Tetrahydrofolate biosynthesis I (Oryza sativa)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Tetrahydrofolate biosynthesis I" Data-Source="Plant Reactome - http://plantreactome.gramene.org" Version="43" Maintainer="Amoss, Kindra" Organism="Oryza sativa"> <Comment Source="WikiPathways-description">Developed by Gramene.org Source:[http://plantreactome.gramene.org/ Plant Reactome].</Comment> <Attribute Key="reactome_id" Value="1119265"/> <Graphics BoardWidth="937.0" BoardHeight="1282.0"/> <DataNode TextLabel="7,8-dihydroneopterin&#10;3'-triphosphate" GraphId="c4ea0" Type="Metabolite"> <Attribute Key="reactome_id" Value="1132020"/> <Graphics CenterX="442.0" CenterY="173.5" Width="156.0" Height="71.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18372"/> </DataNode> <DataNode TextLabel="GTP cyclohydrolase I&#10; (LOC_OS04G56710.1)" GraphId="a3e46" Type="Protein"> <Comment Source="Reactome">Facilitates the conversion of GTP to 7,8-dihydroneopterin 3'-triphosphate.</Comment> <Attribute Key="reactome_id" Value="1127241"/> <Graphics CenterX="552.5" CenterY="104.0" Width="141.0" Height="42.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q0J9B5"/> </DataNode> <DataNode TextLabel="dihydroneopterin&#10;phosphate" GraphId="e828c" Type="Metabolite"> <Attribute Key="reactome_id" Value="1132178"/> <Graphics CenterX="442.0" CenterY="297.0" Width="120.0" Height="58.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:48954"/> </DataNode> <DataNode TextLabel="dihydroneopterin" GraphId="c8146" Type="Metabolite"> <Attribute Key="reactome_id" Value="1130901"/> <Graphics CenterX="442.0" CenterY="422.0" Width="134.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17001"/> </DataNode> <DataNode TextLabel="glycolaldehyde" GraphId="cb24a" Type="Metabolite"> <Attribute Key="reactome_id" Value="1132263"/> <Graphics CenterX="337.0" CenterY="472.0" Width="106.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17071"/> </DataNode> <DataNode TextLabel="" GraphId="df193" Type="Metabolite"> <Graphics CenterX="0.0" CenterY="0.0" Width="0.0" Height="0.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="dihydroneopterin&#10;aldolase" GraphId="ddf3c" Type="Protein"> <Comment Source="Reactome">Facilitates the conversion of dihydro-neo-pterin to 6-hydroxymethyl-dihydropterin.</Comment> <Attribute Key="reactome_id" Value="1121856"/> <Graphics CenterX="572.0" CenterY="458.0" Width="112.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Reactome" ID="1121856"/> </DataNode> <DataNode TextLabel="2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine&#10;diphosphate" GraphId="c0527" Type="Metabolite"> <Attribute Key="reactome_id" Value="1131536"/> <Graphics CenterX="442.5" CenterY="692.0" Width="147.0" Height="96.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15998"/> </DataNode> <DataNode TextLabel="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine&#10;diphosphokinase" GraphId="ede14" Type="Protein"> <Comment Source="Reactome">Facilitates the conversion of 6-hydroxymethyl-dihydropterin to 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate.</Comment> <Attribute Key="reactome_id" Value="1121789"/> <Graphics CenterX="578.5" CenterY="601.0" Width="143.0" Height="90.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Reactome" ID="1121789"/> </DataNode> <DataNode TextLabel="7,8-dihydropteroate" GraphId="fe989" Type="Metabolite"> <Attribute Key="reactome_id" Value="1131783"/> <Graphics CenterX="317.5" CenterY="844.0" Width="141.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:4581"/> </DataNode> <DataNode TextLabel="dihydropteroate&#10;synthase" GraphId="b3a1e" Type="Protein"> <Comment Source="Reactome">Facilitates the combination of p-aminobenzoate and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate to form 7,8-dihydropteroate.</Comment> <Attribute Key="reactome_id" Value="1121951"/> <Graphics CenterX="572.0" CenterY="772.0" Width="110.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Reactome" ID="1121951"/> </DataNode> <DataNode TextLabel="4-amino-4-deoxychorismate" GraphId="ba921" Type="Metabolite"> <Attribute Key="reactome_id" Value="1131074"/> <Graphics CenterX="172.5" CenterY="533.5" Width="119.0" Height="55.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18198"/> </DataNode> <DataNode TextLabel="dihydrofolate&#10;reductase" GraphId="b7550" Type="Protein"> <Comment Source="Reactome">Facilitates the conversion of 7,8-dihydrofolate to tetrahydrofolate.</Comment> <Attribute Key="reactome_id" Value="1121824"/> <Graphics CenterX="423.5" CenterY="1085.0" Width="93.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Reactome" ID="1121824"/> </DataNode> <DataNode TextLabel="phosphoribosylglycinamide&#10;formyltransferase" GraphId="eab2b" Type="Protein"> <Comment Source="Reactome">Facilitates the conversion of N10-formyl-THF to tetrahydrofolate.</Comment> <Attribute Key="reactome_id" Value="1122195"/> <Graphics CenterX="805.5" CenterY="1053.0" Width="129.0" Height="64.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Reactome" ID="1122195"/> </DataNode> <DataNode TextLabel="5,10-methenyl-THF" GraphId="a4422" Type="Metabolite"> <Attribute Key="reactome_id" Value="1132260"/> <Graphics CenterX="691.0" CenterY="854.5" Width="138.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15638"/> </DataNode> <DataNode TextLabel="GTP" GraphId="a4e7c" Type="Metabolite"> <Attribute Key="reactome_id" Value="29438"/> <Graphics CenterX="442.0" CenterY="56.5" Width="48.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15996"/> </DataNode> <DataNode TextLabel="H2O" GraphId="d985d" Type="Metabolite"> <Attribute Key="reactome_id" Value="29356"/> <Graphics CenterX="334.0" CenterY="88.5" Width="50.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15377"/> </DataNode> <DataNode TextLabel="HCOOH" GraphId="b2d4b" Type="Metabolite"> <Attribute Key="reactome_id" Value="29460"/> <Graphics CenterX="334.5" CenterY="131.0" Width="69.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30751"/> </DataNode> <DataNode TextLabel="H2O" GraphId="c416a" Type="Metabolite"> <Attribute Key="reactome_id" Value="29356"/> <Graphics CenterX="334.0" CenterY="215.0" Width="44.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15377"/> </DataNode> <DataNode TextLabel="PPi" GraphId="f9e08" Type="Metabolite"> <Attribute Key="reactome_id" Value="111294"/> <Graphics CenterX="334.5" CenterY="261.5" Width="37.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29888"/> </DataNode> <DataNode TextLabel="H2O" GraphId="c5491" Type="Metabolite"> <Attribute Key="reactome_id" Value="29356"/> <Graphics CenterX="334.0" CenterY="341.0" Width="44.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15377"/> </DataNode> <DataNode TextLabel="Pi" GraphId="f2ad6" Type="Metabolite"> <Attribute Key="reactome_id" Value="29372"/> <Graphics CenterX="334.5" CenterY="385.0" Width="37.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref 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Key="reactome_id" Value="964856"/> <Graphics CenterX="172.0" CenterY="389.0" Width="48.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:17333"/> </DataNode> <DataNode TextLabel="L-Glu" GraphId="dca8c" Type="Metabolite"> <Attribute Key="reactome_id" Value="29404"/> <Graphics CenterX="76.5" CenterY="492.0" Width="51.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16015"/> </DataNode> <DataNode TextLabel="PYR" GraphId="c0e20" Type="Metabolite"> <Attribute Key="reactome_id" Value="29398"/> <Graphics CenterX="76.5" CenterY="620.5" Width="51.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:32816"/> </DataNode> <DataNode TextLabel="PPi" GraphId="ed430" Type="Metabolite"> <Attribute Key="reactome_id" Value="111294"/> <Graphics CenterX="214.0" CenterY="811.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:29888"/> </DataNode> <DataNode TextLabel="ATP" GraphId="e625f" Type="Metabolite"> <Attribute Key="reactome_id" Value="113592"/> <Graphics CenterX="214.5" CenterY="884.0" Width="45.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15422"/> </DataNode> <DataNode TextLabel="Pi" GraphId="f11f4" Type="Metabolite"> <Attribute Key="reactome_id" Value="29372"/> <Graphics CenterX="213.5" CenterY="1000.0" Width="37.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18367"/> </DataNode> <DataNode TextLabel="L-Glu" GraphId="a9884" Type="Metabolite"> <Attribute Key="reactome_id" Value="29404"/> <Graphics CenterX="212.5" CenterY="920.0" Width="51.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16015"/> </DataNode> <DataNode TextLabel="NADPH" GraphId="a1d61" Type="Metabolite"> <Attribute Key="reactome_id" Value="29364"/> <Graphics CenterX="215.5" CenterY="1060.0" Width="67.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16474"/> </DataNode> <DataNode TextLabel="NADP+" GraphId="af664" Type="Metabolite"> <Attribute Key="reactome_id" Value="29366"/> <Graphics CenterX="219.5" CenterY="1145.0" Width="61.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18009"/> </DataNode> <DataNode TextLabel="THF" GraphId="f319e" Type="Metabolite"> <Attribute Key="reactome_id" Value="111355"/> <Graphics CenterX="478.0" CenterY="1194.5" Width="46.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15635"/> </DataNode> <DataNode TextLabel="H2O" GraphId="dd91d" Type="Metabolite"> <Attribute Key="reactome_id" Value="29356"/> <Graphics CenterX="596.0" CenterY="905.0" Width="46.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15377"/> </DataNode> <DataNode TextLabel="H+" GraphId="a92cd" Type="Metabolite"> <Attribute Key="reactome_id" Value="70106"/> <Graphics CenterX="215.0" CenterY="1096.0" Width="36.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15378"/> </DataNode> <DataNode TextLabel="ABENZ" GraphId="b25af" Type="Metabolite"> <Attribute Key="reactome_id" Value="174970"/> <Graphics CenterX="174.5" CenterY="694.0" Width="55.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:30753"/> </DataNode> <DataNode TextLabel="10-formyl-THF" GraphId="ad02f" Type="Metabolite"> <Attribute Key="reactome_id" Value="419151"/> <Graphics CenterX="691.0" CenterY="974.0" Width="108.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15637"/> </DataNode> <DataNode TextLabel="DHF" GraphId="d5e2b" Type="Metabolite"> <Attribute Key="reactome_id" Value="73604"/> <Graphics CenterX="317.0" CenterY="1017.0" Width="40.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15633"/> </DataNode> <DataNode TextLabel="ADP" GraphId="d4076" Type="Metabolite"> <Attribute Key="reactome_id" Value="29370"/> <Graphics CenterX="212.0" CenterY="961.0" Width="42.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16761"/> </DataNode> <DataNode TextLabel="PRGA" GraphId="bab5f" Type="Metabolite"> <Attribute Key="reactome_id" Value="111338"/> <Graphics CenterX="596.5" CenterY="1001.0" Width="49.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18349"/> </DataNode> <DataNode TextLabel="N-Formyl-GAR" GraphId="e0757" Type="Metabolite"> <Attribute Key="reactome_id" Value="111354"/> <Graphics CenterX="596.5" CenterY="1077.0" Width="105.0" Height="30.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:18272"/> </DataNode> <Interaction GraphId="da312"> <Comment Source="Reactome">GTP is converted to 7,8-dihydroneopterin 3'-triphosphate by enzymatic activity of GTP cyclohydrolase I.</Comment> <Attribute Key="reactome_id" Value="1121614"/> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="442.0" Y="88.0"/> <Point X="442.0" Y="120.0"/> <Anchor Position="0.0" Shape="None" GraphId="b2079"/> <Anchor Position="0.99" Shape="None" GraphId="c8fa5"/> <Anchor Position="0.5" Shape="None" GraphId="c5fe8"/> </Graphics> <Xref Database="Reactome" ID="1121614"/> </Interaction> <Interaction GraphId="f530c"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="442.0" Y="70.0" GraphRef="a4e7c" RelX="0.0" 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Database="Reactome" ID="1121346"/> </Interaction> <Interaction GraphId="c2812"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="442.0" Y="254.0" GraphRef="fb2cc" RelX="0.0" RelY="0.3299999999999841"/> <Point X="352.0" Y="261.0" GraphRef="f9e08" RelX="0.9459459459459459" RelY="-0.03225806451612903" ArrowHead="Arrow"/> </Graphics> <Xref Database="Reactome" ID="1121346"/> </Interaction> <Interaction GraphId="c0960"> <Comment Source="Reactome">Dihydroneopterin phosphate is converted to dihydro-neo-pterin by enzymatic activity of an unknown gene product.</Comment> <Attribute Key="reactome_id" Value="1121496"/> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="442.0" Y="340.0"/> <Point X="442.0" Y="373.0"/> <Anchor Position="0.0" Shape="None" GraphId="a9bf2"/> <Anchor Position="0.99" Shape="None" GraphId="f85a1"/> </Graphics> <Xref Database="Reactome" ID="1121496"/> </Interaction> <Interaction GraphId="f2b57"> <Graphics 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Return to Tetrahydrofolate biosynthesis I (Oryza sativa).