Integrin-mediated cell adhesion (Danio rerio)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Integrin-mediated cell adhesion" Last-Modified="10/17/2013" Organism="Danio rerio"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP185&amp;amp;oldid=21067 WP185(r21067)] with a 68% conversion rate.</Comment> <Comment Source="WikiPathways-description">Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]</Comment> <BiopaxRef>d3e</BiopaxRef> <Graphics BoardWidth="1145.1666666666667" BoardHeight="706.6666666666667"/> <DataNode TextLabel="cdc42l" GraphId="e0a" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CDC42; cell division cycle 42 (GTP binding protein 25kD)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="cdc42l"/> <Graphics CenterX="710.0" CenterY="170.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="793158"/> </DataNode> <DataNode TextLabel="LOC563639" GraphId="d86" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SHC1; SHC (Src homology 2 domain containing) transforming protein 1</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC563639"/> <Graphics CenterX="200.0" CenterY="340.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="563639"/> </DataNode> <DataNode TextLabel="LOC100007176" GraphId="ff0" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SHC3; neuronal Sh</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC100007176"/> <Graphics CenterX="200.0" CenterY="360.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100007176"/> </DataNode> <DataNode TextLabel="zgc:92074" GraphId="d05" Type="GeneProduct"> <Comment Source="GenMAPP remarks">ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:92074"/> <Graphics CenterX="396.6666666666667" CenterY="510.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403063"/> </DataNode> <DataNode TextLabel="braf" GraphId="cde" Type="GeneProduct"> <Comment Source="GenMAPP remarks">BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="braf"/> <Graphics CenterX="396.6666666666667" CenterY="490.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="403065"/> </DataNode> <DataNode TextLabel="raf1" GraphId="dd7" Type="GeneProduct"> <Comment Source="GenMAPP remarks">RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="raf1"/> <Graphics CenterX="396.6666666666667" CenterY="470.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="30716"/> </DataNode> <DataNode TextLabel="mapk4" GraphId="fc1" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="mapk4"/> <Graphics CenterX="596.6666666666666" CenterY="490.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="406782"/> </DataNode> <DataNode TextLabel="mapk7" GraphId="d6b" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="mapk7"/> <Graphics CenterX="596.6666666666666" CenterY="530.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="541323"/> </DataNode> <DataNode TextLabel="CAPNS1" GraphId="e13" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPNS1; calpain small subunit 1 [EC:3.4.22.17]</Comment> <Graphics CenterX="206.66666666666666" CenterY="223.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MYLK2" GraphId="fa2" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="mylk2"/> <Graphics CenterX="790.0" CenterY="430.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100169950"/> </DataNode> <DataNode TextLabel="ARHGEF7" GraphId="f96" Type="GeneProduct"> <Comment Source="GenMAPP remarks">ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7</Comment> <Graphics CenterX="886.6666666666666" CenterY="136.66666666666666" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="rac1" GraphId="ed7" Type="GeneProduct"> <Comment Source="GenMAPP remarks">RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rac1"/> <Graphics CenterX="830.0" CenterY="193.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="327204"/> </DataNode> <DataNode TextLabel="rac2" GraphId="bbf" Type="GeneProduct"> <Comment Source="GenMAPP remarks">RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rac2"/> <Graphics CenterX="830.0" CenterY="213.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="415151"/> </DataNode> <DataNode TextLabel="RAC3" GraphId="fcc" Type="GeneProduct"> <Comment Source="GenMAPP remarks">RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rac3"/> <Graphics CenterX="830.0" CenterY="233.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="437027"/> </DataNode> <DataNode TextLabel="zgc:153787" GraphId="cad" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:153787"/> <Graphics CenterX="710.0" CenterY="253.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="768202"/> </DataNode> <DataNode TextLabel="VAV2" GraphId="de7" Type="GeneProduct" GroupRef="d5b16"> <Comment Source="GenMAPP remarks">VAV2; vav 2 oncogene</Comment> <Graphics CenterX="710.0" CenterY="203.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="wu:fk86g11" GraphId="cd2" Type="GeneProduct" GroupRef="d5b16"> <Comment Source="GenMAPP remarks">VAV3; vav 3 oncogene</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="wu:fk86g11"/> <Graphics CenterX="710.0" CenterY="223.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="559145"/> </DataNode> <DataNode TextLabel="rock2a" GraphId="ede" Type="GeneProduct" GroupRef="e1eeb"> <Comment Source="GenMAPP remarks">ROCK2; Rho-associated coiled-coil containing protein kinase</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rock2a"/> <Graphics CenterX="626.6666666666666" CenterY="373.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="317747"/> </DataNode> <DataNode TextLabel="ROCK1" GraphId="ae6" Type="GeneProduct" GroupRef="e1eeb"> <Comment Source="GenMAPP remarks">ROCK1; Rho-associated coiled-coil containing protein kinase</Comment> <Graphics CenterX="626.6666666666666" CenterY="353.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="LOC100002756" GraphId="e65" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SH3D5; SH3-domain protein 5 (ponsin</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC100002756"/> <Graphics CenterX="306.6666666666667" CenterY="80.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100002756"/> </DataNode> <DataNode TextLabel="SOS1" GraphId="a4d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SOS1; son of sevenless homolog 1 (Drosophila)</Comment> <Graphics CenterX="160.0" CenterY="446.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="DKEY-234H16.4" GraphId="edf" Type="GeneProduct"> <Comment Source="GenMAPP remarks">GIT2; G protein-coupled receptor kinase-interactor 2</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="DKEY-234H16.4"/> <Graphics CenterX="760.0" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="793882"/> </DataNode> <DataNode TextLabel="pik3r2" GraphId="da5" Type="GeneProduct" GroupRef="de408"> <Comment Source="GenMAPP remarks">PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="pik3r2"/> <Graphics CenterX="470.0" CenterY="266.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="404211"/> </DataNode> <DataNode TextLabel="zgc:171680" GraphId="a66" Type="GeneProduct"> <Comment Source="GenMAPP remarks">ZYX; zyxin</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:171680"/> <Graphics CenterX="173.33333333333334" CenterY="100.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="564246"/> </DataNode> <DataNode TextLabel="cav1" GraphId="d79" Type="GeneProduct" GroupRef="feaf9"> <Comment Source="GenMAPP remarks">CAV1; caveolin 1 caveolae protein 22kD</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="cav1"/> <Graphics CenterX="116.66666666666667" CenterY="256.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="323695"/> </DataNode> <DataNode TextLabel="cav2" GraphId="cf0" Type="GeneProduct" GroupRef="feaf9"> <Comment Source="GenMAPP remarks">CAV2; caveolin 2</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="cav2"/> <Graphics CenterX="116.66666666666667" CenterY="276.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="415240"/> </DataNode> <DataNode TextLabel="cav3" GraphId="d4f" Type="GeneProduct" GroupRef="feaf9"> <Comment Source="GenMAPP remarks">CAV3; caveolin 3</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="cav3"/> <Graphics CenterX="116.66666666666667" CenterY="296.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="449679"/> </DataNode> <DataNode TextLabel="fynb" GraphId="d21" Type="GeneProduct"> <Comment Source="GenMAPP remarks">FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="fynb"/> <Graphics CenterX="160.0" CenterY="380.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="574422"/> </DataNode> <DataNode TextLabel="grb2" GraphId="f57" Type="GeneProduct"> <Comment Source="GenMAPP remarks">GRB2; growth factor receptor-bound protein 2</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="grb2"/> <Graphics CenterX="240.0" CenterY="380.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="406308"/> </DataNode> <DataNode TextLabel="sepp1a" GraphId="ae2" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SEPP1; selenoprotein P plasma</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="sepp1a"/> <Graphics CenterX="496.6666666666667" CenterY="570.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="352931"/> </DataNode> <DataNode TextLabel="HRAS" GraphId="d66" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="hras"/> <Graphics CenterX="273.3333333333333" CenterY="446.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="550286"/> </DataNode> <DataNode TextLabel="ptk2.1" GraphId="ff6" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ptk2.1"/> <Graphics CenterX="340.0" CenterY="286.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="142986"/> </DataNode> <DataNode TextLabel="ptk2.1" GraphId="a2d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ptk2.1"/> <Graphics CenterX="340.0" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="142986"/> </DataNode> <DataNode TextLabel="p110" GraphId="f05" Type="GeneProduct" GroupRef="de408"> <Graphics CenterX="470.0" CenterY="286.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="rho" GraphId="d5d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rho"/> <Graphics CenterX="493.3333333333333" CenterY="363.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="30295"/> </DataNode> <DataNode TextLabel="PI5K" GraphId="e6a" Type="GeneProduct"> <Graphics CenterX="550.0" CenterY="326.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CSK" GraphId="d4e" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CSK; c-src tyrosine kinase [EC:2.7.1.112]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="csk"/> <Graphics CenterX="463.3333333333333" CenterY="136.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="556454"/> </DataNode> <DataNode TextLabel="zgc:175192" GraphId="c36" Type="GeneProduct"> <Comment Source="GenMAPP remarks">BCAR1; breast cancer anti-estrogen resistance 1</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:175192"/> <Graphics CenterX="463.3333333333333" CenterY="106.66666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="568309"/> </DataNode> <DataNode TextLabel="src" GraphId="e72" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="src"/> <Graphics CenterX="523.3333333333334" CenterY="120.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="325084"/> </DataNode> <DataNode TextLabel="LOC792354" GraphId="f4a" Type="GeneProduct" GroupRef="c03b0"> <Comment Source="GenMAPP remarks">AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC792354"/> <Graphics CenterX="900.0" CenterY="266.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="792354"/> </DataNode> <DataNode TextLabel="akt2" GraphId="ecf" Type="GeneProduct" GroupRef="c03b0"> <Comment Source="GenMAPP remarks">AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="akt2"/> <Graphics CenterX="900.0" CenterY="286.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="378972"/> </DataNode> <DataNode TextLabel="MYO-P" GraphId="ab0" Type="GeneProduct"> <Graphics CenterX="763.3333333333334" CenterY="363.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MYO" GraphId="ee2" Type="GeneProduct"> <Graphics CenterX="900.0" CenterY="363.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="capn2l" GraphId="d8d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="capn2l"/> <Graphics CenterX="106.66666666666667" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="550505"/> </DataNode> <DataNode TextLabel="capn3" GraphId="cb5" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN3; calpain 3 (p94) [EC:3.4.22.17]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="capn3"/> <Graphics CenterX="106.66666666666667" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="447832"/> </DataNode> <DataNode TextLabel="CAPN5" GraphId="ac4" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN5; calpain</Comment> <Graphics CenterX="106.66666666666667" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="capn7" GraphId="dc7" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN7; calpain 7 [EC:3.4.22.17</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="capn7"/> <Graphics CenterX="200.0" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="556792"/> </DataNode> <DataNode TextLabel="capn9" GraphId="a13" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="capn9"/> <Graphics CenterX="200.0" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="445107"/> </DataNode> <DataNode TextLabel="LOC570311" GraphId="d15" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN10; calpain 10 [EC:3.4.22.17</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC570311"/> <Graphics CenterX="200.0" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="570311"/> </DataNode> <DataNode TextLabel="CAPN11" GraphId="d07" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN11; calpain 11 [EC:3.4.22.17]</Comment> <Graphics CenterX="200.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CAPN6" GraphId="b75" Type="GeneProduct"> <Comment Source="GenMAPP remarks">CAPN6; calpain 6 [EC:3.4.22.17]</Comment> <Graphics CenterX="106.66666666666667" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="pak2a" GraphId="e2e" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="pak2a"/> <Graphics CenterX="293.3333333333333" CenterY="596.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="266749"/> </DataNode> <DataNode TextLabel="PAK3" GraphId="eac" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]</Comment> <Graphics CenterX="293.3333333333333" CenterY="616.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="zgc:92014" GraphId="fb9" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:92014"/> <Graphics CenterX="293.3333333333333" CenterY="636.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="431769"/> </DataNode> <DataNode TextLabel="PAK6" GraphId="c2b" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PAK6; p21(CDKN1A)-activated kinase</Comment> <Graphics CenterX="293.3333333333333" CenterY="656.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ACTN" GraphId="a16" Type="GeneProduct"> <Graphics CenterX="170.0" CenterY="156.66666666666666" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="tln1" GraphId="fe5" Type="GeneProduct"> <Comment Source="GenMAPP remarks">TLN1; talin 1</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="tln1"/> <Graphics CenterX="210.0" CenterY="180.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="494453"/> </DataNode> <DataNode TextLabel="MAP2K3" GraphId="e47" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]</Comment> <Graphics CenterX="496.6666666666667" CenterY="510.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="zgc:172137" GraphId="e0d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:172137"/> <Graphics CenterX="496.6666666666667" CenterY="530.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100007679"/> </DataNode> <DataNode TextLabel="map2k6" GraphId="ea6" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAP2K6; 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Source="GenMAPP remarks">RAP1B; RAP1B member of RAS oncogene family</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="rap1b"/> <Graphics CenterX="800.0" CenterY="80.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="321107"/> </DataNode> <DataNode TextLabel="mapk1" GraphId="e4d" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="mapk1"/> <Graphics CenterX="596.6666666666666" CenterY="470.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="360144"/> </DataNode> <DataNode TextLabel="mapk6" GraphId="d81" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="mapk6"/> <Graphics CenterX="596.6666666666666" CenterY="510.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="565830"/> </DataNode> <DataNode TextLabel="map2k1" GraphId="c2f" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="map2k1"/> <Graphics CenterX="496.6666666666667" CenterY="470.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="406728"/> </DataNode> <DataNode TextLabel="zgc:172250" GraphId="d9b" Type="GeneProduct"> <Comment Source="GenMAPP remarks">MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:172250"/> <Graphics CenterX="496.6666666666667" CenterY="490.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref 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FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="407685"/> </DataNode> <DataNode TextLabel="ITGA4" GraphId="a0e" Type="GeneProduct"> <Graphics CenterX="720.0" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="itga5" GraphId="dc8" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itga5"/> <Graphics CenterX="720.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="386787"/> </DataNode> <DataNode TextLabel="itga6" GraphId="f24" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itga6"/> <Graphics CenterX="720.0" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="503893"/> </DataNode> <DataNode TextLabel="ITGA8" GraphId="f6e" Type="GeneProduct"> <Graphics CenterX="796.6666666666666" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="zgc:63474" GraphId="dab" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="zgc:63474"/> <Graphics CenterX="796.6666666666666" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="394012"/> </DataNode> <DataNode TextLabel="LOC572348" GraphId="dcb" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC572348"/> <Graphics CenterX="796.6666666666666" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="572348"/> </DataNode> <DataNode TextLabel="ITGA11" GraphId="f82" Type="GeneProduct"> <Graphics CenterX="796.6666666666666" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="itga2b" GraphId="b20" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itga2b"/> <Graphics CenterX="796.6666666666666" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="445380"/> </DataNode> <DataNode TextLabel="ITGAE" GraphId="a48" Type="GeneProduct"> <Graphics CenterX="873.3333333333334" CenterY="560.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="LOC557935" GraphId="acd" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC557935"/> <Graphics CenterX="873.3333333333334" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="557935"/> </DataNode> <DataNode TextLabel="ITGAL" GraphId="d01" Type="GeneProduct"> <Graphics CenterX="873.3333333333334" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ITGAM" GraphId="a75" Type="GeneProduct"> <Graphics CenterX="873.3333333333334" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="itgav" GraphId="b01" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itgav"/> <Graphics CenterX="873.3333333333334" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100151255"/> </DataNode> <DataNode TextLabel="ITGAX" GraphId="d16" Type="GeneProduct"> <Graphics CenterX="873.3333333333334" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ITGB1" GraphId="d8c" Type="GeneProduct"> <Graphics CenterX="970.0" CenterY="560.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="LOC557797" GraphId="e20" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC557797"/> <Graphics CenterX="970.0" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="557797"/> </DataNode> <DataNode TextLabel="itgb3b" GraphId="a3c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itgb3b"/> <Graphics CenterX="970.0" CenterY="600.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="100001836"/> </DataNode> <DataNode TextLabel="ITGB4" GraphId="c57" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itgb4"/> <Graphics CenterX="970.0" CenterY="620.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="335269"/> </DataNode> <DataNode TextLabel="itgb5" GraphId="f5c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itgb5"/> <Graphics CenterX="970.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="563556"/> </DataNode> <DataNode TextLabel="LOC571984" GraphId="d80" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC571984"/> <Graphics CenterX="970.0" CenterY="660.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="571984"/> </DataNode> <DataNode TextLabel="LOC797491" GraphId="aaa" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="LOC797491"/> <Graphics CenterX="1046.6666666666667" CenterY="560.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="797491"/> </DataNode> <DataNode TextLabel="itgb8" GraphId="ca1" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="itgb8"/> <Graphics CenterX="1046.6666666666667" CenterY="580.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="556752"/> </DataNode> <DataNode TextLabel="src" GraphId="cc0" Type="GeneProduct"> <Comment Source="GenMAPP remarks">SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="src"/> <Graphics CenterX="236.66666666666666" CenterY="286.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="325084"/> </DataNode> <DataNode TextLabel="vcl" GraphId="b0b" Type="GeneProduct"> <Comment Source="GenMAPP remarks">VCL; vinculin</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="vcl"/> <Graphics CenterX="250.0" CenterY="156.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> 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</DataNode> <DataNode TextLabel="ilk" GraphId="a25" Type="GeneProduct"> <Comment Source="GenMAPP remarks">ILK; integrin-linked kinase [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="ilk"/> <Graphics CenterX="86.66666666666667" CenterY="203.33333333333334" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="393543"/> </DataNode> <DataNode TextLabel="pak1" GraphId="f3c" Type="GeneProduct"> <Comment Source="GenMAPP remarks">PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="pak1"/> <Graphics CenterX="293.3333333333333" CenterY="576.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="373103"/> </DataNode> <DataNode TextLabel="zgc:162320" GraphId="ef9" Type="GeneProduct"> <Comment Source="GenMAPP remarks">VASP; vasodilator-stimulated 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