S1P receptor signal transduction (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="S1P receptor signal transduction" Organism="Bos taurus" License="CC BY 2.0"> <Comment Source="GenMAPP notes">Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation. </Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP26_r79950 WP26(79950)] with a 100.0% conversion rate.</Comment> <BiopaxRef>a60</BiopaxRef> <Graphics BoardWidth="620.0" BoardHeight="644.0"/> <DataNode TextLabel="SPHK1" GraphId="c26" Type="GeneProduct" GroupRef="c438c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8877</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SPHK1 | sphingosine kinase 1"/> <Graphics CenterX="312.6666666666667" CenterY="78.33333333333331" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008507"/> </DataNode> <DataNode TextLabel="SPHK2" GraphId="aed" Type="GeneProduct" GroupRef="c438c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56848</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SPHK2 | sphingosine kinase 2"/> <Graphics CenterX="312.6666666666667" CenterY="98.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009872"/> </DataNode> <DataNode TextLabel="ASAH1" GraphId="ad2" Type="GeneProduct" GroupRef="c438c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:427</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ASAH1 | N-acylsphingosine amidohydrolase (acid ..."/> <Graphics CenterX="312.6666666666667" CenterY="118.33333333333334" Width="59.99999999999999" Height="21.89655172413793" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011257"/> </DataNode> <DataNode TextLabel="SMPD2" GraphId="ac5" Type="GeneProduct" GroupRef="c438c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6610</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC51190 | neutral sphingomyelinase"/> <Graphics CenterX="313.485312899106" CenterY="137.3850574712644" Width="59.99999999999999" Height="21.89655172413793" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008145"/> </DataNode> <DataNode TextLabel="S1PR1" GraphId="c95" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1901</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDG1 | endothelial differentiation sphingolipi..."/> <Graphics CenterX="312.6666666666667" CenterY="222.66666666666669" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005990"/> </DataNode> <DataNode TextLabel="S1PR2" GraphId="c06" Type="GeneProduct" GroupRef="ffaf0"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9294</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDG5 | endothelial differentiation sphingolipi..."/> <Graphics CenterX="490.0" CenterY="116.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002738"/> </DataNode> <DataNode TextLabel="S1PR3" GraphId="f8a" Type="GeneProduct" GroupRef="ffaf0"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1903</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDG3 | endothelial differentiation sphingolipi..."/> <Graphics CenterX="490.0" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011374"/> </DataNode> <DataNode TextLabel="S1PR5" GraphId="a2e" Type="GeneProduct" GroupRef="ffaf0"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53637</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDG8 | endothelial differentiation sphingolipi..."/> <Graphics CenterX="490.0" CenterY="156.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000003544"/> </DataNode> <DataNode TextLabel="PLCB1" GraphId="dd1" Type="GeneProduct" GroupRef="c5929"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23236</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLCB1 | phospholipase C beta 1 (phosphoinositi..."/> <Graphics CenterX="153.33333333333334" CenterY="343.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008338"/> </DataNode> <DataNode TextLabel="PLCB2" GraphId="a01" Type="GeneProduct" GroupRef="c5929"> <Comment 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Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3"/> <Graphics CenterX="138.0" CenterY="468.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000016156"/> </DataNode> <DataNode TextLabel="MAPK1" GraphId="a1d" Type="GeneProduct" GroupRef="fb4c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1 | mitogen-activated protein kinase 1"/> <Graphics CenterX="138.0" CenterY="488.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000010312"/> </DataNode> <DataNode TextLabel="MAPK6" GraphId="d4e" Type="GeneProduct" GroupRef="fb4c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK6 | mitogen-activated protein kinase 6"/> <Graphics CenterX="138.0" CenterY="508.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005865"/> </DataNode> <DataNode TextLabel="MAPK4" GraphId="f57" Type="GeneProduct" GroupRef="fb4c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK4 | mitogen-activated protein kinase 4"/> <Graphics CenterX="138.0" CenterY="528.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009907"/> </DataNode> <DataNode TextLabel="MAPK7" GraphId="bec" Type="GeneProduct" GroupRef="fb4c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK7 | mitogen-activated protein kinase 7"/> <Graphics CenterX="138.0" CenterY="548.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001014"/> </DataNode> <DataNode TextLabel="MAPK12" GraphId="f93" Type="GeneProduct" GroupRef="fb4c4"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK12 | mitogen-activated protein kinase 12"/> <Graphics CenterX="138.0" CenterY="568.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019574"/> </DataNode> <DataNode TextLabel="GNAI1" GraphId="f8c" Type="GeneProduct" GroupRef="f713d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAI1 | guanine nucleotide binding protein (G p..."/> <Graphics CenterX="314.0" CenterY="460.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002714"/> </DataNode> <DataNode TextLabel="GNAI2" GraphId="cd6" Type="GeneProduct" GroupRef="f713d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNAI2 | guanine nucleotide binding protein (G p..."/> <Graphics CenterX="314.0" CenterY="480.33333333333337" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020645"/> </DataNode> <DataNode TextLabel="GNAI3" GraphId="a2d" Type="GeneProduct" GroupRef="f713d"> <Comment 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ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape GraphId="bcebc"> <Graphics CenterX="492.25" CenterY="125.0" Width="149.5" Height="106.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Group GroupId="c438c" GraphId="d14fe"/> <Group GroupId="ffaf0" GraphId="a2224" Style="Group"/> <Group GroupId="f713d" GraphId="c5e74" Style="Group"/> <Group GroupId="ed344" GraphId="cc31e" Style="Group"/> <Group GroupId="c5929" GraphId="af1f7" Style="Group"/> <Group GroupId="fb4c4" GraphId="c16ce" Style="Group"/> <InfoBox CenterX="4.633333333333334" CenterY="5.833333333333333"/> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">sphingosine 1-phosphate signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000960</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a60"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11729304</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lysophospholipids--receptor revelations.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hla T</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee MJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ancellin N</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Paik JH</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kluk MJ</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">G protein mediated signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000125</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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