Interferon type I signaling pathways (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Interferon type I signaling pathways" Organism="Bos taurus" License="CC BY 2.0"> <Comment Source="WikiPathways-description">The type I IFNs (IFNα family, IFNβ, IFNω, IFNε and IFNκ) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other accessory proteins. The pathway above (WP585) describes the Type I Interferon signaling pathways and shows both classical IFN signaling via the JAK-STAT pathway (dark lines) and other non-canonical IFN signaling pathways. </Comment> <Comment Source="WikiPathways-category">Physiological Process</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP585_r80201 WP585(80201)] with a 95.0% conversion rate.</Comment> <Graphics BoardWidth="1434.0" BoardHeight="981.0" /> <DataNode TextLabel="GAB2" GraphId="a4afa" Type="Protein"> <BiopaxRef>c3d</BiopaxRef> <Graphics CenterX="631.6190476190459" CenterY="284.00000000000034" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CRK" GraphId="a5aa8" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398</Comment> <BiopaxRef>a39</BiopaxRef> <Graphics CenterX="1279.0" CenterY="461.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005665" /> </DataNode> <DataNode TextLabel="CBL" GraphId="a5e45" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867</Comment> <BiopaxRef>cf0</BiopaxRef> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CBL" /> <Graphics CenterX="1315.4125" CenterY="311.40833333333336" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006817" /> </DataNode> <DataNode TextLabel="RAPGEF1" GraphId="a63d7" Type="Protein"> <Comment>C3G</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889</Comment> <Graphics CenterX="1327.4125" CenterY="521.4083333333333" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020791" /> </DataNode> <DataNode TextLabel="RPS6KB1" GraphId="a6dbc" Type="Protein" GroupRef="f0bb7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198 </Comment> <Graphics CenterX="240.0" CenterY="541.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000016851" /> </DataNode> <DataNode TextLabel="GTP" GraphId="a74bc" Type="Metabolite"> <Graphics CenterX="1185.0" CenterY="367.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15996" /> </DataNode> <DataNode TextLabel="PTPN6" GraphId="a9c87" Type="GeneProduct"> <Comment>SHP1</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5777</Comment> <Graphics CenterX="1123.9582248452234" CenterY="228.50546780072915" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020294" /> </DataNode> <DataNode TextLabel="IFNAR2" GraphId="aa083" Type="Protein" GroupRef="dd352"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3455</Comment> <BiopaxRef>b3e</BiopaxRef> <Graphics CenterX="1000.0" CenterY="106.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015212" /> </DataNode> <DataNode TextLabel="JAK1" GraphId="aa6e3" Type="GeneProduct" GroupRef="c51ee"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716</Comment> <BiopaxRef>ea3</BiopaxRef> <BiopaxRef>eba</BiopaxRef> <Graphics CenterX="949.6666666666667" CenterY="137.33333333333331" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000003147" /> </DataNode> <DataNode TextLabel="MAPKAP1" GraphId="aab24" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79109</Comment> <Graphics CenterX="702.0" CenterY="210.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010271" /> </DataNode> <DataNode TextLabel="CRKL" GraphId="ac8c7" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399</Comment> <BiopaxRef>af6</BiopaxRef> <Graphics CenterX="1336.4125" CenterY="431.40833333333336" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045548" /> </DataNode> <DataNode TextLabel="EIF4E" GraphId="ad5f8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1977</Comment> <Graphics CenterX="99.75" CenterY="685.25" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009522" /> </DataNode> <DataNode TextLabel="PIAS1" GraphId="ae8d9" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8554</Comment> <BiopaxRef>ffc</BiopaxRef> <Graphics CenterX="547.6666666666666" CenterY="841.6666666666666" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005564" /> </DataNode> <DataNode TextLabel="EIF4EBP1" GraphId="b14c8" Type="Protein" GroupRef="f4a3f"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978</Comment> <Graphics CenterX="109.0" CenterY="598.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000027654" /> </DataNode> <DataNode TextLabel="RPTOR" GraphId="b2c8f" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57521</Comment> <Graphics CenterX="207.0" CenterY="473.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002883" /> </DataNode> <DataNode TextLabel="PDCD4" GraphId="b3698" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27250 </Comment> <Graphics CenterX="310.0" CenterY="633.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019434" /> </DataNode> <DataNode TextLabel="STAT3" GraphId="b3a43" Type="Protein" GroupRef="dad4e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774</Comment> <Graphics CenterX="968.0" CenterY="468.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021523" /> </DataNode> <DataNode TextLabel="IRS1" GraphId="b4739" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667</Comment> <BiopaxRef>a05</BiopaxRef> <Graphics CenterX="372.6500000000001" CenterY="208.03296760710555" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021308" /> </DataNode> <DataNode TextLabel="SOCS1" GraphId="b66bb" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651</Comment> <BiopaxRef>c1f</BiopaxRef> <Graphics CenterX="911.5269339813689" CenterY="205.7529364115027" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004386" /> </DataNode> <DataNode TextLabel="SOCS3" GraphId="b6e09" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021</Comment> <Graphics CenterX="946.1310126445675" CenterY="252.42568349096206" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008441" /> </DataNode> <DataNode TextLabel="FYN" GraphId="ba328" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534</Comment> <BiopaxRef>b20</BiopaxRef> <Graphics CenterX="1268.0" CenterY="399.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011851" /> </DataNode> <DataNode TextLabel="IFNAR1" GraphId="bb451" Type="Protein" GroupRef="c51ee"> <Comment>INTERFERON RECEPTOR</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3454</Comment> <BiopaxRef>f54</BiopaxRef> <Graphics CenterX="824.1500000000001" CenterY="103.075" Width="62.0" Height="30.150000000000006" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021819" /> </DataNode> <DataNode TextLabel="STAT1" GraphId="bd249" Type="Protein" GroupRef="b110f"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772</Comment> <Graphics CenterX="627.65" CenterY="453.15000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000007867" /> </DataNode> <DataNode TextLabel="STAT2" GraphId="bf354" Type="Protein" GroupRef="cc13a"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773</Comment> <Graphics CenterX="755.6500000000001" CenterY="407.1500000000001" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004380" /> </DataNode> <DataNode TextLabel="EIF4B" GraphId="c0c7a" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1975</Comment> <Graphics CenterX="232.0" CenterY="600.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006883" /> </DataNode> <DataNode TextLabel="PIK3CD" GraphId="c2702" Type="Protein" GroupRef="c5061"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293</Comment> <Graphics CenterX="171.0" CenterY="311.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000018984" /> </DataNode> <DataNode TextLabel="RAC1" GraphId="c522c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAC1" /> <Graphics CenterX="1042.4125" CenterY="402.40833333333336" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009233" /> </DataNode> <DataNode TextLabel="PTPN11" GraphId="c5757" Type="GeneProduct"> <Comment>SHP2</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781</Comment> <BiopaxRef>dfd</BiopaxRef> <BiopaxRef>c02</BiopaxRef> <Graphics CenterX="1136.3333333333333" CenterY="254.66666666666652" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000002048" /> </DataNode> <DataNode TextLabel="MAP2K3" GraphId="c73c9" Type="Protein" GroupRef="c623d"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606</Comment> <Graphics CenterX="1064.0" CenterY="504.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010576" /> </DataNode> <DataNode TextLabel="STAT4" GraphId="ca195" Type="Protein" GroupRef="be254"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775</Comment> <BiopaxRef>cb6</BiopaxRef> <Graphics CenterX="448.2895833333333" CenterY="526.15" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046699" /> </DataNode> <DataNode TextLabel="ZAP70" GraphId="cd23e" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7535</Comment> <Graphics CenterX="521.6666666666666" CenterY="127.66666666666666" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005892" /> </DataNode> <DataNode TextLabel="GDP" GraphId="cdc41" Type="Metabolite"> <Graphics CenterX="1014.0" CenterY="366.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:17552" /> </DataNode> <DataNode TextLabel="CRKL" GraphId="d1361" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CRKL" /> <Graphics CenterX="503.65" CenterY="256.15000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000045548" /> </DataNode> <DataNode TextLabel="PTPRC" GraphId="d28db" Type="GeneProduct"> <Comment>CD45</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5788</Comment> <Graphics CenterX="1191.6666666666665" CenterY="132.66666666666669" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000023144" /> </DataNode> <DataNode TextLabel="IRF9" GraphId="d40f5" Type="Protein" GroupRef="cc13a"> <Comment Source="HomologyConvert">HomologyConvert: Multiple homologues found: En:ENSBTAG00000005816;En:ENSBTAG00000005815;</Comment> <Graphics CenterX="753.6500000000001" CenterY="442.1500000000001" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PIAS3" GraphId="d412f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401</Comment> <Graphics CenterX="496.66666666666674" CenterY="809.6666666666666" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021634" /> </DataNode> <DataNode TextLabel="RPS6KA4" GraphId="d43d7" Type="Protein" GroupRef="c1501"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8986</Comment> <Graphics CenterX="1183.943573667712" CenterY="605.4858934169282" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000039153" /> </DataNode> <DataNode TextLabel="STAT4" GraphId="d70c9" Type="Protein" GroupRef="be254"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775</Comment> <Graphics CenterX="448.2895833333333" CenterY="563.15" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046699" /> </DataNode> <DataNode TextLabel="TYK2" GraphId="d7a71" Type="Protein" GroupRef="c51ee"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7297</Comment> <BiopaxRef>aa4</BiopaxRef> <Graphics CenterX="849.6666666666667" CenterY="142.33333333333331" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011698" /> </DataNode> <DataNode TextLabel="MTOR" GraphId="d8e9b" Type="Protein"> <Comment>AKT</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475</Comment> <Graphics CenterX="153.3166666666666" CenterY="378.1500000000001" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015325" /> </DataNode> <DataNode TextLabel="MLST8" GraphId="dc815" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64223</Comment> <Graphics CenterX="118.0" CenterY="471.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009928" /> </DataNode> <DataNode TextLabel="EIF4A1" GraphId="dcf74" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1973 </Comment> <Graphics CenterX="304.75" CenterY="681.25" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000000132" /> </DataNode> <DataNode TextLabel="LCK" GraphId="df049" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932</Comment> <Graphics CenterX="448.66666666666663" CenterY="99.66666666666666" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012695" /> </DataNode> <DataNode TextLabel="REL" GraphId="e19b4" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5966 </Comment> <Graphics CenterX="873.0" CenterY="822.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015386" /> </DataNode> <DataNode TextLabel="CREB1" GraphId="e374a" Type="Protein" GroupRef="b7070"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385</Comment> <Graphics CenterX="1006.75" CenterY="701.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000005474" /> </DataNode> <DataNode TextLabel="STAT5A" GraphId="e5d51" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776</Comment> <Graphics CenterX="502.98333333333335" CenterY="295.15000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009496" /> </DataNode> <DataNode TextLabel="PRMT1" GraphId="e891e" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3276</Comment> <Graphics CenterX="639.3260188087769" CenterY="168.75548589341682" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000001357" /> </DataNode> <DataNode TextLabel="MAP2K6" GraphId="eb6a9" Type="Protein" GroupRef="c7b83"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608</Comment> <Graphics CenterX="1158.0" CenterY="503.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000001609" /> </DataNode> <DataNode TextLabel="STAT2" GraphId="ec3f4" Type="Protein" GroupRef="be254"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773</Comment> <Graphics CenterX="454.0" CenterY="493.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000004380" /> </DataNode> <DataNode TextLabel="MTOR" GraphId="ec6f7" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475</Comment> <Graphics CenterX="165.75" CenterY="429.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000015325" /> </DataNode> <DataNode TextLabel="RAP1A" GraphId="ef3c1" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906</Comment> <Graphics CenterX="1279.4125" CenterY="666.4083333333333" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014710" /> </DataNode> <DataNode TextLabel="IRS2" GraphId="f1141" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660</Comment> <BiopaxRef>c8a</BiopaxRef> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IRS2" /> <Graphics CenterX="373.66776384535007" CenterY="235.05073145245555" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000012019" /> </DataNode> <DataNode TextLabel="RPS6KA5" GraphId="f251b" Type="Protein" GroupRef="cb44e"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252</Comment> <Graphics CenterX="1063.0" CenterY="601.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010906" /> </DataNode> <DataNode TextLabel="PIK3R1" GraphId="f2a8d" Type="Protein" GroupRef="c5061"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295</Comment> <Graphics CenterX="106.3166666666666" CenterY="273.48333333333335" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010989" /> </DataNode> <DataNode TextLabel="VAV1" GraphId="f3d7e" Type="Protein" GroupRef="d6984"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409</Comment> <Graphics CenterX="1074.4125" CenterY="308.40833333333336" Width="80.0" Height="21.48333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000039160" /> </DataNode> <DataNode TextLabel="RPS6" GraphId="f82b5" Type="Protein" GroupRef="b9ff7"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194 </Comment> <Graphics CenterX="207.0" CenterY="715.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000014449" /> </DataNode> <DataNode TextLabel="MAP3K1" GraphId="f94dd" Type="Protein" GroupRef="c07c3"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214</Comment> <Graphics CenterX="1155.0" CenterY="450.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000013790" /> </DataNode> <DataNode TextLabel="GNB2L1" GraphId="fb829" Type="Protein"> <Comment>RACK1</Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10399</Comment> <Graphics CenterX="666.6666666666667" CenterY="238.66666666666663" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000019648" /> </DataNode> <DataNode TextLabel="MAPK14" 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