Glycerophospholipid biosynthesis (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Glycerophospholipid biosynthesis" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Glycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids act as precursors of lipid mediators such as platelet-activating factor and eicosanoids. Cellular membranes contains a distinct composition of various glycerophospholipids such as phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidylinositol (PI), cardiolipin (CL), lysophosphatidic acid (LPA) and lysobisphosphatidic acid (also known as bis(monoacylglycerol) hydrogen phosphate - BMP).&lt;br&gt;&lt;br&gt;Glycerophospholipids are first formed by the &lt;i&gt;de novo&lt;/i&gt; (Kennedy) pathway using fatty acids activated as acyl-CoA donors. However, the acyl groups of glycerophospholipids are highly diverse and distributed in an asymmetric manner. Saturated and monounsaturated fatty acids are usually esterified at the &lt;i&gt;sn-1&lt;/i&gt; position, whereas polyunsaturated acyl groups are esterified at the &lt;i&gt;sn-2&lt;/i&gt; position. Subsequent acyl chain remodeling (Lands cycle) generates the diverse glycerophospholipid composition and asymmetry characteristic of cell membranes.&lt;br&gt;&lt;br&gt;In the &lt;i&gt;de novo&lt;/i&gt; pathway of glycerophospholipid biosynthesis, lysophosphatidic acid (LPA) is initially formed from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT), then PA is metabolized into two types of glycerol derivatives. The first is diacylglycerol (DAG) which is converted to triacylglycerol (TAG), PC, and PE. Subsequently, PS is synthesized from PC or PE. The second is cytidine diphosphate-diacylglycerol (CDP-DAG), which is processed into PI, PG, CL, and BMP. Each glycerophospholipid is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by an acyltransferase.&lt;br&gt;&lt;br&gt;Most of the glycerophospholipids are synthesized at the endoplasmic reticulum (ER), however, some, most notably cardiolipin, and BMP are synthesized in the mitochondrial and endosomal membranes respectively. Since the most of the glycerophospholipids are found in all membrane compartments, there must be extensive network of transport of glycerophospholipids from one membrane compartment to another via various mechanisms including diffusion through the cytosol, formation of transportation complexes, and diffusion via membrane contact sites (MCS) (Osman et al. 2011, Lebiedzinska et al. 2009, Lev 2010, Scherer &amp; Schmitz 2011, Orso et al. 2011, Hermansson et al. 2011, Vance &amp; Vance 2008). 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ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="H2O" GraphId="a85f2" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="2393.5" CenterY="528.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="a874b" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="4043.0" CenterY="305.0" Width="84.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="a8798" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="2892.0" CenterY="2198.0" Width="84.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="STARD10 " GraphId="a8b09" Type="Protein" GroupRef="f7fc9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8873863" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2896.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y365" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="a8e7c" Type="Metabolite" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="H2O" GraphId="a8e7f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2264.5" CenterY="1694.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PITPNB " GraphId="a94ae" Type="Protein" GroupRef="b6de3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524117" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48739" /> </DataNode> <DataNode TextLabel="PPi" GraphId="a9851" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="952.5" CenterY="543.0" Width="35.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29888" /> </DataNode> <DataNode TextLabel="CDS1:Mg2+" GraphId="a9b76" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="724.0" CenterY="1096.0" Width="80.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500651" /> </DataNode> <DataNode TextLabel="AGPAT3 " GraphId="a9c21" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NRZ7" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="a9e48" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2008.0" CenterY="562.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="SLC44A5 " GraphId="aa80e" Type="Protein" GroupRef="b5e44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-444452" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NCS7" /> </DataNode> <DataNode TextLabel="PMCHO, PMETAM" GraphId="aae5b" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="4016.0" CenterY="1373.5" Width="66.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-ALL-8874447" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="aaece" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="866.0" CenterY="935.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="CDIPT:Mg2+/Mn2+" GraphId="ab105" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="697.5" CenterY="1216.5" Width="87.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500647" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="ab27c" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1807.5" CenterY="1023.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="ab697" Type="Protein" GroupRef="d9ddd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="PCYT2 " GraphId="ab741" Type="Protein" GroupRef="fcf61"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500642" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99447" /> </DataNode> <DataNode TextLabel="Acyl-CoA" GraphId="ab81e" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1471.5" CenterY="1546.0" Width="65.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="1-acyl LPE" GraphId="abab9" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="2798.0" CenterY="2199.0" Width="78.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29017" /> </DataNode> <DataNode TextLabel="LPCAT3 " GraphId="abac8" Type="Protein" GroupRef="db0a3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P1A2" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="abafc" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="abb28" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1682.5" CenterY="503.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="STARD10:LPCAT1:PC" GraphId="abd1c" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1552.5" CenterY="1067.0" Width="117.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8873921" /> </DataNode> <DataNode TextLabel="ABHD3" GraphId="abddc" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="689.0" CenterY="2195.0" Width="50.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WU67" /> </DataNode> <DataNode TextLabel="FADH2" GraphId="abe15" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1413.5" CenterY="625.5" Width="61.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17877" /> </DataNode> <DataNode TextLabel="LPEAT" GraphId="ac019" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2770.5" CenterY="1647.0" Width="45.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524035" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="ac28e" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="PXLP-K278-ETNPPL " GraphId="ac2c7" Type="Protein" GroupRef="f4870"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Attribute Key="complex_id" Value="R-HSA-5696413" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="1640.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TBG4" /> </DataNode> <DataNode TextLabel="CEPT1 " GraphId="ac7b8" Type="Protein" GroupRef="e4469"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500587" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y6K0" /> </DataNode> <DataNode TextLabel="CO2" GraphId="ac8ab" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1220.5" CenterY="1970.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16526" /> </DataNode> <DataNode TextLabel="Cho" GraphId="acd4b" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1287.0" CenterY="1716.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="ace15" Type="Protein" GroupRef="e7278"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-3215272" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="phosphate monoester" GraphId="acfd6" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="205.5" CenterY="753.0" Width="71.0" Height="48.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:7794" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="ad108" Type="Protein" GroupRef="f3e13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524135" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="CPNE7 " GraphId="ad4bc" Type="Protein" GroupRef="aae87"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333699" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UBL6" /> </DataNode> <DataNode TextLabel="1AGPC" GraphId="ad83f" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="592.5" CenterY="2196.0" Width="57.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:11230" /> </DataNode> <DataNode TextLabel="PI4P" GraphId="ad955" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3075.5" CenterY="1062.5" Width="35.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17526" /> </DataNode> <DataNode TextLabel="PHOSPHO1:Mg2+" GraphId="ad9b2" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="567.5" CenterY="1843.0" Width="77.0" Height="38.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500633" /> </DataNode> <DataNode TextLabel="donepezil " GraphId="adb00" GroupRef="df609"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-9634839" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="0.0" CenterY="0.0" Width="0.0" Height="0.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CMP" GraphId="adeaf" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="498.0" CenterY="1583.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="PLA2G10 " GraphId="ae00b" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15496" /> </DataNode> <DataNode TextLabel="Glycerol" GraphId="ae0e2" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1421.5" CenterY="1751.0" Width="65.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17754" /> </DataNode> <DataNode TextLabel="p-S284-STARD10" GraphId="ae26d" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1485.0" CenterY="919.0" Width="116.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y365" /> </DataNode> <DataNode TextLabel="PLD4 " GraphId="ae2d2" Type="Protein" GroupRef="abedd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524126" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96BZ4" /> </DataNode> <DataNode TextLabel="TAZ" GraphId="aeb88" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1669.0" CenterY="435.0" Width="32.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q16635" /> </DataNode> <DataNode TextLabel="PITPNB " GraphId="aec79" Type="Protein" GroupRef="bd987"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524122" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="3076.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48739" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="af119" Type="Protein" GroupRef="f3e13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524135" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="af2c5" Type="Metabolite" GroupRef="d9ddd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="2616.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="af9d1" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1594.0" CenterY="499.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="afb8c" Type="Protein" GroupRef="e646b"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524095" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PC " GraphId="afbbe" Type="Metabolite" GroupRef="a5be1"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873897" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="H2O" GraphId="afc17" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="4098.0" CenterY="1374.0" Width="36.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="2-acyl LPA" GraphId="aff6b" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="290.0" CenterY="1289.0" Width="78.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17936" /> </DataNode> <DataNode TextLabel="PLBD1 " GraphId="b00f8" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P4A8" /> </DataNode> <DataNode TextLabel="Alcohol" GraphId="b019d" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="205.0" CenterY="935.0" Width="58.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30879" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="b028e" Type="Protein" GroupRef="e3012"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524151" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="b099c" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2(1)" GraphId="b0cd7" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2538.5" CenterY="977.5" Width="41.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500634" /> </DataNode> <DataNode TextLabel="Cho" GraphId="b0de6" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="797.0" CenterY="942.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="Cho" GraphId="b110d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1507.0" CenterY="1689.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="CPNE6 " GraphId="b1176" Type="Protein" GroupRef="cfe86"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333679" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95741" /> </DataNode> <DataNode TextLabel="ADP" GraphId="b15f8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1383.5" CenterY="950.0" Width="41.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:456216" /> </DataNode> <DataNode TextLabel="PLA2G12A " GraphId="b1907" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM1" /> </DataNode> <DataNode TextLabel="H2O" GraphId="b1c29" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="585.5" CenterY="1793.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="LPA,PA" GraphId="b1e18" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Graphics CenterX="1151.0" CenterY="412.0" Width="50.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-ALL-5696037" /> </DataNode> <DataNode TextLabel="PLA2G10 " GraphId="b2002" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15496" /> </DataNode> <DataNode TextLabel="2-acyl LPS" GraphId="b2077" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="2673.5" CenterY="302.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:37646" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="b20cc" Type="Protein" GroupRef="f0af3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="PTPMT1" GraphId="b26e4" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1285.0" CenterY="559.0" Width="58.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WUK0" /> </DataNode> <DataNode TextLabel="ATP" GraphId="b27e3" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Graphics CenterX="850.0" CenterY="391.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30616" /> </DataNode> <DataNode TextLabel="PNPLA3 " GraphId="b299b" Type="Protein" GroupRef="f3002"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500579" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="3036.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NST1" /> </DataNode> <DataNode TextLabel="2-acyl LPG" GraphId="b2dd9" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2170.0" CenterY="1064.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:27923" /> </DataNode> <DataNode TextLabel="PITPNB " GraphId="b3388" Type="Protein" GroupRef="e6591"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524150" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48739" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="b35b5" Type="Metabolite" GroupRef="e4469"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500587" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="DDHD1,2" GraphId="b3a83" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="429.5" CenterY="1187.0" Width="65.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-6786649" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="b3b5f" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="CSNK2A2 " GraphId="b3b6b" Type="Protein" GroupRef="af68d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-201711" /> <Attribute Key="copies_num" Value="12" /> <Graphics CenterX="1780.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P19784" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="b3cfa" Type="Metabolite" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="GNPAT" GraphId="b3d0e" Type="Protein"> <Attribute Key="cellular_location" Value="peroxisomal membrane" /> <Graphics CenterX="1013.0" CenterY="849.0" Width="50.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15228" /> </DataNode> <DataNode TextLabel="H2O" GraphId="b3e6d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2948.5" CenterY="1683.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="HRASLS" GraphId="b3faf" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1156.5" CenterY="1086.5" Width="51.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8858540" /> </DataNode> <DataNode TextLabel="PCYT1A " GraphId="b42a6" Type="Protein" GroupRef="aadd9"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524125" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="380.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P49585" /> </DataNode> <DataNode TextLabel="AGK:Mg2+" GraphId="b43f2" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="953.5" CenterY="343.0" Width="73.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-5696053" /> </DataNode> <DataNode TextLabel="H2O" GraphId="b440d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3431.5" CenterY="1703.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="DGAT1 " GraphId="b44b0" Type="Protein" GroupRef="d36ec"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500588" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="520.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75907" /> </DataNode> <DataNode TextLabel="GPAT2 " GraphId="b456b" Type="Protein" GroupRef="efd41"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500606" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6NUI2" /> </DataNode> <DataNode TextLabel="CDP-ETA" GraphId="b48ea" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="813.0" CenterY="1686.0" Width="72.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16732" /> </DataNode> <DataNode TextLabel="OSBPL5 " GraphId="b49e3" Type="Protein" GroupRef="a39d9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8867857" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H0X9" /> </DataNode> <DataNode TextLabel="CEPT1/EPT1" GraphId="b4b20" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="854.0" CenterY="1647.5" Width="58.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500592" /> </DataNode> <DataNode TextLabel="PS" GraphId="b4c79" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1246.0" CenterY="1651.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18303" /> </DataNode> <DataNode TextLabel="Pi" GraphId="b4e7e" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="171.5" CenterY="906.0" Width="27.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:43474" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="b50c1" Type="Protein" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="PLA2G6 " GraphId="b51e8" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O60733" /> </DataNode> <DataNode TextLabel="H2O" GraphId="b5599" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3135.5" CenterY="973.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G1B " GraphId="b574d" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04054" /> </DataNode> <DataNode TextLabel="LysoPtdCho" GraphId="b59db" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1235.5" CenterY="1088.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:58168" /> </DataNode> <DataNode TextLabel="acetate" GraphId="b5ae5" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="371.5" CenterY="2310.0" Width="63.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30089" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="b5aee" Type="Protein" GroupRef="e2e21"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="CDS1 " GraphId="b5d63" Type="Protein" GroupRef="d93b7"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500651" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92903" /> </DataNode> <DataNode TextLabel="CDS2" GraphId="b6086" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="909.0" CenterY="559.0" Width="40.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95674" /> </DataNode> <DataNode TextLabel="PLA2G" GraphId="b66c0" Type="Complex"> <Comment Source="Reactome">This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.</Comment> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2564.5" CenterY="672.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-3215272" /> </DataNode> <DataNode TextLabel="PLA2G5 " GraphId="b6799" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39877" /> </DataNode> <DataNode TextLabel="H2O" GraphId="b6b03" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1829.5" CenterY="541.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="b6ce6" Type="Metabolite" GroupRef="baf46"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="b6daf" Type="Metabolite" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PCTP:PC" GraphId="b6e3e" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="544.0" CenterY="1298.0" Width="58.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8873866" /> </DataNode> <DataNode TextLabel="1-acyl LPE" GraphId="b6eb1" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1455.5" CenterY="422.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29017" /> </DataNode> <DataNode TextLabel="PLA2(13)" GraphId="b713b" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3618.0" CenterY="993.0" Width="40.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524143" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="b7981" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2170.5" CenterY="1005.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="b799a" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1634.0" CenterY="1700.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="b7a5f" Type="Protein" GroupRef="baf46"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="CTP" GraphId="b820d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="665.0" CenterY="992.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17677" /> </DataNode> <DataNode TextLabel="CPNE7 " GraphId="b8273" Type="Protein" GroupRef="cfe86"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333679" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UBL6" /> </DataNode> <DataNode TextLabel="PCTP " GraphId="b82da" Type="Protein" GroupRef="eb49e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8873866" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UKL6" /> </DataNode> <DataNode TextLabel="CMP" GraphId="b8422" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="532.0" CenterY="1439.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="PLA2(11)" GraphId="b858f" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3845.0" CenterY="977.5" Width="42.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524151" /> </DataNode> <DataNode TextLabel="STARD10:PC" GraphId="b8723" Type="Complex"> <Attribute Key="cellular_location" Value="lamellar body membrane" /> <Graphics CenterX="1493.5" CenterY="666.0" Width="83.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8873863" /> </DataNode> <DataNode TextLabel="2-acyl LPG" GraphId="b8783" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2816.0" CenterY="560.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:27923" /> </DataNode> <DataNode TextLabel="ETNK1 " GraphId="b8b46" Type="Protein" GroupRef="af306"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500619" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="240.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HBU6" /> </DataNode> <DataNode TextLabel="PISD(1-377) " GraphId="b8b5b" Type="Protein" GroupRef="eb616"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500656" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UG56" /> </DataNode> <DataNode TextLabel="MAG" GraphId="b8cdb" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1519.5" CenterY="1597.5" Width="45.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17408" /> </DataNode> <DataNode TextLabel="LPGAT1 " GraphId="b8d75" Type="Protein" GroupRef="d68f8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92604" /> </DataNode> <DataNode TextLabel="LPCAT2 " GraphId="b8e37" Type="Protein" GroupRef="aa2dd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2616.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L5N7" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="b91a8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3937.5" CenterY="1028.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="b94c3" Type="Metabolite" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3036.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PETA" GraphId="b96fa" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="672.5" CenterY="1781.0" Width="47.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17553" /> </DataNode> <DataNode TextLabel="PLA2(4)" GraphId="b9ac0" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2574.0" CenterY="1715.5" Width="42.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524135" /> </DataNode> <DataNode TextLabel="PLD1/2" GraphId="b9f03" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="729.0" CenterY="1328.0" Width="52.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500639" /> </DataNode> <DataNode TextLabel="DLCL" GraphId="ba447" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2075.5" CenterY="1066.0" Width="47.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60431" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="ba472" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="ba691" Type="Protein" GroupRef="d68f8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="H2O" GraphId="ba6d8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="405.5" CenterY="1150.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="CPNEs" GraphId="ba7bb" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="280.0" CenterY="481.0" Width="46.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-5333699" /> </DataNode> <DataNode TextLabel="CEPT1 " GraphId="bab5a" Type="Protein" GroupRef="bb84e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500592" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y6K0" /> </DataNode> <DataNode TextLabel="TMEM86B" GraphId="bab67" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3998.0" CenterY="1443.5" Width="72.0" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N661" /> </DataNode> <DataNode TextLabel="Ac-CoA" GraphId="bae9d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="564.5" CenterY="1987.0" Width="87.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15351" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="bbe84" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3136.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PLA2G4C " GraphId="bbee7" Type="Protein" GroupRef="ae8ba"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524107" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UP65" /> </DataNode> <DataNode TextLabel="PLA2G3 " GraphId="bbf69" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NZ20" /> </DataNode> <DataNode TextLabel="H2O" GraphId="bc1ed" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="189.5" CenterY="1122.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="bc25e" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1112.5" CenterY="781.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="MBOAT1 " GraphId="bc486" Type="Protein" GroupRef="a7d79"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZNC8" /> </DataNode> <DataNode TextLabel="PLA2(16)" GraphId="bc699" Type="Complex"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="2900.5" CenterY="2369.0" Width="41.0" Height="38.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1602354" /> </DataNode> <DataNode TextLabel="PI4P" GraphId="bc949" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3018.0" CenterY="304.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17526" /> </DataNode> <DataNode TextLabel="CHPT1 " GraphId="bc999" Type="Protein" GroupRef="b5a6b"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500652" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WUD6" /> </DataNode> <DataNode TextLabel="RCOOH" GraphId="bcbb4" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="570.0" CenterY="2153.0" Width="60.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:33575" /> </DataNode> <DataNode TextLabel="PC " GraphId="bcdaf" Type="Metabolite" GroupRef="eb49e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8873866" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="PC " GraphId="bce39" Type="Metabolite" GroupRef="a297e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873921" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="BCHE " GraphId="bce65" Type="Protein" GroupRef="aa739"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-3640837" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P06276" /> </DataNode> <DataNode TextLabel="ALPI:2Ca2+:Mg2+&#xA;dimer" GraphId="bd0fe" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="295.5" CenterY="849.0" Width="121.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8878786" /> </DataNode> <DataNode TextLabel="PLA2G5 " GraphId="bd167" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39877" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="bd3ee" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3116.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="CPNEs:PL" GraphId="bd58a" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="279.5" CenterY="613.0" Width="63.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-5333679" /> </DataNode> <DataNode TextLabel="Cho" GraphId="bdb66" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="459.0" CenterY="1918.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="PLA2G3 " GraphId="bdce3" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NZ20" /> </DataNode> <DataNode TextLabel="PG" GraphId="be07d" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="727.5" CenterY="664.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="be3ea" Type="Protein" GroupRef="e7278"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-3215272" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PLA2(16)" GraphId="be42c" Type="Complex"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3879.5" CenterY="197.5" Width="67.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1602354" /> </DataNode> <DataNode TextLabel="HADHB " GraphId="be9c1" Type="Protein" GroupRef="d7123"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524100" /> <Attribute Key="copies_num" Value="7" /> <Graphics CenterX="520.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P55084" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="bec24" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1088.0" CenterY="947.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="bf22e" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1070.0" CenterY="1110.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="OSBPL8 " GraphId="bf831" Type="Protein" GroupRef="a39d9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8867857" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="3116.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZF1" /> </DataNode> <DataNode TextLabel="Na+" GraphId="bf83c" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="209.5" CenterY="2020.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29101" /> </DataNode> <DataNode TextLabel="PI:PITPNB" GraphId="bf8c5" Type="Complex"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="446.0" CenterY="1498.0" Width="66.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524150" /> </DataNode> <DataNode TextLabel="CMP" GraphId="bfa20" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="962.0" CenterY="1697.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="ATP" GraphId="bfd02" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="752.0" CenterY="1910.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30616" /> </DataNode> <DataNode TextLabel="PA " GraphId="bfd28" Type="Metabolite" GroupRef="bfeaa"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Attribute Key="complex_id" Value="R-ALL-5696037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16337" /> </DataNode> <DataNode TextLabel="MBOAT2 " GraphId="c02dc" Type="Protein" GroupRef="a7d79"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZWT7" /> </DataNode> <DataNode TextLabel="ADP" GraphId="c0433" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Graphics CenterX="1079.5" CenterY="391.0" Width="41.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:456216" /> </DataNode> <DataNode TextLabel="AGK " GraphId="c0447" Type="Protein" GroupRef="c64e7"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-5696053" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q53H12" /> </DataNode> <DataNode TextLabel="PLA2G4C" GraphId="c0b2e" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3865.0" CenterY="1564.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UP65" /> </DataNode> <DataNode TextLabel="PG" GraphId="c0d12" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2408.5" CenterY="1063.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="c0d6f" Type="Protein" GroupRef="f214b"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524142" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="c0ea9" Type="Metabolite" GroupRef="e3012"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524151" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PG" GraphId="c0ead" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1359.5" CenterY="594.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="H2O" GraphId="c12a8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3164.5" CenterY="1793.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="Ins" GraphId="c12ff" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="673.0" CenterY="1175.0" Width="62.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17268" /> </DataNode> <DataNode TextLabel="G3P" GraphId="c1486" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1325.0" CenterY="921.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15978" /> </DataNode> <DataNode TextLabel="PLA1A" GraphId="c14d4" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="2934.0" CenterY="213.0" Width="46.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q53H76" /> </DataNode> <DataNode TextLabel="MLCL" GraphId="c14f2" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1862.5" CenterY="1064.0" Width="49.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60430" /> </DataNode> <DataNode TextLabel="PE" GraphId="c16c6" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2665.0" CenterY="1651.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16038" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="c1831" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PI" GraphId="c1e41" Type="Metabolite"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="439.0" CenterY="1447.0" Width="28.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="c211b" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="PPi" GraphId="c2833" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="602.5" CenterY="1617.0" Width="35.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29888" /> </DataNode> <DataNode TextLabel="Na+" GraphId="c29d0" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="332.5" CenterY="2032.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29101" /> </DataNode> <DataNode TextLabel="AGPAT6 " GraphId="c2eb7" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86UL3" /> </DataNode> <DataNode TextLabel="GPD1 " GraphId="c3150" Type="Protein" GroupRef="f85dc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500610" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P21695" /> </DataNode> <DataNode TextLabel="fatty acid" GraphId="c33bd" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2389.0" CenterY="1615.0" Width="74.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:35366" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="c3431" Type="Protein" GroupRef="e3012"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524151" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="PLA2(8)" GraphId="c34f7" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3344.0" CenterY="1706.5" Width="58.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524040" /> </DataNode> <DataNode TextLabel="PC " GraphId="c370b" Type="Metabolite" GroupRef="afa03"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="2-acyl LPE" GraphId="c38cb" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2443.5" CenterY="1652.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28936" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="c3aa8" Type="Metabolite" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2896.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="c3c02" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="c3e1f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="4001.5" CenterY="1740.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PLA2(1)" GraphId="c3fa2" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="874.0" CenterY="754.5" Width="40.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500634" /> </DataNode> <DataNode TextLabel="H2O" GraphId="c4506" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="905.0" CenterY="2002.5" Width="36.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="c4b5f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2024.5" CenterY="1025.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="Pyruvoyl " GraphId="c4c01" Type="Metabolite" GroupRef="eb616"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500656" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:45360" /> </DataNode> <DataNode TextLabel="CH3CHO" GraphId="c4e5d" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1108.5" CenterY="1945.0" Width="71.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15343" /> </DataNode> <DataNode TextLabel="ACHE " GraphId="c4e9c" Type="Protein" GroupRef="aa739"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-3640837" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P22303" /> </DataNode> <DataNode TextLabel="PLA2G16 " GraphId="c5421" Type="Protein" GroupRef="e3012"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524151" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53816" /> </DataNode> <DataNode TextLabel="cardiolipin" GraphId="c5883" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1512.5" CenterY="577.5" Width="75.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28494" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="c5e3a" Type="Protein" GroupRef="e3012"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524151" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="c6014" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="PNPLA8 " GraphId="c6855" Type="Protein" GroupRef="ed316"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524128" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NP80" /> </DataNode> <DataNode TextLabel="DAG" GraphId="c68ff" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="730.5" CenterY="1579.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17815" /> </DataNode> <DataNode TextLabel="LPC(14:0)" GraphId="c69e6" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="771.0" CenterY="2197.0" Width="74.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:64483" /> </DataNode> <DataNode TextLabel="PC:PITPNB" GraphId="c6c9b" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="729.5" CenterY="1400.0" Width="71.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524110" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="c6fc2" Type="Protein" GroupRef="f3e13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524135" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="c7008" Type="Metabolite" GroupRef="b5a6b"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500652" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="HRASLS " GraphId="c7aa1" Type="Protein" GroupRef="ad14e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8858540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HDD0" /> </DataNode> <DataNode TextLabel="PISD:Pyruvoyl" GraphId="c7b5e" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1346.5" CenterY="1901.0" Width="89.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500656" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="c7f6c" Type="Protein" GroupRef="f214b"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524142" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="PG" GraphId="c8453" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1533.5" CenterY="1653.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="PLA2(15)" GraphId="c84b4" Type="Complex"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3366.0" CenterY="206.0" Width="38.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1602359" /> </DataNode> <DataNode TextLabel="PLA2G2D " GraphId="c8668" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UNK4" /> </DataNode> <DataNode TextLabel="PISD(378-409) " GraphId="c89e5" Type="Protein" GroupRef="eb616"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500656" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UG56" /> </DataNode> <DataNode TextLabel="CMP" GraphId="c8b09" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="693.0" CenterY="1255.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="CSNK2B " GraphId="c8c2c" Type="Protein" GroupRef="af68d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-201711" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1780.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P67870" /> </DataNode> <DataNode TextLabel="PLA2(7)" GraphId="c8c63" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3840.5" CenterY="1698.0" Width="41.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524112" /> </DataNode> <DataNode TextLabel="LIPH " GraphId="c8da1" Type="Protein" GroupRef="fff79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-6792447" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WWY8" /> </DataNode> <DataNode TextLabel="TAG" GraphId="c8dab" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1785.0" CenterY="1621.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17855" /> </DataNode> <DataNode TextLabel="H2O" GraphId="c8dad" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1770.5" CenterY="1695.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="HADH octamer" GraphId="c91b2" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1644.5" CenterY="564.0" Width="97.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524100" /> </DataNode> <DataNode TextLabel="PC" GraphId="c92fc" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3183.0" CenterY="2200.0" Width="32.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="PNPLA8 " GraphId="c93fc" Type="Protein" GroupRef="ae8ba"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524107" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NP80" /> </DataNode> <DataNode TextLabel="H2O" GraphId="c982a" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="657.5" CenterY="1421.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="c9879" Type="Protein" GroupRef="f3e13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524135" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="3036.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PLA2G2A:Ca2+" GraphId="c9a33" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="910.0" CenterY="1142.5" Width="80.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500630" /> </DataNode> <DataNode TextLabel="LPCAT1" GraphId="ca050" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1644.0" CenterY="1131.0" Width="54.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="1-acyl LPS" GraphId="ca405" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3354.5" CenterY="1068.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:52603" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="ca76b" Type="Protein" GroupRef="ac145"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524155" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2(1)" GraphId="cafa2" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="915.0" CenterY="1030.5" Width="40.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500634" /> </DataNode> <DataNode TextLabel="H2O" GraphId="cb19e" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="734.5" CenterY="1001.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="CTL1-5" GraphId="cb77a" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="282.0" CenterY="2196.0" Width="54.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-444452" /> </DataNode> <DataNode TextLabel="MLCL" GraphId="cba1b" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1798.5" CenterY="595.0" Width="49.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60430" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="cbaca" Type="Protein" GroupRef="c823c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="cbccb" Type="Protein" GroupRef="d9ddd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="CHK dimer" GraphId="cbefc" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="288.0" CenterY="1862.0" Width="74.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524078" /> </DataNode> <DataNode TextLabel="GPCho" GraphId="cc04b" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3242.5" CenterY="1755.0" Width="57.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16870" /> </DataNode> <DataNode TextLabel="1-acyl LPC" GraphId="cc084" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3027.5" CenterY="2193.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17504" /> </DataNode> <DataNode TextLabel="GPAEA" GraphId="cc1c7" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1438.0" CenterY="1123.0" Width="56.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:52571" /> </DataNode> <DataNode TextLabel="2-acyl LPC" GraphId="cc34e" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="4004.0" CenterY="1655.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16728" /> </DataNode> <DataNode TextLabel="EPT1 " GraphId="cc5c7" Type="Protein" GroupRef="bb84e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500592" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9C0D9" /> </DataNode> <DataNode TextLabel="PLD6 dimer" GraphId="cc63c" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="630.5" CenterY="596.0" Width="77.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-5601921" /> </DataNode> <DataNode TextLabel="GPETAM " GraphId="cca49" Type="Metabolite" GroupRef="fe857"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-ALL-8874450" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="3176.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:36314" /> </DataNode> <DataNode TextLabel="PMETAM " GraphId="cca94" Type="Metabolite" GroupRef="dbaf0"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-ALL-8874447" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17476" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="cca9e" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1899.0" CenterY="1024.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="SLC44A1 " GraphId="ccb4b" Type="Protein" GroupRef="b5e44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-444452" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8WWI5" /> </DataNode> <DataNode TextLabel="Pi" GraphId="cd2e5" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1066.5" CenterY="2008.0" Width="29.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:43474" /> </DataNode> <DataNode TextLabel="DGAT2L6 " GraphId="cd3d5" Type="Protein" GroupRef="e0385"> <BiopaxRef>d3e</BiopaxRef> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-8933132" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZPD8" /> </DataNode> <DataNode TextLabel="ETA" GraphId="cd3e5" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="675.5" CenterY="1909.0" Width="39.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16000" /> </DataNode> <DataNode TextLabel="ETNK2 " GraphId="cd771" Type="Protein" GroupRef="af306"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500619" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="240.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NVF9" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="cd85e" Type="Protein" GroupRef="ccb6c"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="1-acyl LPA" GraphId="cd8a2" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="284.5" CenterY="1242.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16975" /> </DataNode> <DataNode TextLabel="LPGAT" GraphId="cdcbe" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2497.5" CenterY="1065.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524026" /> </DataNode> <DataNode TextLabel="PLA2(15)" GraphId="ce158" Type="Complex"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="129.0" CenterY="1165.0" Width="64.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1602359" /> </DataNode> <DataNode TextLabel="PLBD1 " GraphId="ce35a" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P4A8" /> </DataNode> <DataNode TextLabel="LPCAT3 " GraphId="ce384" Type="Protein" GroupRef="a8a3f"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P1A2" /> </DataNode> <DataNode TextLabel="H2O" GraphId="ce395" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3089.5" CenterY="208.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="GO3P" GraphId="ce46d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1149.0" CenterY="910.0" Width="50.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17197" /> </DataNode> <DataNode TextLabel="PI" GraphId="ce4c2" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="274.5" CenterY="1000.0" Width="27.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="ce531" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2887.0" CenterY="1589.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PLA2(14)" GraphId="ce79a" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2329.5" CenterY="975.0" Width="41.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524142" /> </DataNode> <DataNode TextLabel="CL" GraphId="ceacb" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1644.0" CenterY="1061.0" Width="32.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28494" /> </DataNode> <DataNode TextLabel="PLD1 " GraphId="cedfb" Type="Protein" GroupRef="abedd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524126" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13393" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="cef96" Type="Protein" GroupRef="ecabf"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="CDP-DAG" GraphId="cf049" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="733.5" CenterY="1133.0" Width="75.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17962" /> </DataNode> <DataNode TextLabel="HRASLS2 " GraphId="cf0d0" Type="Protein" GroupRef="ad14e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8858540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NWW9" /> </DataNode> <DataNode TextLabel="BMP" GraphId="cf189" Type="Metabolite"> <Attribute Key="cellular_location" Value="late endosome membrane" /> <Graphics CenterX="1701.5" CenterY="1774.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60815" /> </DataNode> <DataNode TextLabel="ABHD4" GraphId="cf1a0" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1348.0" CenterY="1084.0" Width="50.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TB40" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="cf1a3" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="cf3dc" Type="Protein" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="H2O" GraphId="cf5ac" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3779.5" CenterY="248.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="Mn2+ " GraphId="cf882" Type="Metabolite" GroupRef="d7f1d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500647" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29035" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="cf8b0" Type="Metabolite" GroupRef="e646b"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524095" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="520.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PL" GraphId="cf9ff" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="277.0" CenterY="532.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16247" /> </DataNode> <DataNode TextLabel="MAG,DAG" GraphId="cfc3e" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Graphics CenterX="777.0" CenterY="412.0" Width="66.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-ALL-5696066" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="cfce8" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2(5)" GraphId="cfcfc" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3654.0" CenterY="1725.5" Width="40.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524120" /> </DataNode> <DataNode TextLabel="PLA2G12A " GraphId="cfd39" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="3056.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM1" /> </DataNode> <DataNode TextLabel="PI " GraphId="cfdd2" Type="Metabolite" GroupRef="b6de3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524117" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="DLCL" GraphId="cfea4" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2043.5" CenterY="594.0" Width="47.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60431" /> </DataNode> <DataNode TextLabel="G3P" GraphId="cfedd" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1070.0" CenterY="533.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15978" /> </DataNode> <DataNode TextLabel="2-MAG" GraphId="d000c" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2220.0" CenterY="1649.0" Width="60.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17389" /> </DataNode> <DataNode TextLabel="PLA2(2)" GraphId="d069e" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2820.0" CenterY="1712.0" Width="40.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524137" /> </DataNode> <DataNode TextLabel="GPCho" GraphId="d07c6" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3782.5" CenterY="2293.0" Width="49.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16870" /> </DataNode> <DataNode TextLabel="GPCHO, GPETAM" GraphId="d0986" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="4032.5" CenterY="1528.0" Width="57.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-ALL-8874450" /> </DataNode> <DataNode TextLabel="AcCho" GraphId="d0990" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="542.5" CenterY="2104.0" Width="55.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15355" /> </DataNode> <DataNode TextLabel="AGPAT" GraphId="d0c03" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="970.0" CenterY="1060.0" Width="52.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500583" /> </DataNode> <DataNode TextLabel="DGAT2L6,L7P" GraphId="d0c52" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1868.0" CenterY="1542.0" Width="90.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8933132" /> </DataNode> <DataNode TextLabel="Mn2+ " GraphId="d0e86" Type="Metabolite" GroupRef="e4469"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500587" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29035" /> </DataNode> <DataNode TextLabel="PITPNM2 " GraphId="d0f6a" Type="Protein" GroupRef="bc295"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8869240" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZ72" /> </DataNode> <DataNode TextLabel="MFSD2A" GraphId="d11ca" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="280.0" CenterY="1940.0" Width="56.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NA29" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="d1254" Type="Protein" GroupRef="d9ddd"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="H2O" GraphId="d129f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2714.5" CenterY="1726.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="1-acyl LPE" GraphId="d1887" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2879.5" CenterY="1647.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29017" /> </DataNode> <DataNode TextLabel="PI:PITPNB" GraphId="d19ca" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="730.0" CenterY="1491.0" Width="66.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524117" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="d2902" Type="Protein" GroupRef="a297e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873921" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="SLC44A2 " GraphId="d2b35" Type="Protein" GroupRef="b5e44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-444452" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IWA5" /> </DataNode> <DataNode TextLabel="H2O" GraphId="d2c1c" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3867.5" CenterY="1841.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="DAG" GraphId="d2d39" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2044.5" CenterY="1648.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17815" /> </DataNode> <DataNode TextLabel="Cho" GraphId="d2f15" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="361.0" CenterY="2245.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="PLA2G16 " GraphId="d316e" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53816" /> </DataNode> <DataNode TextLabel="LCLAT1 " GraphId="d343a" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2896.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6UWP7" /> </DataNode> <DataNode TextLabel="PI" GraphId="d34a0" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3700.0" CenterY="1064.0" Width="28.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="MBOAT2 " GraphId="d3c9c" Type="Protein" GroupRef="ecabf"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZWT7" /> </DataNode> <DataNode TextLabel="PCho" GraphId="d3e62" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="467.0" CenterY="1792.0" Width="48.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:36700" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="d3ed6" Type="Protein" GroupRef="a8a3f"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2896.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="PLA2G2E " GraphId="d3fad" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NZK7" /> </DataNode> <DataNode TextLabel="STARD7:PC" GraphId="d41b7" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="983.5" CenterY="1553.0" Width="75.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8873897" /> </DataNode> <DataNode TextLabel="PE" GraphId="d477e" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1199.0" CenterY="1902.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16038" /> </DataNode> <DataNode TextLabel="CTP" GraphId="d48c7" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="851.0" CenterY="533.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17677" /> </DataNode> <DataNode TextLabel="PC " GraphId="d4ebe" Type="Metabolite" GroupRef="f7fc9"> <Attribute Key="cellular_location" Value="lamellar body membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873863" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="d4fc3" Type="Metabolite" GroupRef="c823c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="DDHD2 " GraphId="d518f" Type="Protein" GroupRef="e1c4d"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-6786649" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O94830" /> </DataNode> <DataNode TextLabel="CHAT" GraphId="d548b" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="551.0" CenterY="2043.0" Width="42.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P28329" /> </DataNode> <DataNode TextLabel="LPC (22:6)" GraphId="d55d1" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="171.0" CenterY="1985.0" Width="78.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:64567" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="d59b6" Type="Protein" GroupRef="a6fdb"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="d5b03" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="462.0" CenterY="2114.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PLBD1 " GraphId="d5d78" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P4A8" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="d5ee8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2407.0" CenterY="1021.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="d5fb7" Type="Protein" GroupRef="e2e21"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="d5fd5" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="MYS-LPA" GraphId="d660e" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="905.0" CenterY="484.0" Width="68.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:62833" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="d67b4" Type="Metabolite" GroupRef="ed316"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524128" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="PLA2(9)" GraphId="d6b1c" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3248.5" CenterY="986.0" Width="41.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524157" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="d6c02" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="SLC44A3 " GraphId="d6cba" Type="Protein" GroupRef="b5e44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-444452" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N4M1" /> </DataNode> <DataNode TextLabel="PLA2G2D " GraphId="d6e52" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UNK4" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="d70e2" Type="Metabolite" GroupRef="ae8ba"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524107" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="d71fc" Type="Metabolite" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="H2O" GraphId="d7302" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1242.5" CenterY="1036.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G4A:Ca2+" GraphId="d755d" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1918.5" CenterY="592.0" Width="101.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524095" /> </DataNode> <DataNode TextLabel="LPIN2 " GraphId="d7698" Type="Protein" GroupRef="f1e8d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500636" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92539" /> </DataNode> <DataNode TextLabel="PLD1 " GraphId="d7e06" Type="Protein" GroupRef="f3c95"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500639" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13393" /> </DataNode> <DataNode TextLabel="DGAT2 " GraphId="d819f" Type="Protein" GroupRef="d36ec"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500588" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="520.0" CenterY="3116.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96PD7" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="d84b0" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1939.5" CenterY="1703.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="d88f3" Type="Metabolite" GroupRef="a6fdb"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="d8e3d" Type="Metabolite" GroupRef="bb84e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500592" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="PLA2(8)" GraphId="d8ee4" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3757.5" CenterY="1847.5" Width="39.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524040" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="d9169" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2281.0" CenterY="1560.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="d9716" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="ETA" GraphId="d971d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3052.5" CenterY="1932.0" Width="39.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16000" /> </DataNode> <DataNode TextLabel="PEMT" GraphId="d9798" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="932.5" CenterY="1651.0" Width="41.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UBM1" /> </DataNode> <DataNode TextLabel="PLA2R1(21-?)" GraphId="d9968" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3382.5" CenterY="76.0" Width="89.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13018" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="d9e48" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1805.0" CenterY="1741.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PLA2G2E " GraphId="da043" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NZK7" /> </DataNode> <DataNode TextLabel="1-acyl LPI" GraphId="da085" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3937.5" CenterY="1063.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28914" /> </DataNode> <DataNode TextLabel="PLA2G12A " GraphId="daf44" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM1" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="db2cd" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2885.5" CenterY="1695.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="db300" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3076.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="PA" GraphId="db3da" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="794.5" CenterY="1064.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16337" /> </DataNode> <DataNode TextLabel="PLA2(6)" GraphId="db42f" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3642.5" CenterY="1550.5" Width="39.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524107" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="db490" Type="Metabolite" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="1-MMG" GraphId="db68b" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1143.5" CenterY="484.0" Width="61.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:75562" /> </DataNode> <DataNode TextLabel="NAPE" GraphId="db72e" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1274.0" CenterY="1130.0" Width="48.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:61232" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="db78d" Type="Metabolite" GroupRef="f0af3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500630" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="dba20" Type="Metabolite" GroupRef="f3e13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524135" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="DHAP" GraphId="dbb71" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1426.0" CenterY="538.0" Width="48.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57642" /> </DataNode> <DataNode TextLabel="PLA2G6 " GraphId="dbf9f" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O60733" /> </DataNode> <DataNode TextLabel="GPD1L " GraphId="dc0eb" Type="Protein" GroupRef="f85dc"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500610" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="100.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N335" /> </DataNode> <DataNode TextLabel="PNPLA2/3" GraphId="dc222" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2011.5" CenterY="1541.0" Width="69.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500579" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="dc409" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3512.5" CenterY="1707.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="MGLL " GraphId="dc759" Type="Protein" GroupRef="a053d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500601" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99685" /> </DataNode> <DataNode TextLabel="DAG " GraphId="dc794" Type="Metabolite" GroupRef="b6fdb"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Attribute Key="complex_id" Value="R-ALL-5696066" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17815" /> </DataNode> <DataNode TextLabel="AdoMet" GraphId="dcb8e" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1050.0" CenterY="1683.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15414" /> </DataNode> <DataNode TextLabel="AGPAT6" GraphId="dcf3d" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1174.5" CenterY="961.0" Width="73.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86UL3" /> </DataNode> <DataNode TextLabel="1-acyl LPS" GraphId="dcf8e" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3272.5" CenterY="308.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:52603" /> </DataNode> <DataNode TextLabel="G3P" GraphId="dd088" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1210.0" CenterY="706.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15978" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="dd475" Type="Metabolite" GroupRef="f1e8d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500636" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="Mn2+ " GraphId="dd5a0" Type="Metabolite" GroupRef="b5a6b"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500652" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29035" /> </DataNode> <DataNode TextLabel="CHKB " GraphId="dd705" Type="Protein" GroupRef="af306"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500619" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="240.0" CenterY="2616.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y259" /> </DataNode> <DataNode TextLabel="PTDSS1" GraphId="ddcdb" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1339.0" CenterY="1649.0" Width="52.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48651" /> </DataNode> <DataNode TextLabel="fatty aldehyde" GraphId="ddecf" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="4120.0" CenterY="1527.0" Width="64.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:35746" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="ddfb1" Type="Protein" GroupRef="bb6b8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524141" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="de569" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="SLC44A4 " GraphId="de879" Type="Protein" GroupRef="b5e44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-444452" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q53GD3" /> </DataNode> <DataNode TextLabel="Cholinesterase" GraphId="de8a5" Type="Complex"> <Comment Source="Reactome">This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.</Comment> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="438.5" CenterY="2197.0" Width="93.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-3640837" /> </DataNode> <DataNode TextLabel="LPIN1 " GraphId="dea65" Type="Protein" GroupRef="f1e8d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500636" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14693" /> </DataNode> <DataNode TextLabel="1-acyl LPG" GraphId="deec0" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3947.0" CenterY="305.0" Width="80.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:62747" /> </DataNode> <DataNode TextLabel="CHKB " GraphId="deec1" Type="Protein" GroupRef="e4a5a"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524078" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="380.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y259" /> </DataNode> <DataNode TextLabel="NADH" GraphId="df1d3" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1377.0" CenterY="778.0" Width="52.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57945" /> </DataNode> <DataNode TextLabel="MIGA1 " GraphId="df261" Type="Protein" GroupRef="c3380"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-8954399" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1920.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NAN2" /> </DataNode> <DataNode TextLabel="OSBPL10 " GraphId="df2c5" Type="Protein" GroupRef="a39d9"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8867857" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="3076.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BXB5" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="df3cd" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3761.0" CenterY="1691.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="df4f9" Type="Metabolite" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="GPAM/GPAT2" GraphId="df5a8" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="1137.5" CenterY="662.0" Width="91.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500606" /> </DataNode> <DataNode TextLabel="PETA" GraphId="dfaa7" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="898.5" CenterY="1935.5" Width="39.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17553" /> </DataNode> <DataNode TextLabel="PCYT1B " GraphId="e0048" Type="Protein" GroupRef="aadd9"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524125" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="380.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y5K3" /> </DataNode> <DataNode TextLabel="PLA2G2E " GraphId="e00bf" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NZK7" /> </DataNode> <DataNode TextLabel="PLA2G2D " GraphId="e0156" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UNK4" /> </DataNode> <DataNode TextLabel="PHOSPHO1 " GraphId="e01dc" Type="Protein" GroupRef="c6a82"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500633" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8TCT1" /> </DataNode> <DataNode TextLabel="PLA2G10 " GraphId="e0416" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="3036.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15496" /> </DataNode> <DataNode TextLabel="PLA2G4C" GraphId="e0798" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3711.0" CenterY="1581.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UP65" /> </DataNode> <DataNode TextLabel="Casein kinase II" GraphId="e09ee" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1490.0" CenterY="976.5" Width="62.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-201711" /> </DataNode> <DataNode TextLabel="STARD7 " GraphId="e1052" Type="Protein" GroupRef="afa03"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQZ5" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="e16e4" Type="Protein" GroupRef="ecabf"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="GPD1/GPD1L homodimer" GraphId="e1733" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1415.0" CenterY="841.0" Width="90.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500610" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e199d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2982.5" CenterY="932.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PC " GraphId="e1aeb" Type="Metabolite" GroupRef="bd987"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524122" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="FAD" GraphId="e2071" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1138.0" CenterY="627.0" Width="46.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16238" /> </DataNode> <DataNode TextLabel="LPEAT" GraphId="e20e7" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2536.5" CenterY="1650.0" Width="45.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524035" /> </DataNode> <DataNode TextLabel="AGPAT4 " GraphId="e21d8" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NRZ5" /> </DataNode> <DataNode TextLabel="PGP" GraphId="e22bd" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1221.0" CenterY="591.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:37393" /> </DataNode> <DataNode TextLabel="PLA2G12A " GraphId="e23b1" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2616.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM1" /> </DataNode> <DataNode TextLabel="STARD10 " GraphId="e250c" Type="Protein" GroupRef="a297e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8873921" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y365" /> </DataNode> <DataNode TextLabel="MBOAT2 " GraphId="e2648" Type="Protein" GroupRef="a8a3f"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZWT7" /> </DataNode> <DataNode TextLabel="ADP" GraphId="e279d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="367.0" CenterY="1792.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:456216" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="e27fc" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1360.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="e2867" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e2d29" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="769.5" CenterY="2128.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="e2d6d" Type="Protein" GroupRef="aa2dd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="e2efe" Type="Protein" GroupRef="ac145"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524155" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1080.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PI " GraphId="e305e" Type="Metabolite" GroupRef="e6591"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524150" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="PLD6 " GraphId="e31ad" Type="Protein" GroupRef="abedd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524126" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N2A8" /> </DataNode> <DataNode TextLabel="PLA2G16 " GraphId="e333f" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53816" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="e35e0" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="cytidine&#xA;5'-monophosphate" GraphId="e387a" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1490.0" CenterY="505.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="e3a02" Type="Protein" GroupRef="aa2dd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="HRASLS5 " GraphId="e3bc0" Type="Protein" GroupRef="ad14e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8858540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96KN8" /> </DataNode> <DataNode TextLabel="HADHA " GraphId="e3d92" Type="Protein" GroupRef="d7123"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524100" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="520.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P40939" /> </DataNode> <DataNode TextLabel="GPCHO " GraphId="e41e9" Type="Metabolite" GroupRef="fe857"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-ALL-8874450" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="3156.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:36313" /> </DataNode> <DataNode TextLabel="PLA2G16 " GraphId="e4209" Type="Protein" GroupRef="ad14e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8858540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53816" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="e45d8" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1679.0" CenterY="1024.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PTDSS2" GraphId="e4639" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1144.0" CenterY="1650.0" Width="52.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BVG9" /> </DataNode> <DataNode TextLabel="1-acyl LPC" GraphId="e46f2" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3504.0" CenterY="1643.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17504" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="e49db" Type="Metabolite" GroupRef="d4983"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8878786" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="e4b36" Type="Metabolite" GroupRef="c64e7"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-5696053" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="LPCAT" GraphId="e4b55" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3614.5" CenterY="1649.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524029" /> </DataNode> <DataNode TextLabel="LPGAT1 " GraphId="e4cd1" Type="Protein" GroupRef="ccb6c"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q92604" /> </DataNode> <DataNode TextLabel="Mn2+ " GraphId="e4ee2" Type="Metabolite" GroupRef="bb84e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500592" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="2896.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29035" /> </DataNode> <DataNode TextLabel="Pi" GraphId="e514d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="631.0" CenterY="1551.0" Width="28.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:43474" /> </DataNode> <DataNode TextLabel="DGAT2L7P " GraphId="e5502" Type="Protein" GroupRef="e0385"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-8933132" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2476.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6IED9" /> </DataNode> <DataNode TextLabel="LCLAT1" GraphId="e58f5" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1762.0" CenterY="1102.0" Width="54.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6UWP7" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="e5afd" Type="Protein" GroupRef="ed316"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524128" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="660.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="AWAT2" GraphId="e5d9c" Type="Protein"> <BiopaxRef>d3e</BiopaxRef> <BiopaxRef>a7e</BiopaxRef> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1602.5" CenterY="1543.0" Width="51.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6E213" /> </DataNode> <DataNode TextLabel="LPCAT3 " GraphId="e5ec2" Type="Protein" GroupRef="ecabf"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2816.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P1A2" /> </DataNode> <DataNode TextLabel="PC" GraphId="e5f54" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3760.5" CenterY="1651.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="PNPLA2 " GraphId="e5fb7" Type="Protein" GroupRef="f3002"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500579" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96AD5" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="e6166" Type="Protein" GroupRef="b9d2b"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524143" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="e628f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="733.0" CenterY="745.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="PC" GraphId="e6895" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1769.5" CenterY="470.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="MBOAT1 " GraphId="e6936" Type="Protein" GroupRef="db0a3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZNC8" /> </DataNode> <DataNode TextLabel="PA" GraphId="e6d95" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="793.5" CenterY="662.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16337" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="e6ec7" Type="Protein" GroupRef="e2e21"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="ACP6" GraphId="e703d" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1004.0" CenterY="535.0" Width="40.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPH0" /> </DataNode> <DataNode TextLabel="Glycerol" GraphId="e7681" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2348.5" CenterY="1700.0" Width="65.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17754" /> </DataNode> <DataNode TextLabel="PLD1-4/6" GraphId="e78a8" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1441.5" CenterY="1652.0" Width="67.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524126" /> </DataNode> <DataNode TextLabel="STARD7:PC" GraphId="e7a6e" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="1097.5" CenterY="1873.0" Width="75.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8873896" /> </DataNode> <DataNode TextLabel="Glycerol" GraphId="e7b4f" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2074.5" CenterY="1712.0" Width="65.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17754" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e7f2d" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3573.5" CenterY="2334.5" Width="35.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="e807c" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="GPAM(1-828) " GraphId="e8496" Type="Protein" GroupRef="efd41"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500606" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9HCL2" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e8570" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="2675.5" CenterY="2302.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="OSBPL5,8,10" GraphId="e889d" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2944.0" CenterY="736.0" Width="84.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8867857" /> </DataNode> <DataNode TextLabel="G3P" GraphId="e89cd" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3164.0" CenterY="1920.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15978" /> </DataNode> <DataNode TextLabel="CHKA " GraphId="e8c32" Type="Protein" GroupRef="af306"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500619" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="2596.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P35790" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e8c85" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2137.5" CenterY="1705.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="ETA" GraphId="e906b" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1209.5" CenterY="1685.0" Width="39.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16000" /> </DataNode> <DataNode TextLabel="PLA2G4C " GraphId="e9418" Type="Protein" GroupRef="bb6b8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524141" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UP65" /> </DataNode> <DataNode TextLabel="ACHE:ACHEIs" GraphId="e94cc" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="438.0" CenterY="2348.5" Width="78.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-9634839" /> </DataNode> <DataNode TextLabel="PI" GraphId="e9800" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="729.0" CenterY="1283.0" Width="28.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16749" /> </DataNode> <DataNode TextLabel="PLBD1 " GraphId="e9914" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P4A8" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="e9a16" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="PLA2G2F " GraphId="e9e62" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BZM2" /> </DataNode> <DataNode TextLabel="H2O" GraphId="e9ede" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1562.5" CenterY="531.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="H2O" GraphId="ea070" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3748.5" CenterY="982.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G2A:Ca2+" GraphId="ea446" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2521.5" CenterY="1134.0" Width="101.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500630" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="ea81e" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2703.0" CenterY="1111.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PLA2G4C" GraphId="eaabf" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2670.0" CenterY="1573.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UP65" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="eb043" Type="Metabolite" GroupRef="d7f1d"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500647" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="L-Ser" GraphId="eb22d" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1374.0" CenterY="1700.0" Width="68.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:33384" /> </DataNode> <DataNode TextLabel="CDP-Cho" GraphId="eb2b0" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="514.5" CenterY="1706.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16436" /> </DataNode> <DataNode TextLabel="PLA2G16 " GraphId="eb57e" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3156.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P53816" /> </DataNode> <DataNode TextLabel="PLA2G5 " GraphId="eb5b9" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1360.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39877" /> </DataNode> <DataNode TextLabel="ACHE " GraphId="eb70a" Type="Protein" GroupRef="df609"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-9634839" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="3096.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P22303" /> </DataNode> <DataNode TextLabel="PA" GraphId="eb744" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="793.0" CenterY="577.5" Width="38.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16337" /> </DataNode> <DataNode TextLabel="ALPI " GraphId="eba3e" Type="Protein" GroupRef="d4983"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8878786" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="1920.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P09923" /> </DataNode> <DataNode TextLabel="DGAT1/2" GraphId="ebb69" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1943.0" CenterY="1645.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500588" /> </DataNode> <DataNode TextLabel="PLA2G6" GraphId="ebcb6" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1647.5" CenterY="594.0" Width="55.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O60733" /> </DataNode> <DataNode TextLabel="CRLS1" GraphId="ebf30" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1390.5" CenterY="452.0" Width="45.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UJA2" /> </DataNode> <DataNode TextLabel="PS" GraphId="ec037" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3122.0" CenterY="310.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18303" /> </DataNode> <DataNode TextLabel="PLA2G15" GraphId="ec0f7" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3657.0" CenterY="2246.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NCC3" /> </DataNode> <DataNode TextLabel="cardiolipin" GraphId="ec287" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="653.5" CenterY="524.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28494" /> </DataNode> <DataNode TextLabel="PG" GraphId="ec4fb" Type="Metabolite"> <Attribute Key="cellular_location" Value="late endosome membrane" /> <Graphics CenterX="1569.5" CenterY="1765.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="Cho" GraphId="ecc80" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3273.0" CenterY="1932.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15354" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="eccc3" Type="Protein" GroupRef="db0a3"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="ATP" GraphId="ecf86" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="370.0" CenterY="1920.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30616" /> </DataNode> <DataNode TextLabel="H2O" GraphId="ed24d" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3631.5" CenterY="230.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PS" GraphId="ed28c" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1444.0" CenterY="1901.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18303" /> </DataNode> <DataNode TextLabel="NH3" GraphId="ed3f4" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1096.0" CenterY="1985.5" Width="38.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16134" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="ed49f" Type="Protein" GroupRef="ae8ba"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524107" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="800.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="PG" GraphId="ed587" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2466.5" CenterY="556.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="MBOAT7" GraphId="ed9aa" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3574.5" CenterY="1066.0" Width="61.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96N66" /> </DataNode> <DataNode TextLabel="MIGA2 " GraphId="edada" Type="Protein" GroupRef="c3380"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-8954399" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="1920.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q7L4E1" /> </DataNode> <DataNode TextLabel="PC:PITPNB" GraphId="edc80" Type="Complex"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="445.5" CenterY="1401.0" Width="71.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524122" /> </DataNode> <DataNode TextLabel="1-acyl LPC" GraphId="edf02" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1458.0" CenterY="470.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17504" /> </DataNode> <DataNode TextLabel="PITPNB " GraphId="edf17" Type="Protein" GroupRef="b1596"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524110" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="3176.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P48739" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="edf61" Type="Protein" GroupRef="b9c41"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="MAG " GraphId="ee3b3" Type="Metabolite" GroupRef="b6fdb"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Attribute Key="complex_id" Value="R-ALL-5696066" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2796.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17408" /> </DataNode> <DataNode TextLabel="2-acyl LPS" GraphId="ee8d4" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2789.5" CenterY="1067.0" Width="79.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:37646" /> </DataNode> <DataNode TextLabel="acyl group" GraphId="ef484" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1379.5" CenterY="1161.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:22221" /> </DataNode> <DataNode TextLabel="LPSAT" GraphId="ef598" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2892.5" CenterY="1063.0" Width="45.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524037" /> </DataNode> <DataNode TextLabel="PLA2G1B " GraphId="ef617" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04054" /> </DataNode> <DataNode TextLabel="MBOAT2 " GraphId="ef74f" Type="Protein" GroupRef="aa2dd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524029" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2676.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6ZWT7" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="ef7e9" Type="Protein" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2776.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="efbd5" Type="Protein" GroupRef="c823c"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PLA2G2A " GraphId="eff5b" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2716.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14555" /> </DataNode> <DataNode TextLabel="PCYT2 dimer" GraphId="f01fa" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="757.0" CenterY="1650.0" Width="86.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500642" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="f0476" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3045.0" CenterY="979.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f0591" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="4006.0" CenterY="1606.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PLA2G5 " GraphId="f0942" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P39877" /> </DataNode> <DataNode TextLabel="PPi" GraphId="f0965" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="803.5" CenterY="1758.0" Width="35.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29888" /> </DataNode> <DataNode TextLabel="LPGAT" GraphId="f0ad3" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2288.5" CenterY="1065.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524026" /> </DataNode> <DataNode TextLabel="Glycerol" GraphId="f0e2c" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1711.5" CenterY="1681.0" Width="65.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17754" /> </DataNode> <DataNode TextLabel="PCYT1 dimer" GraphId="f116c" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="730.0" CenterY="1616.0" Width="86.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524125" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="f168e" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2667.0" CenterY="1685.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="H2O" GraphId="f1728" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="2926.5" CenterY="282.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="f199c" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3406.5" CenterY="1026.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PLD6 " GraphId="f1a03" Type="Protein" GroupRef="e24a7"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-5601921" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1920.0" CenterY="2636.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8N2A8" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="f24f8" Type="Metabolite" GroupRef="e2e21"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="ATP" GraphId="f25e3" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1381.0" CenterY="1021.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:30616" /> </DataNode> <DataNode TextLabel="LPC (22:6)" GraphId="f26b2" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="376.0" CenterY="1987.0" Width="78.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:64567" /> </DataNode> <DataNode TextLabel="DHAP" GraphId="f26ca" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1213.0" CenterY="830.0" Width="50.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57642" /> </DataNode> <DataNode TextLabel="PPi" GraphId="f27a7" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="602.5" CenterY="1141.0" Width="35.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29888" /> </DataNode> <DataNode TextLabel="PLA2(12)" GraphId="f2994" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3825.0" CenterY="1161.5" Width="40.0" Height="35.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524141" /> </DataNode> <DataNode TextLabel="Ca2+ " GraphId="f2c92" Type="Metabolite" GroupRef="c81e8"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524040" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="1220.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="2-acyl LPI" GraphId="f2ec2" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3464.5" CenterY="1068.0" Width="77.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:62746" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="f2f71" Type="Protein" GroupRef="ccb6c"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2456.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="LPCAT" GraphId="f304b" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3885.5" CenterY="1650.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524029" /> </DataNode> <DataNode TextLabel="H2O" GraphId="f356a" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="797.5" CenterY="755.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="PLA2G4D " GraphId="f3615" Type="Protein" GroupRef="e7278"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Attribute Key="complex_id" Value="R-HSA-3215272" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1500.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q86XP0" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f3676" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3369.0" CenterY="309.0" Width="84.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PE" GraphId="f3ae4" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="1000.0" CenterY="1648.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16038" /> </DataNode> <DataNode TextLabel="LPCAT4 " GraphId="f3b7b" Type="Protein" GroupRef="a7d79"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524035" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1220.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q643R3" /> </DataNode> <DataNode TextLabel="cytidine&#xA;5'-monophosphate" GraphId="f3b8b" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1156.0" CenterY="533.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17361" /> </DataNode> <DataNode TextLabel="GPD2" GraphId="f4106" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1279.5" CenterY="665.0" Width="53.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P43304" /> </DataNode> <DataNode TextLabel="PC" GraphId="f4598" Type="Metabolite"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="440.5" CenterY="1563.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="GPETA" GraphId="f4653" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3085.5" CenterY="1755.0" Width="55.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16929" /> </DataNode> <DataNode TextLabel="PLA2G4E " GraphId="f46b7" Type="Protein" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2996.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q3MJ16" /> </DataNode> <DataNode TextLabel="CPNE6 " GraphId="f479e" Type="Protein" GroupRef="aae87"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333699" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2576.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95741" /> </DataNode> <DataNode TextLabel="LPA " GraphId="f4a31" Type="Metabolite" GroupRef="bfeaa"> <Attribute Key="cellular_location" Value="mitochondrial intermembrane space" /> <Attribute Key="complex_id" Value="R-ALL-5696037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1920.0" CenterY="2856.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:52288" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="f4bb4" Type="Protein" GroupRef="e2e21"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500634" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="f5096" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="2703.5" CenterY="1025.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PG" GraphId="f510c" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3806.5" CenterY="304.0" Width="33.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17517" /> </DataNode> <DataNode TextLabel="AGPAT5 " GraphId="f54ea" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2836.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NUQ2" /> </DataNode> <DataNode TextLabel="GPCPD1" GraphId="f5753" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3164.5" CenterY="1850.0" Width="57.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NPB8" /> </DataNode> <DataNode TextLabel="PLA2G1B " GraphId="f5813" Type="Protein" GroupRef="bec83"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2876.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04054" /> </DataNode> <DataNode TextLabel="PLD3 " GraphId="f5a04" Type="Protein" GroupRef="abedd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524126" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2756.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8IV08" /> </DataNode> <DataNode TextLabel="Mg2+ " GraphId="f5b9b" Type="Metabolite" GroupRef="c6a82"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1500633" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18420" /> </DataNode> <DataNode TextLabel="AGPAT9 " GraphId="f5ca9" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2916.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q53EU6" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f6383" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3750.0" CenterY="2336.0" Width="56.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="CPNE1 " GraphId="f6764" Type="Protein" GroupRef="cfe86"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333679" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99829" /> </DataNode> <DataNode TextLabel="1-acyl LPG" GraphId="f6a30" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2628.0" CenterY="1063.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:62747" /> </DataNode> <DataNode TextLabel="CHK/ETNK" GraphId="f6b64" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="782.0" CenterY="1846.0" Width="72.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500619" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="f6bf2" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2496.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="LIPH, I" GraphId="f6c18" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="284.0" CenterY="1206.0" Width="44.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-6792447" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f7116" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3193.0" CenterY="1615.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="f74d0" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="3699.0" CenterY="1025.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="f775b" Type="Protein" GroupRef="d68f8"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524026" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="940.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="CRLS1" GraphId="f7a92" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2592.5" CenterY="564.0" Width="45.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UJA2" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f7d0c" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3508.0" CenterY="1589.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PL " GraphId="f7d80" Type="Metabolite" GroupRef="cfe86"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333679" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16247" /> </DataNode> <DataNode TextLabel="1-acyl LPI" GraphId="f7ebb" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="3470.0" CenterY="307.0" Width="74.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:28914" /> </DataNode> <DataNode TextLabel="LPCAT3 " GraphId="f8066" Type="Protein" GroupRef="cd93e"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524037" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1080.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6P1A2" /> </DataNode> <DataNode TextLabel="STARD10" GraphId="f81b1" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1425.0" CenterY="1048.0" Width="64.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9Y365" /> </DataNode> <DataNode TextLabel="DAG" GraphId="f8210" Type="Metabolite"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="388.5" CenterY="1695.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17815" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="f8309" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2616.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="CPNE1 " GraphId="f837c" Type="Protein" GroupRef="aae87"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-5333699" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99829" /> </DataNode> <DataNode TextLabel="PS" GraphId="f83af" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3017.0" CenterY="1066.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:18303" /> </DataNode> <DataNode TextLabel="CoA-SH" GraphId="f873b" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="2462.0" CenterY="494.0" Width="64.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15346" /> </DataNode> <DataNode TextLabel="CEPT1:Mg2+/Mn2+" GraphId="f8873" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="720.5" CenterY="1526.0" Width="129.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500587" /> </DataNode> <DataNode TextLabel="CDP-DAG" GraphId="f88dc" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1004.5" CenterY="594.0" Width="75.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17962" /> </DataNode> <DataNode TextLabel="PLA2G4A " GraphId="f935e" Type="Protein" GroupRef="c7eb3"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524157" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="940.0" CenterY="3056.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P47712" /> </DataNode> <DataNode TextLabel="PGS1" GraphId="f93d8" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1111.5" CenterY="573.0" Width="39.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q32NB8" /> </DataNode> <DataNode TextLabel="PITPNM1,2,3" GraphId="f93fb" Type="Complex"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="362.5" CenterY="1027.0" Width="85.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8869240" /> </DataNode> <DataNode TextLabel="1-acyl LPA" GraphId="f9463" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1080.0" CenterY="1065.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16975" /> </DataNode> <DataNode TextLabel="PE" GraphId="f988a" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="1767.0" CenterY="427.0" Width="30.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16038" /> </DataNode> <DataNode TextLabel="PLA2(3)" GraphId="f99bf" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2801.5" CenterY="1547.5" Width="39.0" Height="33.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1524128" /> </DataNode> <DataNode TextLabel="AGPAT5" GraphId="f9b12" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="869.5" CenterY="663.0" Width="57.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NUQ2" /> </DataNode> <DataNode TextLabel="MGLL dimer" GraphId="f9c94" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2298.0" CenterY="1614.0" Width="80.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500601" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="f9f18" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="2766.0" CenterY="305.0" Width="84.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="fa2b2" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1014.5" CenterY="953.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="acyl-CoA" GraphId="fa4fd" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1295.5" CenterY="875.0" Width="73.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17984" /> </DataNode> <DataNode TextLabel="PLA2G1B " GraphId="fa57a" Type="Protein" GroupRef="da902"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1360.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04054" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="fa74f" Type="Protein" GroupRef="a8753"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524137" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="660.0" CenterY="2556.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="1-acyl LPA" GraphId="fab36" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="1020.0" CenterY="687.0" Width="82.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16975" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="fabb2" Type="Protein" GroupRef="cdd13"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524120" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2536.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="fad65" Type="Metabolite"> <Attribute Key="cellular_location" Value="mitochondrial inner membrane" /> <Graphics CenterX="2717.0" CenterY="594.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="LPCAT1 " GraphId="faead" Type="Protein" GroupRef="bbfda"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500583" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="2936.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q8NF37" /> </DataNode> <DataNode TextLabel="PLA2G4B " GraphId="fb26d" Type="Protein" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="2956.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P0C869" /> </DataNode> <DataNode TextLabel="H2O" GraphId="fb63f" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="508.5" CenterY="2311.0" Width="43.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15377" /> </DataNode> <DataNode TextLabel="L-Ser" GraphId="fb996" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1123.0" CenterY="1681.0" Width="68.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:33384" /> </DataNode> <DataNode TextLabel="PLA2G4F " GraphId="fba1f" Type="Protein" GroupRef="e8b4f"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-1524112" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="800.0" CenterY="3016.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q68DD2" /> </DataNode> <DataNode TextLabel="PLA2G10 " GraphId="fbc25" Type="Protein" GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute 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GroupRef="d4777"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602354" /> <Attribute Key="copies_num" Value="9" /> <Graphics CenterX="1500.0" CenterY="2696.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:29108" /> </DataNode> <DataNode TextLabel="CHPT1:Mg2+/Mn2+" GraphId="fcbb7" Type="Complex"> <Attribute Key="cellular_location" Value="Golgi membrane" /> <Graphics CenterX="401.5" CenterY="1649.0" Width="87.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500652" /> </DataNode> <DataNode TextLabel="PMCHO " GraphId="fcbfd" Type="Metabolite" GroupRef="dbaf0"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-ALL-8874447" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" 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</DataNode> <DataNode TextLabel="ADP" GraphId="fd082" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="769.0" CenterY="1796.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:456216" /> </DataNode> <DataNode TextLabel="RARRES3 " GraphId="fd0df" Type="Protein" GroupRef="ad14e"> <Attribute Key="cellular_location" Value="cytosol" /> <Attribute Key="complex_id" Value="R-HSA-8858540" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1640.0" CenterY="2976.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UL19" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="fd987" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="287.0" CenterY="1338.0" Width="84.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref 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ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PC " GraphId="fe737" Type="Metabolite" GroupRef="b1596"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524110" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="3156.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16110" /> </DataNode> <DataNode TextLabel="AcCho" GraphId="fe825" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="523.5" CenterY="2248.0" Width="55.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15355" /> </DataNode> <DataNode TextLabel="MIGA complexes" GraphId="fe889" Type="Complex"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Graphics CenterX="653.0" CenterY="656.5" Width="72.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8954399" /> </DataNode> <DataNode TextLabel="PLA2G2D " GraphId="fede7" Type="Protein" GroupRef="d1afb"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-1602359" /> <Attribute Key="copies_num" Value="8" /> <Graphics CenterX="1500.0" CenterY="2516.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9UNK4" /> </DataNode> <DataNode TextLabel="CTP" GraphId="ff11b" Type="Metabolite"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="668.0" CenterY="1714.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17677" /> </DataNode> <DataNode TextLabel="MBOAT7" GraphId="ff1f7" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="3794.5" CenterY="1064.0" Width="61.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96N66" /> </DataNode> <DataNode TextLabel="STARD7 " GraphId="ff39a" Type="Protein" GroupRef="a5be1"> <Attribute Key="cellular_location" Value="mitochondrial outer membrane" /> <Attribute Key="complex_id" Value="R-HSA-8873897" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="1780.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9NQZ5" /> </DataNode> <DataNode TextLabel="PLD2 " GraphId="ff4ae" Type="Protein" GroupRef="abedd"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1524126" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2736.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14939" /> </DataNode> <DataNode TextLabel="LPIN" GraphId="ff52f" Type="Complex"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="728.5" CenterY="1364.0" Width="35.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-1500636" /> </DataNode> <DataNode TextLabel="lysoPC" GraphId="ff7ab" Type="Metabolite"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="3551.5" CenterY="2294.0" Width="49.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:60479" /> </DataNode> <DataNode TextLabel="LCFA(-)" GraphId="ffc7d" Type="Metabolite"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="2170.0" CenterY="1103.0" Width="88.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:57560" /> </DataNode> <DataNode TextLabel="PLD2 " GraphId="ffef2" Type="Protein" GroupRef="f3c95"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Attribute Key="complex_id" Value="R-HSA-1500639" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="2656.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14939" /> </DataNode> <Interaction GraphId="a0038"> <Comment Source="Reactome">Plasmalogens (1-alk-1'-enyl- 2-acyl-sn-glycero-3-phosphoethanolamine or 1-alk-1'-enyl-2-acyl-sn-glycero-3-phosphocholine) are abundant (4-32% of total membrane phospholipids) membrane glycerophospholipids found throughout bacterial, invertebrate and vertebrate animal kingdoms. They differ from other membrane glycerophospholipids by having an alk-1'-enyl ether-linked chain at the glycerol sn-1 carbon. Plasmalogens are critical for normal cell function and development and their levels are altered in disease states; decreased in peroxisomal disorders, Alzheimer disease and Down syndrome, and elevated in tumours. Plasmalogens can be hydrolysed into lysoplasmalogens (1-alk-1'-enyl-2-hydroxy-sn-glycero-3-phosphoethanolamine or 1-alk-1'-enyl-2-hydroxy-sn-glycero-3-phosphocholine). Lysoplasmalogens are bioactive metabolites which have membrane-perturbing and cell lysis effects. Their levels are normally maintained at very low levels in cells, with lysoplasmalogens formed by plasmalogen hydrolysis converted back to plasmalogen in a transacylation reaction (a remodelling pathway). Alternatively, lysoplasmalogen may be degraded enzymatically by several hydrolytic enzymes that includes lysoplasmalogenase (THEM86B). THEM86B catalyses the hydrolysis of the vinyl ether bond of lysoplasmenylcholine (PMCHO) and lysoplasmenylethanolamine (PMETAM) to form a fatty aldehyde and glycerophosphocholine (GPCHO) and glycerophosphoethanolamine (GPETAM) respectively. THEM86B is localised to the ER membrane of liver and small intestinal mucosal cells where it is highly active and is probably an important enzyme there, maintaining the balance between plasmalogen and lysoplasmalogen, thereby preserving membrane stability and function (Wu et al. 2011, Honsho et al. 2015).</Comment> <BiopaxRef>aa3</BiopaxRef> <BiopaxRef>f4e</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="4057.0" Y="1408.0" /> <Point X="4057.0" Y="1476.0" /> <Anchor Position="0.0" Shape="None" GraphId="ad226" /> <Anchor Position="0.99" Shape="None" GraphId="ea5e6" /> <Anchor Position="0.5" Shape="None" GraphId="d9899" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8874435" /> </Interaction> <Interaction GraphId="a01fd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1753.0" Y="470.0" GraphRef="e6895" RelX="-1.0" RelY="0.0" /> <Point X="1709.0" Y="458.0" GraphRef="d4c7a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482781" /> </Interaction> <Interaction GraphId="a0413"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3879.0" Y="213.0" GraphRef="be42c" RelX="-0.014925373134328358" RelY="0.9393939393939394" /> <Point X="3878.0" Y="253.0" GraphRef="f2de5" RelX="-6.0" RelY="-0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602368" /> </Interaction> <Interaction GraphId="a074a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1143.0" Y="601.0" GraphRef="ece82" RelX="0.650000000000091" RelY="0.0" /> <Point X="1201.0" Y="591.0" GraphRef="e22bd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482939" /> </Interaction> <Interaction GraphId="a07b3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="870.0" Y="391.0" GraphRef="b27e3" RelX="1.0" RelY="0.0" /> <Point X="892.0" Y="413.0" GraphRef="ce03d" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696074" /> </Interaction> <Interaction GraphId="a0ac3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="915.0" Y="1046.0" GraphRef="cafa2" RelX="0.0" RelY="0.9393939393939394" /> <Point X="913.0" Y="1073.0" GraphRef="f5b25" RelX="-36.0" RelY="-5.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482656" /> </Interaction> <Interaction GraphId="a0b27"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, 1-acyl-lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzymes 1-acyl-sn-glycerol-3-phosphate acyltransferases (AGPAT1 through 11), and lysophosphatidylcholine acyltransferase (LPCAT1) (Aguado and Campbell 1998).&lt;br&gt;&lt;br&gt;See recent review by Agarwal (2012, in press).&lt;br&gt;&lt;br&gt;AGPAT1, 2, 3 and LPCAT1 have been characterized biochemically (AGPAT1, 2: Yamashita et al. 2007, West et al. 1997, Aguado and Campbell 1998, Gale et al. 2006; AGPAT3: Agarwal et al. 2006; LPCAT1: Nakanishi et al. 2006, Chen et al. 2006). Two additional proteins, AGPAT4 and AGPAT5, are inferred to have such activity based on studies of homologous mouse enzymes (Lu et al. 2005). These enzymes differ in their tissue specific patterns of expression in the body and in their preferences for specific acyl CoA molecules (Shindou and Shimizu 2009; Takeuchi and Reue 2009).&lt;br&gt;</Comment> <BiopaxRef>d7f</BiopaxRef> <BiopaxRef>e4c</BiopaxRef> <BiopaxRef>a6a</BiopaxRef> <BiopaxRef>fb1</BiopaxRef> <BiopaxRef>b2a</BiopaxRef> <BiopaxRef>d32</BiopaxRef> <BiopaxRef>a5b</BiopaxRef> <BiopaxRef>d87</BiopaxRef> <BiopaxRef>e1a</BiopaxRef> <BiopaxRef>dab</BiopaxRef> <BiopaxRef>e83</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="999.0" Y="999.0" /> <Point X="877.0" Y="997.0" /> <Anchor Position="0.0" Shape="None" GraphId="a5828" /> <Anchor Position="0.99" Shape="None" GraphId="c7284" /> <Anchor Position="0.5" Shape="None" GraphId="b55ee" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75885" /> </Interaction> <Interaction GraphId="a0ce5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="826.0" Y="697.0" GraphRef="d2455" RelX="-0.82000000000005" RelY="0.0" /> <Point X="793.0" Y="677.0" GraphRef="e6d95" RelX="-0.030303030303030304" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482548" /> </Interaction> <Interaction GraphId="a11bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="286.0" Y="599.0" GraphRef="d9929" RelX="-0.30000000000001137" RelY="0.8700000000000045" /> <Point X="279.0" Y="602.0" GraphRef="bd58a" RelX="-0.015873015873015872" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5333678" /> </Interaction> <Interaction GraphId="a11cd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3846.0" Y="1841.0" GraphRef="d2c1c" RelX="-1.0" RelY="0.0" /> <Point X="3696.0" Y="1624.0" GraphRef="fe31b" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482856" /> </Interaction> <Interaction GraphId="a1841"> <Comment Source="Reactome">DGAT2L6 (Diacylglycerol O-acyltransferase 2-like protein 6, also known as DC3) catalyzes the transfer of an acyl group from acyl-CoA to DAG (diacylglycerol) to form TAG (triacylglycerol). DGAT2L6 catalyzes this reaction with low efficiency in vitro so its physiological role is uncertain. Based on its similarity to other proteins of the DGAT family it is inferred to be localized to the endoplasmic reticulum membrane (Turkish et al. 2005). The putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P may also possess the same activity as DGAT2L6.</Comment> <BiopaxRef>d3e</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1934.0" Y="1739.0" /> <Point X="1867.0" Y="1738.0" /> <Anchor Position="0.0" Shape="None" GraphId="f2d3d" /> <Anchor Position="0.99" Shape="None" GraphId="b8e6b" /> <Anchor Position="0.5" Shape="None" GraphId="cbe6e" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8848580" /> </Interaction> <Interaction GraphId="a1946"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="292.0" Y="532.0" GraphRef="cf9ff" RelX="1.0" RelY="0.0" /> <Point X="316.0" Y="512.0" GraphRef="c8c8e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5333678" /> </Interaction> <Interaction GraphId="a1a03"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3183.0" Y="2215.0" GraphRef="c92fc" RelX="0.0" RelY="1.0" /> <Point X="3152.0" Y="2238.0" GraphRef="b3adc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602399" /> </Interaction> <Interaction GraphId="a1aa1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="979.0" Y="687.0" GraphRef="fab36" RelX="-1.0" RelY="0.0" /> <Point X="908.0" Y="697.0" GraphRef="c0cfb" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482548" /> </Interaction> <Interaction GraphId="a1d27"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="410.0" Y="1826.0" GraphRef="b63fb" RelX="0.0" RelY="-0.7000000000000455" /> <Point X="443.0" Y="1792.0" GraphRef="d3e62" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483004" /> </Interaction> <Interaction GraphId="a1dfd"> <Comment Source="Reactome">Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).</Comment> <BiopaxRef>f23</BiopaxRef> <BiopaxRef>d0b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="724.0" Y="2152.0" /> <Point X="644.0" Y="2152.0" /> <Anchor Position="0.0" Shape="None" GraphId="b6bfc" /> <Anchor Position="0.99" Shape="None" GraphId="afc3d" /> <Anchor Position="0.5" Shape="None" GraphId="fb3d3" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694485" /> </Interaction> <Interaction GraphId="a1e83"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1305.0" Y="921.0" GraphRef="c1486" RelX="-1.0" RelY="0.0" /> <Point X="1264.0" Y="932.0" GraphRef="de32e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-549112" /> </Interaction> <Interaction GraphId="a1ea2"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3) hydrolyze diacylglycerol (DAG), removing an acyl group to form 2-monoacylglycerol (2-MAG) (He et al. 2010, Jenkins et al. 2004, Basantani et al. 2011).</Comment> <BiopaxRef>e87</BiopaxRef> <BiopaxRef>ff8</BiopaxRef> <BiopaxRef>f14</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2098.0" Y="1629.0" /> <Point X="2173.0" Y="1597.0" /> <Anchor Position="0.0" Shape="None" GraphId="b3781" /> <Anchor Position="0.99" Shape="None" GraphId="af152" /> <Anchor Position="0.5" Shape="None" GraphId="cc6b8" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482811" /> </Interaction> <Interaction GraphId="a235a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2782.0" Y="1547.0" GraphRef="f99bf" RelX="-1.0" RelY="-0.030303030303030304" /> <Point X="2801.0" Y="1595.0" GraphRef="a3cc9" RelX="20.0" RelY="-0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482887" /> </Interaction> <Interaction GraphId="a2508"> <Comment Source="Reactome">At the inner mitochondrial (IM) membrane, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1) converts cytidine diphosphate-diacylglycerol (CDP-DAG) and glycerol-3-phosphate (G3P) to phosphatidylglycerophosphate (PGP) and cytidine monophosphate (CMP). This event is inferred from rats. The enzyme PGS1 has been characterized in humans (Ota et al. 2004).</Comment> <BiopaxRef>d88</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1078.0" Y="601.0" /> <Point X="1143.0" Y="601.0" /> <Anchor Position="0.0" Shape="None" GraphId="fab71" /> <Anchor Position="0.99" Shape="None" GraphId="ece82" /> <Anchor Position="0.5" Shape="None" GraphId="cad59" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482939" /> </Interaction> <Interaction GraphId="a27b3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="605.0" Y="1843.0" GraphRef="ad9b2" RelX="0.974025974025974" RelY="0.0" /> <Point X="626.0" Y="1845.0" GraphRef="c04fa" RelX="1.0" RelY="-1.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483096" /> </Interaction> <Interaction GraphId="a2b36"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1190.0" Y="706.0" GraphRef="dd088" RelX="-1.0" RelY="0.0" /> <Point X="1171.0" Y="705.0" GraphRef="f788b" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482695" /> </Interaction> <Interaction GraphId="a2d58"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3107.0" Y="310.0" GraphRef="ec037" RelX="-1.0" RelY="0.0" /> <Point X="2993.0" Y="241.0" GraphRef="d0f7e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8869425" /> </Interaction> <Interaction GraphId="a2d8a"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010) to form 1-acyl lysophosphatidylglycerol (LPG).</Comment> <BiopaxRef>e3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2458.0" Y="1081.0" /> <Point X="2555.0" Y="1082.0" /> <Anchor Position="0.0" Shape="None" GraphId="b2aeb" /> <Anchor Position="0.99" Shape="None" GraphId="d933e" /> <Anchor Position="0.5" Shape="None" GraphId="a04fb" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482900" /> </Interaction> <Interaction GraphId="a2e97"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="755.0" Y="1001.0" GraphRef="cb19e" RelX="0.9534883720930233" RelY="0.0" /> <Point X="871.0" Y="1073.0" GraphRef="ab420" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482679" /> </Interaction> <Interaction GraphId="a3405"> <Comment Source="Reactome">At the inner mitochondrial (IR) membrane, phosphatidylglycerol (PG) is hydrolysed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) (Ghomashchi et al. 2010) to form 2-acyl lysophosphatidylglycerol (LPG). 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The phospholipases are either phospholipase A2 group II alpha (PLA2G2A) (Seihamer et al. 1989, Singer et al. 2002), cytosolic phospholipase A2 group IV gamma (PLA2G4C) (Yamashita et al. 2005, Pickard et al. 1999, Ghomashchi et al. 2010, Yamashita et al. 2009), or calcium-independent phospholipase A2-gamma (PNPLA8) (Murakami et al. 2005, Underwood et al. 1998).</Comment> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>c97</BiopaxRef> <BiopaxRef>b73</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <BiopaxRef>f13</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3676.0" Y="1602.0" /> <Point X="3590.0" Y="1603.0" /> <Anchor Position="0.0" Shape="None" GraphId="ce665" /> <Anchor Position="0.99" Shape="None" GraphId="f9a4a" /> <Anchor Position="0.5" Shape="None" GraphId="d07bb" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482816" /> </Interaction> <Interaction GraphId="a4dbc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2471.0" Y="1134.0" GraphRef="ea446" RelX="-1.0" RelY="0.0" /> <Point X="2518.0" Y="1099.0" GraphRef="d7247" RelX="3.5" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482907" /> </Interaction> <Interaction GraphId="a4e12"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, choline/ethanolaminephosphotransferase 1 (CEPT1) or ethanolaminephosphotransferase 1 (EPT1) converts CDP- ethanolamine (CDP-ETA) and diacylglycerol (DAG) to phosphatidylethanolamine (PE) and cytidine monophosphate (CMP) (Horibata et al. 2007, Wright et al. 2002, Henneberry et al. 1999, Henneberry et al. 2002, Henneberry et al. 2000).</Comment> <BiopaxRef>f4c</BiopaxRef> <BiopaxRef>f82</BiopaxRef> <BiopaxRef>d15</BiopaxRef> <BiopaxRef>afb</BiopaxRef> <BiopaxRef>f18</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="815.0" Y="1617.0" /> <Point X="960.0" Y="1634.0" /> <Anchor Position="0.0" Shape="None" GraphId="fb408" /> <Anchor Position="0.99" Shape="None" GraphId="c7b59" /> <Anchor Position="0.5" Shape="None" GraphId="c7c3c" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482962" /> </Interaction> <Interaction GraphId="a4fdb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2739.0" Y="1025.0" GraphRef="f5096" RelX="0.9726027397260274" RelY="0.0" /> <Point X="2856.0" Y="1020.0" GraphRef="d29fb" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482691" /> </Interaction> <Interaction GraphId="a5055"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1102.0" Y="705.0" GraphRef="aab2e" RelX="-0.6900000000000546" RelY="0.0" /> <Point X="1089.0" Y="736.0" GraphRef="a17ec" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482695" /> </Interaction> <Interaction GraphId="a5059"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3192.0" Y="1850.0" GraphRef="f5753" RelX="0.9649122807017544" RelY="0.0" /> <Point X="3226.0" Y="1851.0" GraphRef="f5fb6" RelX="0.0" RelY="5.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483116" /> </Interaction> <Interaction GraphId="a5335"> <Comment Source="Reactome">At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) acylates 2-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG) (Nie et al. 2010).</Comment> <BiopaxRef>e70</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2642.0" Y="505.0" /> <Point X="2541.0" Y="503.0" /> <Anchor Position="0.0" Shape="None" GraphId="e1eaf" /> <Anchor Position="0.99" Shape="None" GraphId="eae83" /> <Anchor Position="0.5" Shape="None" GraphId="dacef" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482546" /> </Interaction> <Interaction GraphId="a53a5"> <Graphics 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</Graphics> <Xref Database="Reactome" ID="R-HSA-8873923" /> </Interaction> <Interaction GraphId="a57ce"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1426.0" Y="1892.0" GraphRef="baa67" RelX="1.7799999999999727" RelY="2.230000000000018" /> <Point X="1429.0" Y="1901.0" GraphRef="ed28c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483170" /> </Interaction> <Interaction GraphId="a59a8"> <Comment Source="Reactome">At the outer mitochondrial (OM) membrane, 1-acyl lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferases epsilon (AGPAT5) (Prasad et al. 2011).</Comment> <BiopaxRef>b66</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="908.0" Y="697.0" /> <Point X="826.0" Y="697.0" /> <Anchor Position="0.0" Shape="None" GraphId="c0cfb" /> <Anchor Position="0.99" Shape="None" GraphId="d2455" /> <Anchor Position="0.5" Shape="None" GraphId="af50d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482548" /> </Interaction> <Interaction GraphId="a5d57"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3654.0" Y="1710.0" GraphRef="cfcfc" RelX="0.0" RelY="-1.0" /> <Point X="3654.0" Y="1623.0" GraphRef="dd217" RelX="11.0" RelY="-1.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482856" /> </Interaction> <Interaction GraphId="a5de3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="224.0" Y="1310.0" GraphRef="ba48d" RelX="-0.030000000000001137" RelY="1.5599999999999454" /> <Point X="251.0" Y="1289.0" GraphRef="aff6b" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6792445" /> </Interaction> <Interaction GraphId="a6059"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1562.0" Y="546.0" GraphRef="e9ede" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="1570.0" Y="633.0" GraphRef="e826d" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482778" /> </Interaction> <Interaction GraphId="a645e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2920.0" Y="2369.0" GraphRef="bc699" RelX="0.9512195121951219" RelY="0.0" /> <Point X="3066.0" Y="2269.0" GraphRef="bfe8b" RelX="3.0" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602417" /> </Interaction> <Interaction GraphId="a6a10"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2641.0" Y="555.0" GraphRef="a7276" RelX="-1.0" RelY="0.0" /> <Point X="2626.0" Y="527.0" GraphRef="fd206" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482689" /> </Interaction> <Interaction GraphId="a6c0a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="729.0" Y="1298.0" GraphRef="e9800" RelX="0.0" RelY="1.0" /> <Point X="676.0" Y="1339.0" GraphRef="f54e0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483219" /> </Interaction> <Interaction GraphId="a6dcc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2792.0" Y="1647.0" GraphRef="ac019" RelX="0.9555555555555556" RelY="0.0" /> <Point X="2772.0" Y="1688.0" GraphRef="ced7c" RelX="-6.5" RelY="23.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482667" /> </Interaction> <Interaction GraphId="a6f02"> <Comment Source="Reactome">The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. Human PCTP-like protein (STARD10) (Olayioye et al. 2005) is thought to be a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine (PC) (and phosphatidylethanolamine (PE), not shown here) between intracellular membranes, especially to lamellar body membranes. Saturated PC is a major component of pulmonary surfactant, a mixture of proteins and phospholipids that plays an important role in facilitating gas exchange by maintaining alveolar stability. After synthesis in the endoplasmic reticulum, saturated PC is transported to lamellar bodies (LBs) for storage prior to secretion. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) mediated reacylation is a final step in saturated PC synthesis prior to transport and LPCAT1 is proposed to form a complex with STARD10 at the ER membrane to facilitate the synthesis then transport of saturated PC to LBs (Lin et al. 2015).</Comment> <BiopaxRef>e92</BiopaxRef> <BiopaxRef>c7d</BiopaxRef> <BiopaxRef>fb4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1553.0" Y="1130.0" /> <Point X="1552.0" Y="1088.0" /> <Anchor Position="0.0" Shape="None" GraphId="bb16a" /> <Anchor Position="0.99" Shape="None" GraphId="dbab8" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873923" /> </Interaction> <Interaction GraphId="a6fdc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3658.0" Y="1062.0" GraphRef="bb37c" RelX="1.2399999999997817" RelY="0.2599999999999909" /> <Point X="3667.0" Y="1025.0" GraphRef="f74d0" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> 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</Interaction> <Interaction GraphId="a804a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="984.0" Y="535.0" GraphRef="e703d" RelX="-1.0" RelY="0.0" /> <Point X="1006.0" Y="501.0" GraphRef="e970d" RelX="-13.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8878654" /> </Interaction> <Interaction GraphId="a83b4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="665.0" Y="1007.0" GraphRef="b820d" RelX="0.0" RelY="1.0" /> <Point X="694.0" Y="1052.0" GraphRef="babb7" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483121" /> </Interaction> <Interaction GraphId="a8405"> <Comment Source="Reactome">Dilysocardiolipin (DLCL) transports via membrane contact sites between the endoplasmic reticulum (ER) and the inner mitochondria membranes (IM) (Zhao et al. 2009, Buckland et al. 1998).</Comment> <BiopaxRef>f7f</BiopaxRef> <BiopaxRef>ba1</BiopaxRef> <Graphics 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The event is inferred from rats (Vance 1990, Vance 1991).</Comment> <BiopaxRef>c86</BiopaxRef> <BiopaxRef>bee</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1184.0" Y="1884.0" /> <Point X="1003.0" Y="1666.0" /> <Anchor Position="0.0" Shape="None" GraphId="c1672" /> <Anchor Position="0.99" Shape="None" GraphId="f01c3" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483077" /> </Interaction> <Interaction GraphId="a8fbc"> <Comment Source="Reactome">Copine 1, 3, 6 and 7 (CPNE1,3,6,7) are a family of calcium-dependent phospholipid-binding proteins thought to be involved in membrane trafficking processes. 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This reaction is inferred from rats, but PLD enzymes are present in humans (Hammond et al. 1995, Steed et al. 1998, Cao et al. 1997).</Comment> <BiopaxRef>a97</BiopaxRef> <BiopaxRef>e65</BiopaxRef> <BiopaxRef>d36</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1397.0" Y="1592.0" /> <Point X="1465.0" Y="1592.0" /> <Anchor Position="0.0" Shape="None" GraphId="c7a55" /> <Anchor Position="0.99" Shape="None" GraphId="d2a5e" /> <Anchor Position="0.5" Shape="None" GraphId="b2a29" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483142" /> </Interaction> <Interaction GraphId="a9eea"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3963.0" Y="1655.0" GraphRef="cc34e" RelX="-1.0" RelY="0.0" /> <Point X="3931.0" Y="1673.0" GraphRef="ff582" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482533" /> </Interaction> <Interaction GraphId="aa0f8"> <Graphics ConnectorType="Segmented" 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CDP-diacylglycerol-inositol 3-phosphatidyltransferase (CDIPT) converts cytidine diphosphate-diacylglycerol (CDP-DAG) and inositol (Ins) into phosphatidylinositol (PI) and cytidine monophosphate (CMP) (Lykidis et al. 1997).</Comment> <BiopaxRef>c39</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="764.0" Y="1190.0" /> <Point X="764.0" Y="1243.0" /> <Anchor Position="0.0" Shape="None" GraphId="b4ddc" /> <Anchor Position="0.99" Shape="None" GraphId="d681a" /> <Anchor Position="0.5" Shape="None" GraphId="ff2be" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482976" /> </Interaction> <Interaction GraphId="ac169"> <Comment Source="Reactome">In the cytosol, ethanolamine (ETA) is phosphorylated to phosphoethanolamine (PETA) by choline kinase (CHK) dimer or by ethanolamine kinase 1/2 (ETNK1/2) (Lykidis et al. 2001, Gallego-Ortega et al. 2009). CHK dimer consists of either choline kinase alpha subunit (CHKA) or beta subunit (CHKB) homodimer, or of CHKA:CHKB heterodimer.</Comment> <BiopaxRef>e88</BiopaxRef> <BiopaxRef>b3c</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="717.0" Y="1880.0" /> <Point X="718.0" Y="1812.0" /> <Anchor Position="0.0" Shape="None" GraphId="e43e4" /> <Anchor Position="0.99" Shape="None" GraphId="f2e26" /> <Anchor Position="0.5" Shape="None" GraphId="fe92f" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483222" /> </Interaction> <Interaction GraphId="ac1f3"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysocardiolipin acyltransferase 1 (LCLAT1) aka ALCAT1 acylates monolysocardiolipin (MLCL) to cardiolipin (CL) (Cao et al. 2004, Zhao et al. 2009).</Comment> <BiopaxRef>ba1</BiopaxRef> <BiopaxRef>ce4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1803.0" Y="1063.0" /> <Point X="1706.0" 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The missense mutation Q626H lacks the N-terminal PIT domain needed for transport of phospholipids and renewal of photoreceptors membranes is impaired (Kohn et al. 2007).</Comment> <BiopaxRef>f00</BiopaxRef> <BiopaxRef>e95</BiopaxRef> <BiopaxRef>c28</BiopaxRef> <BiopaxRef>d2a</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="434.0" Y="1066.0" /> <Point X="434.0" Y="1000.0" /> <Anchor Position="0.0" Shape="None" GraphId="b8670" /> <Anchor Position="0.99" Shape="None" GraphId="dc802" /> <Anchor Position="0.5" Shape="None" GraphId="e06eb" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8869241" /> </Interaction> <Interaction GraphId="b1c63"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="709.0" Y="1579.0" GraphRef="c68ff" RelX="-1.0" RelY="0.0" /> <Point X="591.0" Y="1572.0" GraphRef="bab11" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482961" /> </Interaction> <Interaction GraphId="b1dcd"> <Comment Source="Reactome">At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylethanolamine (PE) to cardiolipin (CL) and 1-acyl lysophosphatidylethanolamine (LPE) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). 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These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Group III (PLA2G3) (Murakami et al. 2003, Murakami et al. 2005); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).</Comment> <BiopaxRef>d1a</BiopaxRef> <BiopaxRef>bfb</BiopaxRef> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>bd4</BiopaxRef> <BiopaxRef>e18</BiopaxRef> <BiopaxRef>c00</BiopaxRef> <BiopaxRef>d33</BiopaxRef> <BiopaxRef>b28</BiopaxRef> <BiopaxRef>d58</BiopaxRef> <BiopaxRef>b5c</BiopaxRef> <BiopaxRef>b14</BiopaxRef> <BiopaxRef>d05</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3848.0" Y="253.0" /> <Point X="3920.0" Y="254.0" /> <Anchor Position="0.0" Shape="None" GraphId="cbd82" /> <Anchor Position="0.99" Shape="None" GraphId="b414a" /> <Anchor Position="0.5" Shape="None" GraphId="f2de5" /> <Anchor Position="0.5" Shape="None" GraphId="e696a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602368" /> </Interaction> <Interaction GraphId="b36e5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3017.0" Y="2268.0" GraphRef="fdd1d" RelX="-0.9200000000000728" RelY="0.0" /> <Point X="3027.0" Y="2208.0" GraphRef="cc084" RelX="-0.012658227848101266" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602417" /> </Interaction> <Interaction GraphId="b3829"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3680.0" Y="1683.0" GraphRef="b7ce4" RelX="1.0" RelY="-0.01999999999998181" /> <Point X="3729.0" Y="1691.0" GraphRef="df3cd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482547" /> </Interaction> <Interaction GraphId="b3af8"> <Comment Source="Reactome">At the plasma membrane, phosphatidylcholine (PC) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidylcholine (LPC) by membrane-associated phospholipase B1 (PLB1) (Maury et al. 2002, Gassama-Diagne et al. 1992).</Comment> <BiopaxRef>cb6</BiopaxRef> <BiopaxRef>e1c</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3152.0" Y="2238.0" /> <Point X="3064.0" Y="2238.0" /> <Anchor Position="0.0" Shape="None" GraphId="b3adc" /> <Anchor Position="0.99" Shape="None" GraphId="c9f24" /> <Anchor Position="0.5" Shape="None" GraphId="e96d0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602399" /> </Interaction> <Interaction GraphId="b3b49"> <Comment Source="Reactome">At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999).</Comment> <BiopaxRef>a12</BiopaxRef> <BiopaxRef>fa1</BiopaxRef> <BiopaxRef>c76</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1570.0" Y="633.0" /> <Point X="1730.0" Y="634.0" /> <Anchor Position="0.0" Shape="None" GraphId="e826d" /> <Anchor Position="0.99" Shape="None" GraphId="c6884" /> <Anchor Position="0.5" Shape="None" GraphId="db27e" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482778" /> </Interaction> <Interaction GraphId="b3d7b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2714.0" Y="1741.0" GraphRef="d129f" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="2732.0" Y="1770.0" GraphRef="b0193" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482545" /> </Interaction> <Interaction GraphId="b402b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2680.0" Y="1651.0" GraphRef="c16c6" RelX="1.0" RelY="0.0" /> <Point X="2743.0" Y="1618.0" GraphRef="ddaa7" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482884" /> </Interaction> <Interaction GraphId="b4083"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="550.0" Y="1706.0" GraphRef="eb2b0" RelX="0.9726027397260274" RelY="0.0" /> <Point X="591.0" Y="1572.0" GraphRef="bab11" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482961" /> </Interaction> <Interaction GraphId="b40ed"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="529.0" Y="1843.0" GraphRef="ad9b2" RelX="-1.0" RelY="0.0" /> <Point X="512.0" Y="1843.0" GraphRef="e5be8" RelX="0.5" RelY="-8.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483159" /> </Interaction> <Interaction GraphId="b4233"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1617.0" Y="1131.0" GraphRef="ca050" RelX="-1.0" RelY="0.0" /> <Point X="1553.0" Y="1130.0" GraphRef="bb16a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873923" /> </Interaction> <Interaction GraphId="b4313"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylethanolamine (LPE) to form phosphatidylethanolamine (PE). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008).</Comment> <BiopaxRef>aba</BiopaxRef> <BiopaxRef>ee8</BiopaxRef> <BiopaxRef>ae4</BiopaxRef> <BiopaxRef>d4e</BiopaxRef> <BiopaxRef>b3a</BiopaxRef> <BiopaxRef>f24</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2513.0" Y="1689.0" /> <Point X="2597.0" Y="1686.0" /> <Anchor Position="0.0" Shape="None" GraphId="a3741" /> <Anchor Position="0.99" Shape="None" GraphId="bc347" /> <Anchor Position="0.5" Shape="None" GraphId="b7c0e" /> </Graphics> <Xref 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RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482759" /> </Interaction> <Interaction GraphId="b50fc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3590.0" Y="1603.0" GraphRef="f9a4a" RelX="-0.8600000000001273" RelY="0.009999999999990905" /> <Point X="3545.0" Y="1643.0" GraphRef="e46f2" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482816" /> </Interaction> <Interaction GraphId="b52b3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1682.0" Y="518.0" GraphRef="abb28" RelX="-0.0136986301369863" RelY="1.0" /> <Point X="1671.0" Y="533.0" GraphRef="c4a17" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482775" /> </Interaction> <Interaction GraphId="b52de"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3136.0" Y="1850.0" GraphRef="f5753" RelX="-1.0" RelY="0.0" /> <Point X="3099.0" Y="1848.0" GraphRef="b8f16" RelX="-0.5" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483107" /> </Interaction> <Interaction GraphId="b5347"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2714.0" Y="1711.0" GraphRef="d129f" RelX="-0.023255813953488372" RelY="-1.0" /> <Point X="2743.0" Y="1618.0" GraphRef="ddaa7" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482884" /> </Interaction> <Interaction GraphId="b548a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="189.0" Y="1137.0" GraphRef="bc1ed" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="198.0" Y="1154.0" GraphRef="ef9e8" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602446" /> </Interaction> <Interaction GraphId="b57be"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3463.0" Y="1643.0" GraphRef="e46f2" RelX="-1.0" RelY="0.0" /> <Point X="3415.0" Y="1662.0" GraphRef="c873a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482685" /> </Interaction> <Interaction GraphId="b57d0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1512.0" Y="565.0" GraphRef="c5883" RelX="-0.013333333333333334" RelY="-1.0" /> <Point X="1540.0" Y="475.0" GraphRef="bcfc1" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482894" /> </Interaction> <Interaction GraphId="b58f1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2650.0" Y="1651.0" GraphRef="c16c6" RelX="-1.0" RelY="0.0" /> <Point X="2617.0" Y="1624.0" GraphRef="c92e1" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482828" /> </Interaction> <Interaction GraphId="b5e73"> <Comment Source="Reactome">At the plasma membrane, phosphatidylinositol (PI) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidylinositol (LPI) by secretory phospholipase A2 proteins (Singer et al. 2002, Ishizaki et al. 1999). These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).</Comment> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>bd4</BiopaxRef> <BiopaxRef>bfb</BiopaxRef> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>e18</BiopaxRef> <BiopaxRef>c00</BiopaxRef> <BiopaxRef>d33</BiopaxRef> <BiopaxRef>b28</BiopaxRef> <BiopaxRef>d58</BiopaxRef> <BiopaxRef>d1a</BiopaxRef> <BiopaxRef>b5c</BiopaxRef> <BiopaxRef>d05</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3603.0" Y="254.0" /> <Point X="3476.0" Y="254.0" /> <Anchor Position="0.0" Shape="None" GraphId="ad631" /> <Anchor Position="0.99" Shape="None" GraphId="aba21" /> 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membrane contact sites between the endoplasmic reticulum (ER) and the inner mitochondria membranes (IM) (Cao et al. 2004, Zhao et al. 2009, Taylor &amp; Hatch 2009).</Comment> <BiopaxRef>abb</BiopaxRef> <BiopaxRef>ba1</BiopaxRef> <BiopaxRef>ce4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1799.0" Y="613.0" /> <Point X="1859.0" Y="1046.0" /> <Anchor Position="0.0" Shape="None" GraphId="ed498" /> <Anchor Position="0.99" Shape="None" GraphId="fcfa7" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482773" /> </Interaction> <Interaction GraphId="bc396"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3373.0" Y="1706.0" GraphRef="c34f7" RelX="1.0" RelY="-0.03225806451612903" /> <Point X="3343.0" Y="1662.0" GraphRef="f8ae2" RelX="-17.5" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482685" /> </Interaction> <Interaction GraphId="bc41d"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).</Comment> <BiopaxRef>aba</BiopaxRef> <BiopaxRef>ee8</BiopaxRef> <BiopaxRef>b3a</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3278.0" Y="1023.0" /> <Point X="3169.0" Y="1024.0" /> <Anchor Position="0.0" Shape="None" GraphId="c1cc9" /> <Anchor Position="0.99" Shape="None" GraphId="c91ef" /> <Anchor Position="0.5" Shape="None" GraphId="ca7cb" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="bc5bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3356.0" Y="1785.0" GraphRef="cb133" RelX="-5.070000000000164" RelY="0.009999999999990905" /> <Point X="3237.0" Y="1615.0" GraphRef="f7116" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482629" /> </Interaction> <Interaction GraphId="bc90b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1070.0" Y="548.0" GraphRef="cfedd" RelX="0.0" RelY="1.0" /> <Point X="1078.0" Y="601.0" GraphRef="fab71" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482939" /> </Interaction> <Interaction GraphId="bc967"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.</Comment> <BiopaxRef>d66</BiopaxRef> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ae9</BiopaxRef> <BiopaxRef>a12</BiopaxRef> <BiopaxRef>fa1</BiopaxRef> <BiopaxRef>c76</BiopaxRef> <BiopaxRef>b89</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2743.0" Y="1618.0" /> <Point X="2822.0" Y="1620.0" /> <Anchor Position="0.0" Shape="None" GraphId="ddaa7" /> <Anchor Position="0.99" Shape="None" GraphId="d1220" /> <Anchor Position="0.5" Shape="None" GraphId="c0d1a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482884" /> </Interaction> <Interaction GraphId="bca68"> <Comment Source="Reactome">At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts monolysocardiolipin (MLCL) and phosphatidylcholine (PC) to cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009). Although this reaction is reversible, the net effect of the phospholipase A and acyltransferase reactions drives it towards the formation of LPC and CL.</Comment> <BiopaxRef>afe</BiopaxRef> <BiopaxRef>f70</BiopaxRef> <BiopaxRef>f99</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1709.0" Y="458.0" /> <Point X="1569.0" Y="458.0" /> <Anchor Position="0.0" Shape="None" GraphId="d4c7a" /> <Anchor Position="0.99" Shape="None" GraphId="fabdf" /> <Anchor Position="0.5" Shape="None" GraphId="fedd8" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482781" /> </Interaction> <Interaction GraphId="bcc06"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2555.0" Y="1082.0" GraphRef="d933e" RelX="0.9699999999997999" RelY="0.009999999999990905" /> <Point X="2659.0" Y="1111.0" GraphRef="ea81e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482900" /> </Interaction> <Interaction GraphId="bce9a"> <Comment Source="Reactome">At the inner mitochondrial (IM) membrane, phosphatidate cytidylyltransferase 2 (CDS2) converts phosphatidic acid (PA) and cytidine triphosphate (CTP) into cytidine diphosphate-diacylglycerol (CDP-DAG). Both ER and mitochondrial membranes have the capability to synthesise cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997, Schlame &amp; Haldar 1993). However, transport of CDP-DAG between organelles cannot be ruled out (Stuhne-Sekalec et al. 1986).</Comment> <BiopaxRef>c39</BiopaxRef> <BiopaxRef>af4</BiopaxRef> <BiopaxRef>e09</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="877.0" Y="596.0" /> <Point X="947.0" Y="596.0" /> <Anchor Position="0.0" Shape="None" GraphId="b6214" /> <Anchor Position="0.99" Shape="None" GraphId="c1ec8" /> <Anchor Position="0.5" Shape="None" GraphId="a397d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483165" /> </Interaction> <Interaction GraphId="bd3c3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1102.0" Y="705.0" GraphRef="aab2e" RelX="-0.6900000000000546" RelY="0.0" /> <Point X="1061.0" Y="687.0" GraphRef="fab36" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482695" /> </Interaction> <Interaction GraphId="bd3fb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1650.0" Y="1589.0" GraphRef="ce150" RelX="0.7699999999999818" RelY="-0.009999999999990905" /> <Point X="1634.0" Y="1685.0" GraphRef="b799a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696448" /> </Interaction> <Interaction GraphId="bd587"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1706.0" Y="1062.0" GraphRef="ded50" RelX="-0.9700000000000273" RelY="-0.009999999999990905" /> <Point X="1660.0" Y="1061.0" GraphRef="ceacb" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482861" /> </Interaction> <Interaction GraphId="bd663"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3284.0" Y="1107.0" GraphRef="a81bb" RelX="1.1199999999998909" RelY="0.0" /> <Point X="3315.0" Y="1068.0" GraphRef="ca405" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482776" /> </Interaction> <Interaction GraphId="bd74f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="352.0" Y="559.0" GraphRef="a4409" RelX="-1.0" RelY="0.0" /> <Point X="317.0" Y="559.0" GraphRef="ce17f" RelX="16.0" RelY="3.5" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5333678" /> </Interaction> <Interaction GraphId="bdccb"> <Comment Source="Reactome">Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 4 (AGPAT6) at the endoplasmic reticulum (ER) membrane (Cao et al., 2006; Chen et al., 2008).</Comment> <BiopaxRef>e60</BiopaxRef> <BiopaxRef>acf</BiopaxRef> <BiopaxRef>fb1</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1264.0" Y="932.0" /> <Point X="1119.0" Y="1004.0" /> <Anchor Position="0.0" Shape="None" GraphId="de32e" /> <Anchor Position="0.99" Shape="None" GraphId="bab85" /> <Anchor Position="0.5" Shape="None" GraphId="d2a95" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-549112" /> </Interaction> <Interaction GraphId="bdd85"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2265.0" Y="1065.0" GraphRef="f0ad3" RelX="-1.0" RelY="0.0" /> <Point X="2291.0" Y="1030.0" GraphRef="b9402" RelX="-4.5" RelY="-0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482635" /> </Interaction> <Interaction GraphId="bde73"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="438.0" Y="1268.0" GraphRef="fe537" RelX="0.0" RelY="1.0" /> <Point X="474.0" Y="1296.0" GraphRef="b282f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873794" /> </Interaction> <Interaction GraphId="bdf5f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2822.0" Y="1620.0" GraphRef="d1220" RelX="0.7899999999999636" RelY="0.01999999999998181" /> <Point X="2843.0" Y="1589.0" GraphRef="ce531" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482884" /> </Interaction> <Interaction GraphId="bdfe9"> <Comment Source="Reactome">In mitochondria, ethanolamine-phosphate phospho-lyase and 5-phosphohydroxy-L-lysine phospho-lyase (ETNPPL and PHYKPL respectively) are two closely related pyridoxal-phosphate-dependent, homotetrameric ammoniophospholyases that hydrolyse phosphoethanolamine (PETA) and 5-phosphohydroxylysine (5PHL) respectively (Veiga-da-Cunha et al. 2012). PETA is a component and a precursor of phospholipids whereas 5PHL is a breakdown product of collagen. ETNPPL utilises one pyridoxal 5'-phosphate (PXLP) as cofactor per subunit. </Comment> <BiopaxRef>dd2</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="933.0" Y="1965.0" /> <Point X="1019.0" Y="1965.0" /> <Anchor Position="0.0" Shape="None" GraphId="b9eb2" /> <Anchor Position="0.99" Shape="None" GraphId="d3e36" /> <Anchor Position="0.5" Shape="None" GraphId="f3d0d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696415" /> </Interaction> <Interaction GraphId="be36b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2991.0" Y="1768.0" GraphRef="e5f2e" RelX="2.5900000000001455" RelY="-0.01999999999998181" /> <Point X="3149.0" Y="1615.0" GraphRef="f7116" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482545" /> </Interaction> <Interaction GraphId="be4b7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3846.0" Y="1841.0" GraphRef="d2c1c" RelX="-1.0" RelY="0.0" /> <Point X="3676.0" Y="1602.0" GraphRef="ce665" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482816" /> </Interaction> <Interaction GraphId="be708"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="733.0" Y="1148.0" GraphRef="cf049" RelX="-0.013333333333333334" RelY="1.0" /> <Point X="764.0" Y="1190.0" GraphRef="b4ddc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482976" /> </Interaction> <Interaction GraphId="bea6b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="772.0" Y="1717.0" GraphRef="b5560" RelX="0.4700000000000273" RelY="-0.01999999999998181" /> <Point X="803.0" Y="1743.0" GraphRef="f0965" RelX="-0.02857142857142857" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483190" /> </Interaction> <Interaction GraphId="beca4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2541.0" Y="503.0" GraphRef="eae83" RelX="-1.0100000000002183" RelY="-0.01999999999998181" /> <Point X="2494.0" Y="494.0" GraphRef="f873b" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482546" /> </Interaction> <Interaction GraphId="bee94"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1576.0" Y="389.0" GraphRef="a966d" RelX="-1.240000000000009" RelY="0.0" /> <Point X="1512.0" Y="565.0" GraphRef="c5883" RelX="-0.013333333333333334" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482850" /> </Interaction> <Interaction GraphId="bef7a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="267.0" Y="1099.0" GraphRef="fe17c" RelX="-1.0" RelY="0.0" /> <Point X="198.0" Y="1154.0" GraphRef="ef9e8" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602446" /> </Interaction> <Interaction GraphId="bf0b7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3169.0" Y="1024.0" GraphRef="c91ef" RelX="-1.0900000000001455" RelY="0.009999999999990905" /> <Point X="3032.0" Y="1066.0" GraphRef="f83af" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="bf45b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="947.0" Y="596.0" GraphRef="c1ec8" RelX="0.7000000000000455" RelY="0.0" /> <Point X="967.0" Y="594.0" GraphRef="f88dc" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483165" /> </Interaction> <Interaction GraphId="bf4b0"> <Comment Source="Reactome">In the cytosol, choline kinase alpha subunit (CHKA) homodimer, choline kinase beta subunit (CHKB) dimer, or CHKA:CHKB heterodimer phosphorylates choline (Cho) to produce phosphocholine (PCho) (Malito et al. 2006, Gallego-Ortega et al. 2009).</Comment> <BiopaxRef>e88</BiopaxRef> <BiopaxRef>c57</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="410.0" Y="1896.0" /> <Point X="410.0" Y="1826.0" /> <Anchor Position="0.0" Shape="None" GraphId="acf06" /> <Anchor Position="0.99" Shape="None" GraphId="b63fb" /> <Anchor Position="0.5" Shape="None" GraphId="e8d2e" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483004" /> </Interaction> <Interaction GraphId="bf689"> <Comment Source="Reactome">Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.</Comment> <BiopaxRef>ec2</BiopaxRef> <BiopaxRef>b0f</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1316.0" Y="806.0" /> <Point X="1357.0" Y="879.0" /> <Anchor Position="0.0" Shape="None" GraphId="fbb62" /> <Anchor Position="0.99" Shape="None" GraphId="d8fea" /> <Anchor Position="0.5" Shape="None" GraphId="bf68a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75889" /> </Interaction> <Interaction GraphId="bf782"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3807.0" Y="1658.0" GraphRef="a2a51" RelX="-1.2399999999997817" RelY="-0.15000000000009095" /> <Point X="3793.0" Y="1691.0" GraphRef="df3cd" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482533" /> </Interaction> <Interaction GraphId="bf97c"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) hydrolyzes 1-acyl lysophosphatidylethanolamine (LPE) to produce glycerophosphoethanolamine (GPETA) (Yamashita et al. 2005, Yamashita et al. 2009).</Comment> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2955.0" Y="1642.0" /> <Point X="3012.0" Y="1642.0" /> <Anchor Position="0.0" Shape="None" GraphId="cf928" /> <Anchor Position="0.99" Shape="None" GraphId="a5d9c" /> <Anchor Position="0.5" Shape="None" GraphId="af8df" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482571" /> </Interaction> <Interaction GraphId="bf9e5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3119.0" Y="2199.0" GraphRef="a661f" RelX="0.9459459459459459" RelY="0.0" /> <Point X="3100.0" Y="2238.0" GraphRef="e96d0" RelX="-8.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602399" /> </Interaction> <Interaction GraphId="bfbbc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3315.0" Y="1068.0" GraphRef="ca405" RelX="-1.0" RelY="0.0" /> <Point X="3278.0" Y="1023.0" GraphRef="c1cc9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="bfdae"> <Comment Source="Reactome">The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. Human StAR-related lipid transfer protein 7 (STARD7, aka GTT1) is a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily that can bind phospholipids and sphingolipids such as phosphatidylcholine (PC). STARD7 is located on the outer mitochondrial membrane and binds ER-membrane PC (Flores-Martin et al. 2013).</Comment> <BiopaxRef>ab2</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="929.0" Y="1732.0" /> <Point X="979.0" Y="1567.0" /> <Anchor Position="0.0" Shape="None" GraphId="bdee6" /> <Anchor Position="0.99" Shape="None" GraphId="a8087" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8877153" /> </Interaction> <Interaction GraphId="bfe22"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="688.0" Y="1714.0" GraphRef="ff11b" RelX="1.0" RelY="0.0" /> <Point X="725.0" Y="1719.0" GraphRef="cc406" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483190" /> </Interaction> <Interaction GraphId="c00dc"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, monoglyceride lipase (MGLL) hydrolyzes 2-monoacylglycerol (2-MAG) to form a fatty acid and glycerol (Dinh et al. 2004, Zvonok et al. 2008, Bertrand et al. 2010, Labar et al. 2010).</Comment> <BiopaxRef>dd3</BiopaxRef> <BiopaxRef>bf7</BiopaxRef> <BiopaxRef>b62</BiopaxRef> <BiopaxRef>f60</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2274.0" Y="1650.0" /> <Point X="2328.0" Y="1650.0" /> <Anchor Position="0.0" Shape="None" GraphId="c5e62" /> <Anchor Position="0.99" Shape="None" GraphId="f6775" /> <Anchor Position="0.5" Shape="None" GraphId="c983a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482543" /> </Interaction> <Interaction GraphId="c0458"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="797.0" Y="740.0" GraphRef="f356a" RelX="-0.023255813953488372" RelY="-1.0" /> <Point X="832.0" Y="709.0" GraphRef="d0d74" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482604" /> </Interaction> <Interaction GraphId="c05b8"> <Comment Source="Reactome">Lysobisphosphatidic acid, also known as bis(monoacylglycerol) hydrogen phosphate (BMP), is enriched in late endosomes and not found in the endoplasmic reticulum (ER) or mitochondria where phosphatidylglycerol (PG) is synthesised. Late endosomes form membrane contact sites with the ER, providing a means for PG to enter the late endosome and be converted to BMP (Levine 2004, Eden et al. 2010, Kobayashi et al. 1998, Hullin-Matsuda et al. 2007, Kobayashi et al. 1999).</Comment> <BiopaxRef>e22</BiopaxRef> <BiopaxRef>c14</BiopaxRef> <BiopaxRef>a83</BiopaxRef> <BiopaxRef>b8c</BiopaxRef> <BiopaxRef>e24</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1532.0" Y="1671.0" /> <Point X="1550.0" Y="1756.0" /> <Anchor Position="0.0" Shape="None" GraphId="d8e7a" /> <Anchor Position="0.99" Shape="None" GraphId="a78f3" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483218" /> </Interaction> <Interaction GraphId="c060e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="815.0" Y="1456.0" GraphRef="a033c" RelX="-0.030303030303030304" RelY="-1.0" /> <Point X="815.0" Y="1422.0" GraphRef="e4530" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483182" /> </Interaction> <Interaction GraphId="c0698"> <Comment Source="Reactome">Glycerophospholipids are important structural and functional components of biological membranes, of serum lipoproteins and pulmonary surfactant and act as precursors of lipid mediators such as platelet-activating factor and eicosanoids. Phosphatidic acid (PA) is a common glycerophospholipid and its hydrolysis can mediate its functions described above. Phospholipases DDHD1 and 2 can mediate the hydrolysis of PA (Inoue et al. 2012, Nakajima et al. 2002). Defects in DDHD1 or DDHD2 can cause autosomal recessive spastic paraplegias 28 or 54 respectively (SPG28, MIM:609340; SPG54, MIM:615033). These are forms of neurodegenerative spastic paraplegia, characterised by slow, gradual, progressive weakness and spasticity of the lower limbs (Tesson et al. 2012, Schuurs-Hoeijmakers et al. 2012).</Comment> <BiopaxRef>c08</BiopaxRef> <BiopaxRef>b77</BiopaxRef> <BiopaxRef>fe1</BiopaxRef> <BiopaxRef>d3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="354.0" Y="1168.0" /> <Point X="355.0" Y="1244.0" /> <Anchor Position="0.0" Shape="None" GraphId="bb757" /> <Anchor Position="0.99" Shape="None" GraphId="a8bca" /> <Anchor Position="0.5" Shape="None" GraphId="a5e5f" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6786650" /> </Interaction> <Interaction GraphId="c0b30"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3085.0" Y="1770.0" GraphRef="f4653" RelX="-0.01818181818181818" RelY="1.0" /> <Point X="3101.0" Y="1808.0" GraphRef="b5ca0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483107" /> </Interaction> <Interaction GraphId="c11d3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2474.0" Y="1731.0" GraphRef="a437e" RelX="0.9726027397260274" RelY="0.0" /> <Point X="2513.0" Y="1689.0" GraphRef="a3741" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482646" /> </Interaction> <Interaction GraphId="c1201"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A,B,D/E/F) (Ghomashchi et al. 2010), or by group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008). This produces 1-acyl lysophosphatidylserine (LPS).</Comment> <BiopaxRef>ae9</BiopaxRef> <BiopaxRef>e3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3180.0" Y="1088.0" /> <Point X="3279.0" Y="1087.0" /> <Anchor Position="0.0" Shape="None" GraphId="ad7cc" /> <Anchor Position="0.99" Shape="None" GraphId="d8ff0" /> <Anchor Position="0.5" Shape="None" GraphId="ad65c" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482771" /> </Interaction> <Interaction GraphId="c1215"> <Comment Source="Reactome">At the plasma membrane, phosphatidylserine (PS) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidylserine (LPS) by secretory phospholipase A2 proteins (Singer et al. 2002, Ishizaki et al. 1999). These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).</Comment> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>bd4</BiopaxRef> <BiopaxRef>bfb</BiopaxRef> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>e18</BiopaxRef> <BiopaxRef>c00</BiopaxRef> <BiopaxRef>d33</BiopaxRef> <BiopaxRef>b28</BiopaxRef> <BiopaxRef>d58</BiopaxRef> <BiopaxRef>d1a</BiopaxRef> <BiopaxRef>b5c</BiopaxRef> <BiopaxRef>d05</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3160.0" Y="259.0" /> <Point X="3248.0" Y="254.0" /> <Anchor Position="0.0" Shape="None" GraphId="c9b90" /> <Anchor Position="0.99" Shape="None" GraphId="af527" /> <Anchor Position="0.5" Shape="None" GraphId="b821b" /> <Anchor Position="0.5" Shape="None" GraphId="f9fcc" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602374" /> </Interaction> <Interaction GraphId="c1259"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="230.0" Y="2020.0" GraphRef="bf83c" RelX="0.9534883720930233" RelY="0.0" /> <Point X="243.0" Y="1985.0" GraphRef="c0518" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8865637" /> </Interaction> <Interaction GraphId="c1299"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="648.0" Y="1714.0" GraphRef="ff11b" RelX="-1.0" RelY="0.0" /> <Point X="627.0" Y="1711.0" GraphRef="f6021" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483081" /> </Interaction> <Interaction GraphId="c1ad0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3279.0" Y="1087.0" GraphRef="d8ff0" RelX="0.9899999999997817" RelY="-0.009999999999990905" /> <Point X="3360.0" Y="1117.0" GraphRef="a8072" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482771" /> </Interaction> <Interaction GraphId="c1c09"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2880.0" Y="2369.0" GraphRef="bc699" RelX="-1.0" RelY="0.0" /> <Point X="2736.0" Y="2266.0" GraphRef="a4ec5" RelX="-2.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602398" /> </Interaction> <Interaction GraphId="c1c31"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2251.0" Y="1093.0" GraphRef="af12d" RelX="-1.0199999999999818" RelY="0.0" /> <Point X="2214.0" Y="1103.0" GraphRef="ffc7d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482920" /> </Interaction> <Interaction GraphId="c1d11"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="718.0" Y="1812.0" GraphRef="f2e26" RelX="0.009999999999990905" RelY="-0.6800000000000637" /> <Point X="748.0" Y="1796.0" GraphRef="fd082" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483222" /> </Interaction> <Interaction GraphId="c1daf"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3744.0" Y="1651.0" GraphRef="e5f54" RelX="-1.0" RelY="0.0" /> <Point X="3676.0" Y="1602.0" GraphRef="ce665" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482816" /> </Interaction> <Interaction GraphId="c1e13"> <Comment Source="Reactome">Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 1 (GPAT, also known as GPAM) and glycerol-3-phosphate acyltransferase 2 (GPAT2), at the outer mitochondrial (OM) membrane (Shindou &amp; Shimizu 2009, Chen et al. 2008, Takeuchi &amp; Reue 2009).</Comment> <BiopaxRef>acf</BiopaxRef> <BiopaxRef>fb1</BiopaxRef> <BiopaxRef>b2a</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1171.0" Y="705.0" /> <Point X="1102.0" Y="705.0" /> <Anchor Position="0.0" Shape="None" GraphId="f788b" /> <Anchor Position="0.99" Shape="None" GraphId="aab2e" /> <Anchor Position="0.5" Shape="None" GraphId="bc440" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482695" /> </Interaction> <Interaction GraphId="c1fdf"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="910.0" Y="1124.0" GraphRef="c9a33" RelX="0.0" RelY="-1.0" /> <Point X="915.0" Y="1097.0" GraphRef="f52cd" RelX="-9.5" RelY="12.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482679" /> </Interaction> <Interaction GraphId="c211a"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.</Comment> <BiopaxRef>d66</BiopaxRef> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ffa</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3415.0" Y="1662.0" /> <Point X="3306.0" Y="1662.0" /> <Anchor Position="0.0" Shape="None" GraphId="c873a" /> <Anchor Position="0.99" Shape="None" GraphId="b9dbf" /> <Anchor Position="0.5" Shape="None" GraphId="f8ae2" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482685" /> </Interaction> <Interaction GraphId="c2169"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, (PLA2G2A) or by calcium-independent phospholipase A2-gamma (PNPLA8), to form 1-acyl lysophosphatidylethanolamine (LPE) (Murakami et al. 2005, Kramer et al. 1989, Singer et al. 2002).</Comment> <BiopaxRef>f7a</BiopaxRef> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>f13</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2740.0" Y="1596.0" /> <Point X="2822.0" Y="1595.0" /> <Anchor Position="0.0" Shape="None" GraphId="a91cb" /> <Anchor Position="0.99" Shape="None" GraphId="ef237" /> <Anchor Position="0.5" Shape="None" GraphId="a3cc9" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482887" /> </Interaction> <Interaction GraphId="c231b"> <Comment Source="Reactome">At the outer mitochondrial (OM) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).</Comment> <BiopaxRef>e3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="832.0" Y="709.0" /> <Point X="909.0" Y="709.0" /> <Anchor Position="0.0" Shape="None" GraphId="d0d74" /> <Anchor Position="0.99" Shape="None" GraphId="fcf04" /> <Anchor Position="0.5" Shape="None" GraphId="ccfc4" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482604" /> </Interaction> <Interaction GraphId="c233d"> <Comment Source="Reactome">Phosphatidylcholine transfer protein (PCTP aka STARD2) is a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain superfamily, a functionally diverse group of proteins that share a unique structural motif for binding lipids (the START domain). PCTP is widely expressed with highest expression levels in oxidative tissues, including liver, heart, muscle, kidney and brown fat but very little expression in white adipose tissue. PCTP exclusively binds phosphatidylcholine (PC) in the cytosol of cells and may mediate PC exchange at cellular membranes (Roderick et al. 2002). Recent mouse studies reveals a key regulatory role for PCTP in lipid and glucose metabolism. PCTP appears to limit access of fatty acids to mitochondria by binding to (Ersoy et al. 2013) and stimulating the activity of acyl-coenzyme A thioesterase 13 (ACOT13, aka Acyl-CoA thioesterase 13, THEM2), an enzyme that catalyses the hydrolysis of acyl-CoAs to their free fatty acids (Kawano et al. 2014). Ultimately, insulin signaling is downregulated (Kang et al. 2010).</Comment> <BiopaxRef>a75</BiopaxRef> <BiopaxRef>b8a</BiopaxRef> <BiopaxRef>fa2</BiopaxRef> <BiopaxRef>c2f</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="474.0" Y="1296.0" /> <Point X="512.0" Y="1297.0" /> <Anchor Position="0.0" Shape="None" GraphId="b282f" /> <Anchor Position="0.99" Shape="None" GraphId="b385d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873794" /> </Interaction> <Interaction GraphId="c2604"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="299.0" Y="1099.0" GraphRef="fe17c" RelX="1.0" RelY="0.0" /> <Point X="434.0" Y="1066.0" GraphRef="b8670" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8869241" /> </Interaction> <Interaction GraphId="c27e8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1838.0" Y="1659.0" GraphRef="c6c95" RelX="-0.8299999999999272" RelY="-0.14000000000010004" /> <Point X="1805.0" Y="1726.0" GraphRef="d9e48" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482889" /> </Interaction> <Interaction GraphId="c2b0c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1357.0" Y="879.0" GraphRef="d8fea" RelX="0.41000000000008185" RelY="0.7300000000000182" /> <Point X="1325.0" Y="906.0" GraphRef="c1486" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75889" /> </Interaction> <Interaction GraphId="c2e67"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="714.0" Y="2195.0" GraphRef="abddc" RelX="1.0" RelY="0.0" /> <Point X="690.0" Y="2152.0" GraphRef="fb3d3" RelX="6.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694485" /> </Interaction> <Interaction GraphId="c3078"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="794.0" Y="1079.0" GraphRef="db3da" RelX="-0.030303030303030304" RelY="1.0" /> <Point X="782.0" Y="1108.0" GraphRef="a097a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483203" /> </Interaction> <Interaction GraphId="c316c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1238.0" Y="830.0" GraphRef="f26ca" RelX="1.0" RelY="0.0" /> <Point X="1316.0" Y="806.0" GraphRef="fbb62" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75889" /> </Interaction> <Interaction GraphId="c32d9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3902.0" Y="1620.0" GraphRef="b6514" RelX="0.6999999999998181" RelY="-0.029999999999972715" /> <Point X="3963.0" Y="1655.0" GraphRef="cc34e" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482862" /> </Interaction> <Interaction GraphId="c358b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2341.0" Y="1031.0" GraphRef="c35fd" RelX="0.9099999999998545" RelY="0.009999999999990905" /> <Point X="2392.0" Y="1063.0" GraphRef="c0d12" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482635" /> </Interaction> <Interaction GraphId="c38f2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3143.0" Y="1793.0" GraphRef="c12a8" RelX="-1.0" RelY="0.0" /> <Point X="3101.0" Y="1808.0" GraphRef="b5ca0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483107" /> </Interaction> <Interaction GraphId="c3903"> <Comment Source="Reactome">Phospholipase A1 member A (PLA1A, aka PS-PLA1) is a widely expressed, extracellular protein belonging to the pancreatic lipase family. Phospholipases are conserved in a wide range of organisms. PLA1A specifically hydrolyses PS to produce its corresponding lysophospholipid 2-acyl LPS. 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Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.</Comment> <BiopaxRef>e3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3642.0" Y="1090.0" /> <Point X="3536.0" Y="1082.0" /> <Anchor Position="0.0" Shape="None" GraphId="a1487" /> <Anchor Position="0.99" Shape="None" GraphId="cb8af" /> <Anchor Position="0.5" Shape="None" GraphId="bd6ad" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482932" /> </Interaction> <Interaction GraphId="c4f0e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2052.0" Y="1066.0" GraphRef="ba447" RelX="-1.0" RelY="0.0" /> <Point X="2018.0" Y="1064.0" GraphRef="bfc87" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482867" /> </Interaction> <Interaction GraphId="c5208"> <Comment Source="Reactome">At the plasma membrane, phosphatidylethanolamine (PE) is hydrolyzed, removing one of its acyl groups, to 1-acyl phosphatidylethanolamine (LPE) by secretory phospholipase A2 proteins (Singer et al. 2002, Ishizaki et al. 1999). These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Group III (PLA2G3) (Murakami et al. 2003, Murakami et al. 2005); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).</Comment> <BiopaxRef>d1a</BiopaxRef> <BiopaxRef>bfb</BiopaxRef> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>bd4</BiopaxRef> <BiopaxRef>e18</BiopaxRef> <BiopaxRef>c00</BiopaxRef> <BiopaxRef>d33</BiopaxRef> <BiopaxRef>b28</BiopaxRef> <BiopaxRef>d58</BiopaxRef> <BiopaxRef>b5c</BiopaxRef> <BiopaxRef>b14</BiopaxRef> <BiopaxRef>d05</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2699.0" Y="2266.0" /> <Point X="2777.0" Y="2266.0" /> <Anchor 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ID="R-HSA-1482691" /> </Interaction> <Interaction GraphId="c5534"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine N-methyltransferase (PEMT) methylates phosphatidylethanolamine (PE) and produces phosphatidylcholine (PC) (Vance &amp; Ridgway 1998, Shields et al. 2001, Guan et al. 1999).</Comment> <BiopaxRef>cce</BiopaxRef> <BiopaxRef>c02</BiopaxRef> <BiopaxRef>d07</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="996.0" Y="1591.0" /> <Point X="912.0" Y="1587.0" /> <Anchor Position="0.0" Shape="None" GraphId="f5e20" /> <Anchor Position="0.99" Shape="None" GraphId="fa218" /> <Anchor Position="0.5" Shape="None" GraphId="bcc8b" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483174" /> </Interaction> <Interaction GraphId="c5603"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="475.0" Y="1617.0" GraphRef="c5702" RelX="0.009999999999990905" RelY="-0.6099999999999" 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<Interaction GraphId="c63dd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="395.0" Y="1425.0" GraphRef="d2c34" RelX="0.18999999999999773" RelY="-1.2100000000000364" /> <Point X="425.0" Y="1447.0" GraphRef="c1e41" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483087" /> </Interaction> <Interaction GraphId="c6427"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2098.0" Y="1648.0" GraphRef="f9fc0" RelX="-0.8899999999998727" RelY="0.0" /> <Point X="2065.0" Y="1648.0" GraphRef="d2d39" RelX="0.9534883720930233" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482654" /> </Interaction> <Interaction GraphId="c6598"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2666.0" Y="644.0" GraphRef="c0db4" RelX="1.4200000000000728" RelY="0.01999999999998181" /> <Point X="2673.0" Y="594.0" GraphRef="fad65" RelX="-1.0" 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<Point X="893.0" Y="1074.0" GraphRef="fb5c4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482656" /> </Interaction> <Interaction GraphId="c6b83"> <Comment Source="Reactome">Lysophosphatidic acid (LPA) is a bioactive phospholipid. It consists of a single fatty acyl chain, a glycerol backbone and a free phosphate group. The acyl chain can be of varying length and degree of saturation hence many forms of LPA can exist. LPA is an important extracellular signalling molecule and an intermediate lipid in phospholipid metabolism inside the cell, playing an important role in modulating the structure and fluidity of lipid rafts. Degradation of LPA is important for termination of signalling and for the finetuning of lipid raft structure. Degradation of LPA can occur via either acylation or hydrolysis. Lysophosphatidic acid phosphatase type 6 (ACP6) can hydrolyse LPA of varying lengths. It is a monomeric enzyme located in mitochondria where it preferentially hydrolyses myristoyl LPA (C14:0) and other LPAs such as monounsaturated oleate (C18:1) or palmitate (C16:0) (latter two not shown here) (Hiroyama &amp; Takenawa 1999, Li et al. 2013).</Comment> <BiopaxRef>d47</BiopaxRef> <BiopaxRef>d7a</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="975.0" Y="501.0" /> <Point X="1063.0" Y="501.0" /> <Anchor Position="0.0" Shape="None" GraphId="a5db2" /> <Anchor Position="0.99" Shape="None" GraphId="a6083" /> <Anchor Position="0.5" Shape="None" GraphId="e970d" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8878654" /> </Interaction> <Interaction GraphId="c6ba3"> <Comment Source="Reactome">Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A, aka NLS1) plays an essential role in blood-brain barrier (BBB) formation and function and transports LPC into the brain via a flipping motion (Nguyen et al. 2014, Guemez-Gamboa et al. 2015, Quek et al. 2016). LPCs are synthesised by the liver, circulate bound to albumin and serve as the chemical carrier for DHA uptake via MFSD2A. LPC can contain docosahexanoic acid (DHA), the most abundant omega-3 fatty acid in brain. Despite large DHA content in phospholipids, the brain does not synthesise it. 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</Graphics> <Xref Database="Reactome" ID="R-HSA-1482685" /> </Interaction> <Interaction GraphId="c98a4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="979.0" Y="1567.0" GraphRef="a8087" RelX="0.5" RelY="-1.650000000000091" /> <Point X="983.0" Y="1564.0" GraphRef="d41b7" RelX="-0.013333333333333334" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8877153" /> </Interaction> <Interaction GraphId="c98ee"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1357.0" Y="879.0" GraphRef="d8fea" RelX="0.41000000000008185" RelY="0.7300000000000182" /> <Point X="1361.0" Y="911.0" GraphRef="a3f47" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75889" /> </Interaction> <Interaction GraphId="c99e3"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, PLA2G2A, to form 1-acyl lysophosphatidylserine (LPS) (Singer et al. 2002).</Comment> <BiopaxRef>b27</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3172.0" Y="1107.0" /> <Point X="3284.0" Y="1107.0" /> <Anchor Position="0.0" Shape="None" GraphId="bfc7a" /> <Anchor Position="0.99" Shape="None" GraphId="a81bb" /> <Anchor Position="0.5" Shape="None" GraphId="e16ce" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482776" /> </Interaction> <Interaction GraphId="ca2dd"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009).</Comment> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" 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This event has been inferred from rats and limited data for a human PISD (Forbes et al. 2007).</Comment> <BiopaxRef>fbc</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1430.0" Y="1919.0" /> <Point X="1290.0" Y="1945.0" /> <Anchor Position="0.0" Shape="None" GraphId="e4863" /> <Anchor Position="0.99" Shape="None" GraphId="ba9dd" /> <Anchor Position="0.5" Shape="None" GraphId="b229c" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483212" /> </Interaction> <Interaction GraphId="ca561"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG). 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These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).</Comment> <BiopaxRef>b27</BiopaxRef> <BiopaxRef>bd4</BiopaxRef> <BiopaxRef>bfb</BiopaxRef> <BiopaxRef>ab6</BiopaxRef> <BiopaxRef>e18</BiopaxRef> <BiopaxRef>c00</BiopaxRef> <BiopaxRef>d33</BiopaxRef> <BiopaxRef>b28</BiopaxRef> <BiopaxRef>d58</BiopaxRef> <BiopaxRef>d1a</BiopaxRef> <BiopaxRef>b5c</BiopaxRef> <BiopaxRef>d05</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="198.0" Y="1154.0" /> <Point X="197.0" Y="1235.0" /> <Anchor Position="0.0" Shape="None" GraphId="ef9e8" /> <Anchor Position="0.99" Shape="None" GraphId="a1d85" /> <Anchor Position="0.5" Shape="None" GraphId="f1fa5" /> <Anchor Position="0.5" Shape="None" GraphId="f2290" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602446" /> </Interaction> <Interaction GraphId="cc6bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3963.0" Y="1655.0" GraphRef="cc34e" RelX="-1.0" RelY="0.0" /> <Point X="3913.0" Y="1761.0" GraphRef="e6543" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482612" /> </Interaction> <Interaction GraphId="cc9d2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2414.0" Y="528.0" GraphRef="a85f2" RelX="0.9534883720930233" RelY="0.0" /> <Point X="2524.0" Y="642.0" GraphRef="dd2c2" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482847" /> </Interaction> <Interaction GraphId="ccb26"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2478.0" Y="1024.0" GraphRef="cf0e6" RelX="-0.7100000000000364" RelY="-0.009999999999990905" /> <Point X="2424.0" Y="1063.0" GraphRef="c0d12" RelX="0.9393939393939394" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482539" /> </Interaction> <Interaction GraphId="ccf2e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3776.0" Y="1847.0" GraphRef="d8ee4" RelX="0.9487179487179487" RelY="-0.02857142857142857" /> <Point X="3753.0" Y="1762.0" GraphRef="f9676" RelX="116.0" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482612" /> </Interaction> <Interaction GraphId="cd373"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2173.0" Y="1597.0" GraphRef="af152" RelX="0.75" RelY="-0.31999999999993634" /> <Point X="2237.0" Y="1560.0" GraphRef="d9169" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482811" /> </Interaction> <Interaction GraphId="cd4b7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="656.0" Y="1526.0" GraphRef="f8873" RelX="-1.0" RelY="0.0" /> <Point X="591.0" Y="1529.0" GraphRef="ca439" RelX="1.0" RelY="9.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482961" /> </Interaction> <Interaction GraphId="cd60e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3017.0" Y="2268.0" GraphRef="fdd1d" RelX="-0.9200000000000728" RelY="0.0" /> <Point X="2934.0" Y="2198.0" GraphRef="a8798" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602417" /> </Interaction> <Interaction GraphId="cdba2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2298.0" Y="1625.0" GraphRef="f9c94" RelX="0.0" RelY="1.0" /> <Point X="2299.0" Y="1652.0" GraphRef="c983a" RelX="-2.0" RelY="2.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482543" /> </Interaction> <Interaction GraphId="cdc54"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2637.0" Y="621.0" GraphRef="e0359" RelX="1.0399999999999636" RelY="0.0" /> <Point X="2673.0" Y="594.0" GraphRef="fad65" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482745" /> </Interaction> <Interaction GraphId="cdde2"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). 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<Point X="3776.0" Y="1651.0" GraphRef="e5f54" RelX="0.9393939393939394" RelY="0.0" /> <Point X="3832.0" Y="1623.0" GraphRef="b041d" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482862" /> </Interaction> <Interaction GraphId="ce53f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1706.0" Y="1062.0" GraphRef="ded50" RelX="-0.9700000000000273" RelY="-0.009999999999990905" /> <Point X="1679.0" Y="1039.0" GraphRef="e45d8" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482861" /> </Interaction> <Interaction GraphId="ce7e3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1408.0" Y="1652.0" GraphRef="e78a8" RelX="-1.0" RelY="0.0" /> <Point X="1439.0" Y="1592.0" GraphRef="b2a29" RelX="8.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483142" /> </Interaction> <Interaction GraphId="ce7e9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="694.0" Y="1400.0" GraphRef="c6c9b" RelX="-1.0" RelY="0.0" /> <Point X="676.0" Y="1339.0" GraphRef="f54e0" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483219" /> </Interaction> <Interaction GraphId="ce9cb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2328.0" Y="1650.0" GraphRef="f6775" RelX="0.5399999999999636" RelY="0.0" /> <Point X="2352.0" Y="1615.0" GraphRef="c33bd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482543" /> </Interaction> <Interaction GraphId="ceb12"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2190.0" Y="1649.0" GraphRef="d000c" RelX="-1.0" RelY="0.0" /> <Point X="2099.0" Y="1519.0" GraphRef="fd3ac" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482647" /> </Interaction> <Interaction GraphId="ceb22"> <Graphics 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</Interaction> <Interaction GraphId="cf29f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="299.0" Y="1099.0" GraphRef="fe17c" RelX="1.0" RelY="0.0" /> <Point X="354.0" Y="1168.0" GraphRef="bb757" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6786650" /> </Interaction> <Interaction GraphId="cf44e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="831.0" Y="1471.0" GraphRef="a033c" RelX="0.9393939393939394" RelY="0.0" /> <Point X="1397.0" Y="1592.0" GraphRef="c7a55" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483142" /> </Interaction> <Interaction GraphId="cf669"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3356.0" Y="1785.0" GraphRef="cb133" RelX="-5.070000000000164" RelY="0.009999999999990905" /> <Point X="3270.0" Y="1755.0" GraphRef="cc04b" RelX="0.9649122807017544" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482629" /> </Interaction> <Interaction GraphId="cf795"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="689.0" Y="656.0" GraphRef="fe889" RelX="1.0" RelY="-0.037037037037037035" /> <Point X="703.0" Y="596.0" GraphRef="b6592" RelX="-11.5" RelY="6.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8954398" /> </Interaction> <Interaction GraphId="cf94c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="755.0" Y="1001.0" GraphRef="cb19e" RelX="0.9534883720930233" RelY="0.0" /> <Point X="893.0" Y="1074.0" GraphRef="fb5c4" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482656" /> </Interaction> <Interaction GraphId="cfbeb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3135.0" Y="988.0" GraphRef="b5599" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="3180.0" Y="1088.0" GraphRef="ad7cc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482771" /> </Interaction> <Interaction GraphId="cfc09"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3476.0" Y="254.0" GraphRef="aba21" RelX="-1.2699999999999818" RelY="0.0" /> <Point X="3411.0" Y="309.0" GraphRef="f3676" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602377" /> </Interaction> <Interaction GraphId="cfca0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2948.0" Y="1668.0" GraphRef="b3e6d" RelX="-0.023255813953488372" RelY="-1.0" /> <Point X="2955.0" Y="1642.0" GraphRef="cf928" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482571" /> </Interaction> <Interaction GraphId="cfd83"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="728.0" Y="1353.0" GraphRef="ff52f" RelX="-0.02857142857142857" RelY="-1.0" /> <Point X="786.0" Y="1367.0" GraphRef="d59d6" RelX="0.0" RelY="37.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483203" /> </Interaction> <Interaction GraphId="cfea7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1459.0" Y="976.0" GraphRef="e09ee" RelX="-1.0" RelY="-0.030303030303030304" /> <Point X="1425.0" Y="976.0" GraphRef="c84fb" RelX="0.0" RelY="0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873929" /> </Interaction> <Interaction GraphId="cff60"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1241.0" Y="591.0" GraphRef="e22bd" RelX="1.0" RelY="0.0" /> <Point X="1265.0" Y="602.0" GraphRef="b4fbd" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483197" /> </Interaction> <Interaction GraphId="d0027"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1295.0" Y="890.0" GraphRef="fa4fd" RelX="-0.0136986301369863" RelY="1.0" /> <Point X="1264.0" Y="932.0" GraphRef="de32e" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-549112" /> </Interaction> <Interaction GraphId="d02e2"> <Comment Source="Reactome">In the cytosol, glycerophosphocholine phosphodiesterase (GPCPD1, also known as GDE5) hydrolyzes glycerophosphoethanolamine (GPETA) to produce ethanolamine (ETA) and glycerol-3-phosphate (G3P). This event has been inferred from mice. GPCPD1 has also been characterized in humans (Ota et al. 2004).</Comment> <BiopaxRef>d88</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3101.0" Y="1808.0" /> <Point X="3098.0" Y="1888.0" /> <Anchor Position="0.0" Shape="None" GraphId="b5ca0" /> <Anchor Position="0.99" Shape="None" GraphId="d9b5f" /> <Anchor Position="0.5" Shape="None" GraphId="b8f16" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483107" /> </Interaction> <Interaction GraphId="d072f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="4049.0" Y="1373.0" GraphRef="aae5b" RelX="1.0" RelY="-0.03225806451612903" /> <Point X="4057.0" Y="1408.0" GraphRef="ad226" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8874435" /> </Interaction> <Interaction GraphId="d08d8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2045.0" Y="1541.0" GraphRef="dc222" RelX="0.9710144927536232" RelY="0.0" 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<Xref Database="Reactome" ID="R-HSA-1482745" /> </Interaction> <Interaction GraphId="d16e5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3172.0" Y="2284.0" GraphRef="a291f" RelX="-0.023255813953488372" RelY="-1.0" /> <Point X="3152.0" Y="2238.0" GraphRef="b3adc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602399" /> </Interaction> <Interaction GraphId="d17a6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1616.0" Y="532.0" GraphRef="f10c7" RelX="-0.5499999999999545" RelY="-0.009999999999990905" /> <Point X="1594.0" Y="514.0" GraphRef="af9d1" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482775" /> </Interaction> <Interaction GraphId="d1cbe"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2714.0" Y="1658.0" GraphRef="d19a5" RelX="-1.2899999999999636" RelY="-0.14000000000010004" /> <Point X="2699.0" Y="1685.0" GraphRef="f168e" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482667" /> </Interaction> <Interaction GraphId="d1d06"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="825.0" Y="1647.0" GraphRef="b4b20" RelX="-1.0" RelY="-0.030303030303030304" /> <Point X="855.0" Y="1604.0" GraphRef="c7c3c" RelX="-32.5" RelY="-21.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482962" /> </Interaction> <Interaction GraphId="d20b8"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylethanolamine (LPE) to form phosphatidylethanolamine (PE). 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Y="427.0" GraphRef="f988a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482894" /> </Interaction> <Interaction GraphId="d423e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1653.0" Y="435.0" GraphRef="aeb88" RelX="-1.0" RelY="0.0" /> <Point X="1632.0" Y="407.0" GraphRef="f5936" RelX="-8.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482794" /> </Interaction> <Interaction GraphId="d4408"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 4C, PLA2G4C (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009), to form 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.</Comment> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3824.0" Y="1600.0" /> <Point X="3906.0" Y="1599.0" /> <Anchor Position="0.0" Shape="None" GraphId="ffed7" /> <Anchor Position="0.99" Shape="None" GraphId="c9e4c" /> <Anchor Position="0.5" Shape="None" GraphId="ce6f0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482827" /> </Interaction> <Interaction GraphId="d46a9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1041.0" Y="594.0" GraphRef="f88dc" RelX="0.9733333333333334" RelY="0.0" /> <Point X="1270.0" Y="511.0" GraphRef="cc1cc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483063" /> </Interaction> 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Human StAR-related lipid transfer protein 7 (STARD7, aka GTT1) is a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily that can bind phospholipids and sphingolipids (Flores-Martin et al. 2013). It was first identified as a gene overexpressed in a choriocarcinoma cell line (Durand et al. 2004). Human STARD7 is thought to transport phosphatidylcholine (PC) from ER membranes to mitochondrial membranes, inferred from rat experiments (Horibata &amp; Sugimoto 2010). Increasing evidence suggests that asthma pathogenesis is linked to mitochondrial dysfunction and STARD7 could play a protective role in mucosal tissues by preventing pathogenic immune responses (Yang et al. 2015).</Comment> <BiopaxRef>b87</BiopaxRef> <BiopaxRef>d54</BiopaxRef> <BiopaxRef>ab2</BiopaxRef> <BiopaxRef>e00</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1024.0" Y="1562.0" /> <Point X="1096.0" Y="1859.0" /> <Anchor Position="0.0" Shape="None" GraphId="f06c8" /> <Anchor Position="0.99" Shape="None" GraphId="fec35" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873830" /> </Interaction> <Interaction GraphId="dce0d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1977.0" Y="1541.0" GraphRef="dc222" RelX="-1.0" RelY="0.0" /> <Point X="1908.0" Y="1619.0" GraphRef="f0577" RelX="5.0" RelY="-1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482777" /> </Interaction> 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RelX="-1.0" RelY="0.0" /> <Point X="3362.0" Y="1643.0" GraphRef="bce32" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482696" /> </Interaction> <Interaction GraphId="e0442"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3370.0" Y="1026.0" GraphRef="f199c" RelX="-1.0" RelY="0.0" /> <Point X="3278.0" Y="1023.0" GraphRef="c1cc9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="e0448"> <Comment Source="Reactome">At the inner mitochondrial (IR) membrane, cardiolipin synthase (CRLS1) acylates 1-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG) (Nie et al. 2010).</Comment> <BiopaxRef>e70</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2626.0" Y="527.0" /> <Point X="2535.0" Y="525.0" /> <Anchor Position="0.0" Shape="None" GraphId="fd206" /> <Anchor Position="0.99" Shape="None" GraphId="a06c8" /> <Anchor Position="0.5" Shape="None" GraphId="b20ba" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482689" /> </Interaction> <Interaction GraphId="e05cc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="764.0" Y="1243.0" GraphRef="d681a" RelX="0.0" RelY="0.5299999999999727" /> <Point X="729.0" Y="1268.0" GraphRef="e9800" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482976" /> </Interaction> <Interaction GraphId="e066d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3806.0" Y="289.0" GraphRef="f510c" RelX="-0.030303030303030304" RelY="-1.0" /> <Point X="3848.0" Y="253.0" GraphRef="cbd82" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602368" /> </Interaction> <Interaction GraphId="e06e8"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="654.0" Y="1120.0" GraphRef="ff0bb" RelX="-0.39999999999997726" RelY="0.6800000000000637" /> <Point X="696.0" Y="1133.0" GraphRef="cf049" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483121" /> </Interaction> <Interaction GraphId="e0b71"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="877.0" Y="997.0" GraphRef="c7284" RelX="-1.2200000000000273" RelY="-0.01999999999998181" /> <Point X="810.0" Y="1064.0" GraphRef="db3da" RelX="0.9393939393939394" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75885" /> </Interaction> <Interaction GraphId="e10f6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1063.0" Y="501.0" GraphRef="a6083" RelX="0.8800000000001091" RelY="0.0" /> <Point X="1359.0" Y="534.0" GraphRef="a2e37" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8878654" /> </Interaction> <Interaction GraphId="e18fd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3590.0" Y="1625.0" GraphRef="f2911" RelX="-1.0599999999999454" RelY="0.009999999999990905" /> <Point X="3552.0" Y="1589.0" GraphRef="f7d0c" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482856" /> </Interaction> <Interaction GraphId="e2126"> <Comment Source="Reactome">The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRASLS members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains (Golczak et al. 2012), as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines (Mardian et al. 2015). Acyl chain remodelling can play a key role in regulating triglyceride accumulation and energy expenditure in adipocytes, making this process a potential target for treatment of metabolic disorders causing obesity. The example here describes the N-acyltransferase activity of HRASLSs for the production of N-acylphosphatidylethanolamines (NAPEs) (Uyama et al. 2012).</Comment> <BiopaxRef>c33</BiopaxRef> <BiopaxRef>ed9</BiopaxRef> <BiopaxRef>a1b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1056.0" Y="1385.0" /> <Point X="1192.0" Y="1129.0" /> <Anchor Position="0.0" Shape="None" GraphId="ec45c" /> <Anchor Position="0.99" Shape="None" GraphId="dbbec" /> <Anchor Position="0.5" Shape="None" GraphId="f7bc9" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8858298" /> </Interaction> <Interaction GraphId="e24b5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3151.0" Y="2299.0" GraphRef="a291f" RelX="-1.0" RelY="0.0" /> <Point X="3109.0" Y="2268.0" GraphRef="c8c10" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602417" /> </Interaction> <Interaction GraphId="e284c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="810.0" Y="1064.0" GraphRef="db3da" RelX="0.9393939393939394" RelY="0.0" /> <Point X="871.0" Y="1073.0" GraphRef="ab420" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482679" /> </Interaction> <Interaction GraphId="e2b71"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="475.0" Y="1617.0" GraphRef="c5702" RelX="0.009999999999990905" RelY="-0.6099999999999" /> <Point X="440.0" Y="1578.0" GraphRef="f4598" RelX="-0.030303030303030304" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482973" /> </Interaction> <Interaction GraphId="e2c1d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="668.0" Y="596.0" GraphRef="cc63c" RelX="0.974025974025974" RelY="0.0" /> <Point X="703.0" Y="596.0" GraphRef="a7998" RelX="-11.5" RelY="6.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8954398" /> </Interaction> <Interaction GraphId="e2ded"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3169.0" Y="1024.0" GraphRef="c91ef" RelX="-1.0900000000001455" RelY="0.009999999999990905" /> <Point X="3077.0" Y="979.0" GraphRef="f0476" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="e3637"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="817.0" Y="1108.0" GraphRef="e2a6a" RelX="0.01999999999998181" RelY="-3.1399999999998727" /> <Point X="797.0" Y="957.0" GraphRef="b0de6" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483182" /> </Interaction> <Interaction GraphId="e39a0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1425.0" Y="1037.0" GraphRef="f81b1" RelX="0.0" RelY="-1.0" /> <Point X="1425.0" Y="1002.0" GraphRef="e5c40" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873929" /> </Interaction> <Interaction GraphId="e3b07"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1199.0" Y="1887.0" GraphRef="d477e" RelX="0.0" RelY="-1.0" /> <Point X="1184.0" Y="1884.0" GraphRef="c1672" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483077" /> </Interaction> <Interaction GraphId="e3b8e"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylcholine (LPC) to form phosphatidylcholine (PC). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006); lysophosphatidylcholine acyltransferase 2 (LPCAT2) (Shindou et al. 2006); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008).</Comment> <BiopaxRef>b3a</BiopaxRef> <BiopaxRef>e0f</BiopaxRef> <BiopaxRef>ee8</BiopaxRef> <BiopaxRef>e1a</BiopaxRef> <BiopaxRef>dab</BiopaxRef> <BiopaxRef>f41</BiopaxRef> <BiopaxRef>ae4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3580.0" Y="1685.0" /> <Point X="3680.0" Y="1683.0" /> <Anchor Position="0.0" Shape="None" GraphId="fe411" /> <Anchor Position="0.99" Shape="None" GraphId="b7ce4" /> <Anchor Position="0.5" Shape="None" GraphId="b4292" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482547" /> </Interaction> <Interaction GraphId="e3bd4"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="606.0" Y="1793.0" GraphRef="b1c29" RelX="0.9534883720930233" RelY="0.0" /> <Point X="625.0" Y="1813.0" GraphRef="cf08c" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483096" /> </Interaction> <Interaction GraphId="e3c96"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="4034.0" Y="1443.0" GraphRef="bab67" RelX="1.0" RelY="-0.05263157894736842" /> <Point X="4057.0" Y="1443.0" GraphRef="d9899" RelX="0.0" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8874435" /> </Interaction> <Interaction GraphId="e3cc9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2983.0" Y="1608.0" GraphRef="fccbb" RelX="0.0" RelY="1.0" /> <Point X="2985.0" Y="1641.0" GraphRef="af8df" RelX="1.5" RelY="-1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482571" /> </Interaction> <Interaction GraphId="e3d75"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1019.0" Y="1965.0" GraphRef="d3e36" RelX="0.8600000000000136" RelY="0.0" /> <Point X="1073.0" Y="1945.0" GraphRef="c4e5d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696415" /> </Interaction> <Interaction GraphId="e3f29"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, PLA2G2A (Singer et al. 2002), to form 1-acyl lysophosphatidylglycerol (LPG).</Comment> <BiopaxRef>b27</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2465.0" Y="1098.0" /> <Point X="2564.0" Y="1098.0" /> <Anchor Position="0.0" Shape="None" GraphId="d28a0" /> <Anchor Position="0.99" Shape="None" GraphId="e3cfb" /> <Anchor Position="0.5" Shape="None" GraphId="d7247" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482907" /> </Interaction> <Interaction GraphId="e40bc"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, diacylglycerol (DAG) is acylated and forms triacylglycerol (TAG) by the action of diacylglycerol O-acyltransferase 1 (DGAT1) tetramer or by diacylglycerol O-acyltransferase 2 (DGAT2) (Wakimoto et al. 2003, Oelkers et al. 1998, Cases et al. 2001).</Comment> <BiopaxRef>d96</BiopaxRef> <BiopaxRef>ce2</BiopaxRef> <BiopaxRef>b95</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1921.0" Y="1673.0" /> <Point X="1838.0" Y="1659.0" /> <Anchor Position="0.0" Shape="None" GraphId="ea92f" /> <Anchor Position="0.99" Shape="None" GraphId="c6c95" /> <Anchor Position="0.5" Shape="None" GraphId="dc10e" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482889" /> </Interaction> <Interaction GraphId="e41dc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="793.0" Y="677.0" GraphRef="e6d95" RelX="-0.030303030303030304" RelY="1.0" /> <Point X="832.0" Y="709.0" GraphRef="d0d74" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482604" /> </Interaction> <Interaction GraphId="e4fdf"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="751.0" Y="1579.0" GraphRef="c68ff" RelX="0.9534883720930233" RelY="0.0" /> <Point X="815.0" Y="1617.0" GraphRef="fb408" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482962" /> </Interaction> <Interaction GraphId="e52ab"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3845.0" Y="994.0" GraphRef="b858f" RelX="0.0" RelY="0.9428571428571428" /> <Point X="3845.0" Y="1101.0" 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The phospholipases are either cytosolic phospholipase A2 alpha/beta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). 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This produces 2-acyl lysophosphatidylcholine (LPC). 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It appears to involve multiple steps including hydrolysis of phosphatidylglycerol (PG) by a phospholipase A2, acylation, and a reorientation of the phosphoryl ester (Poorthuis &amp; Hostetler 1978, Heravi &amp; Waite 1999, Hullin-Matsuda et al. 2007, Gallala &amp; Sandhoff 2010).</Comment> <BiopaxRef>e58</BiopaxRef> <BiopaxRef>e1e</BiopaxRef> <BiopaxRef>a18</BiopaxRef> <BiopaxRef>e22</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1589.0" Y="1765.0" /> <Point X="1677.0" Y="1770.0" /> <Anchor Position="0.0" Shape="None" GraphId="c1375" /> <Anchor Position="0.99" Shape="None" GraphId="aab63" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483209" /> </Interaction> <Interaction GraphId="ec626"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="478.0" Y="1706.0" GraphRef="eb2b0" RelX="-1.0" RelY="0.0" /> <Point X="474.0" Y="1678.0" GraphRef="aff35" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482973" /> </Interaction> <Interaction GraphId="ec7b0"> <Comment Source="Reactome">Choline (Cho) transports from the extracellular space through the plasma membrane via the choline transporter-like proteins (SLC44A1-5 also known as CTL1-5) to the cytosol (Okuda &amp; Haga 2000, Traiffort et al. 2005, O'Regan et al. 2000).&lt;br&gt;&lt;br&gt;CTL1 is broadly expressed on leukocytes and endothelial cells (Wille et al. 2001). CTL2 is highly expressed in human inner ear and is the target of antibody-induced hearing loss (Nair et al. 2004).</Comment> <BiopaxRef>d91</BiopaxRef> <BiopaxRef>fa8</BiopaxRef> <BiopaxRef>dcb</BiopaxRef> <BiopaxRef>ad7</BiopaxRef> <BiopaxRef>e3e</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="360.0" Y="2227.0" /> <Point X="453.0" Y="1936.0" /> <Anchor Position="0.0" Shape="None" GraphId="f8310" /> <Anchor Position="0.99" Shape="None" GraphId="f3e43" /> <Anchor Position="0.5" Shape="None" GraphId="db3b4" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-444433" /> </Interaction> <Interaction GraphId="ec8a3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1290.0" Y="1945.0" GraphRef="ba9dd" RelX="-1.400000000000091" RelY="0.2599999999999909" /> <Point X="1241.0" Y="1970.0" GraphRef="ac8ab" RelX="0.9534883720930233" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483212" /> </Interaction> <Interaction GraphId="eca38"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1859.0" Y="1046.0" GraphRef="fcfa7" RelX="0.599999999999909" RelY="4.329999999999927" /> <Point X="1862.0" Y="1049.0" GraphRef="c14f2" RelX="-0.02040816326530612" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482773" /> </Interaction> <Interaction GraphId="ecc7d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3625.0" Y="2246.0" GraphRef="ec0f7" RelX="-1.0" RelY="0.0" /> <Point X="3658.0" Y="2293.0" GraphRef="dc84f" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8952251" /> </Interaction> <Interaction GraphId="ece01"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3279.0" Y="1087.0" GraphRef="d8ff0" RelX="0.9899999999997817" RelY="-0.009999999999990905" /> <Point X="3315.0" Y="1068.0" GraphRef="ca405" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482771" /> </Interaction> <Interaction GraphId="ed18d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1512.0" Y="565.0" GraphRef="c5883" RelX="-0.013333333333333334" RelY="-1.0" /> <Point X="1581.0" Y="407.0" GraphRef="a93e8" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482794" /> </Interaction> <Interaction GraphId="ed314"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="970.0" Y="1049.0" GraphRef="d0c03" RelX="0.0" RelY="-1.0" /> <Point X="969.0" Y="998.0" GraphRef="b55ee" RelX="31.0" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75885" /> </Interaction> <Interaction GraphId="ed4da"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1541.0" Y="1597.0" GraphRef="b8cdb" RelX="0.9555555555555556" RelY="-0.030303030303030304" /> <Point X="1573.0" Y="1590.0" GraphRef="bd7f3" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696448" /> </Interaction> <Interaction GraphId="ee122"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="755.0" Y="1328.0" GraphRef="b9f03" RelX="1.0" RelY="0.0" /> <Point X="815.0" Y="1296.0" GraphRef="d6a0d" RelX="-1.0" RelY="31.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483182" /> </Interaction> <Interaction GraphId="ee132"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3032.0" Y="1066.0" GraphRef="f83af" RelX="1.0" RelY="0.0" /> <Point X="3172.0" Y="1107.0" GraphRef="bfc7a" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482776" /> </Interaction> <Interaction GraphId="ee441"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3824.0" Y="1064.0" GraphRef="ff1f7" RelX="0.9672131147540983" RelY="0.0" /> <Point X="3797.0" Y="1027.0" GraphRef="a4070" RelX="-16.5" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482598" /> </Interaction> <Interaction GraphId="ee4ac"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/delta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010). This produces 2-acyl lysophosphatidylserine (LPS). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.</Comment> <BiopaxRef>e3b</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2960.0" Y="1091.0" /> <Point X="2865.0" Y="1092.0" /> <Anchor Position="0.0" Shape="None" GraphId="dfe05" /> <Anchor Position="0.99" Shape="None" GraphId="b2fa6" /> <Anchor Position="0.5" Shape="None" GraphId="a2a24" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482897" /> </Interaction> <Interaction GraphId="ee4e1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2492.0" Y="1601.0" GraphRef="eb462" RelX="-1.3099999999999454" RelY="-0.009999999999990905" /> <Point X="2325.0" Y="1560.0" GraphRef="d9169" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482892" /> </Interaction> <Interaction GraphId="ee5a2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1226.0" Y="548.0" GraphRef="a1dd8" RelX="-0.023255813953488372" RelY="1.0" /> <Point X="1265.0" Y="602.0" GraphRef="b4fbd" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483197" /> </Interaction> <Interaction GraphId="ee6c6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1798.0" Y="580.0" GraphRef="cba1b" RelX="-0.02040816326530612" RelY="-1.0" /> <Point X="1700.0" Y="389.0" GraphRef="fe0dc" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482850" /> </Interaction> <Interaction GraphId="eeb51"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="434.0" Y="1000.0" GraphRef="dc802" RelX="0.0" RelY="-0.6599999999999682" /> <Point X="287.0" Y="1000.0" GraphRef="ce4c2" RelX="0.9259259259259259" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8869241" /> </Interaction> <Interaction GraphId="eebf6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="459.0" Y="1933.0" GraphRef="bdb66" RelX="0.0" RelY="1.0" /> <Point X="495.0" Y="1994.0" GraphRef="de4a9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-264622" /> </Interaction> <Interaction GraphId="eec51"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="678.0" Y="1421.0" GraphRef="c982a" RelX="0.9534883720930233" RelY="0.0" /> <Point X="815.0" Y="1422.0" GraphRef="e4530" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483182" /> </Interaction> <Interaction GraphId="ef10c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2518.0" Y="1618.0" GraphRef="d0440" RelX="-0.9899999999997817" RelY="-0.05999999999994543" /> <Point X="2482.0" Y="1652.0" GraphRef="c38cb" RelX="0.9746835443037974" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482828" /> </Interaction> <Interaction GraphId="ef1ae"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3018.0" Y="319.0" GraphRef="bc949" RelX="0.0" RelY="1.0" /> <Point X="3017.0" Y="800.0" GraphRef="d9a7d" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8867876" /> </Interaction> <Interaction GraphId="ef4c6"> <Comment Source="Reactome">Lipase members H and I (LIPH, I) specifically hydrolyse phosphatidic acid (PA) to the potent bioactive lipid mediator 2-acyl lysophosphatidic acid (2-acyl LPA) (Hiramatsu et al. 2003, Sonoda et al. 2002). LIPH is expressed in most tissues at low levels whereas LIPI is mainly expressed in the testis.</Comment> <BiopaxRef>f7e</BiopaxRef> <BiopaxRef>cd0</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="227.0" Y="1154.0" /> <Point X="224.0" Y="1310.0" /> <Anchor Position="0.0" Shape="None" GraphId="f5556" /> <Anchor Position="0.99" Shape="None" GraphId="ba48d" /> <Anchor Position="0.5" Shape="None" GraphId="d4ac6" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-6792445" /> </Interaction> <Interaction GraphId="efb5e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="815.0" Y="1486.0" GraphRef="a033c" RelX="-0.030303030303030304" RelY="1.0" /> <Point X="929.0" Y="1732.0" GraphRef="bdee6" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8877153" /> </Interaction> <Interaction GraphId="efdd0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1305.0" Y="770.0" GraphRef="a071a" RelX="-0.02857142857142857" RelY="1.0" /> <Point X="1316.0" Y="806.0" GraphRef="fbb62" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75889" /> </Interaction> <Interaction GraphId="eff9b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1210.0" Y="961.0" GraphRef="dcf3d" RelX="0.9726027397260274" RelY="0.0" /> <Point X="1175.0" Y="1003.0" GraphRef="d2a95" RelX="-16.5" RelY="35.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-549112" /> </Interaction> <Interaction GraphId="f0023"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="905.0" Y="1987.0" GraphRef="c4506" RelX="0.0" RelY="-1.0" /> <Point X="933.0" Y="1965.0" GraphRef="b9eb2" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5696415" /> </Interaction> <Interaction GraphId="f0105"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="424.0" Y="1563.0" GraphRef="f4598" RelX="-1.0" RelY="0.0" /> <Point X="376.0" Y="1546.0" GraphRef="d49b9" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483087" /> </Interaction> <Interaction GraphId="f021a"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.</Comment> <BiopaxRef>d66</BiopaxRef> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ffa</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3913.0" Y="1761.0" /> <Point X="3361.0" Y="1761.0" /> <Anchor Position="0.0" Shape="None" GraphId="e6543" /> <Anchor Position="0.99" Shape="None" GraphId="da82b" /> <Anchor Position="0.5" Shape="None" GraphId="f9676" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482612" /> </Interaction> <Interaction GraphId="f05d5"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, choline/ethanolaminephosphotransferase (CEPT1) converts CDP-choline (CDP-Cho) and diacylglycerol (DAG) to phosphatidylcholine (PC) and cytidine monophosphate (CMP) (Wright et al. 2002, Henneberry et al. 1999, Henneberry et al. 2002, Henneberry et al. 2000).</Comment> <BiopaxRef>f4c</BiopaxRef> <BiopaxRef>f82</BiopaxRef> <BiopaxRef>d15</BiopaxRef> <BiopaxRef>afb</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="591.0" Y="1572.0" /> <Point X="589.0" Y="1467.0" /> <Anchor Position="0.0" Shape="None" GraphId="bab11" /> <Anchor Position="0.99" Shape="None" GraphId="cbda5" /> <Anchor Position="0.5" Shape="None" GraphId="ca439" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482961" /> </Interaction> <Interaction GraphId="f07c1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3700.0" Y="1079.0" GraphRef="d34a0" RelX="0.0" RelY="1.0" /> <Point X="3756.0" Y="1118.0" GraphRef="f85b3" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482868" /> </Interaction> <Interaction GraphId="f085a"> <Comment Source="Reactome">At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).</Comment> <BiopaxRef>a02</BiopaxRef> <BiopaxRef>f91</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1270.0" Y="511.0" /> <Point X="1445.0" Y="508.0" /> <Anchor Position="0.0" Shape="None" GraphId="cc1cc" /> <Anchor Position="0.99" Shape="None" GraphId="aa0ec" /> <Anchor Position="0.5" Shape="None" GraphId="c2b87" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483063" /> </Interaction> <Interaction GraphId="f09b9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2665.0" Y="1636.0" GraphRef="c16c6" RelX="0.0" RelY="-1.0" /> <Point X="2623.0" Y="1602.0" GraphRef="b6651" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482892" /> </Interaction> <Interaction GraphId="f0a35"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1090.0" Y="533.0" GraphRef="cfedd" RelX="1.0" RelY="0.0" /> <Point X="1235.0" Y="629.0" GraphRef="d6649" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-188467" /> </Interaction> <Interaction GraphId="f0bb2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2023.0" Y="1648.0" GraphRef="d2d39" RelX="-1.0" RelY="0.0" /> <Point X="1921.0" Y="1673.0" GraphRef="ea92f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482889" /> </Interaction> <Interaction GraphId="f0d21"> <Comment Source="Reactome">The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. Human PCTP-like protein (STARD10) (Olayioye et al. 2005) is thought to be a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine (PC) (and phosphatidylethanolamine (PE), not shown here) between intracellular membranes, especially to lamellar body membranes. Saturated PC is a major component of pulmonary surfactant, a mixture of proteins and phospholipids that plays an important role in facilitating gas exchange by maintaining alveolar stability. After synthesis in the endoplasmic reticulum, saturated PC is transported to lamellar bodies (LBs) for storage prior to secretion. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) mediated reacylation is a final step in saturated PC synthesis prior to transport and LPCAT1 is proposed to form a complex with STARD10 at the ER membrane to facilitate the synthesis then transport of saturated PC to LBs (Lin et al. 2015).</Comment> <BiopaxRef>e92</BiopaxRef> <BiopaxRef>c7d</BiopaxRef> <BiopaxRef>fb4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1552.0" Y="1046.0" /> <Point X="1553.0" Y="890.0" /> <Anchor Position="0.0" Shape="None" GraphId="df01d" /> <Anchor Position="0.99" Shape="None" GraphId="cfae6" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873834" /> </Interaction> <Interaction GraphId="f0d48"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1445.0" Y="508.0" GraphRef="aa0ec" RelX="1.75" RelY="-0.029999999999972715" /> <Point X="1468.0" Y="505.0" GraphRef="e387a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref 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GraphRef="ecf86" RelX="1.0" RelY="0.0" /> <Point X="410.0" Y="1896.0" GraphRef="acf06" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483004" /> </Interaction> <Interaction GraphId="f28f3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3110.0" Y="208.0" GraphRef="ce395" RelX="0.9534883720930233" RelY="0.0" /> <Point X="3160.0" Y="259.0" GraphRef="c9b90" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602374" /> </Interaction> <Interaction GraphId="f2acb"> <Comment Source="Reactome">Transport of phosphatidylserine (PS) occurs via membrane contact sites between the endoplasmic reticulum (ER) membrane and the inner mitochondrial (IM) membrane. 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Mitochondrial acylglycerol kinase (AGK) can phosphorylate both monoacylglycerol (MAG) and diacylglycerol (DAG) in the mitochondrial intermembrane space to form LPA and PA, respectively thus may play an important role in the pathophysiology of certain cancers (Bektas et al. 2005). AGK is mitochondrial outer membrane-bound (Hung et al. 2014) and requires Mg2+ as cofactor.&lt;br&gt;Defects in AGK can cause mitochondrial DNA depletion syndrome 10 (MTDPS10 aka Sengers syndrome; MIM:212350), an autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. 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2010, Schouten et al. 2002, Vordtriede et al. 2005, Shadan et al. 2008).</Comment> <BiopaxRef>a3a</BiopaxRef> <BiopaxRef>a80</BiopaxRef> <BiopaxRef>c0c</BiopaxRef> <BiopaxRef>ff1</BiopaxRef> <BiopaxRef>bdc</BiopaxRef> <BiopaxRef>ce5</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="676.0" Y="1339.0" /> <Point X="626.0" Y="1445.0" /> <Anchor Position="0.0" Shape="None" GraphId="f54e0" /> <Anchor Position="0.99" Shape="None" GraphId="bfedc" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483219" /> </Interaction> <Interaction GraphId="f3ed5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2840.0" Y="1647.0" GraphRef="d1887" RelX="-1.0" RelY="0.0" /> <Point X="2843.0" Y="1672.0" GraphRef="baf07" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482667" /> </Interaction> <Interaction GraphId="f3ff7"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point 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2-monoacylglycerol (2-MAG) molecule and a diacylglycerol (DAG) molecule are transacylated by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). This forms triacylglycerol (TAG) and glycerol (Jenkins et al. 2004).</Comment> <BiopaxRef>e87</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2099.0" Y="1519.0" /> <Point X="1824.0" Y="1503.0" /> <Anchor Position="0.0" Shape="None" GraphId="fd3ac" /> <Anchor Position="0.99" Shape="None" GraphId="f76ab" /> <Anchor Position="0.5" Shape="None" GraphId="b4af0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482647" /> </Interaction> <Interaction GraphId="f4a65"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="410.0" Y="1826.0" GraphRef="b63fb" RelX="0.0" RelY="-0.7000000000000455" /> <Point X="388.0" Y="1792.0" GraphRef="e279d" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483004" /> </Interaction> <Interaction GraphId="f4bf5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3338.0" Y="76.0" GraphRef="d9968" RelX="-1.0" RelY="0.0" /> <Point X="3206.0" Y="254.0" GraphRef="f9fcc" RelX="2.0" RelY="-2.5" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602374" /> </Interaction> <Interaction GraphId="f50b3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="851.0" Y="548.0" GraphRef="d48c7" RelX="0.0" RelY="1.0" /> <Point X="877.0" Y="596.0" GraphRef="b6214" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483165" /> </Interaction> <Interaction GraphId="f51ed"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1988.0" Y="632.0" GraphRef="a197f" RelX="1.3099999999999454" RelY="0.009999999999990905" /> <Point X="2008.0" Y="577.0" GraphRef="a9e48" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482759" /> </Interaction> <Interaction GraphId="f5525"> <Comment Source="Reactome">Abhydrolase domain-containing protein 4 (ABHD4) is a regulator of endocannabinoid signalling and suppressor of tumor growth. Its physiological substrates are both N-acyl phosphatidylethanolamine (NAPE) and a wide range of lysoNAPEs. Shown here, ANHD4 mediates the hydrolysis of NAPE to glycerophospho-arachidonyl ethanolamine (GPAEA), an endocannabanoid (Simon &amp; Cravatt 2006).</Comment> <BiopaxRef>e8a</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1328.0" Y="1123.0" /> <Point X="1371.0" Y="1123.0" /> <Anchor Position="0.0" Shape="None" GraphId="a0337" /> <Anchor Position="0.99" Shape="None" GraphId="cb5fc" /> <Anchor Position="0.5" Shape="None" GraphId="a6738" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-5694583" /> </Interaction> <Interaction GraphId="f565a"> <Comment Source="Reactome">PCTP-like protein (STARD10) is a member of the steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins that are implicated in lipid transport, metabolism, and signaling. STARD10 is thought to function as a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes. Its lipid transfer activity is negatively regulated by casein kinase, a serine/threonine-protein kinase which phosphorylates STARD10 on a serine residue at position 284 (Olayioye et al. 2007).</Comment> <BiopaxRef>c7d</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1425.0" Y="1002.0" /> <Point X="1425.0" Y="949.0" /> <Anchor Position="0.0" Shape="None" GraphId="e5c40" /> <Anchor Position="0.99" Shape="None" GraphId="e9bb2" /> <Anchor Position="0.5" Shape="None" GraphId="c84fb" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8873929" /> </Interaction> <Interaction GraphId="f577c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2666.0" Y="644.0" GraphRef="c0db4" RelX="1.4200000000000728" RelY="0.01999999999998181" /> <Point X="2775.0" Y="560.0" GraphRef="b8783" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482847" /> </Interaction> <Interaction GraphId="f5c4b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1365.0" Y="1649.0" GraphRef="ddcdb" RelX="1.0" RelY="0.0" /> <Point X="1321.0" Y="1606.0" GraphRef="d2859" RelX="-14.5" RelY="-20.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483186" /> </Interaction> <Interaction GraphId="f5ca6"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1039.0" Y="1065.0" GraphRef="f9463" RelX="-1.0" RelY="0.0" /> <Point X="999.0" Y="999.0" GraphRef="a5828" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-75885" /> </Interaction> <Interaction GraphId="f5e2c"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylserine synthase 1 (PTDSS1) converts phosphatidylcholine (PC) into phosphatidylserine (PS) by facilitating the exchange of L-Serine (L-Ser) with the choline (Cho) head group (Saito et al. 1998, Tomohiro et al. 2009).</Comment> <BiopaxRef>c21</BiopaxRef> <BiopaxRef>bec</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1374.0" Y="1601.0" /> <Point X="1297.0" Y="1652.0" /> <Anchor Position="0.0" Shape="None" GraphId="be1b9" /> <Anchor Position="0.99" Shape="None" GraphId="f7a9a" /> <Anchor Position="0.5" Shape="None" GraphId="d2859" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483186" /> </Interaction> <Interaction GraphId="f6138"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2865.0" Y="1092.0" GraphRef="b2fa6" RelX="-0.9499999999998181" RelY="0.009999999999990905" /> <Point X="2747.0" Y="1111.0" GraphRef="ea81e" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482897" /> </Interaction> <Interaction GraphId="f6184"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1253.0" Y="665.0" GraphRef="f4106" RelX="-1.0" RelY="0.0" /> <Point X="1279.0" Y="629.0" GraphRef="af007" RelX="-3.0" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-188467" /> </Interaction> <Interaction GraphId="f6373"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3426.0" Y="76.0" GraphRef="d9968" RelX="0.9775280898876404" RelY="0.0" /> <Point X="3555.0" Y="253.0" GraphRef="a6d4d" RelX="15.5" RelY="-1.0" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1602377" /> </Interaction> <Interaction GraphId="f6539"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3235.0" Y="1061.0" GraphRef="fcd34" RelX="0.9555555555555556" RelY="0.0" /> <Point X="3215.0" Y="1023.0" GraphRef="ca7cb" RelX="-8.5" RelY="-0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482636" /> </Interaction> <Interaction GraphId="f65eb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3965.0" Y="1740.0" GraphRef="c3e1f" RelX="-1.0" RelY="0.0" /> <Point X="3931.0" Y="1673.0" GraphRef="ff582" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482533" /> </Interaction> <Interaction GraphId="f6720"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylcholine (LPC) to form phosphatidylcholine (PC). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006); lysophosphatidylcholine acyltransferase 2 (LPCAT2) (Shindou et al. 2006); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008).</Comment> <BiopaxRef>b3a</BiopaxRef> <BiopaxRef>e0f</BiopaxRef> <BiopaxRef>ee8</BiopaxRef> <BiopaxRef>e1a</BiopaxRef> <BiopaxRef>dab</BiopaxRef> <BiopaxRef>f41</BiopaxRef> <BiopaxRef>ae4</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3931.0" Y="1673.0" /> <Point X="3807.0" Y="1658.0" /> <Anchor Position="0.0" Shape="None" GraphId="ff582" /> <Anchor Position="0.99" Shape="None" GraphId="a2a51" /> <Anchor Position="0.5" Shape="None" GraphId="d0d39" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482533" /> </Interaction> <Interaction GraphId="f67c3"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3840.0" Y="1682.0" GraphRef="c8c63" RelX="-0.024390243902439025" RelY="-1.0" /> <Point X="3863.0" Y="1621.0" GraphRef="fe3cf" RelX="-4.0" RelY="-0.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482862" /> </Interaction> <Interaction GraphId="f6edc"> <Comment Source="Reactome">In the cytosol, phosphoethanolamine (PETA) is dephosphorylated to ethanolamine (ETA) by phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) (Roberts et al. 2004).</Comment> <BiopaxRef>b1c</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="625.0" Y="1813.0" /> <Point X="625.0" Y="1880.0" /> <Anchor Position="0.0" Shape="None" GraphId="cf08c" /> <Anchor Position="0.99" Shape="None" GraphId="d2983" /> <Anchor Position="0.5" Shape="None" GraphId="c04fa" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483096" /> </Interaction> <Interaction GraphId="f70be"> <Comment Source="Reactome">At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off by membrane-associated phospholipase A2 gamma 2A, PLA2G2A, to form 2-acyl lysophosphatidylethanolamine (LPE) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolyzing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.</Comment> <BiopaxRef>e3b</BiopaxRef> <BiopaxRef>ab5</BiopaxRef> <BiopaxRef>f04</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2623.0" Y="1602.0" /> <Point X="2492.0" Y="1601.0" /> <Anchor Position="0.0" Shape="None" GraphId="b6651" /> <Anchor Position="0.99" Shape="None" GraphId="eb462" /> <Anchor Position="0.5" Shape="None" GraphId="de861" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482892" /> </Interaction> <Interaction GraphId="f7240"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2670.0" Y="1584.0" GraphRef="eaabf" RelX="0.0" RelY="1.0" /> <Point X="2758.0" Y="1769.0" GraphRef="f8868" RelX="-103.5" RelY="0.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482545" /> 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Both ER and mitochondrial membranes have the capability to synthesize cytidine diphosphate-diacylglycerol (CDP-DAG) with phosphatidate cytidylyltransferase 1 and 2 (CDS1 and CDS2) (Lykidis et al. 1997). 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The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006), lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or acyl-CoA:lysophosphatidylglycerol acyltransferase (LPGAT1) (Yang et al. 2004).</Comment> <BiopaxRef>b3a</BiopaxRef> <BiopaxRef>e0f</BiopaxRef> <BiopaxRef>dde</BiopaxRef> <BiopaxRef>e1a</BiopaxRef> <BiopaxRef>dab</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2549.0" Y="1025.0" /> <Point X="2478.0" Y="1024.0" /> <Anchor Position="0.0" Shape="None" GraphId="e549b" /> <Anchor Position="0.99" Shape="None" GraphId="cf0e6" /> <Anchor Position="0.5" Shape="None" GraphId="d0a65" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482539" /> </Interaction> <Interaction GraphId="fb121"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3805.0" Y="1161.0" GraphRef="f2994" RelX="-1.0" RelY="-0.02857142857142857" /> <Point X="3822.0" Y="1120.0" GraphRef="f76fa" RelX="7.5" RelY="1.0" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482868" /> </Interaction> <Interaction GraphId="fb2ad"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1076.0" Y="781.0" GraphRef="bc25e" RelX="-1.0" RelY="0.0" /> <Point X="908.0" Y="697.0" GraphRef="c0cfb" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482548" /> </Interaction> <Interaction GraphId="fb57d"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="512.0" Y="1889.0" GraphRef="bef6c" RelX="0.009999999999990905" RelY="0.75" /> <Point X="574.0" Y="1915.0" GraphRef="a59b2" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1483159" /> </Interaction> <Interaction GraphId="fb6fc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1644.0" Y="1046.0" GraphRef="ceacb" RelX="0.0" RelY="-1.0" /> <Point X="1643.0" Y="1043.0" GraphRef="f1633" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482857" /> </Interaction> <Interaction GraphId="fb8e0"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="2597.0" Y="1686.0" GraphRef="bc347" RelX="0.8400000000001455" RelY="-0.029999999999972715" /> <Point X="2650.0" Y="1651.0" GraphRef="c16c6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482646" /> </Interaction> <Interaction GraphId="fbb76"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="3743.0" Y="1581.0" GraphRef="e0798" RelX="1.0" RelY="0.0" /> <Point X="3717.0" Y="1786.0" GraphRef="ba1de" RelX="107.5" RelY="1.5" ArrowHead="mim-catalysis" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-1482629" /> </Interaction> <Interaction GraphId="fbb80"> <Comment Source="Reactome">Mitochondrial cardiolipin hydrolase (PLD6 aka MitoPLD) is located on the outer mitochondrial membrane and promotes trans-mitochondrial membrane adherence (mitochondrial fusion) in a Mfn-dependent manner by hydrolysing cardiolipin to generate the acidic fusogenic lipid phosphatidic acid (PA) and phosphatidylglycerol (PG) (Choi et al. 2006). 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Uyama T, Ikematsu N, Inoue M, Shinohara N, Jin XH, Tsuboi K, Tonai T, Tokumura A, Ueda N.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bdc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11980708</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schouten A, Agianian B, Westerman J, Kroon J, Wirtz KW, Gros P.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b14"> <bp:ID 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Characterization of lipid components and possible involvement in intramitochondrial translocation of phospholipids.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simbeni R, Pon L, Zinser E, Paltauf F, Daum G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d1a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11031251</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cloning and recombinant expression of a structurally novel human secreted phospholipase A2.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fbc"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17478478</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d3e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15671038</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Turkish AR, Henneberry AL, Cromley D, Padamsee M, Oelkers P, Bazzi H, Christiano AM, Billheimer JT, Sturley SL.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="aba"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18287005</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hishikawa D, Shindou H, Kobayashi S, Nakanishi H, Taguchi R, Shimizu T.</bp:AUTHORS> 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