RalA downstream regulated genes (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="RalA downstream regulated genes" Version="20120830" Organism="Bos taurus"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP2290_r79988 WP2290(79988)] with a 91.0% conversion rate.</Comment> <BiopaxRef>c40</BiopaxRef> <Graphics BoardWidth="618.0" BoardHeight="336.0" /> <DataNode TextLabel="CSDA" GraphId="a245f" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8531</Comment> <Graphics CenterX="86.0" CenterY="292.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009663" /> </DataNode> <DataNode TextLabel="EXOC2" GraphId="e01fc" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55770</Comment> <Graphics CenterX="332.0" CenterY="292.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000020215" /> </DataNode> <DataNode TextLabel="EXOC8" GraphId="b2ab1" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:149371</Comment> <Graphics CenterX="209.0" CenterY="292.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006111" /> </DataNode> <DataNode TextLabel="RALBP1" GraphId="a41b9" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10928</Comment> <Graphics CenterX="360.0" CenterY="198.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000021250" /> </DataNode> <DataNode TextLabel="CDC42" GraphId="c9b31" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998</Comment> <Graphics CenterX="548.0" CenterY="104.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000001700" /> </DataNode> <DataNode TextLabel="RAC3" GraphId="bc678" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881</Comment> <Graphics CenterX="548.0" CenterY="164.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000022927" /> </DataNode> <DataNode TextLabel="RAC2" GraphId="c94dd" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880</Comment> <Graphics CenterX="548.0" CenterY="235.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011043" /> </DataNode> <DataNode TextLabel="RAC1" GraphId="e315a" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879</Comment> <Graphics CenterX="548.0" CenterY="293.0" Width="80.0" Height="26.0" ZOrder="32768" FontSize="12" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000009233" /> </DataNode> <DataNode TextLabel="HRAS" GraphId="c7f9b" Type="GeneProduct" GroupRef="c28b8"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265</Comment> <Graphics CenterX="209.20920920920898" CenterY="62.0420420420418" Width="80.00000000000001" Height="20.000000000000018" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046644" /> </DataNode> <DataNode TextLabel="KRAS" GraphId="db247" Type="GeneProduct" GroupRef="c28b8"> <Graphics CenterX="209.20920920920898" CenterY="82.04204204204171" Width="80.00000000000001" Height="20.000000000000018" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="NRAS" GraphId="c3265" Type="GeneProduct" GroupRef="c28b8"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893</Comment> <Graphics CenterX="209.20920920920892" CenterY="102.04204204204171" Width="80.00000000000001" Height="20.000000000000018" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000046797" /> </DataNode> <DataNode TextLabel="RALA" GraphId="b65c2" Type="GeneProduct"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5898</Comment> <Graphics CenterX="209.0" CenterY="198.0" Width="80.0" Height="26.0" ZOrder="32772" FontWeight="Bold" FontSize="12" Valign="Middle" LineThickness="2.0" /> <Xref Database="Ensembl" ID="ENSBTAG00000006661" /> </DataNode> <Interaction GraphId="id971e4653"> <Attribute Key="org.pathvisio.core.ds" Value="" /> <Attribute Key="org.pathvisio.core.id" Value="" /> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="400.0" Y="198.0" GraphRef="a41b9" RelX="1.0" RelY="0.0" /> <Point X="508.0" Y="104.0" GraphRef="c9b31" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> 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ID="" /> </Interaction> <Interaction GraphId="af20f"> <Attribute Key="org.pathvisio.core.ds" Value="" /> <Attribute Key="org.pathvisio.core.id" Value="" /> <Graphics ZOrder="32771" LineThickness="1.0"> <Point X="400.0" Y="198.0" GraphRef="a41b9" RelX="1.0" RelY="0.0" /> <Point X="508.0" Y="293.0" GraphRef="e315a" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="ef386"> <Attribute Key="org.pathvisio.core.ds" Value="" /> <Attribute Key="org.pathvisio.core.id" Value="" /> <Graphics ZOrder="32773" LineThickness="1.0"> <Point X="209.0" Y="211.0" GraphRef="b65c2" RelX="0.0" RelY="1.0" /> <Point X="312.0" Y="279.0" GraphRef="e01fc" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Interaction GraphId="a95b8"> <Attribute Key="org.pathvisio.core.ds" Value="" /> <Attribute Key="org.pathvisio.core.id" Value="" /> <Graphics ZOrder="32774" LineThickness="1.0"> <Point X="209.0" Y="211.0" GraphRef="b65c2" RelX="0.0" RelY="1.0" /> <Point X="106.0" Y="279.0" GraphRef="a245f" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="" ID="" /> </Interaction> <Label TextLabel="RAS" GraphId="ead65" GroupRef="c28b8"> <Graphics CenterX="209.20920920920892" CenterY="40.04004004003981" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="ff0000" /> </Label> <Group GroupId="c28b8" GraphId="b28ed" /> <InfoBox CenterX="0.0" CenterY="0.0" /> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c40"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22442671</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML).</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PLoS One</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fei J</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhu X</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Luo X</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ras family mediated signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000158</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CML - chronic Myelogenous Leukemia</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:8552</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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