Microglia pathogen phagocytosis pathway (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Microglia pathogen phagocytosis pathway" Author="Kristina Hanspers" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal]</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate.</Comment> <BiopaxRef>f4f</BiopaxRef> <Graphics BoardWidth="1112.0" BoardHeight="665.0"/> <DataNode TextLabel="Oxygen" GraphId="a3593" Type="Metabolite"> <Graphics CenterX="880.0" CenterY="124.0" Width="46.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0001377"/> </DataNode> <DataNode TextLabel="Pik3" GraphId="a6dc7" Type="GeneProduct"> <Graphics CenterX="576.0" CenterY="407.0" Width="36.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="009999"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="IgG" GraphId="a8fda" Type="GeneProduct"> <Graphics CenterX="328.0" CenterY="118.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="HCK" GraphId="aad71" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283</Comment> <Graphics CenterX="388.0" CenterY="309.0" Width="34.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000101336"/> </DataNode> <DataNode TextLabel="C1QA" GraphId="adb3f" Type="GeneProduct" GroupRef="f05af"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887</Comment> <Graphics CenterX="328.0" CenterY="40.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000173372"/> </DataNode> <DataNode TextLabel="TYROBP" GraphId="c8356" Type="GeneProduct" GroupRef="ea93c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579</Comment> <Graphics CenterX="513.0" CenterY="233.0" Width="56.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000011600"/> </DataNode> <DataNode TextLabel="SYK" GraphId="c8803" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457</Comment> <Graphics CenterX="509.0" CenterY="315.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000165025"/> </DataNode> <DataNode TextLabel="PIK3R1" GraphId="cfb94" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417</Comment> <Graphics CenterX="139.0" CenterY="204.0" Width="57.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000145675"/> </DataNode> <DataNode TextLabel="SIGLEC7" GraphId="d1d6d" Type="GeneProduct" GroupRef="c9cd3"> <Comment>Siglece interacts with Ptpn6 according to BioGRID</Comment> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474</Comment> <Graphics CenterX="284.5" CenterY="309.0" Width="53.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000168995"/> </DataNode> <DataNode TextLabel="TREM1" GraphId="d330a" Type="GeneProduct" GroupRef="f3006"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265</Comment> <Graphics CenterX="475.0" CenterY="173.0" Width="54.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000124731"/> </DataNode> <DataNode TextLabel="PIP2" GraphId="d7a56" Type="Metabolite"> <Graphics CenterX="621.5" CenterY="194.0" Width="41.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="Wikidata" ID="Q27088398"/> </DataNode> <DataNode TextLabel="FCER1G" GraphId="d8a3d" Type="GeneProduct" GroupRef="ea93c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715</Comment> <Graphics CenterX="442.0" CenterY="233.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000158869"/> </DataNode> <DataNode TextLabel="FCGR1A" GraphId="f4098" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947</Comment> <Graphics CenterX="391.0" CenterY="219.0" Width="52.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000150337"/> </DataNode> <DataNode TextLabel="ITGAM" GraphId="ffaf8" Type="GeneProduct" GroupRef="f82bd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786</Comment> <Graphics CenterX="542.5" CenterY="193.0" Width="53.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000169896"/> </DataNode> <DataNode TextLabel="TREM2" GraphId="fa9da" Type="GeneProduct" GroupRef="f3006"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992</Comment> <Graphics CenterX="475.0" CenterY="193.0" Width="54.0" Height="20.0" ZOrder="32769" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000095970"/> </DataNode> <DataNode TextLabel="TREM3" GraphId="bef2c" Type="GeneProduct" GroupRef="f3006"> <Comment Source="HomologyMapper">No homologues found for original id En:ENSMUSG00000041754</Comment> <Graphics CenterX="475.0" CenterY="213.0" Width="54.0" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="ITGB2" GraphId="bbcb5" Type="GeneProduct" GroupRef="f82bd"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290</Comment> <Graphics CenterX="542.5" CenterY="213.0" Width="53.0" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000160255"/> </DataNode> <DataNode TextLabel="LYN" GraphId="be6a8" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228</Comment> <Graphics CenterX="371.0" CenterY="268.0" Width="34.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000254087"/> </DataNode> <DataNode TextLabel="PTPN6" GraphId="f7fe2" Type="GeneProduct" GroupRef="c9cd3"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266</Comment> <Graphics CenterX="324.5" CenterY="336.0" Width="45.0" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000111679"/> </DataNode> <DataNode TextLabel="PLCG2" GraphId="ef07b" Type="GeneProduct" GroupRef="b1008"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330</Comment> <Graphics CenterX="693.5" CenterY="235.0" Width="45.0" Height="22.0" ZOrder="32775" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000197943"/> </DataNode> <DataNode TextLabel="LAT" GraphId="bf6f2" Type="GeneProduct" GroupRef="b1008"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742</Comment> <Graphics CenterX="707.5" CenterY="214.0" Width="45.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000213658"/> </DataNode> <DataNode TextLabel="RAC1" GraphId="e1720" Type="GeneProduct" GroupRef="d3138"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment> <Graphics CenterX="753.5" CenterY="342.0" Width="45.0" Height="22.0" ZOrder="32777" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136238"/> </DataNode> <DataNode TextLabel="RAC2" GraphId="b10c6" Type="GeneProduct" GroupRef="d3138"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment> <Graphics CenterX="753.5" CenterY="364.0" Width="45.0" Height="22.0" ZOrder="32778" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000128340"/> </DataNode> <DataNode TextLabel="RAC3" GraphId="fb211" Type="GeneProduct" GroupRef="d3138"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment> <Graphics CenterX="753.5" CenterY="386.0" Width="45.0" Height="22.0" ZOrder="32779" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000169750"/> </DataNode> <DataNode TextLabel="VAV1" GraphId="d0362" Type="GeneProduct" GroupRef="b1008"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116</Comment> <Graphics CenterX="753.5" CenterY="224.0" Width="45.0" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000141968"/> </DataNode> <DataNode TextLabel="VAV2" GraphId="af215" Type="GeneProduct" GroupRef="b1008"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621</Comment> <Graphics CenterX="753.5" CenterY="244.0" Width="45.0" Height="20.0" ZOrder="32781" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000160293"/> </DataNode> <DataNode TextLabel="VAV3" GraphId="c016f" Type="GeneProduct" GroupRef="b1008"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721</Comment> <Graphics CenterX="753.5" CenterY="264.0" Width="45.0" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000134215"/> </DataNode> <DataNode TextLabel="NCKAP1L" GraphId="e2518" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488</Comment> <Graphics CenterX="655.5" CenterY="452.0" Width="60.0" Height="22.0" ZOrder="32783" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000123338"/> </DataNode> <DataNode TextLabel="ARPC1B" GraphId="dd45f" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622</Comment> <Graphics CenterX="655.5" CenterY="555.5" Width="45.0" Height="22.0" ZOrder="32784" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000130429"/> </DataNode> <DataNode TextLabel="NCF4" GraphId="c53ff" Type="GeneProduct" GroupRef="c50e8"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment> <Graphics CenterX="728.5" CenterY="538.0" Width="45.0" Height="22.0" ZOrder="32785" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100365"/> </DataNode> <DataNode TextLabel="NCF2" GraphId="fc72f" Type="GeneProduct" GroupRef="c50e8"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment> <Graphics CenterX="743.5" CenterY="516.0" Width="45.0" Height="22.0" ZOrder="32786" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000116701"/> </DataNode> <DataNode TextLabel="NCF1" GraphId="a5899" Type="GeneProduct" GroupRef="c50e8"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment> <Graphics CenterX="738.5" CenterY="494.0" Width="45.0" Height="22.0" ZOrder="32787" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000158517"/> </DataNode> <DataNode TextLabel="CYBB" GraphId="b1743" Type="GeneProduct" GroupRef="b1453"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment> <Graphics CenterX="878.5" CenterY="460.0" Width="45.0" Height="22.0" ZOrder="32788" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000165168"/> </DataNode> <DataNode TextLabel="CYBA" GraphId="b86eb" Type="GeneProduct" GroupRef="b1453"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment> <Graphics CenterX="921.5" CenterY="482.0" Width="45.0" Height="22.0" ZOrder="32789" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000051523"/> </DataNode> <DataNode TextLabel="NCF1" GraphId="bd8a4" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment> <Graphics CenterX="873.5" CenterY="350.0" Width="45.0" Height="22.0" ZOrder="32790" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000158517"/> </DataNode> <DataNode TextLabel="NCF4" GraphId="f5c7f" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment> <Graphics CenterX="919.5" CenterY="343.0" Width="45.0" Height="22.0" ZOrder="32791" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000100365"/> </DataNode> <DataNode TextLabel="NCF2" GraphId="c8e62" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment> <Graphics CenterX="881.5" CenterY="325.0" Width="45.0" Height="22.0" ZOrder="32792" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000116701"/> </DataNode> <DataNode TextLabel="RAC1" GraphId="c7ed8" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment> <Graphics CenterX="838.5" CenterY="282.0" Width="45.0" Height="22.0" ZOrder="32794" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000136238"/> </DataNode> <DataNode TextLabel="RAC2" GraphId="da134" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment> <Graphics CenterX="838.5" CenterY="304.0" Width="45.0" Height="22.0" ZOrder="32795" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000128340"/> </DataNode> <DataNode TextLabel="RAC3" GraphId="f3951" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment> <Graphics CenterX="838.5" CenterY="326.0" Width="45.0" Height="22.0" ZOrder="32796" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000169750"/> </DataNode> <DataNode TextLabel="CYBB" GraphId="bee15" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment> <Graphics CenterX="854.5" CenterY="256.0" Width="45.0" Height="22.0" ZOrder="32797" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000165168"/> </DataNode> <DataNode TextLabel="CYBA" GraphId="b99bf" Type="GeneProduct" GroupRef="ca49c"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment> <Graphics CenterX="900.5" CenterY="272.0" Width="45.0" Height="22.0" ZOrder="32798" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000051523"/> </DataNode> <DataNode TextLabel="C1QB" GraphId="fe05b" Type="GeneProduct" GroupRef="f05af"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905</Comment> <Graphics CenterX="328.0" CenterY="60.0" Width="44.0" Height="20.0" ZOrder="32810" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000173369"/> </DataNode> <DataNode TextLabel="C1QC" GraphId="cba5d" Type="GeneProduct" GroupRef="f05af"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896</Comment> <Graphics CenterX="328.0" CenterY="80.0" Width="44.0" Height="20.0" ZOrder="32811" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000159189"/> </DataNode> <DataNode TextLabel="PIP3" GraphId="a4f18" Type="Metabolite"> <Graphics CenterX="699.5" CenterY="194.0" Width="41.0" Height="20.0" ZOrder="32812" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="HMDB" ID="HMDB0004249"/> </DataNode> <DataNode TextLabel="PIK3CG" GraphId="f18be" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573</Comment> <Graphics CenterX="139.0" CenterY="224.0" Width="57.0" Height="20.0" ZOrder="32813" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000105851"/> </DataNode> <DataNode TextLabel="PIK3CA" GraphId="ccea2" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665</Comment> <Graphics CenterX="139.0" CenterY="244.0" Width="57.0" Height="20.0" ZOrder="32814" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000121879"/> </DataNode> <DataNode TextLabel="PIK3CD" GraphId="ac5ec" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936</Comment> <Graphics CenterX="139.0" CenterY="264.0" Width="57.0" Height="20.0" ZOrder="32815" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000171608"/> </DataNode> <DataNode TextLabel="PIK3CB" GraphId="e411c" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462</Comment> <Graphics CenterX="139.0" CenterY="284.0" Width="57.0" Height="20.0" ZOrder="32816" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000051382"/> </DataNode> <DataNode TextLabel="PIK3R2" GraphId="db275" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834</Comment> <Graphics CenterX="139.0" CenterY="304.0" Width="57.0" Height="20.0" ZOrder="32817" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000105647"/> </DataNode> <DataNode TextLabel="PIK3C3" GraphId="a87de" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628</Comment> <Graphics CenterX="139.0" CenterY="324.0" Width="57.0" Height="20.0" ZOrder="32818" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000078142"/> </DataNode> <DataNode TextLabel="PIK3C2A" GraphId="ed399" Type="GeneProduct" GroupRef="bbc2b"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660</Comment> <Graphics CenterX="139.0" CenterY="344.0" Width="57.0" Height="20.0" ZOrder="32819" FontSize="10" Valign="Middle"/> <Xref Database="Ensembl" ID="ENSG00000011405"/> </DataNode> <DataNode TextLabel="PIK3R6" GraphId="b1b21" Type="GeneProduct" GroupRef="bbc2b"> <Comment 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xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000015</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">innate immune response pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000234</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alzheimer disease pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000015</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">innate immune response pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000234</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">microglial cell</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000129</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology> </bp:openControlledVocabulary> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">microglial cell</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">CL:0000129</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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