p53 signaling (Mus musculus)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="p53 signaling" Version="20150223" Organism="Mus musculus"> <Comment Source="WikiPathways-description">http://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.</Comment> <BiopaxRef>dfd</BiopaxRef> <Graphics BoardWidth="1941.0147665625009" BoardHeight="1085.4848521874999"/> <DataNode TextLabel="Atm" GraphId="b61ad" Type="GeneProduct"> <Graphics CenterX="293.24573420910485" CenterY="249.38916532359508" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="11920"/> </DataNode> <DataNode TextLabel="Chek2" GraphId="c806c" Type="GeneProduct"> <Graphics CenterX="509.6127191877598" CenterY="251.16909219666158" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="50883"/> </DataNode> <DataNode TextLabel="Atr" GraphId="dc14f" Type="GeneProduct"> <Graphics CenterX="295.232277122499" CenterY="279.386785452974" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="245000"/> </DataNode> <DataNode TextLabel="Chek1" GraphId="d61f3" Type="GeneProduct"> <Graphics CenterX="438.76011079117785" CenterY="279.87638974539504" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12649"/> </DataNode> <DataNode TextLabel="Cdkn2a" GraphId="f12c9" Type="GeneProduct"> <Graphics CenterX="206.8166739037919" CenterY="483.3678296927131" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12578"/> </DataNode> <DataNode TextLabel="Mdm2" GraphId="a49bc" Type="GeneProduct"> <Graphics CenterX="317.2053856147222" CenterY="483.3247784905643" Width="80.0" Height="31.083165660630407" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="17246"/> </DataNode> <DataNode TextLabel="Mdm4" GraphId="dd0f4" Type="GeneProduct"> <Graphics CenterX="317.1567187077628" CenterY="543.0040407610884" Width="80.0" Height="26.58462490741855" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="17248"/> </DataNode> <DataNode TextLabel="Trp53" GraphId="dda96" Type="GeneProduct"> <Graphics CenterX="451.02348635499953" CenterY="481.4516811037412" Width="80.0" Height="30.103957075787964" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22059"/> </DataNode> <DataNode TextLabel="Cdkn1a" GraphId="c4b27" Type="GeneProduct"> <Graphics CenterX="669.9917941642816" CenterY="125.20938545206094" Width="80.00000000000001" Height="20.000000000000004" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12575"/> </DataNode> <DataNode TextLabel="Ccnd1" GraphId="bf917" Type="GeneProduct" GroupRef="dc015"> <Graphics CenterX="816.2870361843344" CenterY="39.109775477795935" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12443"/> </DataNode> <DataNode TextLabel="Ccnd2" GraphId="ee7f2" Type="GeneProduct" GroupRef="dc015"> <Graphics CenterX="816.2870361843344" CenterY="59.10977547779593" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12444"/> </DataNode> <DataNode TextLabel="Ccnd3" GraphId="a0000" Type="GeneProduct" GroupRef="dc015"> <Graphics CenterX="816.2870361843344" CenterY="79.1097754777959" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12445"/> </DataNode> <DataNode TextLabel="Cdk4" GraphId="a0001" Type="GeneProduct" GroupRef="dc015"> <Graphics CenterX="816.2870361843344" CenterY="99.10977547779589" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12567"/> </DataNode> <DataNode TextLabel="Cdk6" GraphId="f75cb" Type="GeneProduct" GroupRef="dc015"> <Graphics CenterX="816.2870361843344" CenterY="119.10977547779598" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12571"/> </DataNode> <DataNode TextLabel="Ccne1" GraphId="b8ef5" Type="GeneProduct" GroupRef="b1741"> <Graphics CenterX="815.2032510740306" CenterY="157.21247607561605" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12447"/> </DataNode> <DataNode TextLabel="Ccne2" GraphId="a7435" Type="GeneProduct" GroupRef="b1741"> <Graphics CenterX="815.2032510740306" CenterY="177.212476075616" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12448"/> </DataNode> <DataNode TextLabel="Cdk2" GraphId="d24d0" Type="GeneProduct" GroupRef="b1741"> <Graphics CenterX="815.2032510740306" CenterY="197.21247607561602" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12566"/> </DataNode> <DataNode TextLabel="Sfn" GraphId="d7441" Type="GeneProduct"> <Graphics CenterX="669.9917941642817" CenterY="153.726094169977" Width="80.00000000000001" Height="20.000000000000004" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="55948"/> </DataNode> <DataNode TextLabel="Rprm" GraphId="b5cc7" Type="GeneProduct"> <Graphics CenterX="669.9917941642816" CenterY="181.026130213905" Width="80.00000000000001" Height="20.000000000000004" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="67874"/> </DataNode> <DataNode TextLabel="Ccnb1" GraphId="a0002" Type="GeneProduct" GroupRef="cab33"> <Graphics CenterX="816.1133467146559" CenterY="237.4472847943669" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="268697"/> </DataNode> <DataNode TextLabel="Ccnb2" GraphId="a0003" Type="GeneProduct" GroupRef="cab33"> <Graphics CenterX="816.1133467146559" CenterY="257.44728479436685" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12442"/> </DataNode> <DataNode TextLabel="Ccnb3" GraphId="a0004" Type="GeneProduct" GroupRef="cab33"> <Graphics CenterX="816.1133467146559" CenterY="277.4472847943665" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="209091"/> </DataNode> <DataNode TextLabel="Gm5593" GraphId="a0005" Type="GeneProduct" GroupRef="cab33"> <Graphics CenterX="816.1133467146559" CenterY="297.44728479436634" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSMUSG00000048574"/> </DataNode> <DataNode TextLabel="Cdk1" GraphId="dee86" Type="GeneProduct" GroupRef="cab33"> <Graphics CenterX="816.1133467146559" CenterY="317.4472847943662" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12534"/> </DataNode> <DataNode TextLabel="Gadd45a" GraphId="c5ae6" Type="GeneProduct" GroupRef="bd250"> <Graphics CenterX="669.7295935988325" CenterY="217.09080244989073" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13197"/> </DataNode> <DataNode TextLabel="Gadd45b" GraphId="df6c1" Type="GeneProduct" GroupRef="bd250"> <Graphics CenterX="669.7295935988325" CenterY="237.09080244989073" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="17873"/> </DataNode> <DataNode TextLabel="Gadd45g" GraphId="d814a" Type="GeneProduct" GroupRef="bd250"> <Graphics CenterX="669.7295935988325" CenterY="257.0908024498907" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="23882"/> </DataNode> <DataNode TextLabel="Gtse1" GraphId="b8284" Type="GeneProduct"> <Graphics CenterX="669.9917941642813" CenterY="291.2740576880468" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="29870"/> </DataNode> <DataNode TextLabel="Fas" GraphId="ba3a6" Type="GeneProduct"> <Graphics CenterX="657.1651644611563" CenterY="387.6617248861122" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="14102"/> </DataNode> <DataNode TextLabel="Pidd1" GraphId="edbd4" Type="GeneProduct"> <Graphics CenterX="657.1651644611561" CenterY="417.66172488611153" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="57913"/> </DataNode> <DataNode TextLabel="Casp8" GraphId="f9284" Type="GeneProduct"> <Graphics CenterX="876.5572116617528" CenterY="366.1821797280557" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12370"/> </DataNode> <DataNode TextLabel="Bid" GraphId="ffd7e" Type="GeneProduct"> <Graphics CenterX="1073.6938613721334" CenterY="403.8747541869484" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12122"/> </DataNode> <DataNode TextLabel="Bax" GraphId="d0251" Type="GeneProduct"> <Graphics CenterX="657.1651644611561" CenterY="445.6114185127236" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12028"/> </DataNode> <DataNode TextLabel="Pmaip1" GraphId="ad294" Type="GeneProduct"> <Graphics CenterX="744.8369416415942" CenterY="446.7757901068656" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="58801"/> </DataNode> <DataNode TextLabel="Bbc3" GraphId="e9291" Type="GeneProduct"> <Graphics CenterX="830.829344204093" CenterY="446.77730880999064" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="170770"/> </DataNode> <DataNode TextLabel="Ei24" GraphId="ae079" Type="GeneProduct"> <Graphics CenterX="657.1651644611563" CenterY="485.6239037394251" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13663"/> </DataNode> <DataNode TextLabel="Shisa5" GraphId="e0ca7" Type="GeneProduct"> <Graphics CenterX="657.1651644611561" CenterY="548.5072490874011" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="66940"/> </DataNode> <DataNode TextLabel="Perp" GraphId="cd651" Type="GeneProduct"> <Graphics CenterX="747.7563596342758" CenterY="548.7891918074735" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="64058"/> </DataNode> <DataNode TextLabel="Zmat3" GraphId="eb608" Type="GeneProduct"> <Graphics CenterX="831.4088802266997" CenterY="548.41908852548" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22401"/> </DataNode> <DataNode TextLabel="Siah1a" GraphId="a4c0b" Type="GeneProduct" GroupRef="de3cc"> <Graphics CenterX="1074.970142934634" CenterY="539.8462862458301" Width="80.00000000000004" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20437"/> </DataNode> <DataNode TextLabel="Siah1b" GraphId="cf2d7" Type="GeneProduct" GroupRef="de3cc"> <Graphics CenterX="1074.9701429346335" CenterY="559.8462862458301" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20438"/> </DataNode> <DataNode TextLabel="Cycs" GraphId="a0009" Type="GeneProduct" GroupRef="df0dc"> <Graphics CenterX="1231.6648693805305" CenterY="460.35256938456087" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13063"/> </DataNode> <DataNode TextLabel="Cyct" GraphId="c8c55" Type="GeneProduct" GroupRef="df0dc"> <Graphics CenterX="1231.6648693805305" CenterY="480.3525693845611" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13067"/> </DataNode> <DataNode TextLabel="Apaf1" GraphId="c8aa8" Type="GeneProduct"> <Graphics CenterX="1231.6648693805307" CenterY="516.0525693845614" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="11783"/> </DataNode> <DataNode TextLabel="Casp9" GraphId="c8760" Type="GeneProduct"> <Graphics CenterX="1368.0355266520164" CenterY="479.47975503753224" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12371"/> </DataNode> <DataNode TextLabel="Casp3" GraphId="c4b73" Type="GeneProduct"> <Graphics CenterX="1527.777328163534" CenterY="485.19964837577265" Width="80.0" Height="20.522008624026753" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12367"/> </DataNode> <DataNode TextLabel="Igfbp3" GraphId="f51d6" Type="GeneProduct"> <Graphics CenterX="658.7058882301535" CenterY="574.4455847008165" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="16009"/> </DataNode> <DataNode TextLabel="Igf1" GraphId="d87ec" Type="GeneProduct"> <Graphics CenterX="1074.7795913682342" CenterY="593.8035243021587" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="16000"/> </DataNode> <DataNode TextLabel="Serpine1" GraphId="a9296" Type="GeneProduct"> <Graphics CenterX="678.5827012482019" CenterY="677.3606063191488" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="18787"/> </DataNode> <DataNode TextLabel="Bai1" GraphId="ceba1" Type="GeneProduct"> <Graphics CenterX="771.6487092444131" CenterY="677.5459530036169" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="107831"/> </DataNode> <DataNode TextLabel="Cd82" GraphId="e552a" Type="GeneProduct"> <Graphics CenterX="863.901466329703" CenterY="682.528845354664" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12521"/> </DataNode> <DataNode TextLabel="Thbs1" GraphId="af626" Type="GeneProduct"> <Graphics CenterX="963.8180365159296" CenterY="683.6779940374614" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="21825"/> </DataNode> <DataNode TextLabel="Serpinb5" GraphId="c3369" Type="GeneProduct"> <Graphics CenterX="1065.014562500219" CenterY="682.2745795952578" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20724"/> </DataNode> <DataNode TextLabel="Ddb2" GraphId="f55c0" Type="GeneProduct"> <Graphics CenterX="666.3342267636784" CenterY="737.7286017507705" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="107986"/> </DataNode> <DataNode TextLabel="Rrm2b" GraphId="c3fa5" Type="GeneProduct" GroupRef="b7855"> <Graphics CenterX="756.0500030742714" CenterY="739.0726843152282" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="382985"/> </DataNode> <DataNode TextLabel="Rrm2" GraphId="a0010" Type="GeneProduct" GroupRef="b7855"> <Graphics CenterX="756.0500030742714" CenterY="759.0726843152282" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20135"/> </DataNode> <DataNode TextLabel="Sesn1" GraphId="a5003" Type="GeneProduct" GroupRef="b0e17"> <Graphics CenterX="1072.1611823428805" CenterY="739.1660393198193" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="140742"/> </DataNode> <DataNode TextLabel="Sesn2" GraphId="a1988" Type="GeneProduct" GroupRef="b0e17"> <Graphics CenterX="1072.1611823428805" CenterY="759.1660393198193" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="230784"/> </DataNode> <DataNode TextLabel="Sesn3" GraphId="a0011" Type="GeneProduct" GroupRef="b0e17"> <Graphics CenterX="1072.1611823428805" CenterY="779.1660393198193" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="75747"/> </DataNode> <DataNode TextLabel="Pten" GraphId="ade33" Type="GeneProduct"> <Graphics CenterX="662.6842087417145" CenterY="812.7297499856086" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="19211"/> </DataNode> <DataNode TextLabel="Tsc2" GraphId="de351" Type="GeneProduct"> <Graphics CenterX="754.4698135905377" CenterY="812.5674759060788" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22084"/> </DataNode> <DataNode TextLabel="Steap3" GraphId="d2e7a" Type="GeneProduct"> <Graphics CenterX="678.4612363054655" CenterY="883.3067258797179" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="68428"/> </DataNode> <DataNode TextLabel="Rfwd2" GraphId="db7f1" Type="GeneProduct"> <Graphics CenterX="748.0214484184014" CenterY="979.0871685137286" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="26374"/> </DataNode> <DataNode TextLabel="Rchy1" GraphId="f0d3e" Type="GeneProduct"> <Graphics CenterX="839.454399868599" CenterY="977.3928453563417" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="68098"/> </DataNode> <DataNode TextLabel="Ccng1" GraphId="a0012" Type="GeneProduct" GroupRef="fdb04"> <Graphics CenterX="935.7351759840975" CenterY="983.7285618472753" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12450"/> </DataNode> <DataNode TextLabel="Ccng2" GraphId="a0013" Type="GeneProduct" GroupRef="fdb04"> <Graphics CenterX="935.7351759840975" CenterY="1003.7285618472754" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12452"/> </DataNode> <DataNode TextLabel="Ppm1d" GraphId="f68fa" Type="GeneProduct"> <Graphics CenterX="1133.7066860725952" CenterY="974.9865557669533" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="53892"/> </DataNode> <DataNode TextLabel="Trp73" GraphId="fc02f" Type="GeneProduct"> <Graphics CenterX="1222.2804567389214" CenterY="977.0639178989285" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22062"/> </DataNode> <DataNode TextLabel="mmu-miR-425-5p" GraphId="cfc9e" Type="GeneProduct" GroupRef="ee8e4"> <Graphics CenterX="1367.5356942187482" CenterY="529.002029470487" Width="128.9044378125" Height="19.999999999999936" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-425-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-29b-3p" GraphId="cd8ab" Type="GeneProduct"> <Graphics CenterX="790.0174682767057" CenterY="488.09577632600013" Width="135.28420780341133" Height="17.901820075087358" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-29b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-16-5p" GraphId="eb4ec" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="53.98101560484705" Width="152.80293862876934" Height="20.0000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-16-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-291a-3p" GraphId="b7945" Type="GeneProduct" GroupRef="dffa6"> <Graphics CenterX="490.7724049447112" CenterY="74.58545837502024" Width="151.8775059375" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-291a-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-291b-3p" GraphId="a0014" Type="GeneProduct" GroupRef="dffa6"> <Graphics CenterX="490.7724049447112" CenterY="94.58545837502024" Width="151.8775059375" Height="19.999999999999993" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-291b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-294-3p" GraphId="aea14" Type="GeneProduct" GroupRef="dffa6"> <Graphics CenterX="490.7724049447112" CenterY="115.16185381752267" Width="151.87750593750002" Height="21.152790885004865" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-294-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-295-3p" GraphId="a0015" Type="GeneProduct" GroupRef="dffa6"> <Graphics CenterX="490.7724049447112" CenterY="135.73824926002513" Width="151.8775059375" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-295-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-302d-3p" GraphId="a0016" Type="GeneProduct" GroupRef="dffa6"> <Graphics CenterX="490.7724049447112" CenterY="155.73824926002513" Width="151.8775059375" Height="19.999999999999975" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-302d-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-18a-5p" GraphId="a0017" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="743.1996094942335" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-18a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-20a-5p" GraphId="a0020" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="763.1996094942335" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-20a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-503-5p" GraphId="a86ba" Type="GeneProduct" GroupRef="bc81e"> <Graphics CenterX="1528.8356267083063" CenterY="541.9333206445148" Width="145.30012087504647" Height="13.735502460970567" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-503-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-181b-5p" GraphId="a0021" Type="GeneProduct" GroupRef="bc81e"> <Graphics CenterX="1528.8356267083063" CenterY="558.801071875" Width="145.30012087504642" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-181b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-223-3p" GraphId="a0022" Type="GeneProduct" GroupRef="ee8e4"> <Graphics CenterX="1367.5356942187484" CenterY="549.002029470487" Width="128.90443781250008" Height="19.999999999999936" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-223-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-122-5p" GraphId="a0023" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="73.9810156048471" Width="152.80293862876934" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-122-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-216a-5p" GraphId="a0024" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501895" CenterY="783.1996094942335" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-216a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-217-5p" GraphId="fbd77" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501895" CenterY="803.1996094942334" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-217-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-195a-5p" GraphId="bd1d8" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587305" CenterY="33.98101560484694" Width="152.80293862876943" Height="20.00000000000011" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-195a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-103a-3p" GraphId="e1277" Type="GeneProduct"> <Graphics CenterX="1219.5983107678617" CenterY="171.4920259544942" Width="154.20751346425806" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-103a-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-486-5p" GraphId="f9efe" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="863.1996094942333" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-486-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-21-5p" GraphId="bda2e" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="823.1996094942333" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-21-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-34b-5p" GraphId="be587" Type="GeneProduct" GroupRef="a22c1"> <Graphics CenterX="1115.0348140625001" CenterY="844.2788936226406" Width="146.68336179564386" Height="19.99999999999998" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-34b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-15a-5p" GraphId="fe6a1" Type="GeneProduct" GroupRef="f5815"> <Graphics CenterX="1240.1801426607387" CenterY="644.5072438393223" Width="151.40203202675622" Height="20.00000000000008" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-15a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-1a-3p" GraphId="ae256" Type="GeneProduct" GroupRef="f5815"> <Graphics CenterX="1240.1801426607387" CenterY="624.5072438393217" Width="151.4020320267562" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-1a-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-301b-3p" GraphId="cbff0" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="439.4026465470995" Width="134.43866079588943" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-301b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-9-5p" GraphId="ae748" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="499.4026465470992" Width="134.43866079588943" Height="19.999999999999936" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-9-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-7b-5p" GraphId="b3c00" Type="GeneProduct" GroupRef="ee8e4"> <Graphics CenterX="1367.5356942187484" CenterY="569.002029470487" Width="128.9044378125" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-7b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-24-3p" GraphId="dfaef" Type="GeneProduct" GroupRef="ee8e4"> <Graphics CenterX="1367.5356942187484" CenterY="589.002029470487" Width="128.9044378125" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-24-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-19b-3p" GraphId="a3594" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="903.1996094942335" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-19b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-758-3p" GraphId="b76a1" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="93.98101560484714" Width="152.80293862876934" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-758-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-145a-5p" GraphId="a67d2" Type="GeneProduct" GroupRef="c2cca"> <Graphics CenterX="971.2498933548235" CenterY="220.42654583049855" Width="153.15453891535282" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-145a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-449a-5p" GraphId="a3d10" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="113.98101560484714" Width="152.80293862876934" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-449a-5p"/> </DataNode> <DataNode TextLabel="mmu-let-7b-5p" GraphId="b5af0" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="133.98101560484724" Width="152.80293862876934" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-let-7b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-362-5p" GraphId="a10ac" Type="GeneProduct" GroupRef="ad37f"> <Graphics CenterX="1219.5983107678617" CenterY="206.2617383564588" Width="154.2075134642581" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-362-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-17-5p" GraphId="bd2ef" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="883.1996094942333" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-17-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-181a-5p" GraphId="e9d47" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.66762885949" CenterY="479.4026465470994" Width="134.43866079588938" Height="19.999999999999936" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-181a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-297a-5p" GraphId="fb88f" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="519.4026465470993" Width="134.43866079588943" Height="19.999999999999936" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-297a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-340-5p" GraphId="d4872" Type="GeneProduct" GroupRef="a22c1"> <Graphics CenterX="968.3514522668561" CenterY="844.2788936226406" Width="146.6833617956439" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-340-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-21a-5p" GraphId="fe7a6" Type="GeneProduct" GroupRef="bbce9"> <Graphics CenterX="464.1721345501896" CenterY="843.1996094942333" Width="139.6022634753791" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-21a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-149-5p" GraphId="db3d8" Type="GeneProduct" GroupRef="af74d"> <Graphics CenterX="317.63952677450425" CenterY="609.8071914941708" Width="139.70454416299572" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-149-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-124-3p" GraphId="d8fe9" Type="GeneProduct" GroupRef="c2cca"> <Graphics CenterX="971.2498933548235" CenterY="240.42654583049855" Width="153.15453891535282" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-124-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-30e-5p" GraphId="ba02a" Type="GeneProduct" GroupRef="ad37f"> <Graphics CenterX="1219.5983107678617" CenterY="226.2617383564588" Width="154.2075134642581" Height="20.00000000000001" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-30e-5p"/> </DataNode> <DataNode TextLabel="Gadd45g" GraphId="e7b93" Type="GeneProduct" GroupRef="dd576"> <Graphics CenterX="968.5613030374208" CenterY="778.6705595055425" Width="80.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="23882"/> </DataNode> <DataNode TextLabel="Gadd45b" GraphId="dd3b7" Type="GeneProduct" GroupRef="dd576"> <Graphics CenterX="968.5613030374208" CenterY="758.6705595055425" Width="80.0" Height="20.0" ZOrder="32777" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="17873"/> </DataNode> <DataNode TextLabel="Gadd45a" GraphId="c3a32" Type="GeneProduct" GroupRef="dd576"> <Graphics CenterX="968.5613030374208" CenterY="738.6705595055425" Width="80.0" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13197"/> </DataNode> <DataNode TextLabel="Igfbp3" GraphId="b88ed" Type="GeneProduct"> <Graphics CenterX="855.1552630831438" CenterY="817.3744922905879" Width="79.99999999999997" Height="19.999999999999968" ZOrder="32781" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="16009"/> </DataNode> <DataNode TextLabel="Mdm2" GraphId="ddda5" Type="GeneProduct"> <Graphics CenterX="656.1651176902684" CenterY="978.3264971537471" Width="80.0" Height="19.466762783808083" ZOrder="32784" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="17246"/> </DataNode> <DataNode TextLabel="Siah1a" GraphId="bd2d9" Type="GeneProduct" GroupRef="cee2a"> <Graphics CenterX="1038.3552742165293" CenterY="981.4711391641416" Width="80.0" Height="20.0" ZOrder="32786" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20437"/> </DataNode> <DataNode TextLabel="Siah1b" GraphId="ceffc" Type="GeneProduct" GroupRef="cee2a"> <Graphics CenterX="1038.3552742165293" CenterY="1001.4711391641416" Width="80.0" Height="20.0" ZOrder="32787" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="20438"/> </DataNode> <DataNode TextLabel="mmu-miR-425-5p" GraphId="cf826" Type="GeneProduct"> <Graphics CenterX="971.2498933548235" CenterY="316.46486285556085" Width="153.15453891535276" Height="20.0" ZOrder="32804" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-425-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-16-5p" GraphId="b6c37" Type="GeneProduct" GroupRef="af74d"> <Graphics CenterX="317.6395267745042" CenterY="589.8071914941708" Width="139.70454416299572" Height="19.99999999999998" ZOrder="32805" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-16-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-17-5p" GraphId="f24c8" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594902" CenterY="459.40264654709944" Width="134.43866079588943" Height="19.999999999999936" ZOrder="32806" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-17-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-301b-3p" GraphId="bca17" Type="GeneProduct"> <Graphics CenterX="1133.8486976968081" CenterY="1035.1501810692655" Width="141.92219460638728" Height="20.24883723646775" ZOrder="32807" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-301b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-301b-3p" GraphId="f65d6" Type="GeneProduct" GroupRef="c3658"> <Graphics CenterX="490.7724049447111" CenterY="200.71818742366628" Width="149.32494281250013" Height="20.0" ZOrder="32808" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-301b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-301b-3p" GraphId="c5599" Type="GeneProduct" GroupRef="d4e6c"> <Graphics CenterX="855.9336952672905" CenterY="738.7768620520801" Width="85.39746414997882" Height="20.0" ZOrder="32809" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-301b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-19b-3p" GraphId="eff9c" Type="GeneProduct" GroupRef="fa578"> <Graphics CenterX="778.752674964872" CenterY="606.046671228105" Width="137.18221534762807" Height="20.00000000000008" ZOrder="32810" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-19b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-19b-3p" GraphId="acf9d" Type="GeneProduct" GroupRef="d4e6c"> <Graphics CenterX="855.9336952672905" CenterY="758.7768620520801" Width="85.3974641499788" Height="20.0" ZOrder="32811" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-19b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-19b-3p" GraphId="c676b" Type="GeneProduct" GroupRef="c3658"> <Graphics CenterX="490.7724049447111" CenterY="220.71818742366628" Width="149.32494281250013" Height="20.00000000000001" ZOrder="32812" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-19b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-503-5p" GraphId="f2de0" Type="GeneProduct" GroupRef="c2cca"> <Graphics CenterX="971.2498933548235" CenterY="200.42654583049858" Width="153.15453891535282" Height="20.00000000000001" ZOrder="32813" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-503-5p"/> </DataNode> <DataNode TextLabel="mmu-let-7b-5p" GraphId="f9466" Type="GeneProduct"> <Graphics CenterX="1048.8720826021581" CenterY="635.1418839418478" Width="115.3280641706881" Height="20.0" ZOrder="32814" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-let-7b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-19b-3p" GraphId="a5d23" Type="GeneProduct" GroupRef="a22c1"> <Graphics CenterX="968.3514522668562" CenterY="864.2788936226406" Width="146.6833617956439" Height="20.00000000000001" ZOrder="32815" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-19b-3p"/> </DataNode> <DataNode TextLabel="mmu-miR-340-5p" GraphId="c5675" Type="GeneProduct" GroupRef="fa578"> <Graphics CenterX="778.7526749648721" CenterY="626.0466712281049" Width="137.18221534762807" Height="20.00000000000008" ZOrder="32816" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-340-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-34b-5p" GraphId="b9045" Type="GeneProduct" GroupRef="fa578"> <Graphics CenterX="915.9348903125" CenterY="606.046671228105" Width="137.18221534762807" Height="20.00000000000008" ZOrder="32817" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-34b-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-149-5p" GraphId="d4f57" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="419.4026465470995" Width="134.43866079588943" Height="19.999999999999936" ZOrder="32818" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-149-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-362-5p" GraphId="a0f7d" Type="GeneProduct" GroupRef="f5815"> <Graphics CenterX="1240.1801426607387" CenterY="664.5072438393225" Width="151.40203202675622" Height="20.000000000000156" ZOrder="32819" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-362-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-15a-5p" GraphId="cccce" Type="GeneProduct" GroupRef="fa578"> <Graphics CenterX="915.9348903125002" CenterY="626.0466712281049" Width="137.18221534762807" Height="20.00000000000008" ZOrder="32821" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-15a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-362-5p" GraphId="f9411" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="539.4026465470993" Width="134.43866079588943" Height="20.00000000000008" ZOrder="32822" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-362-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-15a-5p" GraphId="ff2b6" Type="GeneProduct"> <Graphics CenterX="703.5912931097239" CenterY="842.6482639222414" Width="129.4604150305523" Height="17.263076530517083" ZOrder="32823" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-15a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-15a-5p" GraphId="ce3e8" Type="GeneProduct" GroupRef="ed1ac"> <Graphics CenterX="973.3126710587306" CenterY="153.9810156048472" Width="152.80293862876934" Height="20.000000000000135" ZOrder="32824" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-15a-5p"/> </DataNode> <DataNode TextLabel="mmu-miR-24-3p" GraphId="fe2fc" Type="GeneProduct" GroupRef="ba661"> <Graphics CenterX="950.6676288594903" CenterY="399.40264654709955" Width="134.43866079588943" Height="20.00000000000001" ZOrder="32825" FontSize="10" Valign="Middle"/> <Xref Database="miRBase mature sequence" ID="mmu-miR-24-3p"/> </DataNode> <Interaction GraphId="id7d863a59"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="333.24573420910485" Y="249.38916532359508" GraphRef="b61ad" RelX="1.0" RelY="0.0"/> <Point X="469.6127191877598" Y="251.1690921966616" GraphRef="c806c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id8f6630ab"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="335.232277122499" Y="279.386785452974" GraphRef="dc14f" RelX="1.0" RelY="0.0"/> <Point X="398.76011079117785" Y="279.87638974539504" GraphRef="d61f3" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2945860"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="295.232277122499" Y="289.386785452974" GraphRef="dc14f" RelX="0.0" RelY="1.0"/> <Point X="431.02348635499953" Y="466.3997025658472" GraphRef="dda96" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idb76df336"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="438.76011079117785" Y="289.87638974539504" GraphRef="d61f3" RelX="0.0" RelY="1.0"/> <Point X="451.02348635499953" Y="466.3997025658472" GraphRef="dda96" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ida9f47555"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="509.6127191877598" Y="261.1690921966616" GraphRef="c806c" RelX="0.0" RelY="1.0"/> <Point X="471.02348635499953" Y="466.3997025658472" GraphRef="dda96" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id43b0c49c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="357.2053856147222" Y="475.5539870754067" GraphRef="a49bc" RelX="1.0" RelY="-0.5"/> <Point X="411.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="-1.0" RelY="-0.5" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3a84600f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="411.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="-1.0" RelY="0.5"/> <Point X="357.2053856147222" Y="491.0955699057219" GraphRef="a49bc" RelX="1.0" RelY="0.5" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id4037cd92"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="246.8166739037919" Y="483.3678296927131" GraphRef="f12c9" RelX="1.0" RelY="0.0"/> <Point X="277.2053856147222" Y="483.3247784905643" GraphRef="a49bc" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id60136a8d"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="337.2053856147222" Y="498.8663613208795" GraphRef="a49bc" RelX="0.5" RelY="1.0"/> <Point X="337.1567187077628" Y="529.7117283073792" GraphRef="dd0f4" RelX="0.5" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idd28d2b35"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="317.1567187077628" Y="529.7117283073792" GraphRef="dd0f4" RelX="0.0" RelY="-1.0"/> <Point X="317.2053856147222" Y="498.8663613208795" GraphRef="a49bc" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="iddb7ccf21"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="357.1567187077628" Y="543.0040407610884" GraphRef="dd0f4" RelX="1.0" RelY="0.0"/> <Point X="451.02348635499953" Y="496.5036596416352" GraphRef="dda96" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id5af4cdee"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="629.9917941642816" Y="125.20938545206096" GraphRef="c4b27" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idcb4e49e9"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="629.9917941642817" Y="153.726094169977" GraphRef="d7441" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfb41e0c4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="629.9917941642816" Y="181.026130213905" GraphRef="b5cc7" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id29fa2910"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="621.7295935988325" Y="237.0908024498907" GraphRef="f63ad" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2823993d"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="629.9917941642813" Y="291.2740576880468" GraphRef="b8284" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id65fa11e1"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="617.1651644611563" Y="387.6617248861122" GraphRef="ba3a6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ida9bfa52b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="617.1651644611561" Y="417.66172488611153" GraphRef="edbd4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id438d7a29"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="473.9256918347942" GraphRef="dda96" RelX="1.0" RelY="-0.5"/> <Point X="617.1651644611561" Y="445.6114185127236" GraphRef="d0251" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id38b6692e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="638.4612363054655" Y="883.3067258797179" GraphRef="d2e7a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id41b6d080"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="622.6842087417145" Y="812.7297499856086" GraphRef="ade33" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idc1296837"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="626.3342267636784" Y="737.7286017507705" GraphRef="f55c0" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id6b3b1e86"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="638.5827012482019" Y="677.3606063191488" GraphRef="a9296" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id99762d6d"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="618.7058882301535" Y="574.4455847008165" GraphRef="f51d6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idcd4eebfb"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="617.1651644611561" Y="548.5072490874011" GraphRef="e0ca7" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide4f2eb0f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="617.1651644611563" Y="485.6239037394251" GraphRef="ae079" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idefadce87"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="709.9917941642816" Y="125.20938545206096" GraphRef="c4b27" RelX="1.0" RelY="0.0"/> <Point X="768.2870361843344" Y="79.10977547779595" GraphRef="f8c41" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id8861544b"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="709.9917941642816" Y="125.20938545206096" GraphRef="c4b27" RelX="1.0" RelY="0.0"/> <Point X="767.2032510740306" Y="177.21247607561605" GraphRef="a1924" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id878fcbb8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="709.9917941642817" Y="153.726094169977" GraphRef="d7441" RelX="1.0" RelY="0.0"/> <Point X="768.1133467146559" Y="248.44728479436674" GraphRef="bbdf1" RelX="-1.0" RelY="-0.5" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id7aed0abb"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="717.7295935988325" Y="237.0908024498907" GraphRef="f63ad" RelX="1.0" RelY="0.0"/> <Point X="768.1133467146559" Y="277.44728479436657" GraphRef="bbdf1" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id916c468e"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="744.8369416415942" Y="456.7757901068656" GraphRef="ad294" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide9fc959a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="747.7563596342758" Y="538.7891918074735" GraphRef="cd651" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id1df45ae4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="831.4088802266997" Y="538.41908852548" GraphRef="eb608" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfa48d3bd"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="830.829344204093" Y="456.77730880999064" GraphRef="e9291" RelX="0.0" RelY="1.0"/> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2712e6fe"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1113.6938613721334" Y="403.8747541869484" GraphRef="ffd7e" RelX="1.0" RelY="0.0"/> <Point X="1183.6648693805305" Y="456.3525693845609" GraphRef="c3acc" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id45922a92"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1279.6648693805305" Y="470.352569384561" GraphRef="c3acc" RelX="1.0" RelY="0.0"/> <Point X="1328.0355266520164" Y="479.47975503753224" GraphRef="c8760" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id484a6951"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1271.6648693805307" Y="516.0525693845614" GraphRef="c8aa8" RelX="1.0" RelY="0.0"/> <Point X="1328.0355266520164" Y="479.47975503753224" GraphRef="c8760" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3db17c2a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1408.0355266520164" Y="479.47975503753224" GraphRef="c8760" RelX="1.0" RelY="0.0"/> <Point X="1487.777328163534" Y="485.19964837577265" GraphRef="c4b73" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide37ab6af"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="916.5572116617528" Y="366.1821797280557" GraphRef="f9284" RelX="1.0" RelY="0.0"/> <Point X="1263.6783870967736" Y="366.7057258064514"/> <Point X="1487.777328163534" Y="485.19964837577265" GraphRef="c4b73" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idf9befc4a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="698.7058882301535" Y="574.4455847008165" GraphRef="f51d6" RelX="1.0" RelY="0.0"/> <Point X="1034.7795913682342" Y="593.8035243021587" GraphRef="d87ec" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2f0b06f1"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="616.1651176902684" Y="978.3264971537471" GraphRef="ddda5" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idd1176861"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="864.2870361843344" Y="79.10977547779595" GraphRef="f8c41" RelX="1.0" RelY="0.0"/> <Point X="885.792410594758" Y="13.54838709677422"/> <Point X="1324.3065334215053" Y="17.65511595474908"/> <Point X="1373.0" Y="99.0" GraphRef="f0130" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> <Anchor Position="0.043271001346712225" Shape="None"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3725cac5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="863.2032510740306" Y="177.21247607561605" GraphRef="a1924" RelX="1.0" RelY="0.0"/> <Point X="871.7213502657338" Y="258.2060708382047"/> <Point X="1330.754365089209" Y="260.4129603325483"/> <Point X="1373.0" Y="99.0" GraphRef="f0130" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idc9beba7e"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="864.1133467146559" Y="277.44728479436657" GraphRef="bbdf1" RelX="1.0" RelY="0.0"/> <Point X="1378.3840874999999" Y="278.0" GraphRef="c8cc4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idaa24e2ff"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="1262.2804567389214" Y="977.0639178989285" GraphRef="fc02f" RelX="1.0" RelY="0.0"/> <Point X="1668.7384850000005" Y="968.0" GraphRef="b8514" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id6f2b2966"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="208.0" Y="263.0" GraphRef="ae661" RelX="1.0" RelY="0.0"/> <Point X="253.24573420910485" Y="249.38916532359508" GraphRef="b61ad" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide2e40397"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="208.0" Y="263.0" GraphRef="ae661" RelX="1.0" RelY="0.0"/> <Point X="255.232277122499" Y="279.386785452974" GraphRef="dc14f" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfb687ef5"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1367.5356942187484" Y="511.00202947048695" GraphRef="da5f2" RelX="0.0" RelY="-1.0"/> <Point X="1368.0355266520164" Y="489.47975503753224" GraphRef="c8760" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id2290f850"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1295.0834753124982" Y="535.002029470487" GraphRef="da5f2" RelX="-1.0" RelY="-0.5"/> <Point X="1271.6648693805307" Y="516.0525693845614" GraphRef="c8aa8" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idc62a97a"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="894.6726238971471" Y="316.46486285556085" GraphRef="cf826" RelX="-1.0" RelY="0.0"/> <Point X="856.1133467146559" Y="317.4472847943662" GraphRef="dee86" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id808d9bf2"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="790.0174682767056" Y="479.14486628845646" GraphRef="cd8ab" RelX="0.0" RelY="-1.0"/> <Point X="810.829344204093" Y="456.77730880999064" GraphRef="e9291" RelX="-0.5" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide9dd5b81"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="317.6395267745042" Y="579.8071914941708" GraphRef="b6c37" RelX="0.0" RelY="-1.0"/> <Point X="317.1567187077628" Y="556.2963532147976" GraphRef="dd0f4" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id7c846b45"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="888.9112017443458" Y="93.98101560484707" GraphRef="d325c" RelX="-1.0" RelY="0.0"/> <Point X="856.2870361843344" Y="39.109775477795935" GraphRef="bf917" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idb2fe1c56"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="896.9112017443458" Y="53.98101560484705" GraphRef="eb4ec" RelX="-1.0" RelY="0.0"/> <Point X="855.2032510740306" Y="157.21247607561605" GraphRef="b8ef5" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3e7cdac3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="574.7111579134612" Y="115.16185381752267" GraphRef="c958d" RelX="1.0" RelY="0.0"/> <Point X="629.9917941642816" Y="125.20938545206096" GraphRef="c4b27" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id4ceabdb8"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="541.9732662878791" Y="823.1996094942335" GraphRef="fe35e" RelX="1.0" RelY="0.0"/> <Point X="622.6842087417145" Y="812.7297499856086" GraphRef="ade33" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id82c59008"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="875.4482984615454" Y="469.4026465470995" GraphRef="d945f" RelX="-1.0" RelY="0.0"/> <Point X="831.4088802266997" Y="538.41908852548" GraphRef="eb608" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id8d209bde"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1133.8486976968084" Y="1025.0257624510316" GraphRef="bca17" RelX="0.0" RelY="-1.0"/> <Point X="1133.7066860725952" Y="984.9865557669533" GraphRef="f68fa" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id67fb99c6"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="573.4348763509612" Y="210.71818742366628" GraphRef="b729a" RelX="1.0" RelY="0.0"/> <Point X="629.7295935988325" Y="217.09080244989073" GraphRef="c5ae6" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idb005b942"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="906.6324273422799" Y="748.7768620520801" GraphRef="b5b48" RelX="1.0" RelY="0.0"/> <Point X="928.5613030374208" Y="738.6705595055425" GraphRef="c3a32" RelX="-1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id559be3ea"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="702.161567291058" Y="602.046671228105" GraphRef="d8b2e" RelX="-1.0" RelY="-0.5"/> <Point X="658.7058882301535" Y="584.4455847008165" GraphRef="f51d6" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ide8a7d557"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1528.8356267083063" Y="527.0655694140295" GraphRef="a5154" RelX="0.0" RelY="-1.0"/> <Point X="1527.777328163534" Y="495.460652687786" GraphRef="c4b73" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id61306e5c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="886.6726238971471" Y="220.42654583049858" GraphRef="ab749" RelX="-1.0" RelY="0.0"/> <Point X="856.2870361843344" Y="59.10977547779592" GraphRef="ee7f2" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idf4454cf3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="896.9112017443458" Y="33.98101560484693" GraphRef="bd1d8" RelX="-1.0" RelY="0.0"/> <Point X="856.2870361843344" Y="119.10977547779598" GraphRef="f75cb" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idbe204df3"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1048.8720826021581" Y="645.1418839418478" GraphRef="f9466" RelX="0.0" RelY="1.0"/> <Point X="963.8180365159296" Y="673.6779940374614" GraphRef="af626" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idfb1b3519"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="887.0097713690343" Y="854.2788936226406" GraphRef="a0f05" RelX="-1.0" RelY="0.0"/> <Point X="855.1552630831438" Y="827.3744922905879" GraphRef="b88ed" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id8be89af4"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="1156.4791266473603" Y="644.5072438393222" GraphRef="bc87b" RelX="-1.0" RelY="0.0"/> <Point X="1074.7795913682342" Y="603.8035243021587" GraphRef="d87ec" RelX="0.0" RelY="1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id3e2dbb58"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1134.4945540357326" Y="216.2617383564588" GraphRef="f9ce6" RelX="-1.0" RelY="0.0"/> <Point X="1055.4848521874999" Y="176.126855625"/> <Point X="886.0661319789674" Y="176.5511595474904"/> <Point X="855.2032510740306" Y="177.212476075616" GraphRef="a7435" RelX="1.0" RelY="0.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idf63ed8bc"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="703.5912931097239" Y="851.2798021875" GraphRef="ff2b6" RelX="0.0" RelY="1.0"/> <Point X="698.4612363054655" Y="873.3067258797179" GraphRef="d2e7a" RelX="0.5" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id93e286bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1142.4945540357326" Y="171.4920259544942" GraphRef="e1277" RelX="-1.0" RelY="0.0"/> <Point X="989.789938213118" Y="176.5511595474904"/> <Point X="889.3764662204829" Y="177.65460429466222"/> <Point X="863.2032510740306" Y="196.21247607561605" GraphRef="a1924" RelX="1.0" RelY="0.5" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d3f1c"> <Graphics ConnectorType="Segmented" ZOrder="32769" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="644.2259202699871" Y="645.1212949157957"/> <Point X="863.901466329703" Y="672.528845354664" GraphRef="e552a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="be2ed"> <Graphics ConnectorType="Segmented" ZOrder="32770" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="641.90844851001" Y="657.86738959567"/> <Point X="771.6487092444131" Y="667.5459530036169" GraphRef="ceba1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="caa9e"> <Graphics ConnectorType="Segmented" ZOrder="32771" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="646.5433920299643" Y="633.5339361159101"/> <Point X="963.8180365159296" Y="673.6779940374614" GraphRef="af626" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c34c5"> <Graphics ConnectorType="Segmented" ZOrder="32772" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="646.5433920299643" Y="624.2640490760016"/> <Point X="1065.014562500219" Y="672.2745795952578" GraphRef="c3369" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f0476"> <Graphics ConnectorType="Segmented" ZOrder="32773" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="611.9597480895754" Y="561.6533763104538"/> <Point X="1026.9701429346335" Y="563.8462862458301" GraphRef="da20c" RelX="-1.0" RelY="0.5" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c4781"> <Graphics ConnectorType="Segmented" ZOrder="32774" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="625.2480871624299" Y="705.1226482097421"/> <Point X="756.0500030742714" Y="721.0726843152282" GraphRef="dc4ae" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e4cd9"> <Graphics ConnectorType="Segmented" ZOrder="32779" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="630.8687901431459" Y="697.9699119791285"/> <Point X="968.5613030374208" Y="720.6705595055425" GraphRef="c173f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c9a80"> <Graphics ConnectorType="Segmented" ZOrder="32780" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="636.3806421294204" Y="688.0892307739102"/> <Point X="1072.1611823428805" Y="721.1660393198193" GraphRef="fae7f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b2c2f"> <Graphics ConnectorType="Segmented" ZOrder="32782" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="626.6472607375164" Y="793.0880825390743"/> <Point X="754.4698135905377" Y="802.5674759060788" GraphRef="de351" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c3954"> <Graphics ConnectorType="Segmented" ZOrder="32783" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="632.7306241074563" Y="784.5713738211583"/> <Point X="855.1552630831438" Y="807.3744922905879" GraphRef="b88ed" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="dd976"> <Graphics ConnectorType="Segmented" ZOrder="32788" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="618.3130529206984" Y="960.684743380921"/> <Point X="748.0214484184014" Y="969.0871685137286" GraphRef="db7f1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d134d"> <Graphics ConnectorType="Segmented" ZOrder="32789" LineThickness="1.0"> <Point X="491.02348635499953" Y="488.9776703726882" GraphRef="dda96" RelX="1.0" RelY="0.5"/> <Point X="623.4230781514481" Y="954.297211842484"/> <Point X="839.454399868599" Y="967.3928453563417" GraphRef="f0d3e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="f4fbb"> <Graphics ConnectorType="Segmented" ZOrder="32790" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="628.5331033821976" Y="945.3546676886722"/> <Point X="935.7351759840975" Y="965.7285618472754" GraphRef="ae7ee" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e2dde"> <Graphics ConnectorType="Segmented" ZOrder="32791" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="631.0881159975725" Y="937.6896298425478"/> <Point X="1038.3552742165293" Y="963.4711391641416" GraphRef="e290b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="cc95e"> <Graphics ConnectorType="Segmented" ZOrder="32792" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="636.1981412283221" Y="923.6370604579863"/> <Point X="1133.7066860725952" Y="964.9865557669533" GraphRef="f68fa" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e7399"> <Graphics ConnectorType="Segmented" ZOrder="32793" LineThickness="1.0"> <Point X="491.02348635499953" Y="481.4516811037412" GraphRef="dda96" RelX="1.0" RelY="0.0"/> <Point X="640.0306601513844" Y="915.9720226118619"/> <Point X="1222.2804567389214" Y="967.0639178989285" GraphRef="fc02f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d045e"> <Graphics ConnectorType="Segmented" ZOrder="32795" LineStyle="Broken" LineThickness="1.0"> <Point X="1503.1051262499998" Y="278.0" GraphRef="c8cc4" RelX="1.0" RelY="0.0"/> <Point X="1524.2194994674305" Y="279.0281690140845"/> <Point X="1670.909640312501" Y="169.0" GraphRef="c4f7d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="b79d9"> <Graphics ConnectorType="Segmented" ZOrder="32796" LineStyle="Broken" LineThickness="1.0"> <Point X="1501.0" Y="99.0" GraphRef="f0130" RelX="1.0" RelY="0.0"/> <Point X="1523.2194994674305" Y="100.56338028169013"/> <Point X="1670.909640312501" Y="169.0" GraphRef="c4f7d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="e9a57"> <Graphics ConnectorType="Segmented" ZOrder="32797" LineStyle="Broken" LineThickness="1.0"> <Point X="1567.777328163534" Y="485.19964837577265" GraphRef="c4b73" RelX="1.0" RelY="0.0"/> <Point X="1599.1807978124998" Y="504.1312171875"/> <Point X="1671.909640312501" Y="548.0" GraphRef="dfcdd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="a9fc8"> <Graphics ConnectorType="Segmented" ZOrder="32798" LineStyle="Broken" LineThickness="1.0"> <Point X="1114.7795913682342" Y="593.8035243021587" GraphRef="d87ec" RelX="1.0" RelY="0.0"/> <Point X="1168.2886867439513" Y="601.21814516129"/> <Point X="1623.870138356854" Y="601.9649999999997"/> <Point X="1671.909640312501" Y="548.0" GraphRef="dfcdd" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id9dd5a22d"> <Graphics ZOrder="32826" LineStyle="Broken" LineThickness="1.0"> <Point X="1105.014562500219" Y="682.2745795952578" GraphRef="c3369" RelX="1.0" RelY="0.0"/> <Point X="1672.909640312501" Y="680.5" GraphRef="b5d6d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id91c75616"> <Graphics ZOrder="32827" LineStyle="Broken" LineThickness="1.0"> <Point X="1120.1611823428805" Y="759.1660393198193" GraphRef="fae7f" RelX="1.0" RelY="0.0"/> <Point X="1673.2051284374993" Y="746.5" GraphRef="c11e5" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id912ffaa6"> <Graphics ZOrder="32828" LineStyle="Broken" LineThickness="1.0"> <Point X="895.1552630831438" Y="817.3744922905879" GraphRef="b88ed" RelX="1.0" RelY="0.0"/> <Point X="1673.0147665625009" Y="814.6203524999999" GraphRef="da086" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idb7d48488"> <Graphics ZOrder="32829" LineStyle="Broken" LineThickness="1.0"> <Point X="718.4612363054655" Y="883.3067258797179" GraphRef="d2e7a" RelX="1.0" RelY="0.0"/> <Point X="1665.8045140625018" Y="879.4222653124998" GraphRef="ea0a5" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id40aa17af"> <Graphics ZOrder="32830" LineStyle="Broken" LineThickness="1.0"> <Point X="91.302563125" Y="200.0" GraphRef="d7616" RelX="0.5" RelY="1.0"/> <Point X="128.0" Y="263.0" GraphRef="ae661" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id61d3ca54"> <Graphics ZOrder="32832" LineStyle="Broken" LineThickness="1.0"> <Point X="1122.970142934634" Y="549.8462862458301" GraphRef="da20c" RelX="1.0" RelY="0.0"/> <Point X="1183.6648693805305" Y="484.35256938456104" GraphRef="c3acc" RelX="-1.0" RelY="0.5" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="Cell cycle arrest" GraphId="c4f7d"> <Graphics CenterX="1733.9570401562505" CenterY="169.0" Width="126.09479968749875" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle"/> </Label> <Label TextLabel="Apoptosis" GraphId="dfcdd"> <Graphics CenterX="1717.2272390625005" CenterY="548.0" Width="90.63519749999877" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle"/> </Label> <Label TextLabel="Inhibition of&#10;angiogenesis&#10;and metastasis" GraphId="b5d6d"> <Graphics CenterX="1737.5096032812505" CenterY="680.5" Width="129.19992593749893" Height="59.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle" Align="Left"/> </Label> <Label TextLabel="DNA repair and damage&#10;prevention" GraphId="c11e5"> <Graphics CenterX="1774.0313718749994" CenterY="746.5" Width="201.65248687500002" Height="59.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle" Align="Left"/> </Label> <Label TextLabel="Inhibition of IGF-1/mTOR &#10;pathway" GraphId="da086"> <Graphics CenterX="1792.0147665625009" CenterY="814.6203525" Width="238.0" Height="45.240704999999856" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle" Align="Left"/> </Label> <Label TextLabel="Exosome mediated secretion" GraphId="ea0a5"> <Graphics CenterX="1783.0938803125007" CenterY="879.4222653124999" Width="234.5787324999985" Height="22.844530624999976" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle"/> </Label> <Label TextLabel="p53 negative feedback" GraphId="b8514"> <Graphics CenterX="1762.8640792187502" CenterY="968.0" Width="188.25118843749934" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="16" Valign="Middle"/> </Label> <Label TextLabel="G1 arrest (sustained)" GraphId="f0130"> <Graphics CenterX="1437.0" CenterY="99.0" Width="128.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="13" Valign="Middle"/> </Label> <Label TextLabel="G2 arrest (sustained)" GraphId="c8cc4"> <Graphics CenterX="1440.7446068749998" CenterY="278.0" Width="124.72103874999985" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="13" Valign="Middle"/> </Label> <Label TextLabel="DNA damage" GraphId="ae661"> <Graphics CenterX="168.0" CenterY="263.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="13" Valign="Middle" Color="cc0033"/> </Label> <Label TextLabel="Genotoxic stress" GraphId="d7616"> <Graphics CenterX="55.052563125000006" CenterY="190.0" Width="145.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="14" Valign="Middle" Color="cc0033"/> </Label> <Label TextLabel="Endpoint" GraphId="ce253"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="1714.909640312501" CenterY="29.999999999999993" Width="80.0" Height="20.0" ZOrder="28672" FillColor="000000" FontWeight="Bold" FontSize="17" Valign="Middle"/> </Label> <Label TextLabel="Target genes" GraphId="c6243"> <Graphics CenterX="670.0" CenterY="30.0" Width="108.0" Height="20.0" ZOrder="28672" FillColor="000000" FontWeight="Bold" FontSize="17" Valign="Middle"/> </Label> <Label TextLabel="Stress signals" GraphId="cae1a"> <Graphics CenterX="56.5" CenterY="93.0" Width="131.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="17" Valign="Middle"/> </Label> <Shape GraphId="df060"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Mitochondria"/> <Graphics CenterX="1151.0370739028453" CenterY="490.6396845807608" Width="53.266034680690574" Height="137.5" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="Mitochondria" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape GraphId="b3b6c"> <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="1012.6735185739435" CenterY="530.5046728976653" Width="1793.0637927728872" Height="1049.9603585796692" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/> </Shape> <Shape GraphId="e2071"> <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/> <Graphics CenterX="1783.7310785470186" CenterY="525.8797755547735" Width="235.60737730737375" Height="1031.6691162320606" ZOrder="16384" FillColor="cccccc" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/> </Shape> <Group GroupId="bd250" GraphId="f63ad"/> <Group GroupId="dc015" GraphId="f8c41"/> <Group GroupId="b1741" GraphId="a1924"/> <Group GroupId="cab33" GraphId="bbdf1"/> <Group GroupId="de3cc" GraphId="da20c"/> <Group GroupId="df0dc" GraphId="c3acc"/> <Group GroupId="b7855" GraphId="dc4ae"/> <Group GroupId="dd576" GraphId="c173f"/> <Group GroupId="b0e17" GraphId="fae7f"/> <Group GroupId="fdb04" GraphId="ae7ee"/> <Group GroupId="cee2a" GraphId="e290b"/> <Group GroupId="c9762" GraphId="fa84f"/> <Group GroupId="cbec2" GraphId="ed03e"/> <Group GroupId="ca6d9" GraphId="f4eb3" Style="Group"/> <Group GroupId="dffa6" GraphId="c958d"/> <Group GroupId="bbce9" GraphId="fe35e"/> <Group GroupId="d4e6c" GraphId="b5b48"/> <Group GroupId="c3658" GraphId="b729a"/> <Group GroupId="c2cca" GraphId="ab749"/> <Group GroupId="bc81e" GraphId="a5154"/> <Group GroupId="a22c1" GraphId="a0f05"/> <Group GroupId="af74d" GraphId="f1b09"/> <Group GroupId="f5815" GraphId="bc87b"/> <Group GroupId="ad37f" GraphId="f9ce6"/> <Group GroupId="fa578" GraphId="d8b2e"/> <Group GroupId="ed1ac" GraphId="d325c"/> <Group GroupId="ee8e4" GraphId="da5f2"/> <Group GroupId="ba661" GraphId="d945f"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dfd"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25976910</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mutagenesis</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rieswijk L</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brauers KJ</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coonen ML</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van Breda SG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jennen DG</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kleinjans JC</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>p53 signaling pathway</bp:TERM><bp:ID>PW:0000718</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

Return to p53 signaling (Mus musculus).