RuMP cycle, oxidative branch of the pentose phosphate pathway and formaldehyde assimilation (Saccharomyces cerevisiae)

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Although there are other biochemical pathways that generate NADPH in yeast, the pentose phosphate pathway is considered the major source of NADPH, and insufficient NADPH probably contributes to the fitness defects seen in mutants of the oxidative branch of the pentose phosphate pathway.</Comment> <Comment Source="GenMAPP notes"/> <Comment Source="GenMAPP remarks">Based on http://pathway.yeastgenome.org/biocyc/</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <BiopaxRef>bed</BiopaxRef> <BiopaxRef>b81</BiopaxRef> <BiopaxRef>c19</BiopaxRef> <Graphics BoardWidth="1261.909040793826" BoardHeight="881.5"/> <DataNode TextLabel="fructose-6-phosphate" GraphId="a0e" Type="Metabolite"> <Graphics CenterX="676.4000000000001" CenterY="656.2050716648291" Width="184.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="CAS" ID="643-13-0"/> </DataNode> <DataNode TextLabel="S-hydroxymethylglutathione" GraphId="a46c8" Type="Metabolite"> 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