2" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4331</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MNAT1 | menage a trois 1 (CAK assembly factor)"/> <Graphics CenterX="346.6666666666667" CenterY="276.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000030801"/> </DataNode> <DataNode TextLabel="GTF2H3" GraphId="d6a" Type="GeneProduct" GroupRef="cd07d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2967</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GTF2H3 | general transcription factor IIH poly..."/> <Graphics CenterX="346.6666666666667" CenterY="176.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007270"/> </DataNode> <DataNode TextLabel="POLR1E" GraphId="d3f" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64425</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR1E"/> <Graphics CenterX="613.3333333333334" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012243"/> </DataNode> <DataNode TextLabel="POLR1D" GraphId="f75" Type="GeneProduct" GroupRef="e671e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51082</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLR1D | polymerase (RNA) I polypeptide D 16kD..."/> <Graphics CenterX="613.3333333333334" CenterY="200.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008642"/> </DataNode> <Interaction GraphId="b8bb3" GroupRef="ec62c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="396.6666666666667" Y="415.0"/> <Point X="483.3333333333333" Y="415.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ea89e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="503.3333333333333" Y="400.0"/> <Point X="503.3333333333333" Y="403.3333333333333"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a9f73" GroupRef="ec62c"> <Graphics ZOrder="12288" 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