Integrated breast cancer pathway (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Integrated breast cancer pathway" Version="20110320" Author="Sara Ibrahim" Organism="Bos taurus"> <Comment Source="WikiPathways-description">This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP1984_r80445 WP1984(80445)] with a 91.0% conversion rate.</Comment> <Graphics BoardWidth="1865.0383526112132" BoardHeight="1477.8638020545673"/> <DataNode TextLabel="NUP85" GraphId="a0ad5" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125450</Comment> <Graphics CenterX="1030.8814922735503" CenterY="489.7759227172333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000016126"/> </DataNode> <DataNode TextLabel="SMAD1" GraphId="a1785" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15797</Comment> <Graphics CenterX="1014.792899408284" CenterY="1141.301775147928" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002835"/> </DataNode> <DataNode TextLabel="NOXA1" GraphId="a2b5d" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86UR1</Comment> <Graphics CenterX="1092.9880168805328" CenterY="398.287236823695" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012121"/> </DataNode> <DataNode TextLabel="PLK3" GraphId="a2bbe" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173846</Comment> <Graphics CenterX="689.89378080054" CenterY="720.0338347346982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000006125"/> </DataNode> <DataNode TextLabel="Flutamide" GraphId="a32ce" Type="Metabolite"> <Graphics CenterX="1429.5626662770037" CenterY="47.97142403030482" Width="76.68751372880683" Height="21.404090714900555" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="3397"/> </DataNode> <DataNode TextLabel="ATR" GraphId="a34a8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13535</Comment> <Graphics CenterX="774.9092356687901" CenterY="948.7945859872608" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000011529"/> </DataNode> <DataNode TextLabel="CHUK" GraphId="a3613" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15111</Comment> <Graphics CenterX="775.5184366092785" CenterY="724.045746858041" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007591"/> </DataNode> <DataNode TextLabel="RPP38" GraphId="a36c8" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152464</Comment> <Graphics CenterX="1220.1946472019467" CenterY="967.1532846715345" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007702"/> </DataNode> <DataNode TextLabel="EDAR" GraphId="a4a89" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UNE0</Comment> <Graphics CenterX="1352.7719196132045" CenterY="369.66129697824334" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019628"/> </DataNode> <DataNode TextLabel="TPR" GraphId="a5062" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P12270</Comment> <Graphics CenterX="1526.0196905766516" CenterY="614.627285513361" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011943"/> </DataNode> <DataNode TextLabel="WEE1" GraphId="a651a" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30291</Comment> <Graphics CenterX="1245.7500000000002" CenterY="723.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005278"/> </DataNode> <DataNode TextLabel="MYT1" GraphId="a6685" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q01538</Comment> <Graphics CenterX="1111.999999999999" CenterY="722.6666666666663" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006352"/> </DataNode> <DataNode TextLabel="MAP3K7IP1" GraphId="a69b3" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15750</Comment> <Graphics CenterX="1277.3722627737236" CenterY="1087.5912408759139" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019828"/> </DataNode> <DataNode TextLabel="MMP1" GraphId="a6e3e" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P03956</Comment> <Graphics CenterX="1054.5456700620489" CenterY="294.4103684298283" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000048029"/> </DataNode> <DataNode TextLabel="E-CADHERIN" GraphId="a6eda" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000039068</Comment> <Graphics CenterX="1264.3452021800333" CenterY="790.1037874555293" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000015991"/> </DataNode> <DataNode TextLabel="FOSL1" GraphId="a75b7" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061</Comment> <Graphics CenterX="1542.8973277074547" CenterY="1216.427566807314" Width="80.00000000000016" Height="20.00000000000004" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006194"/> </DataNode> <DataNode TextLabel="E2F1" GraphId="a7770" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869</Comment> <Graphics CenterX="1175.3375616344765" CenterY="196.88601686094654" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003971"/> </DataNode> <DataNode TextLabel="Apoptosis" GraphId="a7ad5"> <Graphics CenterX="1522.1541328000135" CenterY="920.6174200661521" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="UBE2F" GraphId="a7ca0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q969M7</Comment> <Graphics CenterX="896.8650942407535" CenterY="908.9537929065746" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000026114"/> </DataNode> <DataNode TextLabel="SMARCA4" GraphId="a8473" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P51532</Comment> <Graphics CenterX="784.2099761051369" CenterY="424.48327359617696" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000019220"/> </DataNode> <DataNode TextLabel="CDC25A" GraphId="a9563" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993</Comment> <Graphics CenterX="601.397160335509" CenterY="474.6881925321609" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000009586"/> </DataNode> <DataNode TextLabel="BMPRII" GraphId="a9c33" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13873</Comment> <Graphics CenterX="856.7382743809275" CenterY="1255.4691689008052" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006420"/> </DataNode> <DataNode TextLabel="Lithium Chloride" GraphId="ab198" Type="Metabolite"> <Graphics CenterX="1751.8925666257514" CenterY="84.99646327001894" Width="123.09859154929609" Height="28.30985915492958" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="433294"/> </DataNode> <DataNode TextLabel="GRN" GraphId="ab2e6" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000030582</Comment> <Graphics CenterX="925.7472871941798" CenterY="233.41312251027855" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000018823"/> </DataNode> <DataNode TextLabel="RRAS" GraphId="ab2f8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10301</Comment> <Graphics CenterX="122.15556144815201" CenterY="844.4797845170473" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020983"/> </DataNode> <DataNode TextLabel="SMAD7" GraphId="ab79f" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15105</Comment> <Graphics CenterX="750.4225352112676" CenterY="1209.1408450704216" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012441"/> </DataNode> <DataNode TextLabel="BAD" GraphId="abbe8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92934</Comment> <Graphics CenterX="852.5779257610411" CenterY="625.7749665812349" Width="80.0" Height="22.10125726144912" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012511"/> </DataNode> <DataNode TextLabel="C9JNK1" GraphId="ac463" Type="Protein"> <Graphics CenterX="608.9429796857636" CenterY="426.22010492796744" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="HIPK2" GraphId="ac497" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9H2X6</Comment> <Graphics CenterX="230.21498599439758" CenterY="276.0679271708685" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017860"/> </DataNode> <DataNode TextLabel="RASGRP3" GraphId="ad5c0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152689</Comment> <Graphics CenterX="60.75" CenterY="198.75" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008006"/> </DataNode> <DataNode TextLabel="CERK" GraphId="ae4a6" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64781</Comment> <Graphics CenterX="162.37217951831678" CenterY="749.3216205466107" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000046654"/> </DataNode> <DataNode TextLabel="C1H21ORF7" GraphId="ae4ac" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P57077</Comment> <Graphics CenterX="1277.3722627737216" CenterY="1109.4890510948921" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000007444"/> </DataNode> <DataNode TextLabel="Protein" GraphId="aefab" Type="Protein"> <Graphics CenterX="685.3766617429837" CenterY="444.6085672082718" Width="1.0" Height="1.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CHEK2" GraphId="af326" Type="Protein"> <Comment>Phosphorylated </Comment> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O96017</Comment> <Graphics CenterX="455.714640837062" CenterY="586.3692198047689" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000004956"/> </DataNode> <DataNode TextLabel="TGFBR1" GraphId="afa83" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P36897</Comment> <Graphics CenterX="1228.7104622871036" CenterY="1282.2384428223836" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018035"/> </DataNode> <DataNode TextLabel="PLK1" GraphId="b0a12" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53350</Comment> <Graphics CenterX="1041.333333333333" CenterY="771.9999999999999" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014453"/> </DataNode> <DataNode TextLabel="bta-mir-21" GraphId="b0c95" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004</Comment> <Graphics CenterX="856.5" CenterY="1318.0" Width="55.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSBTAG00000029897"/> </DataNode> <DataNode TextLabel="MAP3K13" GraphId="b0cf0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:C9JP65</Comment> <Graphics CenterX="1328.9181205424904" CenterY="1010.3585592349004" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017103"/> </DataNode> <DataNode TextLabel="FADD" GraphId="b1135" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168040</Comment> <Graphics CenterX="168.82782900380172" CenterY="439.8054872210422" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018274"/> </DataNode> <DataNode TextLabel="MDM2" GraphId="b1493" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q00987</Comment> <Graphics CenterX="823.7772717326329" CenterY="244.43820270926707" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000010422"/> </DataNode> <DataNode TextLabel="RAC1" GraphId="b1770" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P63000</Comment> <Graphics CenterX="506.346527259149" CenterY="245.86557132188221" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009233"/> </DataNode> <DataNode TextLabel="ATR" GraphId="b19a8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13535</Comment> <Graphics CenterX="550.2171185272234" CenterY="568.6012106359505" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011529"/> </DataNode> <DataNode TextLabel="JUN" GraphId="b1de2" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725</Comment> <Graphics CenterX="1542.8973277074547" CenterY="1156.4275668073137" Width="80.00000000000016" Height="20.00000000000004" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004037"/> </DataNode> <DataNode TextLabel="ATM" GraphId="b1e4b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13315</Comment> <Graphics CenterX="503.26918247608637" CenterY="886.7748784329849" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003111"/> </DataNode> <DataNode TextLabel="ERAL1" GraphId="b2081" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132591</Comment> <Graphics CenterX="796.2165459935263" CenterY="140.25979997699412" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015639"/> </DataNode> <DataNode TextLabel="APOBEC3A" GraphId="b24b3" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9HC16</Comment> <Graphics CenterX="245.09720534629423" CenterY="133.75334143377876" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000037800"/> </DataNode> <DataNode TextLabel="DHTKD1" GraphId="b24c1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181192</Comment> <Graphics CenterX="1348.281216567763" CenterY="505.73858433964034" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000291"/> </DataNode> <DataNode TextLabel="MSH6" GraphId="b2b81" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P52701</Comment> <Graphics CenterX="362.333333333332" CenterY="854.6666666666691" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000001424"/> </DataNode> <DataNode TextLabel="HDAC1" GraphId="b3fcf" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116478</Comment> <Graphics CenterX="407.5552963538967" CenterY="1017.4099706238122" Width="103.0" Height="19.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000012698"/> </DataNode> <DataNode TextLabel="RRAS" GraphId="b412a" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10301</Comment> <Graphics CenterX="328.63426488456867" CenterY="121.95747266099625" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020983"/> </DataNode> <DataNode TextLabel="SMAD6" GraphId="b430b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O43541</Comment> <Graphics CenterX="848.4671109290387" CenterY="1154.3393760221743" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000625"/> </DataNode> <DataNode TextLabel="MAPK1" GraphId="b4974" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment> <Graphics CenterX="1594.4762070263841" CenterY="286.80984923827583" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Hexagon"/> <Xref Database="Ensembl" ID="ENSBTAG00000010312"/> </DataNode> <DataNode TextLabel="Dihydrotestosterone" GraphId="b4e26" Type="Metabolite"> <Graphics CenterX="1211.6676415017978" CenterY="12.544610010325608" Width="139.4897959183666" Height="29.132653061224474" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="HMDB" ID="HMDB0002961"/> </DataNode> <DataNode TextLabel="TSC1" GraphId="b4ed4" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165699</Comment> <Graphics CenterX="455.35714285714283" CenterY="1100.765306122449" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005190"/> </DataNode> <DataNode TextLabel="BLM" GraphId="b5ef0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P54132</Comment> <Graphics CenterX="362.24031031942286" CenterY="815.0846928132427" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000020301"/> </DataNode> <DataNode TextLabel="CASP8" GraphId="b662d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064012</Comment> <Graphics CenterX="625.8015094351325" CenterY="1029.0411970034595" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000015718"/> </DataNode> <DataNode TextLabel="Gene Expression" GraphId="b6a4f"> <Graphics CenterX="702.3865740740737" CenterY="1121.0324074074072" Width="123.00462962963024" Height="21.82407407407436" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CASP9" GraphId="b6eac" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132906</Comment> <Graphics CenterX="1459.4529378804648" CenterY="768.912103073079" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002472"/> </DataNode> <DataNode TextLabel="Hydroxyurea" GraphId="b71b7" Type="Metabolite"> <Graphics CenterX="1076.4195239141056" CenterY="8.508693324879093" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="3657"/> </DataNode> <DataNode TextLabel="IMPA1" GraphId="b7be3" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133731</Comment> <Graphics CenterX="1445.8509142053424" CenterY="535.8649789029539" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011709"/> </DataNode> <DataNode TextLabel="Exemstane" GraphId="b8022"> <Graphics CenterX="1735.2325581395348" CenterY="775.5581395348837" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RAD51" GraphId="b829b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q06609</Comment> <Graphics CenterX="818.8316541613666" CenterY="888.7822548511525" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000002918"/> </DataNode> <DataNode TextLabel="MRE11A" GraphId="b8b34" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49959</Comment> <Graphics CenterX="360.0268209329814" CenterY="894.91390918067" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000008925"/> </DataNode> <DataNode TextLabel="RAP1A" GraphId="b8dc4" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116473</Comment> <Graphics CenterX="250.30133657351166" CenterY="183.51640340218722" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014710"/> </DataNode> <DataNode TextLabel="bta-mir-21" GraphId="b9f95" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004</Comment> <Graphics CenterX="1219.999999999999" CenterY="242.85714285714292" Width="55.23809523809499" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSBTAG00000029897"/> </DataNode> <DataNode TextLabel="Transcription" GraphId="ba999"> <Graphics CenterX="899.9123185140933" CenterY="441.86033630301887" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="GDI1" GraphId="bbe6f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2664</Comment> <Graphics CenterX="594.6393131707599" CenterY="865.2184770371609" Width="80.0" Height="22.658227848101184" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012125"/> </DataNode> <DataNode TextLabel="MDM2" GraphId="bc3cf" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q00987</Comment> <Graphics CenterX="666.0508221341896" CenterY="676.4859151276606" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000010422"/> </DataNode> <DataNode TextLabel="BCL2" GraphId="bc577" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10415</Comment> <Graphics CenterX="1220.2219638568763" CenterY="293.92696036261333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000019302"/> </DataNode> <DataNode TextLabel="RHO" GraphId="bcab1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163914</Comment> <Graphics CenterX="922.602535832414" CenterY="749.2441606435536" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Hexagon"/> <Xref Database="Ensembl" ID="ENSBTAG00000001310"/> </DataNode> <DataNode TextLabel="Penicillin G" GraphId="bce6b" Type="Metabolite"> <Graphics CenterX="1705.199660928534" CenterY="24.875717266562333" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Chemspider" ID="5693"/> </DataNode> <DataNode TextLabel="ITPKC" GraphId="bd8c7" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000086544</Comment> <Graphics CenterX="102.2518307472428" CenterY="310.9950357614502" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019465"/> </DataNode> <DataNode TextLabel="KRAS" GraphId="bdb8a" Type="GeneProduct"> <Graphics CenterX="67.85084033613447" CenterY="257.44957983193285" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ZMYND8" GraphId="bdbc0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9ULU4</Comment> <Graphics CenterX="66.71506682867557" CenterY="163.25546780072912" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013114"/> </DataNode> <DataNode TextLabel="USP38" GraphId="bdd9c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84640</Comment> <Graphics CenterX="1512.5777800460887" CenterY="197.2797566044173" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001356"/> </DataNode> <DataNode TextLabel="PTEN" GraphId="bff8c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P60484</Comment> <Graphics CenterX="408.13341057409355" CenterY="537.3075789216506" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000009498"/> </DataNode> <DataNode TextLabel="Ampicillin" GraphId="c012e" Type="Metabolite"> <Graphics CenterX="985.0153424318341" CenterY="53.317538761621186" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="6249"/> </DataNode> <DataNode TextLabel="CSNK1D" GraphId="c02d8" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141551</Comment> <Graphics CenterX="314.8487394957982" CenterY="291.76750700280127" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019986"/> </DataNode> <DataNode TextLabel="Raloxifene" GraphId="c07c2" Type="Metabolite"> <Graphics CenterX="1795.0383526112132" CenterY="164.08124692494104" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Chemspider" ID="4859"/> </DataNode> <DataNode TextLabel="CASP3" GraphId="c1ce4" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305</Comment> <Graphics CenterX="498.7296594100764" CenterY="1023.9406163119711" Width="80.0" Height="20.504248326654626" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015874"/> </DataNode> <DataNode TextLabel="CREB1" GraphId="c2cf5" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118260</Comment> <Graphics CenterX="891.8445361529451" CenterY="364.82283508705876" Width="80.0" Height="27.675359856485475" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000005474"/> </DataNode> <DataNode TextLabel="SMAD2" GraphId="c3018" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15796</Comment> <Graphics CenterX="1031.8259122088589" CenterY="913.4080582129224" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000039916"/> </DataNode> <DataNode TextLabel="Conjugated Estrogens&#10;" GraphId="c3172"> <Graphics CenterX="653.0" CenterY="66.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="BRCA1" GraphId="c385b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P38398</Comment> <Graphics CenterX="1345.7018598805196" CenterY="315.8819828877134" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000022520"/> </DataNode> <DataNode TextLabel="TSC1" GraphId="c3957" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92574</Comment> <Graphics CenterX="694.8061880754559" CenterY="177.17548240809114" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005190"/> </DataNode> <DataNode TextLabel="IRS1" GraphId="c3b4e" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169047</Comment> <Graphics CenterX="1526.3411960230044" CenterY="245.80803691472633" Width="80.0" Height="27.127340621461098" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000021308"/> </DataNode> <DataNode TextLabel="DNA" GraphId="c42d4"> <Graphics CenterX="143.25954652215327" CenterY="639.4245586399859" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Cycloheximide" GraphId="c44e0" Type="Metabolite"> <Graphics CenterX="400.19461654086666" CenterY="14.069986985759614" Width="116.54921020656161" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="6197"/> </DataNode> <DataNode TextLabel="FAU" GraphId="c6107" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35544</Comment> <Graphics CenterX="1209.9514563106795" CenterY="360.43689320388347" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000031786"/> </DataNode> <DataNode TextLabel="bta-mir-21" GraphId="c6198" Type="Rna"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199004</Comment> <Graphics CenterX="410.3809523809524" CenterY="661.952380952381" Width="62.0" Height="18.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSBTAG00000029897"/> </DataNode> <DataNode TextLabel="cyc-D" GraphId="c61da" Type="Protein"> <Graphics CenterX="1542.8973277074547" CenterY="1196.427566807314" Width="80.00000000000016" Height="20.00000000000004" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MYCBP2" GraphId="c646b" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005810</Comment> <Graphics CenterX="471.56875154682393" CenterY="641.1538809958274" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000018851"/> </DataNode> <DataNode TextLabel="BARD1" GraphId="c6815" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138376</Comment> <Graphics CenterX="380.26615279840814" CenterY="726.022417431447" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000033690"/> </DataNode> <DataNode TextLabel="TGFBR2" GraphId="c718b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P37173</Comment> <Graphics CenterX="1228.7104622871036" CenterY="1302.2384428223834" Width="79.99999999999999" Height="20.000000000000064" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019832"/> </DataNode> <DataNode TextLabel="RAD50" GraphId="c73a5" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92878</Comment> <Graphics CenterX="362.333333333332" CenterY="917.7697160883305" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011252"/> </DataNode> <DataNode TextLabel="PIGR" GraphId="c75df" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01833</Comment> <Graphics CenterX="1324.031007751938" CenterY="849.6124031007752" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019798"/> </DataNode> <DataNode TextLabel="MYC" GraphId="c86fe" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609</Comment> <Graphics CenterX="1542.8973277074547" CenterY="1136.4275668073137" Width="80.00000000000016" Height="20.00000000000004" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008409"/> </DataNode> <DataNode TextLabel="CTNNB1" GraphId="c8f1c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P35222</Comment> <Graphics CenterX="1222.586320417425" CenterY="831.4338449577097" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000016420"/> </DataNode> <DataNode TextLabel="GSK3A" GraphId="c943c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49840</Comment> <Graphics CenterX="682.4664572182975" CenterY="273.4011899859698" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020756"/> </DataNode> <DataNode TextLabel="Plicamycin" GraphId="ca63f" Type="Metabolite"> <Graphics CenterX="1596.577986848973" CenterY="47.51621825054306" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="457831"/> </DataNode> <DataNode TextLabel="Anastrozole" GraphId="ca83c" Type="Metabolite"> <Graphics CenterX="1721.5653310918087" CenterY="725.9425298091589" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Chemspider" ID="2102"/> </DataNode> <DataNode TextLabel="TP53" GraphId="cab04" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04637</Comment> <Graphics CenterX="268.37853867396296" CenterY="530.824129239927" Width="71.03458607219632" Height="22.99279429867715" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000001069"/> </DataNode> <DataNode TextLabel="FER" GraphId="cacf0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P16591</Comment> <Graphics CenterX="1368.39779245538" CenterY="259.4894068089353" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003051"/> </DataNode> <DataNode TextLabel="NCOA3" GraphId="cb29e" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124151</Comment> <Graphics CenterX="1025.198936247201" CenterY="470.850415810911" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007489"/> </DataNode> <DataNode TextLabel="MIR29B1" GraphId="cb57f" Type="Rna" GroupRef="f1666"> <Graphics CenterX="408.00000000000017" CenterY="457.3333333333333" Width="63.333333333333336" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="MSH2" GraphId="cb8e5" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P43246</Comment> <Graphics CenterX="361.5258145005518" CenterY="834.4747837807505" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000002742"/> </DataNode> <DataNode TextLabel="JAKMIP1" GraphId="cb9cf" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96N16</Comment> <Graphics CenterX="903.8717534451526" CenterY="799.833404442283" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011170"/> </DataNode> <DataNode TextLabel="CDC25A" GraphId="cbacb" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30304</Comment> <Graphics CenterX="189.66929996069078" CenterY="241.16994095335298" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000009586"/> </DataNode> <DataNode TextLabel="PIK3R2" GraphId="cbcfe" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00459</Comment> <Graphics CenterX="1626.4483370378682" CenterY="376.628349178911" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000002350"/> </DataNode> <DataNode TextLabel="FILIP1" GraphId="cbd81" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q7Z7B0</Comment> <Graphics CenterX="1388.7399463806973" CenterY="1116.62198391421" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000053"/> </DataNode> <DataNode TextLabel="NCOA3" GraphId="cc0e6" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124151</Comment> <Graphics CenterX="274.36751730823994" CenterY="773.7622281429655" Width="76.98979591836715" Height="23.347112567654726" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007489"/> </DataNode> <DataNode TextLabel="ESR1" GraphId="cc4fa" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831</Comment> <Graphics CenterX="673.1843753575953" CenterY="559.7524130033004" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007159"/> </DataNode> <DataNode TextLabel="Hydrocortisone" GraphId="cd6a6" Type="Metabolite"> <BiopaxRef>f8e</BiopaxRef> <Graphics CenterX="1151.3962475372289" CenterY="45.561857966659375" Width="111.20743034055735" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Wikidata" ID="Q26981430"/> </DataNode> <DataNode TextLabel="USP15" GraphId="cd80f" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y4E8</Comment> <Graphics CenterX="778.1494906420273" CenterY="784.248469035396" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000010428"/> </DataNode> <DataNode TextLabel="RRAS" GraphId="cddae" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10301</Comment> <Graphics CenterX="1039.0156863229597" CenterY="1288.0669060728767" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020983"/> </DataNode> <DataNode TextLabel="Testosterone" GraphId="ce33d" Type="Metabolite"> <Graphics CenterX="1773.9463601532568" CenterY="458.49297573435507" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Chemspider" ID="5791"/> </DataNode> <DataNode TextLabel="CDK2" GraphId="ce6e9" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24941</Comment> <Graphics CenterX="610.7606817055843" CenterY="768.6135599488016" Width="80.0" Height="23.530671418545353" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000004021"/> </DataNode> <DataNode TextLabel="Donepezil" GraphId="cec83" Type="Metabolite"> <Graphics CenterX="1549.8644876347219" CenterY="17.784866309279906" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="3152"/> </DataNode> <DataNode TextLabel="CHUK" GraphId="ceff2" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15111</Comment> <Graphics CenterX="144.48436395730175" CenterY="1089.7524757974736" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007591"/> </DataNode> <DataNode TextLabel="Letrozole" GraphId="cf514" Type="Metabolite"> <Graphics CenterX="1742.8837209302324" CenterY="676.0775193798444" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="Chemspider" ID="3765"/> </DataNode> <DataNode TextLabel="Dexamethasone" GraphId="cf525" Type="Metabolite"> <Graphics CenterX="923.705890333282" CenterY="18.674974906507437" Width="120.19441069258767" Height="23.365735115431335" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="5743"/> </DataNode> <DataNode TextLabel="ATF1" GraphId="cfd2c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P18846</Comment> <Graphics CenterX="162.7488388809959" CenterY="709.3762567647585" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018131"/> </DataNode> <DataNode TextLabel="RHO" GraphId="d0493" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6010</Comment> <Graphics CenterX="436.25" CenterY="159.25" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001310"/> </DataNode> <DataNode TextLabel="AKT1" GraphId="d1fac" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749</Comment> <Graphics CenterX="853.7132660667097" CenterY="204.90795959252372" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017636"/> </DataNode> <DataNode TextLabel="BRCA2" GraphId="d2192" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139618</Comment> <Graphics CenterX="705.8070994640304" CenterY="913.117924470438" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000000988"/> </DataNode> <DataNode TextLabel="MAX" GraphId="d288a" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P61244</Comment> <Graphics CenterX="1139.6498629302455" CenterY="807.9227332724128" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017994"/> </DataNode> <DataNode TextLabel="SMEK2" GraphId="d2b6e" Type="GeneProduct"> <Graphics CenterX="318.0534629404619" CenterY="222.5273390036456" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="FOXO1" GraphId="d2dec" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150907</Comment> <Graphics CenterX="706.0273133057656" CenterY="332.55139760148273" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000044105"/> </DataNode> <DataNode TextLabel="HDAC1" GraphId="d35f3" Type="Protein"> <Graphics CenterX="510.64139941690996" CenterY="454.61175898930964" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ALKBH1" GraphId="d38e1" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13686</Comment> <Graphics CenterX="700.0" CenterY="127.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008133"/> </DataNode> <DataNode TextLabel="Proteasome" GraphId="d3df2"> <Graphics CenterX="1505.1698670605613" CenterY="971.9350073855243" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="E2F1" GraphId="d3ff9" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q01094</Comment> <Graphics CenterX="584.3155833296778" CenterY="705.836700462915" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003971"/> </DataNode> <DataNode TextLabel="ABL1" GraphId="d4a16" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000097007</Comment> <Graphics CenterX="1607.754045092142" CenterY="494.1958210187703" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017976"/> </DataNode> <DataNode TextLabel="TCF/LEF" GraphId="d505c" Type="Protein"> <Graphics CenterX="1385.3727144866384" CenterY="974.6835443037976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="HMGCR" GraphId="d55eb" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161</Comment> <Graphics CenterX="321.53355287492616" CenterY="485.2896570030686" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007840"/> </DataNode> <DataNode TextLabel="CASP3" GraphId="d6b68" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305</Comment> <Graphics CenterX="1493.2565734759132" CenterY="847.2221888471805" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000015874"/> </DataNode> <DataNode TextLabel="SELK" GraphId="d7005" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y6D0</Comment> <Graphics CenterX="414.50923862248527" CenterY="361.5766106181965" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000032374"/> </DataNode> <DataNode TextLabel="Tamoxifen" GraphId="d76c6" Type="Metabolite"> <Graphics CenterX="844.5212740871017" CenterY="57.47415081842914" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="2733526"/> </DataNode> <DataNode TextLabel="STK11" GraphId="d78f4" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118046</Comment> <Graphics CenterX="246.1734693877551" CenterY="1213.0102040816328" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000011639"/> </DataNode> <DataNode TextLabel="Nocodazole" GraphId="d7a21" Type="Metabolite"> <Graphics CenterX="197.6676542201994" CenterY="26.285919299375614" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="4122"/> </DataNode> <DataNode TextLabel="TSC2" GraphId="d96a0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103197</Comment> <Graphics CenterX="455.35714285714283" CenterY="1121.1734693877547" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020617"/> </DataNode> <DataNode TextLabel="AKT1" GraphId="da327" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P31749</Comment> <Graphics CenterX="752.1998563493878" CenterY="658.1110529618171" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017636"/> </DataNode> <DataNode TextLabel="RB1" GraphId="da3d8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P06400</Comment> <Graphics CenterX="723.3058114989567" CenterY="472.1267884548972" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000006640"/> </DataNode> <DataNode TextLabel="Corticosterone" GraphId="dbfd6" Type="Metabolite"> <Graphics CenterX="86.51051901972689" CenterY="52.243204503219545" Width="101.41367323290845" Height="25.06373117033607" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="5753"/> </DataNode> <DataNode TextLabel="TFPI" GraphId="dc44a" Type="GeneProduct"> <Graphics CenterX="437.86422346716455" CenterY="944.8055555555557" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Fulvestrant" GraphId="dc885" Type="Metabolite"> <Graphics CenterX="1747.0" CenterY="426.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="PubChem-compound" ID="104741"/> </DataNode> <DataNode TextLabel="Cancer Development" GraphId="dcf93"> <Graphics CenterX="1441.985989362608" CenterY="668.862073354835" Width="141.74029451137903" Height="32.75769745649245" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="XRCC3" GraphId="dd240" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126215</Comment> <Graphics CenterX="823.1769794614399" CenterY="907.9606785210015" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000009966"/> </DataNode> <DataNode TextLabel="HDAC1" GraphId="dd693" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13547</Comment> <Graphics CenterX="319.21849783716436" CenterY="747.1164834517833" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000012698"/> </DataNode> <DataNode TextLabel="AHR" GraphId="ddca1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106546</Comment> <Graphics CenterX="1287.0653389795323" CenterY="537.2322733538659" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Hexagon"/> <Xref Database="Ensembl" ID="ENSBTAG00000007746"/> </DataNode> <DataNode TextLabel="Cell proliferation" GraphId="ddeb8"> <Graphics CenterX="642.2904798464547" CenterY="989.2901315455975" Width="108.52713178294584" Height="28.60465116279057" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="P13" GraphId="de59b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UHV8</Comment> <Graphics CenterX="1461.9501664734862" CenterY="320.6969269110204" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000047030"/> </DataNode> <DataNode TextLabel="EP300" GraphId="de853" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100393</Comment> <Graphics CenterX="893.5182883044594" CenterY="389.1615013555547" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000016198"/> </DataNode> <DataNode TextLabel="RHEB" GraphId="de989" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15382</Comment> <Graphics CenterX="674.685456256005" CenterY="228.98976666555356" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000031861"/> </DataNode> <DataNode TextLabel="BAD" GraphId="dece8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q92934</Comment> <Graphics CenterX="1051.619633628703" CenterY="282.18526000334583" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012511"/> </DataNode> <DataNode TextLabel="BRCA1" GraphId="dedcb" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P38398</Comment> <Graphics CenterX="307.02941031839833" CenterY="669.505045658311" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000022520"/> </DataNode> <DataNode TextLabel="ANXA1" GraphId="dede0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135046</Comment> <Graphics CenterX="1303.7120851441607" CenterY="912.085139624238" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Hexagon"/> <Xref Database="Ensembl" ID="ENSBTAG00000015978"/> </DataNode> <DataNode TextLabel="CDC25B" GraphId="df0e3" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30305</Comment> <Graphics CenterX="188.12755576491963" CenterY="221.50978898000503" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000008436"/> </DataNode> <DataNode TextLabel="SP1" GraphId="df468" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591</Comment> <Graphics CenterX="494.9243656147419" CenterY="986.7311834201222" Width="80.0" Height="22.75769745649268" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003021"/> </DataNode> <DataNode TextLabel="CDK2" GraphId="df604" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24941</Comment> <Graphics CenterX="989.036368760075" CenterY="706.8269251133232" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004021"/> </DataNode> <DataNode TextLabel="AR" GraphId="e0194" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10275</Comment> <Graphics CenterX="875.1612426596429" CenterY="496.3158289342806" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000022255"/> </DataNode> <DataNode TextLabel="RASGEF1A" GraphId="e01db" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:221002</Comment> <Graphics CenterX="148.0" CenterY="187.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006870"/> </DataNode> <DataNode TextLabel="NAB1" GraphId="e08de" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13506</Comment> <Graphics CenterX="683.4331210191091" CenterY="867.8152866242035" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000266"/> </DataNode> <DataNode TextLabel="NF1" GraphId="e0ad2" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21359</Comment> <Graphics CenterX="438.0" CenterY="119.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011829"/> </DataNode> <DataNode TextLabel="DCAKD" GraphId="e10ab" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8WVC6</Comment> <Graphics CenterX="528.2299247511237" CenterY="520.9353419791967" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006048"/> </DataNode> <DataNode TextLabel="Tetradecanoylphorbol Acetate" GraphId="e1602" Type="Metabolite"> <Graphics CenterX="610.0974377117085" CenterY="21.163153696455964" Width="197.95868772782464" Height="30.37667071688943" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="27924"/> </DataNode> <DataNode TextLabel="SMAD4" GraphId="e18a7" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13485</Comment> <Graphics CenterX="1012.1283371431558" CenterY="1118.0372818207538" Width="80.0" Height="30.228893165883562" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000006919"/> </DataNode> <DataNode TextLabel="BARD1" GraphId="e1c75" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:580</Comment> <Graphics CenterX="1546.9660760993106" CenterY="122.98749085980168" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000033690"/> </DataNode> <DataNode TextLabel="FOSL1" GraphId="e1cc7" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061</Comment> <Graphics CenterX="1542.8973277074547" CenterY="1176.4275668073137" Width="80.00000000000016" Height="20.00000000000004" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006194"/> </DataNode> <DataNode TextLabel="C9JNK1" GraphId="e1eba" Type="Protein"> <Graphics CenterX="212.07089517325343" CenterY="376.1831026762998" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="SMAD4" GraphId="e3fca" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13485</Comment> <Graphics CenterX="852.7500986129339" CenterY="975.0589943267016" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000006919"/> </DataNode> <DataNode TextLabel="SMAD2" GraphId="e4797" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15796</Comment> <Graphics CenterX="1073.6791375459436" CenterY="1057.0832464807197" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000039916"/> </DataNode> <DataNode TextLabel="BAX" GraphId="e47f0" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087088</Comment> <Graphics CenterX="859.0" CenterY="279.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013340"/> </DataNode> <DataNode TextLabel="SMEK1" GraphId="e4dd2" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100796</Comment> <Graphics CenterX="59.63681086617346" CenterY="797.6802597710175" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005040"/> </DataNode> <DataNode TextLabel="Methyl Methanesulfonate" GraphId="e611a" Type="Metabolite"> <Graphics CenterX="1400.0788769748876" CenterY="16.931842920615164" Width="174.8724179829882" Height="19.720534629404618" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="PubChem-compound" ID="4156"/> </DataNode> <DataNode TextLabel="ATM" GraphId="e631c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13315</Comment> <Graphics CenterX="547.1888715192682" CenterY="548.8121114580326" Width="78.16824743931232" Height="20.126886045960646" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003111"/> </DataNode> <DataNode TextLabel="AQP73" GraphId="e6d28" Type="Protein"> <Graphics CenterX="910.3379525573114" CenterY="659.8945921601729" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CTNB1 degradation" GraphId="e6e80"> <Graphics CenterX="1562.0384047267355" CenterY="1024.940915805022" Width="149.18759231905466" Height="26.248153618907054" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="USP21" GraphId="e7015" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9UK80</Comment> <Graphics CenterX="160.91928769294054" CenterY="558.0172244479783" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000021893"/> </DataNode> <DataNode TextLabel="FADD" GraphId="e7701" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13158</Comment> <Graphics CenterX="1426.2734584450413" CenterY="1235.924932975871" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000018274"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="e8cf5" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P23458</Comment> <Graphics CenterX="267.89360215158024" CenterY="859.5980319674244" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000003147"/> </DataNode> <DataNode TextLabel="B3KP27" GraphId="e978a" Type="Protein"> <Graphics CenterX="900.8395142649044" CenterY="682.3342019001807" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="STAT1" GraphId="e9ff6" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P42224</Comment> <Graphics CenterX="238.73137202443385" CenterY="659.7102333885638" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000007867"/> </DataNode> <DataNode TextLabel="Q8NBS1" GraphId="eb6be" Type="Protein"> <Graphics CenterX="362.333333333332" CenterY="874.6666666666691" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="BID2" GraphId="ebcc0" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P55957</Comment> <Graphics CenterX="1494.7725133850543" CenterY="1087.2658109721854" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013988"/> </DataNode> <DataNode TextLabel="PHB" GraphId="ebcf1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167085</Comment> <Graphics CenterX="625.0000000000001" CenterY="1222.222222222222" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017120"/> </DataNode> <DataNode TextLabel="EGFR" GraphId="ec1b3" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P00533</Comment> <Graphics CenterX="312.5273889095494" CenterY="954.5570543072982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000011628"/> </DataNode> <DataNode TextLabel="Cell Survival" GraphId="ec1ea"> <Graphics CenterX="820.9104045453728" CenterY="320.4202708053473" Width="95.06546482505469" Height="26.66222382026945" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="JUN" GraphId="ec80d" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606</Comment> <Graphics CenterX="627.4341378848115" CenterY="930.2043412546502" Width="80.0" Height="23.886418530181164" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000004037"/> </DataNode> <DataNode TextLabel="Mitomycin" GraphId="ecc90" Type="Metabolite"> <Graphics CenterX="288.0635805591122" CenterY="26.873622649601757" Width="80.0" Height="20.846671372308293" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="RoundedRectangle"/> <Xref Database="ChEBI" ID="CHEBI:25357"/> </DataNode> <DataNode TextLabel="NFKB1" GraphId="eceb2" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P19838</Comment> <Graphics CenterX="302.9405306242825" CenterY="1080.5473841633623" Width="80.0" Height="26.379876347321552" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000020270"/> </DataNode> <DataNode TextLabel="SIRT1" GraphId="ed0ce" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q96EB6</Comment> <Graphics CenterX="338.03750756200907" CenterY="606.5922565033271" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000014023"/> </DataNode> <DataNode TextLabel="Paclitaxel" GraphId="edede" Type="Metabolite"> <Graphics CenterX="1793.1034482758623" CenterY="287.35632183908046" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Chemspider" ID="10368587"/> </DataNode> <DataNode TextLabel="PLK3" GraphId="ee1fb" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1263</Comment> <Graphics CenterX="500.0764582858721" CenterY="772.6446923189507" Width="80.0" Height="25.666666666668277" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000006125"/> </DataNode> <DataNode TextLabel="BMPR-IA" GraphId="ee37c" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107779</Comment> <Graphics CenterX="728.2824353270784" CenterY="1321.742289129283" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000000231"/> </DataNode> <DataNode TextLabel="WEE1" GraphId="ee479" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P30291</Comment> <Graphics CenterX="727.4915848067793" CenterY="601.3088198239518" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005278"/> </DataNode> <DataNode TextLabel="BACH1" GraphId="ee86c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14867</Comment> <Graphics CenterX="159.04849956067892" CenterY="784.1638705425263" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000004139"/> </DataNode> <DataNode TextLabel="VEGFA" GraphId="ef241" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112715</Comment> <Graphics CenterX="127.57274577725046" CenterY="584.3712841333933" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000047561"/> </DataNode> <DataNode TextLabel="P13K" GraphId="ef6c3" Type="GeneProduct"> <Graphics CenterX="796.8226919256845" CenterY="159.6843619307668" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="TP53" GraphId="ef777" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04637</Comment> <Graphics CenterX="943.7823947702366" CenterY="325.6510287435277" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000001069"/> </DataNode> <DataNode TextLabel="CHEK1" GraphId="ef977" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O14757</Comment> <Graphics CenterX="535.4674347976561" CenterY="831.8389184081276" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017582"/> </DataNode> <DataNode TextLabel="ATR" GraphId="effc1" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13535</Comment> <Graphics CenterX="333.52777777777794" CenterY="435.9722222222219" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000011529"/> </DataNode> <DataNode TextLabel="AURKA" GraphId="f04d1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087586</Comment> <Graphics CenterX="71.99894698838857" CenterY="368.52752384938293" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Hexagon"/> <Xref Database="Ensembl" ID="ENSBTAG00000013009"/> </DataNode> <DataNode TextLabel="GADD45A" GraphId="f0a5f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116717</Comment> <Graphics CenterX="851.8734734317088" CenterY="540.7326083106658" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000013860"/> </DataNode> <DataNode TextLabel="Fluoxymesterone" GraphId="f0b7a" Type="Metabolite"> <Graphics CenterX="1761.0" CenterY="381.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Chemspider" ID="6205"/> </DataNode> <DataNode TextLabel="MTOR" GraphId="f0dac" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793</Comment> <Graphics CenterX="410.6568748663055" CenterY="1201.9373556606915" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015325"/> </DataNode> <DataNode TextLabel="ODC1" GraphId="f186b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4953</Comment> <Graphics CenterX="1180.2067946824234" CenterY="1022.1565731166913" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000017924"/> </DataNode> <DataNode TextLabel="TRADD" GraphId="f1afb" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15628</Comment> <Graphics CenterX="1426.273458445041" CenterY="1215.8176943699732" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012642"/> </DataNode> <DataNode TextLabel="Proliferative genes" GraphId="f1df0"> <Graphics CenterX="59.391969786455185" CenterY="627.0764420702438" Width="89.17450404801524" Height="57.60709010339728" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RAD54L" GraphId="f1e3f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085999</Comment> <Graphics CenterX="731.6595448425262" CenterY="1005.2852730427794" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000019901"/> </DataNode> <DataNode TextLabel="Cell Cycle arrest" GraphId="f204d"> <Graphics CenterX="1223.7477804435423" CenterY="621.5348548510533" Width="89.81773997569798" Height="25.79586877278257" ZOrder="32768" FontSize="12" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Lapatnib" GraphId="f221e" Type="Metabolite"> <Graphics CenterX="131.57082841902343" CenterY="1437.8638020545673" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="PubChem-compound" ID="208908"/> </DataNode> <DataNode TextLabel="ZMIZ1" GraphId="f3d86" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9ULJ6</Comment> <Graphics CenterX="1157.8678038379533" CenterY="762.5785358919686" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000019313"/> </DataNode> <DataNode TextLabel="BRAF" GraphId="f404b" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15056</Comment> <Graphics CenterX="349.29040097205336" CenterY="176.74240583232086" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000021761"/> </DataNode> <DataNode TextLabel="B5MEC1" GraphId="f406d" Type="Protein"> <Graphics CenterX="1098.4595591229365" CenterY="637.9072379543882" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RALA" GraphId="f466c" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P11233</Comment> <Graphics CenterX="547.0" CenterY="159.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000006661"/> </DataNode> <DataNode TextLabel="PML" GraphId="f4b31" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P29590</Comment> <Graphics CenterX="163.97263264138016" CenterY="531.8033077202082" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000015779"/> </DataNode> <DataNode TextLabel="USP16" GraphId="f4b47" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y5T5</Comment> <Graphics CenterX="607.4763771489241" CenterY="794.0313807325174" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000020122"/> </DataNode> <DataNode TextLabel="CCNB1IP1" GraphId="f4f93" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9NPC3</Comment> <Graphics CenterX="995.9126099115794" CenterY="807.1519795657726" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000008466"/> </DataNode> <DataNode TextLabel="DAG1" GraphId="f5029" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173402</Comment> <Graphics CenterX="34.002531389226405" CenterY="121.75546780072906" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000011580"/> </DataNode> <DataNode TextLabel="MYC" GraphId="f53ef" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01106</Comment> <Graphics CenterX="1126.126278973871" CenterY="885.5830060173986" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000008409"/> </DataNode> <DataNode TextLabel="Cell survival and Proliferation" GraphId="f570b"> <Graphics CenterX="1466.8770397437322" CenterY="423.86591890253106" Width="208.7763713080178" Height="39.53586497890129" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CCND1" GraphId="f607a" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P24385</Comment> <Graphics CenterX="671.4003197596053" CenterY="412.4914654393593" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000017514"/> </DataNode> <DataNode TextLabel="SMEK1" GraphId="f63a3" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100796</Comment> <Graphics CenterX="224.17957593713177" CenterY="806.8203191211376" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000005040"/> </DataNode> <DataNode TextLabel="SMAD7" GraphId="f6da8" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15105</Comment> <Graphics CenterX="1263.773722627737" CenterY="1211.6788321167885" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000012441"/> </DataNode> <DataNode TextLabel="ARAF" GraphId="f76fa" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10398</Comment> <Graphics CenterX="178.04207885816757" CenterY="908.061510220029" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000005039"/> </DataNode> <DataNode TextLabel="CDC42" GraphId="f820f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831</Comment> <Graphics CenterX="582.0" CenterY="118.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSBTAG00000001700"/> </DataNode> <DataNode TextLabel="CDK4" GraphId="f83b3" Type="Protein"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P11802</Comment> <Graphics CenterX="504.18005881261695" CenterY="688.0889755539471" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle" ShapeType="Oval"/> <Xref Database="Ensembl" ID="ENSBTAG00000046091"/> </DataNode> <DataNode TextLabel="Apoptosis" GraphId="f9556"> <Graphics CenterX="73.81145073686858" CenterY="430.33917670730466" Width="80.0" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Anti-Apoptosis" GraphId="f9d4e"> <Graphics CenterX="494.0306122448979" CenterY="1280.612244897959" Width="111.42857142857144" Height="20.0" ZOrder="32768" FontSize="15" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="CERK" GraphId="faef9" Type="GeneProduct"> <Comment 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