RNA interference (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="RNA interference" Version="20140513" Organism="Bos taurus"> <Comment Source="WikiPathways-description">The process of RNA-interference in eukaryotic cells. Long precursor microRNA (miRNA), called pri-miRNA, is cleaved by RNase III endonuclease (Drosha) into pieces of approximately 70 nucleotides each (called pre-miRNA) in the nucleus. Following transportation into the cytoplasm by exportin 5 another RNase III endonuclease (Dicer) cleaves it into mature miRNA segments. Degradation of messenger RNA (mRNA) and translational repression occurs after miRNA binds to the RNA-induced silencing complex (RISC). Cytoplasmic long double-stranded RNA (dsRNA) is cleaved by Dicer into small interfering RNA (siRNA), which is incorporated into RISC, resulting in the cleavage and degradation of specific target mRNA. Synthetic double-stranded siRNA is not processed by Dicer and directly incorporated by the RISC.</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2805_r78493 WP2805(78493)] with a 46.0% conversion rate.</Comment> <BiopaxRef>b26</BiopaxRef> <Graphics BoardWidth="792.3554153522609" BoardHeight="771.8611987381704" /> <DataNode TextLabel="DICER1" GraphId="af552" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23405</Comment> <Graphics CenterX="645.6361724500529" CenterY="392.21871713985286" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012852" /> </DataNode> <DataNode TextLabel="XPO5" GraphId="cd457" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57510</Comment> <Graphics CenterX="278.6540483701368" 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ozpolat B</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sood AK</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lopez-Berestein G</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

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