Transcriptional activation by Nfe2l2 in response to phytochemicals (Rattus norvegicus)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Transcriptional activation by Nfe2l2 in response to phytochemicals" Last-Modified="5/17/2012" Organism="Rattus norvegicus"> <Comment Source="WikiPathways-description">Based on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP3&amp;amp;oldid=29720 WP3(r29720)] with a 88% conversion rate.</Comment> <BiopaxRef>dba</BiopaxRef> <Graphics BoardWidth="914.0" BoardHeight="728.0"/> <DataNode TextLabel="Prkca" GraphId="a62fe" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Prkca"/> <Graphics CenterX="327.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24680"/> </DataNode> <DataNode TextLabel="Mapk8" GraphId="a859f" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Mapk8"/> <Graphics CenterX="434.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="116554"/> </DataNode> <DataNode TextLabel="Sulforaphane" GraphId="b03a0" Type="Metabolite"> <Graphics CenterX="767.0" CenterY="216.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0005792"/> </DataNode> <DataNode TextLabel="Jtv1" GraphId="b06bd" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Jtv1"/> <Graphics CenterX="220.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="288480"/> </DataNode> <DataNode TextLabel="Cebpb" GraphId="b3620" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cebpb"/> <Graphics CenterX="217.0" CenterY="499.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24253"/> </DataNode> <DataNode TextLabel="6-HITC" GraphId="b366d" Type="Metabolite"> <Comment>Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi</Comment> <Graphics CenterX="461.0" CenterY="291.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Nfe2l2" GraphId="b68db" Type="GeneProduct" GroupRef="d6759"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nfe2l2"/> <Graphics CenterX="366.0" CenterY="492.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="83619"/> </DataNode> <DataNode TextLabel="Keap1" GraphId="be345" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Keap1"/> <Graphics CenterX="493.0" CenterY="188.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="117519"/> </DataNode> <DataNode TextLabel="Cebpb" GraphId="c9ebb" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cebpb"/> <Graphics CenterX="108.0" CenterY="284.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24253"/> </DataNode> <DataNode TextLabel="Gclc" GraphId="cecad" Type="GeneProduct" GroupRef="b8fb5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gclc"/> <Graphics CenterX="656.0" CenterY="558.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="25283"/> </DataNode> <DataNode TextLabel="Nfe2l2" GraphId="d3b16" Type="GeneProduct" GroupRef="d9c0e"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nfe2l2"/> <Graphics CenterX="365.0" CenterY="216.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="83619"/> </DataNode> <DataNode TextLabel="Hmox1" GraphId="d4c77" Type="GeneProduct" GroupRef="b8fb5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Hmox1"/> <Graphics CenterX="656.0" CenterY="598.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24451"/> </DataNode> <DataNode TextLabel="Caffeic acid phenethyl ester" GraphId="d739f" Type="Metabolite"> <Graphics CenterX="804.5" CenterY="188.0" Width="159.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Maf" GraphId="d79c3" Type="GeneProduct" GroupRef="d6759"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Maf"/> <Graphics CenterX="446.0" CenterY="492.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="54267"/> </DataNode> <DataNode TextLabel="Ephb2" GraphId="dbe12" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ephb2"/> <Graphics CenterX="539.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="313633"/> </DataNode> <DataNode TextLabel="PI3K" GraphId="dea4c" Type="GeneProduct"> <Graphics CenterX="108.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="GSTA2" GraphId="dfa5a" Type="GeneProduct" GroupRef="b8fb5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gsta2"/> <Graphics CenterX="656.0" CenterY="518.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24422"/> </DataNode> <DataNode TextLabel="Nqo1" GraphId="f553c" Type="GeneProduct" GroupRef="b8fb5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nqo1"/> <Graphics CenterX="656.0" CenterY="538.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="24314"/> </DataNode> <DataNode TextLabel="Gclm" GraphId="f5ed1" Type="GeneProduct" GroupRef="b8fb5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gclm"/> <Graphics CenterX="656.0" CenterY="578.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="29739"/> </DataNode> <DataNode TextLabel="Nfe2l2" GraphId="fbb3a" Type="GeneProduct" GroupRef="cf595"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Nfe2l2"/> <Graphics CenterX="618.0" CenterY="212.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="83619"/> </DataNode> <DataNode TextLabel="Keap1" GraphId="fdb18" Type="GeneProduct" GroupRef="cf595"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Keap1"/> <Graphics CenterX="618.0" CenterY="192.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="117519"/> </DataNode> <DataNode TextLabel="Curcumin" GraphId="ff3f4" Type="Metabolite"> <Graphics CenterX="732.0" CenterY="122.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0002269"/> </DataNode> <Interaction GraphId="b2be9"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="327.0" Y="79.0" GraphRef="a62fe" RelX="0.0" RelY="1.0"/> <Point X="365.0" Y="206.0" GraphRef="d3b16" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b7518"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="108.0" Y="79.0" GraphRef="dea4c" RelX="0.0" RelY="1.0"/> <Point X="325.0" Y="216.0" GraphRef="d3b16" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b8a8f"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="cccccc"> <Point X="498.0" Y="483.0" GraphRef="e3879" RelX="1.0" RelY="0.0"/> <Point X="616.0" Y="598.0" GraphRef="d4c77" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bcfe7"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="365.0" Y="226.0" GraphRef="d3b16" RelX="0.0" RelY="1.0"/> <Point X="366.0" Y="482.0" GraphRef="b68db" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> <Anchor Position="0.25393289286967663" Shape="None" GraphId="f1d61"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bd859"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="108.0" Y="294.0" GraphRef="c9ebb" RelX="0.0" RelY="1.0"/> <Point X="217.0" Y="489.0" GraphRef="b3620" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="bff9c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="108.0" Y="79.0" GraphRef="dea4c" RelX="0.0" RelY="1.0"/> <Point X="108.0" Y="274.0" GraphRef="c9ebb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c1c18" GroupRef="ec9a3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="545.0" Y="476.0"/> <Point X="596.0" Y="476.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c1cbf"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="566.0" Y="202.0" GraphRef="d7839" RelX="-1.0" RelY="0.0"/> <Point X="533.0" Y="188.0" GraphRef="be345" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c4827"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="566.0" Y="202.0" GraphRef="d7839" RelX="-1.0" RelY="0.0"/> <Point X="405.0" Y="216.0" GraphRef="d3b16" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c8e6f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="434.0" Y="79.0" GraphRef="a859f" RelX="0.0" RelY="1.0"/> <Point X="365.0" Y="206.0" GraphRef="d3b16" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cb4a3"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="cccccc"> <Point X="498.0" Y="483.0" GraphRef="e3879" RelX="1.0" RelY="0.0"/> <Point X="616.0" Y="538.0" GraphRef="f553c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cf48f"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="cccccc"> <Point X="498.0" Y="483.0" GraphRef="e3879" RelX="1.0" RelY="0.0"/> <Point X="616.0" Y="578.0" GraphRef="f5ed1" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cf751"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="cccccc"> <Point X="498.0" Y="483.0" GraphRef="e3879" RelX="1.0" RelY="0.0"/> <Point X="616.0" Y="518.0" GraphRef="dfa5a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d2864"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> <Point X="692.0" Y="122.0" GraphRef="ff3f4" RelX="-1.0" RelY="0.0"/> <Point X="644.0" Y="170.0" GraphRef="d7839" RelX="0.5" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d3ea2"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="220.0" Y="79.0" GraphRef="b06bd" RelX="0.0" RelY="1.0"/> <Point X="345.0" Y="206.0" GraphRef="d3b16" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="dc948"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="727.0" Y="216.0" GraphRef="b03a0" RelX="-1.0" RelY="0.0"/> <Point X="670.0" Y="218.0" GraphRef="d7839" RelX="1.0" RelY="0.5" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e1c56" GroupRef="ec9a3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="148.0" Y="509.0"/> <Point X="726.0" Y="509.00000000000006"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f0473"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="421.0" Y="291.0" GraphRef="b366d" RelX="-1.0" RelY="0.0"/> <Point X="365.25393289286967" Y="291.00682057463723" GraphRef="f1d61" RelX="0.0" RelY="0.0" ArrowHead="mim-stimulation"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f19c4"> <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0" Color="cccccc"> <Point X="498.0" Y="483.0" GraphRef="e3879" RelX="1.0" RelY="0.0"/> <Point X="616.0" Y="558.0" GraphRef="cecad" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f3c7e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="539.0" Y="79.0" GraphRef="dbe12" RelX="0.0" RelY="1.0"/> <Point X="385.0" Y="206.0" GraphRef="d3b16" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="fbcd9" GroupRef="ec9a3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="545.0" Y="511.0"/> <Point X="545.0" Y="475.0"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ff20b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="725.0" Y="188.0" GraphRef="d739f" RelX="-1.0" RelY="0.0"/> <Point X="670.0" Y="186.0" GraphRef="d7839" RelX="1.0" RelY="-0.5" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="S-P" GraphId="b2d27" GroupRef="d6759"> <Graphics CenterX="341.0" CenterY="474.0" Width="26.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle"/> </Label> <Label TextLabel="S-P" GraphId="bf455" GroupRef="d9c0e"> <Graphics CenterX="340.0" CenterY="232.0" Width="26.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle"/> </Label> <Label TextLabel="Nucleus" GraphId="caf0a"> <Graphics CenterX="437.0" CenterY="352.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontName="Dialog" FontWeight="Bold" FontStyle="Italic" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="ARE" GraphId="dcb34" GroupRef="ec9a3"> <Graphics CenterX="363.0" CenterY="517.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="T-P" GraphId="dd206" GroupRef="d6759"> <Graphics CenterX="387.0" CenterY="474.0" Width="26.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle"/> </Label> <Label TextLabel="Phase II enzymes" GraphId="edfb9" GroupRef="b8fb5"> <Graphics CenterX="658.0" CenterY="496.0" Width="116.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="CCAAT/XRE" GraphId="f13bb" GroupRef="ec9a3"> <Graphics CenterX="217.0" CenterY="517.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="T-P" GraphId="f433f" GroupRef="d9c0e"> <Graphics CenterX="386.0" CenterY="232.0" Width="26.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle"/> </Label> <Shape GraphId="df31a"> <Graphics CenterX="432.48333333333335" CenterY="522.4833333333333" Width="803.0333333333333" Height="351.03333333333336" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Oval" Rotation="0.0"/> </Shape> <Group GroupId="b8fb5" GraphId="b7936" Style="Group"/> <Group GroupId="d9c0e" GraphId="c3ec0" Style="Group"/> <Group GroupId="ec9a3" GraphId="c7147" Style="Group"/> <Group GroupId="cf595" GraphId="d7839" Style="Complex"/> <Group GroupId="d6759" GraphId="e3879" Style="Complex"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nuclear factor, erythroid derived 2, like 2 signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000369</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dba"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14570043</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cancer chemoprevention with dietary phytochemicals.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Cancer</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Surh YJ</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

• Template:AuthorInfo
• Template:CheckAvailable (protected)
• Template:PathwayPage:History
• Template:PathwayPage:Xrefs

Return to Transcriptional activation by Nfe2l2 in response to phytochemicals (Rattus norvegicus).