G1 to S cell cycle control (Rattus norvegicus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="G1 to S cell cycle control" Last-Modified="10/17/2013" Organism="Rattus norvegicus" License="CC BY 2.0"> <Comment Source="GenMAPP notes">Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.</Comment> <Comment Source="GenMAPP remarks"></Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;FOCUS_SPECIES=Homo%20sapiens&amp;ID=69615&amp;</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP45_r95145 WP45 (r95145)] with a 92.0% conversion rate.</Comment> <BiopaxRef>a31</BiopaxRef> <Graphics BoardWidth="1478.3333333333333" BoardHeight="831.6067" /> <DataNode TextLabel="Rb1" GraphId="a1f" Type="GeneProduct" GroupRef="e51cb"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5925</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RB1 | retinoblastoma 1 (including osteosarcoma)..." /> <Graphics CenterX="300.0" CenterY="432.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000016029" /> </DataNode> <DataNode TextLabel="E2f2" GraphId="a3a" Type="GeneProduct" GroupRef="f1537"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1870</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2F2 | E2F transcription factor 2" /> <Graphics CenterX="376.0" CenterY="489.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000047741" /> </DataNode> <DataNode TextLabel="E2f1" GraphId="a3b" Type="GeneProduct" GroupRef="f1537"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1869</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2F1 | E2F transcription factor 1" /> <Graphics CenterX="376.0" CenterY="449.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000016708" /> </DataNode> <DataNode TextLabel="Pole" GraphId="a3c" Type="GeneProduct" GroupRef="b3014"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5426</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="POLE | polymerase (DNA directed) epsilon" /> <Graphics CenterX="1006.6666666666666" CenterY="586.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000037449" /> </DataNode> <DataNode TextLabel="Cdkn1b" GraphId="a51" Type="GeneProduct" GroupRef="e0a93"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1027</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN1B | cyclin-dependent kinase inhibitor 1B (..." /> <Graphics CenterX="620.0" CenterY="102.00000063578288" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000007249" /> </DataNode> <DataNode TextLabel="Cdk6" GraphId="a5f" Type="GeneProduct" GroupRef="e1a85"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1021</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK6 | cyclin-dependent kinase 6" /> <Graphics CenterX="1106.6666666666667" CenterY="699.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000009258" /> </DataNode> <DataNode TextLabel="Pcna" GraphId="a7d" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5111</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PCNA | proliferating cell nuclear antigen" /> <Graphics CenterX="680.0" CenterY="418.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000021264" /> </DataNode> <DataNode TextLabel="Cdk4" GraphId="abd" Type="GeneProduct" GroupRef="e1a85"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1019</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK4 | cyclin-dependent kinase 4" /> <Graphics CenterX="1106.6666666666667" CenterY="679.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000025602" /> </DataNode> <DataNode TextLabel="Cdkn1a" GraphId="acc" Type="GeneProduct" GroupRef="e0a93"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1026</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN1A | cyclin-dependent kinase inhibitor 1A (..." /> <Graphics CenterX="620.0" CenterY="122.00000127156575" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000000521" /> </DataNode> <DataNode TextLabel="Cdc45" GraphId="add" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8318</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDC45L | CDC45 cell division cycle 45-like (S. ..." /> <Graphics CenterX="1006.6666666666666" CenterY="484.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000050071" /> </DataNode> <DataNode TextLabel="CDKN2A" GraphId="afb" Type="GeneProduct" GroupRef="c7189"> <Comment Source="HomologyMapper">No homologues found for original id L:1029</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN2A | cyclin-dependent kinase inhibitor 2A (..." /> <Graphics CenterX="488.6666666666667" CenterY="76.33333325386047" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Cdk1" GraphId="b0b" Type="GeneProduct" GroupRef="ae99b"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:983</Comment> <Graphics CenterX="162.33333333333334" CenterY="717.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000000632" /> </DataNode> <DataNode TextLabel="CDK" GraphId="b2e" Type="GeneProduct" GroupRef="e1db1"> <Graphics CenterX="1192.4435994930288" CenterY="256.382762991128" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="E2f" GraphId="b4c" Type="GeneProduct" GroupRef="c6782"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2f" /> <Graphics CenterX="160.0" CenterY="584.0" Width="40.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Tp53" GraphId="b74" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TP53 | tumor protein p53 (Li-Fraumeni syndrome)..." /> <Graphics CenterX="657.0" CenterY="207.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000010756" /> </DataNode> <DataNode TextLabel="Prim2" GraphId="b87" Type="GeneProduct" GroupRef="f8b94"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5558</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRIM2A | primase polypeptide 2A 58kDa" /> <Graphics CenterX="1107.6666666666667" CenterY="778.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000012486" /> </DataNode> <DataNode TextLabel="Cdkn1c" GraphId="b8e" Type="GeneProduct" GroupRef="e0a93"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1028</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN1C | cyclin-dependent kinase inhibitor 1C (..." /> <Graphics CenterX="620.0" CenterY="82.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000059500" /> </DataNode> <DataNode TextLabel="Ccnd2" GraphId="ba0" Type="GeneProduct" GroupRef="b14d3"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:894</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCND2 | cyclin D2" /> <Graphics CenterX="213.08618504435992" CenterY="122.32192394609544" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000057710" /> </DataNode> <DataNode TextLabel="E2f5" GraphId="bb0" Type="GeneProduct" GroupRef="f1537"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1875</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2F5 | E2F transcription factor 5 p130-binding..." /> <Graphics CenterX="376.0" CenterY="469.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000010760" /> </DataNode> <DataNode TextLabel="Ccne1" GraphId="bd6" Type="GeneProduct" GroupRef="e1db1"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:898</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCNE1 | cyclin E1" /> <Graphics CenterX="1192.4435994930288" CenterY="236.38276299112803" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000014786" /> </DataNode> <DataNode TextLabel="CDK" GraphId="bec" Type="GeneProduct" GroupRef="e82a0"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cdk" /> <Graphics CenterX="983.6666666666666" CenterY="257.0" Width="56.46666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Creb3l4" GraphId="bf4" Type="GeneProduct" GroupRef="cf085"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:148327</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREB3L4 | cAMP responsive element binding prote..." /> <Graphics CenterX="1294.3333333333333" CenterY="622.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000023493" /> </DataNode> <DataNode TextLabel="Cdkn2b" GraphId="c04" Type="GeneProduct" GroupRef="c7189"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1030</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN2B | cyclin-dependent kinase inhibitor 2B (..." /> <Graphics CenterX="488.6666666666667" CenterY="56.333333333333336" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000006735" /> </DataNode> <DataNode TextLabel="Mdm2" GraphId="c06" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4193</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MDM2 | Mdm2 transformed 3T3 cell double minute..." /> <Graphics CenterX="756.6666666666666" CenterY="205.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000006304" /> </DataNode> <DataNode TextLabel="Cdk7" GraphId="c16" Type="GeneProduct" GroupRef="bddc6"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1022</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK7 | cyclin-dependent kinase 7 (MO15 homolog..." /> <Graphics CenterX="241.0" CenterY="218.49999491373697" Width="60.0" Height="18.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000018510" /> </DataNode> <DataNode TextLabel="Ccng2" GraphId="c19" Type="GeneProduct" GroupRef="ae99b"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:901</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCNG2 | cyclin G2" /> <Graphics CenterX="282.3333333333333" CenterY="718.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000002089" /> </DataNode> <DataNode TextLabel="Rpa2" GraphId="c1b" Type="GeneProduct" GroupRef="aeb5d"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6118</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPA2 | replication protein A2 32kDa" /> <Graphics CenterX="1006.6666666666666" CenterY="659.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000013005" /> </DataNode> <DataNode TextLabel="Cdk4" GraphId="c4a" Type="GeneProduct" GroupRef="b72e4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1019</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK4 | cyclin-dependent kinase 4" /> <Graphics CenterX="113.94930291508238" CenterY="135.40114068441062" Width="60.0" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000025602" /> </DataNode> <DataNode TextLabel="Cdk2" GraphId="c54" Type="GeneProduct" GroupRef="cfc7c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1017</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK2 | cyclin-dependent kinase 2" /> <Graphics CenterX="1143.3333333333333" CenterY="142.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000006469" /> </DataNode> <DataNode TextLabel="E2f4" GraphId="c70" Type="GeneProduct" GroupRef="f1537"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1874</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="E2F4 | E2F transcription factor 4 p107/p130-bi..." /> <Graphics CenterX="376.0" CenterY="429.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000015708" /> </DataNode> <DataNode TextLabel="Tp53" GraphId="c7d" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TP53 | tumor protein p53 (Li-Fraumeni syndrome)..." /> <Graphics CenterX="854.6666666666666" CenterY="208.33333333333334" Width="41.06666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000010756" /> </DataNode> <DataNode TextLabel="CDKN2D" GraphId="c80" Type="GeneProduct" GroupRef="c7189"> <Comment Source="HomologyMapper">No homologues found for original id L:1032</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDKN2D | cyclin-dependent kinase inhibitor 2D (..." /> <Graphics CenterX="488.6666666666667" CenterY="116.33333841959636" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Cdk7" GraphId="ca6" Type="GeneProduct" GroupRef="e1a85"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1022</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK7 | cyclin-dependent kinase 7 (MO15 homolog..." /> <Graphics CenterX="1106.6666666666667" CenterY="719.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000018510" /> </DataNode> <DataNode TextLabel="Creb3" GraphId="cb1" Type="GeneProduct" GroupRef="cf085"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREB3 | cAMP responsive element binding protein..." /> <Graphics CenterX="1294.3333333333333" CenterY="602.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000016452" /> </DataNode> <DataNode TextLabel="Creb3l3" GraphId="cb9" Type="GeneProduct" GroupRef="cf085"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84699</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CREB3L3 | cAMP responsive element binding prote..." /> <Graphics CenterX="1294.3333333333333" CenterY="642.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000032202" /> </DataNode> <DataNode TextLabel="Myt1" GraphId="cc8" Type="GeneProduct" GroupRef="cb29c"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4661</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYT1 | myelin transcription factor 1" /> <Graphics CenterX="1087.3333333333333" CenterY="256.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000017346" /> </DataNode> <DataNode TextLabel="Tfdp2" GraphId="cc9" Type="GeneProduct" GroupRef="e3954"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7029</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TFDP2 | transcription factor Dp-2 (E2F dimeriza..." /> <Graphics CenterX="203.33333333333334" CenterY="476.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000011241" /> </DataNode> <DataNode TextLabel="Ccnb1" GraphId="cf1" Type="GeneProduct" GroupRef="ae99b"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:891</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCNB1 | cyclin B1" /> <Graphics CenterX="162.33333333333334" CenterY="757.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000058539" /> </DataNode> <DataNode TextLabel="Rb1" GraphId="d0d" Type="GeneProduct" GroupRef="aa81b"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5925</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RB1 | retinoblastoma 1 (including osteosarcoma)..." /> <Graphics CenterX="456.6666666666667" CenterY="429.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000016029" /> </DataNode> <DataNode TextLabel="Ccnd3" GraphId="d19" Type="GeneProduct" GroupRef="b14d3"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:896</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCND3 | cyclin D3" /> <Graphics CenterX="213.08618504435992" CenterY="142.32192140296408" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000050258" /> </DataNode> <DataNode TextLabel="Ccnd1" GraphId="d1f" Type="GeneProduct" GroupRef="b14d3"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:595</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCND1 | cyclin D1 (PRAD1: parathyroid adenomato..." /> <Graphics CenterX="213.08618504435992" CenterY="102.32192648922684" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000020918" /> </DataNode> <DataNode TextLabel="Ccnh" GraphId="d2c" Type="GeneProduct" GroupRef="bddc6"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:902</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCNH | cyclin H" /> <Graphics CenterX="241.0" CenterY="236.8333282470703" Width="60.0" Height="18.333343505859375" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000031656" /> </DataNode> <DataNode TextLabel="Myc" GraphId="d30" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MYC | v-myc myelocytomatosis viral oncogene hom..." /> <Graphics CenterX="463.3333333333333" CenterY="191.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000004500" /> </DataNode> <DataNode TextLabel="LOC100362927" GraphId="d37" Type="GeneProduct" GroupRef="aeb5d"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6119</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RPA3 | replication protein A3 14kDa" /> <Graphics CenterX="1006.6666666666666" CenterY="679.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000037481" /> </DataNode> <DataNode TextLabel="Mcm4" GraphId="d3e" Type="GeneProduct" GroupRef="c9c57"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4173</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MCM4 | MCM4 minichromosome maintenance deficien..." /> <Graphics CenterX="1106.6666666666667" CenterY="552.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000001833" /> </DataNode> <DataNode TextLabel="Mcm3" GraphId="d5b" Type="GeneProduct" GroupRef="c9c57"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4172</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MCM3 | MCM3 minichromosome maintenance deficien..." /> <Graphics CenterX="1106.6666666666667" CenterY="532.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSRNOG00000012543" /> </DataNode> <DataNode TextLabel="Atf6b" GraphId="d66" Type="GeneProduct" GroupRef="cf085"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens 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Return to G1 to S cell cycle control (Rattus norvegicus).