let-7 inhibition of ES cell reprogramming (Homo sapiens)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="let-7 inhibition of ES cell reprogramming" Version="20150803" Organism="Homo sapiens"><Comment Source="WikiPathways-description">Four transcription factors (OCT4, KLF4, SOX2, and c-MYC) reprogram adult cells into stem cells. MicroRNA let-7 is a barrier to reprogramming that inhibits LIN-41, a strong reprogramming factor that is expressed in pluripotent embryonic stem cells. LIN-41 inhibits the transcription factor EGR1, which promotes cell differentiation and is another barrier to reprogramming. (Description from Worringer et al)</Comment> <BiopaxRef>de9</BiopaxRef> <Graphics BoardWidth="739.0" BoardHeight="395.0"/> <DataNode TextLabel="c-MYC" GraphId="abe25" Type="GeneProduct" GroupRef="f88cf"> <Graphics CenterX="69.5" CenterY="250.0" Width="45.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136997"/> </DataNode> <DataNode TextLabel="LIN-41" GraphId="c610c" Type="GeneProduct"> <Graphics CenterX="280.0" CenterY="261.0" Width="58.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000206557"/> </DataNode> <DataNode TextLabel="EGR1" GraphId="ec30f" Type="GeneProduct"> <Graphics CenterX="280.5" CenterY="353.0" Width="57.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000120738"/> </DataNode> <DataNode TextLabel="MIRLET7A1" GraphId="e09d2" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="240.0" CenterY="90.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199165"/> </DataNode> <DataNode TextLabel="SOX2" GraphId="b6609" Type="GeneProduct" GroupRef="f88cf"> <Graphics CenterX="69.5" CenterY="230.0" Width="45.0" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000181449"/> </DataNode> <DataNode TextLabel="KLF4" GraphId="b2c8e" Type="GeneProduct" GroupRef="f88cf"> <Graphics CenterX="69.5" CenterY="290.0" Width="45.0" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136826"/> </DataNode> <DataNode TextLabel="OCT4" GraphId="d5da0" Type="GeneProduct" GroupRef="f88cf"> <Graphics CenterX="69.5" CenterY="270.0" Width="45.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="5460"/> </DataNode> <DataNode TextLabel="MIRLET7A2" GraphId="ef82d" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="240.0" CenterY="110.0" Width="80.0" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000198975"/> </DataNode> <DataNode TextLabel="MIRLET7A3" GraphId="c5527" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="240.0" CenterY="130.0" Width="80.0" Height="20.0" ZOrder="32775" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000198986"/> </DataNode> <DataNode TextLabel="MIRLET7C" GraphId="dce25" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="240.0" CenterY="150.0" Width="80.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199030"/> </DataNode> <DataNode TextLabel="MIRLET7D" GraphId="b5037" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="240.0" CenterY="170.0" Width="80.0" Height="20.0" ZOrder="32777" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199133"/> </DataNode> <DataNode TextLabel="MIRLET7E" GraphId="bacae" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="320.0" CenterY="90.0" Width="80.0" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000198972"/> </DataNode> <DataNode TextLabel="MIRLET7F1" GraphId="f9266" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="320.0" CenterY="110.0" Width="80.0" Height="20.0" ZOrder="32779" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199072"/> </DataNode> <DataNode TextLabel="MIRLET7F2" GraphId="d78e1" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="320.0" CenterY="130.0" Width="80.0" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000208012"/> </DataNode> <DataNode TextLabel="MIRLET7G" GraphId="b3b74" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="320.0" CenterY="150.0" Width="80.0" Height="20.0" ZOrder="32781" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199150"/> </DataNode> <DataNode TextLabel="MIRLET7I" GraphId="c3961" Type="GeneProduct" GroupRef="ce4d7"> <Graphics CenterX="320.0" CenterY="170.0" Width="80.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle" Color="990099"/> <Xref Database="Ensembl" ID="ENSG00000199179"/> </DataNode> <Interaction GraphId="idf51aa44f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="309.0" Y="261.0" GraphRef="c610c" RelX="1.0" RelY="0.0"/> <Point X="473.0" Y="261.0" GraphRef="c03f6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="idd6e36655"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="309.0" Y="353.0" GraphRef="ec30f" RelX="1.0" RelY="0.0"/> <Point X="471.0" Y="353.0" GraphRef="f0199" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="ida709002f"> <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> <Point X="280.0" Y="188.0" GraphRef="b9dcf" RelX="0.0" RelY="1.0"/> <Point X="280.0" Y="251.0" GraphRef="c610c" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id38497fad"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="280.0" Y="271.0" GraphRef="c610c" RelX="0.0" RelY="1.0"/> <Point X="280.5" Y="343.0" GraphRef="ec30f" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="id8f858a2c"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="100.0" Y="260.0" GraphRef="fa367" RelX="1.0" RelY="0.0"/> <Point X="251.0" Y="261.0" GraphRef="c610c" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="Differentiation" GraphId="f0199"> <Graphics CenterX="521.0" CenterY="353.0" Width="100.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="let-7 miRNAs" GraphId="b6284" GroupRef="ce4d7"> <Graphics CenterX="284.0" CenterY="69.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Label TextLabel="Pluripotency" GraphId="c03f6"> <Graphics CenterX="523.0" CenterY="261.0" Width="100.0" Height="20.0" ZOrder="32773" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/> </Label> <Group GroupId="f88cf" GraphId="fa367" Style="Group"/> <Group GroupId="ce4d7" GraphId="b9dcf" Style="Group"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="de9"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24239284</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Stem Cell</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Worringer KA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rand TA</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hayashi Y</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sami S</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takahashi K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tanabe K</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Narita M</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Srivastava D</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yamanaka S</bp:AUTHORS> </bp:PublicationXref> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>regulatory pathway</bp:TERM><bp:ID>PW:0000004</bp:ID><bp:Ontology>Pathway Ontology</bp:Ontology></bp:openControlledVocabulary></Biopax> </Pathway>

Return to let-7 inhibition of ES cell reprogramming (Homo sapiens).