SALM protein interactions at the synapse (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="SALM protein interactions at the synapse" Data-Source="Reactome - http://www.reactome.org" Version="56" Author="Garapati, Phani Vijay" Maintainer="Garapati, Phani Vijay" Email="phani@ebi.ac.uk" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Recruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD95)/Discs large/zona occludens-1 (PDZ) proteins, thus linking them to the postsynaptic scaffold and providing a mechanism for both retaining the protein at the synapse and keeping its proximity to signaling molecules known to associate with PDZ proteins (Nourry et al. 2003, Kim &amp; Sheng 2004, Montgomery et al. 2004, Sheng and Kim 2011). The synaptic adhesion-like molecules (SALM) family belongs to the superfamily of leucine-rich repeat (LRR)-containing adhesion molecules, alternatively referred as LRFN (leucine-rich repeat and fibronectin III domain-containing) is an synapse adhesion molecule linked to NMDA and AMPA receptors. It includes five known members (SALMs 1-5 or LRFN1-5), which have been implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation. SLAM proteins are distributed to both dendrites and axons in neurons (Ko et al. 2006, Wang et al. 2006, Morimura et al. 2006, Nam ett al. 2011). The family members, SALM1-SALM5, have a single transmembrane (TM) domain and contain extracellular leucine-rich repeats, an Ig C2 type domain, a fibronectin type III domain, and an intracellular postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1 (PDZ) binding domain, which is present on all members except SALM4 and SALM5. View original pathway at:[http://www.reactome.org/PathwayBrowser/#DIAGRAM=8849932 Reactome].</Comment> <Comment Source="Reactome Converter">Pathway is converted from Reactome id: </Comment> <BiopaxRef>bd7</BiopaxRef> <BiopaxRef>eb5</BiopaxRef> <BiopaxRef>a53</BiopaxRef> <Attribute Key="reactome_id" Value="8849932" /> <Graphics BoardWidth="1575.0" BoardHeight="1008.0" /> <DataNode TextLabel="NMDA receptor&#xA;complex" GraphId="a323d" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="83.0" CenterY="42.0" Width="102.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849905" /> </DataNode> <DataNode TextLabel="L-Glu " GraphId="a36c4" Type="Metabolite" GroupRef="d748e"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-8849905" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="308.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16015" /> </DataNode> <DataNode TextLabel="Gly " GraphId="c04cf" Type="Metabolite" GroupRef="d748e"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-8849905" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="100.0" CenterY="328.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15428" /> </DataNode> <DataNode TextLabel="GRIN1 " GraphId="ff2b4" Type="Protein" GroupRef="d748e"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849905" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="348.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q05586" /> </DataNode> 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Value="R-HSA-8849905" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="100.0" CenterY="408.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14957" /> </DataNode> <DataNode TextLabel="GRIN2D " GraphId="f0a53" Type="Protein" GroupRef="d748e"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849905" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="100.0" CenterY="428.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15399" /> </DataNode> <DataNode TextLabel="PSD-95" GraphId="bafdc" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="160.0" CenterY="67.0" Width="54.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P78352" /> </DataNode> <DataNode TextLabel="NMDAR:PSD-95" 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/> <Xref Database="ChEBI" ID="CHEBI:16015" /> </DataNode> <DataNode TextLabel="Gly " GraphId="afd8e" Type="Metabolite" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="240.0" CenterY="828.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15428" /> </DataNode> <DataNode TextLabel="GRIN1 " GraphId="c487a" Type="Protein" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="240.0" CenterY="848.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q05586" /> </DataNode> <DataNode TextLabel="GRIN2A " GraphId="a7702" Type="Protein" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="240.0" CenterY="868.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12879" /> </DataNode> <DataNode TextLabel="GRIN2B " GraphId="cb541" Type="Protein" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="240.0" CenterY="888.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13224" /> </DataNode> <DataNode TextLabel="GRIN2C " GraphId="dcf69" Type="Protein" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="240.0" CenterY="908.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14957" /> </DataNode> <DataNode TextLabel="GRIN2D " GraphId="ca839" Type="Protein" GroupRef="b0cd4"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849876" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="240.0" CenterY="928.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15399" /> </DataNode> <DataNode TextLabel="SALM2" GraphId="f394d" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="794.5" CenterY="260.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P244" /> </DataNode> <DataNode TextLabel="SALM2:AMPA, NMDA&#xA;receptors" GraphId="a5edc" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="954.0" CenterY="236.0" Width="132.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849914" /> </DataNode> <DataNode TextLabel="Ca permeable AMPA receptors " GraphId="d581f" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="368.0" Width="100.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Reactome" ID="R-HSA-399714" /> </DataNode> <DataNode TextLabel="L-Glu " GraphId="d4aec" Type="Metabolite" GroupRef="fda44"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="388.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:16015" /> </DataNode> <DataNode TextLabel="Gly " GraphId="df4d7" Type="Metabolite" GroupRef="fda44"> <Attribute Key="cellular_location" Value="extracellular region" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="408.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="ChEBI" ID="CHEBI:15428" /> </DataNode> <DataNode TextLabel="GRIN1 " GraphId="bc1c4" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="380.0" CenterY="428.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q05586" /> </DataNode> <DataNode TextLabel="GRIN2A " GraphId="e9f0d" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="380.0" CenterY="448.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q12879" /> </DataNode> <DataNode TextLabel="GRIN2B " GraphId="e961b" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="4" /> <Graphics CenterX="380.0" CenterY="468.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13224" /> </DataNode> <DataNode TextLabel="GRIN2C " GraphId="b45cf" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="5" /> <Graphics CenterX="380.0" CenterY="488.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14957" /> </DataNode> <DataNode TextLabel="GRIN2D " GraphId="ddf52" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="380.0" CenterY="508.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O15399" /> </DataNode> <DataNode TextLabel="SALM2 " GraphId="a1649" Type="Protein" GroupRef="fda44"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849914" /> <Attribute Key="copies_num" Value="6" /> <Graphics CenterX="380.0" CenterY="528.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P244" /> </DataNode> <DataNode TextLabel="SALM3,SALM5" GraphId="f7238" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="73.5" CenterY="245.0" Width="89.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849939" /> </DataNode> <DataNode TextLabel="SALM5 " GraphId="fcb01" Type="Protein" GroupRef="b5e11"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849939" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="588.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96NI6" /> </DataNode> <DataNode TextLabel="SALM3 " GraphId="e5d28" Type="Protein" GroupRef="b5e11"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849939" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="608.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <DataNode TextLabel="SALM3,SALM5:PSD-95" GraphId="ab157" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="264.5" CenterY="245.0" Width="115.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849899" /> </DataNode> <DataNode TextLabel="PSD-95 " GraphId="e5917" Type="Protein" GroupRef="ce614"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849899" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="668.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P78352" /> </DataNode> <DataNode TextLabel="SALM5 " GraphId="ff187" Type="Protein" GroupRef="ce614"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849899" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="688.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q96NI6" /> </DataNode> <DataNode TextLabel="SALM3 " GraphId="be9b7" Type="Protein" GroupRef="ce614"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849899" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="708.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <DataNode TextLabel="SALM2,3(SALM1,4)" GraphId="e40a5" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1024.5" CenterY="36.0" Width="117.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849896" /> </DataNode> <DataNode TextLabel="SALM4 " GraphId="bdd87" Type="Protein" GroupRef="ba8b3"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="768.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BTN0" /> </DataNode> <DataNode TextLabel="SALM1 " GraphId="f5daa" Type="Protein" GroupRef="ba8b3"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="788.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9ULH4" /> </DataNode> <DataNode TextLabel="SALM2 " GraphId="b93a4" Type="Protein" GroupRef="ba8b3"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="808.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P244" /> </DataNode> <DataNode TextLabel="SALM3 " GraphId="fe522" Type="Protein" GroupRef="ba8b3"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849896" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="828.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <DataNode TextLabel="RTN3" GraphId="e1585" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1114.0" CenterY="59.0" Width="42.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95197" /> </DataNode> <DataNode TextLabel="SALM2,3(SALM1,4):RTN3" GraphId="ba1a3" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1246.5" CenterY="36.0" Width="111.0" Height="40.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849893" /> </DataNode> <DataNode TextLabel="RTN3 " GraphId="ca301" Type="Protein" GroupRef="ffe79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849893" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="888.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O95197" /> </DataNode> <DataNode TextLabel="SALM4 " GraphId="f527b" Type="Protein" GroupRef="ffe79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849893" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="908.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BTN0" /> </DataNode> <DataNode TextLabel="SALM1 " GraphId="b2f0c" Type="Protein" GroupRef="ffe79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849893" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="380.0" CenterY="928.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9ULH4" /> </DataNode> <DataNode TextLabel="SALM2 " GraphId="e30ea" Type="Protein" GroupRef="ffe79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849893" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="380.0" CenterY="948.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9P244" /> </DataNode> <DataNode TextLabel="SALM3 " GraphId="e8b8d" Type="Protein" GroupRef="ffe79"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849893" /> <Attribute Key="copies_num" Value="3" /> <Graphics CenterX="380.0" CenterY="968.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <DataNode TextLabel="FLOT1(FLOT2)" GraphId="a610b" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1088.5" CenterY="269.0" Width="91.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849894" /> </DataNode> <DataNode TextLabel="FLOT2 " GraphId="cd2c5" Type="Protein" GroupRef="a3e22"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849894" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="348.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14254" /> </DataNode> <DataNode TextLabel="FLOT1 " GraphId="b1d2a" Type="Protein" GroupRef="a3e22"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849894" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="368.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75955" /> </DataNode> <DataNode TextLabel="SALM4" GraphId="b3029" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1076.5" CenterY="238.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BTN0" /> </DataNode> <DataNode TextLabel="SALM4:FLOT1(FLOT2)" GraphId="f8524" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1254.0" CenterY="238.0" Width="88.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8849870" /> </DataNode> <DataNode TextLabel="FLOT2 " GraphId="cb905" Type="Protein" GroupRef="b5fa8"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849870" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="428.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14254" /> </DataNode> <DataNode TextLabel="FLOT1 " GraphId="e866a" Type="Protein" GroupRef="b5fa8"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849870" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="520.0" CenterY="448.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O75955" /> </DataNode> <DataNode TextLabel="SALM4 " GraphId="e14a5" Type="Protein" GroupRef="b5fa8"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8849870" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="520.0" CenterY="468.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9BTN0" /> </DataNode> <DataNode TextLabel="LAR,PTPRS,PTPRD" GraphId="d8caf" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1404.0" CenterY="47.0" Width="114.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-6798238" /> </DataNode> <DataNode TextLabel="PTPRF " GraphId="f4bc4" Type="Protein" GroupRef="d09c5"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-6798238" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="528.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P10586" /> </DataNode> <DataNode TextLabel="PTPRD " GraphId="eb017" Type="Protein" GroupRef="d09c5"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-6798238" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="548.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P23468" /> </DataNode> <DataNode TextLabel="PTPRS " GraphId="d9ba4" Type="Protein" GroupRef="d09c5"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-6798238" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="568.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13332" /> </DataNode> <DataNode TextLabel="SALM3" GraphId="dbc3f" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1350.5" CenterY="257.0" Width="47.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <DataNode TextLabel="SALM3:LAR-RPTPs" GraphId="f952f" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="1503.0" CenterY="257.0" Width="84.0" Height="44.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8855645" /> </DataNode> <DataNode TextLabel="PTPRF " GraphId="b0380" Type="Protein" GroupRef="bfeeb"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" 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Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13332" /> </DataNode> <DataNode TextLabel="SALM3 " GraphId="f204b" Type="Protein" GroupRef="bfeeb"> <Attribute Key="cellular_location" Value="plasma membrane" /> <Attribute Key="complex_id" Value="R-HSA-8855645" /> <Attribute Key="copies_num" Value="1" /> <Graphics CenterX="520.0" CenterY="688.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q6PJG9" /> </DataNode> <Interaction GraphId="c3e1b"> <Comment Source="Reactome">Many membrane proteins that contain a PDZ-binding domain require an interaction with a PDZ protein for correct targeting to the cell surface. 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SALM2 associates with AMPA receptors and, to a lesser extent, with NMDA receptors. 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SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. 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rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ko J, Kim S, Chung HS, Kim K, Han K, Kim H, Jun H, Kaang BK, Kim E.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cc1"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8601796</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Niethammer M, Kim E, Sheng M.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d6e"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19681166</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reticulon 3 is an interacting partner of the SALM family of adhesion molecules.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chang K, Seabold GK, Wang CY, Wenthold RJ.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a61"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18227064</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The SALM family of adhesion-like molecules forms heteromeric and homomeric complexes.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Seabold GK, Wang PY, Chang K, Wang CY, Wang YX, Petralia RS, Wenthold RJ.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e5a"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7569905</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kornau HC, Schenker LT, Kennedy MB, Seeburg PH.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f22"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26321637</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.</bp:TITLE> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li Y, Zhang P, Choi TY, Park SK, Park H, Lee EJ, Lee D, Roh JD, Mah W, Kim R, Kim Y, Kwon H, Bae YC, Choi SY, Craig AM, Kim E.</bp:AUTHORS> </bp:PublicationXref> <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e82"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20600927</bp:ID> 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