Type II interferon signaling (IFNG) (Canis familiaris)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Type II interferon signaling (IFNG)" Organism="Canis familiaris"> <Comment Source="WikiPathways-description">Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&amp;amp;amp;amp;amp;oldid=28124 WP619(r28124)] with a 91% conversion rate.</Comment> <BiopaxRef>f74</BiopaxRef> <Graphics BoardWidth="1830.0" BoardHeight="969.0"/> <DataNode TextLabel="IFNG" GraphId="ad082" Type="GeneProduct" GroupRef="e2df7"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="207.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403801"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="b506a" Type="GeneProduct" GroupRef="e2df7"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="227.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403801"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="b739b" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="342.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403801"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="e6eda" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="346.0" CenterY="187.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="476216"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="c97af" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="346.0" CenterY="207.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="487739"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="d6a35" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="346.0" CenterY="227.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="442952"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="fa442" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="346.0" CenterY="247.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="484185"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="dd317" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="344.0" CenterY="388.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="484185"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="f8b8c" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="344.0" CenterY="348.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="487739"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="e9f60" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="344.0" CenterY="328.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="476216"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="db588" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="344.0" CenterY="368.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="442952"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="a32aa" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="344.0" CenterY="408.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403801"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="ad68c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="535.0" CenterY="252.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="484185"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="ddd82" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="535.0" CenterY="204.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="487739"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="d35ca" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="535.0" CenterY="180.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="476216"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="b9575" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="535.0" CenterY="228.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="442952"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="cc9ce" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="344.0" CenterY="559.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="487739"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="e8714" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="344.0" CenterY="619.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403801"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="cfb8b" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="344.0" CenterY="579.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="442952"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="d928c" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="344.0" CenterY="599.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="484185"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="cd5f3" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="344.0" CenterY="539.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="476216"/> </DataNode> <DataNode TextLabel="SOCS3" GraphId="ef5d9" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOCS3"/> <Graphics CenterX="568.0" CenterY="428.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="442949"/> </DataNode> <DataNode TextLabel="SOCS1" GraphId="c2574" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOCS1"/> <Graphics CenterX="568.0" CenterY="490.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="490006"/> </DataNode> <DataNode TextLabel="PTPN11" GraphId="c653c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTPN11"/> <Graphics CenterX="455.0" CenterY="650.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="477488"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="af7d0" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="567.0" CenterY="639.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="e5f09" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="731.0" CenterY="591.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT2" GraphId="a116d" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT2"/> <Graphics CenterX="636.0" CenterY="362.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="481111"/> </DataNode> <DataNode TextLabel="STAT2" GraphId="c0538" Type="GeneProduct" GroupRef="d6745"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT2"/> <Graphics CenterX="839.0" CenterY="372.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="481111"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="c01a3" Type="GeneProduct" GroupRef="d6745"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="839.0" CenterY="352.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT2" GraphId="f1b4c" Type="GeneProduct" GroupRef="eb6ed"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT2"/> <Graphics CenterX="1031.0" CenterY="352.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="481111"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="b86da" Type="GeneProduct" GroupRef="eb6ed"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1031.0" CenterY="332.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="f12bf" Type="GeneProduct" GroupRef="eb6ed"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1031.0" CenterY="372.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="c55d5" Type="GeneProduct" GroupRef="eb6ed"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1031.0" CenterY="392.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="fd7aa" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="826.0" CenterY="251.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="a3a1b" Type="GeneProduct" GroupRef="b0e36"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1033.0" CenterY="213.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="f278f" Type="GeneProduct" GroupRef="b0e36"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1033.0" CenterY="193.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="a6b62" Type="GeneProduct" GroupRef="b0e36"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1033.0" CenterY="233.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="e43af" Type="GeneProduct" GroupRef="f670b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="955.0" CenterY="600.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="bb1a6" Type="GeneProduct" GroupRef="f670b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="955.0" CenterY="580.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="b053a" Type="GeneProduct" GroupRef="fc3bb"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1090.0" CenterY="644.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="e9498" Type="GeneProduct" GroupRef="fc3bb"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1090.0" CenterY="664.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="PRKCD" GraphId="f3293" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD"/> <Graphics CenterX="955.0" CenterY="725.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="494005"/> </DataNode> <DataNode TextLabel="PTP" GraphId="fc163" Type="GeneProduct"> <Graphics CenterX="1417.0" CenterY="683.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="IRF4" GraphId="f5f51" Type="GeneProduct"> <Graphics CenterX="1258.0" CenterY="575.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="SPI1" GraphId="a3d94" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SPI1"/> <Graphics CenterX="1258.0" CenterY="619.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="611255"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="f4bc4" Type="GeneProduct" GroupRef="d26f3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1476.0" CenterY="816.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="ce73a" Type="GeneProduct" GroupRef="d26f3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1476.0" CenterY="836.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="df0bd" Type="GeneProduct" GroupRef="d33ca"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1264.0" CenterY="730.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="bcdd8" Type="GeneProduct" GroupRef="d33ca"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1264.0" CenterY="750.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT2" GraphId="e17e7" Type="GeneProduct" GroupRef="be9a3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT2"/> <Graphics CenterX="1259.0" CenterY="320.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="481111"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="d7cdb" Type="GeneProduct" GroupRef="be9a3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1259.0" CenterY="300.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="ab68a" Type="GeneProduct" GroupRef="be9a3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1259.0" CenterY="340.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="cd168" Type="GeneProduct" GroupRef="be9a3"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1259.0" CenterY="360.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="f1b5a" Type="GeneProduct" GroupRef="be472"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1259.0" CenterY="213.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="STAT1" GraphId="e6a2b" Type="GeneProduct" GroupRef="be472"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="STAT1"/> <Graphics CenterX="1259.0" CenterY="193.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="488449"/> </DataNode> <DataNode TextLabel="IRF9" GraphId="fff72" Type="GeneProduct" GroupRef="be472"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRF9"/> <Graphics CenterX="1259.0" CenterY="233.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="607899"/> </DataNode> <DataNode TextLabel="IFNA" GraphId="c23d3" Type="GeneProduct"> <Graphics CenterX="1744.0" CenterY="157.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="IFNB1" GraphId="d6a3c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNB1"/> <Graphics CenterX="1744.0" CenterY="197.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="481558"/> </DataNode> <DataNode TextLabel="HLA-B" GraphId="f68fe" Type="GeneProduct"> <Graphics CenterX="1744.0" CenterY="237.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="NOS2" GraphId="e4dd1" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NOS2"/> <Graphics CenterX="1744.0" CenterY="277.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403822"/> </DataNode> <DataNode TextLabel="GBP1" GraphId="ca90d" Type="GeneProduct"> <Attribute 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Return to Type II interferon signaling (IFNG) (Canis familiaris).