Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). The identified upregulated proteins are: BOLA2, PSME2, MTAP, CA1, GSTA2, RALA, CNN2, CFL1, TCP1, HNRNPDL, MIF, AIP, SOD1, PPIA and PDCD4.&lt;br&gt;And the identified downregulated proteins are:&lt;br&gt;ANXA2, RPLP0, CAPZA1, SOD2, SNRPA1, LMNB1, LCP1, HSPA9, SERPINB2, HNRNPF, TALDO1, PAK2, TCP1, HNRNPA2B1, MSN, PITPNA, ARF1, SOD2, ANXA2, CDC42, RAP1B and GSTO1. View original pathway at [http://www.reactome.org/PathwayBrowser/#DIAGRAM=8950505 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 8950505</Comment> <Comment Source="Reactome-version">Reactome version: 75</Comment> <Comment Source="Reactome Author">Reactome Author: Duenas, Corina</Comment> <BiopaxRef>c44</BiopaxRef> <Attribute Key="reactome_id" Value="8950505" /> <Graphics BoardWidth="1931.0" BoardHeight="2015.0" /> <DataNode TextLabel="HNRNPF" GraphId="a03dc" Type="Protein"> <BiopaxRef>b53</BiopaxRef> <Attribute Key="cellular_location" Value="plasma membrane" /> <Graphics CenterX="82.5" CenterY="673.0" Width="111.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P52597" /> </DataNode> <DataNode TextLabel="RPLP0 gene" GraphId="a22ef" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="665.5" CenterY="1213.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000089157" /> </DataNode> <DataNode TextLabel="ANXA2 gene" GraphId="a30e4" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="685.5" CenterY="626.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000182718" /> </DataNode> <DataNode TextLabel="LMNB1" GraphId="a34dc" Type="Protein"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1485.0" CenterY="1499.5" Width="74.0" Height="29.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P20700" /> </DataNode> <DataNode TextLabel="HNRNPDL" GraphId="a3602" Type="Protein"> <BiopaxRef>c44</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1747.0" CenterY="1189.5" Width="94.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O14979" /> </DataNode> <DataNode TextLabel="HNRNPDL gene" GraphId="a405d" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1451.5" CenterY="834.5" Width="101.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000152795" /> </DataNode> <DataNode TextLabel="Y963-STAT4 dimer" GraphId="a5f15" Type="Complex"> <BiopaxRef>cc3</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1122.5" CenterY="968.0" Width="113.0" Height="46.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a" /> <Xref Database="Reactome" ID="R-HSA-8950759" /> </DataNode> <DataNode TextLabel="TALDO1" GraphId="a6105" Type="Protein"> <BiopaxRef>d49</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="409.5" CenterY="1008.0" Width="103.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P37837" /> </DataNode> <DataNode TextLabel="MSN gene" GraphId="a83c0" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="650.5" CenterY="1147.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000147065" /> </DataNode> <DataNode TextLabel="CNN2" GraphId="a94c5" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="1295.0" CenterY="212.0" Width="74.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q99439" /> </DataNode> <DataNode TextLabel="p-Y693-STAT4 " GraphId="aab6c" Type="Protein" GroupRef="e9722"> <BiopaxRef>cc3</BiopaxRef> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Attribute Key="complex_id" Value="R-HSA-8950759" /> <Attribute Key="copies_num" Value="2" /> <Graphics CenterX="100.0" CenterY="1975.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q14765" /> </DataNode> <DataNode TextLabel="MIF" GraphId="aae2a" Type="Protein"> <Attribute Key="cellular_location" Value="secretory granule lumen" /> <Graphics CenterX="1783.5" CenterY="1407.0" Width="97.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P14174" /> </DataNode> <DataNode TextLabel="PITPNA gene" GraphId="ab179" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="660.5" CenterY="1384.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000174238" /> </DataNode> <DataNode TextLabel="MSN" GraphId="ad3d6" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="408.5" CenterY="1098.0" Width="87.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P26038" /> </DataNode> <DataNode TextLabel="GGC-RALA" GraphId="adace" Type="Protein"> <Attribute Key="cellular_location" Value="cytoplasmic vesicle membrane" /> <Graphics CenterX="1122.0" CenterY="352.5" Width="136.0" Height="37.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P11233" /> </DataNode> <DataNode TextLabel="HNRNPA2B1 gene" GraphId="aef60" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1108.0" CenterY="800.5" Width="94.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000122566" /> </DataNode> <DataNode TextLabel="CAPZA1" GraphId="af278" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="403.5" CenterY="1588.0" Width="107.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P52907" /> </DataNode> <DataNode TextLabel="MTAP" GraphId="b0b40" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1734.5" CenterY="1117.0" Width="59.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13126" /> </DataNode> <DataNode TextLabel="IL10 gene" GraphId="b30e2" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="933.0" CenterY="604.5" Width="66.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000136634" /> </DataNode> <DataNode TextLabel="PAK2 gene" GraphId="b3f09" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="677.5" CenterY="1468.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000180370" /> </DataNode> <DataNode TextLabel="SERPINB2 gene" GraphId="b42bc" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="815.5" CenterY="611.5" Width="97.0" Height="51.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000197632" /> </DataNode> <DataNode TextLabel="LCP1 gene" GraphId="b4973" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="626.5" CenterY="725.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000136167" /> </DataNode> <DataNode TextLabel="TCP1" GraphId="b4dfd" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1730.5" CenterY="1153.5" Width="57.0" Height="23.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P17987" /> </DataNode> <DataNode TextLabel="PAK2" GraphId="b90f5" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="414.5" CenterY="1399.0" Width="91.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q13177" /> </DataNode> <DataNode TextLabel="BOLA2" GraphId="bf540" Type="Protein"> <BiopaxRef>af9</BiopaxRef> <BiopaxRef>c44</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1744.5" CenterY="1261.0" Width="83.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q9H3K6" /> </DataNode> <DataNode TextLabel="ARF1" GraphId="c0685" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="408.5" CenterY="1493.0" Width="89.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P84077" /> </DataNode> <DataNode TextLabel="PITPNA" GraphId="c4695" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="407.5" CenterY="1314.0" Width="97.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q00169" /> </DataNode> <DataNode TextLabel="CAPZA1 gene" GraphId="c599b" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="702.5" CenterY="1658.5" Width="95.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000116489" /> </DataNode> <DataNode TextLabel="SOD1 gene" GraphId="c5d56" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1008.5" CenterY="1526.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000142168" /> </DataNode> <DataNode TextLabel="SNRPA1 gene" GraphId="c675b" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1313.5" CenterY="1677.5" Width="95.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000131876" /> </DataNode> <DataNode TextLabel="IL10" GraphId="c6cac" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="973.0" CenterY="448.0" Width="34.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P22301" /> </DataNode> <DataNode TextLabel="TCP1 gene" GraphId="c7e35" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1412.5" CenterY="763.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000120438" /> </DataNode> <DataNode TextLabel="PPIA" GraphId="c9174" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular exosome" /> <Graphics CenterX="1455.5" CenterY="103.0" Width="121.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P62937" /> </DataNode> <DataNode TextLabel="CNN2 gene" GraphId="c9bba" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1078.5" CenterY="661.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000064666" /> </DataNode> <DataNode TextLabel="SOD2" GraphId="c9d63" Type="Protein"> <BiopaxRef>e19</BiopaxRef> <BiopaxRef>bd8</BiopaxRef> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="979.5" CenterY="1799.5" Width="57.0" Height="25.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P04179" /> </DataNode> <DataNode TextLabel="RAPB1 gene" GraphId="ca733" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="673.5" CenterY="892.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000127314" /> </DataNode> <DataNode TextLabel="MTAP gene" GraphId="cc137" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1479.5" CenterY="682.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000099810" /> </DataNode> <DataNode TextLabel="LCP1" GraphId="cca61" Type="Protein"> <BiopaxRef>a8b</BiopaxRef> <Attribute Key="cellular_location" Value="cell junction" /> <Graphics CenterX="384.0" CenterY="190.0" Width="100.0" Height="32.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P13796" /> </DataNode> <DataNode TextLabel="IFNG gene" GraphId="d1685" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1159.0" CenterY="584.5" Width="94.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000111537" /> </DataNode> <DataNode TextLabel="HNRNPF gene" GraphId="d1a7a" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="681.5" CenterY="813.5" Width="93.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000169813" /> </DataNode> <DataNode TextLabel="CFL1" GraphId="d269b" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1728.0" CenterY="1078.0" Width="52.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P23528" /> </DataNode> <DataNode TextLabel="CDC42 gene" GraphId="d287c" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="679.5" CenterY="991.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000070831" /> </DataNode> <DataNode TextLabel="HSP9 gene" GraphId="d2bc6" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1123.5" CenterY="1636.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000113013" /> </DataNode> <DataNode TextLabel="RAP1B" GraphId="d37b9" Type="Protein"> <Attribute Key="cellular_location" Value="azurophil granule membrane" /> <Graphics CenterX="235.5" CenterY="784.0" Width="127.0" Height="36.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P61224" /> </DataNode> <DataNode TextLabel="BOLA2 gene" GraphId="d383c" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1379.0" CenterY="961.5" Width="86.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000183336" /> </DataNode> <DataNode TextLabel="AIP gene" GraphId="d47fb" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1544.5" CenterY="556.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000110711" /> </DataNode> <DataNode TextLabel="RPLP0" GraphId="d5080" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="405.5" CenterY="1168.0" Width="93.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P05388" /> </DataNode> <DataNode TextLabel="GSTA2" GraphId="d6557" Type="Protein"> <BiopaxRef>ff8</BiopaxRef> <Attribute Key="cellular_location" Value="extracellular exosome" /> <Graphics CenterX="1576.5" CenterY="102.0" Width="95.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P09210" /> </DataNode> <DataNode TextLabel="HSPA9" GraphId="d7fdd" Type="Protein"> <Attribute Key="cellular_location" Value="mitochondrial matrix" /> <Graphics CenterX="1178.0" CenterY="1803.0" Width="46.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P38646" /> </DataNode> <DataNode TextLabel="LMNB1 gene" GraphId="dac2c" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1268.5" CenterY="1524.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000113368" /> </DataNode> <DataNode TextLabel="TALDO1 gene" GraphId="db591" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="668.5" CenterY="1086.5" Width="91.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000177156" /> </DataNode> <DataNode TextLabel="PSME2 gene" GraphId="dbea1" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1294.5" CenterY="1600.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000100911" /> </DataNode> <DataNode TextLabel="GSTO1 gene" GraphId="dcbba" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="649.5" CenterY="1303.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000148834" /> </DataNode> <DataNode TextLabel="ARF1 gene" GraphId="df488" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="689.5" CenterY="1565.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000143761" /> </DataNode> <DataNode TextLabel="AIP" GraphId="e0bf7" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1716.5" CenterY="1045.0" Width="29.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="O00170" /> </DataNode> <DataNode TextLabel="GSTO1" GraphId="e6ed7" Type="Protein"> <BiopaxRef>dac</BiopaxRef> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="410.5" CenterY="1239.0" Width="99.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P78417" /> </DataNode> <DataNode TextLabel="MIF gene" GraphId="e73d2" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1463.5" CenterY="1436.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000240972" /> </DataNode> <DataNode TextLabel="PDCD4" GraphId="e8919" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1746.0" CenterY="1226.0" Width="84.0" Height="24.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="Q53EL6" /> </DataNode> <DataNode TextLabel="RALA gene" GraphId="e8fd1" Type="GeneProduct"> <Attribute Key="cellular_location" Value="nucleoplasm" /> <Graphics CenterX="1059.5" CenterY="555.5" Width="89.0" Height="65.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSG00000006451" /> </DataNode> <DataNode TextLabel="SERPINB2" GraphId="e95c0" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="866.5" CenterY="452.0" Width="63.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P05120" /> </DataNode> <DataNode TextLabel="IFNG" GraphId="ebf29" Type="Protein"> <Attribute Key="cellular_location" Value="extracellular region" /> <Graphics CenterX="1202.5" CenterY="211.5" Width="77.0" Height="27.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P01579" /> </DataNode> <DataNode TextLabel="CDC42" GraphId="ed442" Type="Protein"> <Attribute Key="cellular_location" Value="endoplasmic reticulum membrane" /> <Graphics CenterX="232.5" CenterY="925.0" Width="133.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Uniprot-TrEMBL" ID="P60953" /> </DataNode> <DataNode TextLabel="CA1" GraphId="edb29" Type="Protein"> <Attribute Key="cellular_location" Value="cytosol" /> <Graphics CenterX="1744.5" CenterY="1294.0" Width="83.0" 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</Graphics> <Xref Database="Reactome" ID="R-HSA-8950623" /> </Interaction> <Interaction GraphId="ce0bb"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="463.0" Y="1240.0" GraphRef="b0074" RelX="-2.3999999999999773" RelY="-0.32999999999992724" /> <Point X="459.0" Y="1239.0" GraphRef="e6ed7" RelX="0.9797979797979798" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950175" /> </Interaction> <Interaction GraphId="ce3d4"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 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Among the up-regulated proteins is :Cofilin-1(CFL1).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1564.0" Y="587.0" /> <Point X="1699.0" Y="1085.0" /> <Anchor Position="0.0" Shape="None" GraphId="dd387" /> <Anchor Position="0.99" Shape="None" GraphId="c729d" /> <Anchor Position="0.5" Shape="None" GraphId="cdd0b" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950581" /> </Interaction> <Interaction GraphId="d66e0"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Superoxide dismutase [Mn], mitochondrial(SOD2).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="888.0" Y="1616.0" /> <Point X="975.0" Y="1784.0" /> <Anchor Position="0.0" Shape="None" GraphId="acc6c" /> <Anchor Position="0.99" Shape="None" GraphId="b5fbf" /> <Anchor Position="0.5" Shape="None" GraphId="a3ae6" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9617941" /> </Interaction> <Interaction GraphId="d6ff5"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1066.0" Y="968.0" GraphRef="a5f15" RelX="-1.0" RelY="0.0" /> <Point X="719.0" Y="1106.0" GraphRef="e4730" RelX="139.5" RelY="-2.0" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950218" /> </Interaction> <Interaction GraphId="d7514"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="456.0" Y="1494.0" GraphRef="cdc29" RelX="-2.8700000000000045" RelY="-0.41000000000008185" /> <Point X="452.0" Y="1493.0" GraphRef="c0685" RelX="0.9775280898876404" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950173" /> </Interaction> <Interaction GraphId="d7fd1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="729.0" Y="237.0" GraphRef="b54ca" RelX="-0.10000000000002274" RelY="-3.589999999999975" /> <Point X="729.0" Y="234.0" GraphRef="f489f" RelX="-0.010526315789473684" RelY="1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950480" /> </Interaction> <Interaction GraphId="d800d"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Glutathione S-transferase A2(GSTA2).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1149.0" Y="704.0" /> <Point X="1567.0" Y="130.0" /> <Anchor Position="0.0" Shape="None" GraphId="c175b" /> <Anchor Position="0.99" Shape="None" GraphId="b63e5" /> <Anchor Position="0.5" Shape="None" GraphId="c5a0f" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950586" /> </Interaction> <Interaction GraphId="d9f5f"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1178.0" Y="1789.0" GraphRef="e232f" RelX="0.009999999999990905" RelY="1.8299999999999272" /> <Point X="1178.0" Y="1792.0" GraphRef="d7fdd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950389" /> </Interaction> <Interaction GraphId="d9fff"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1702.0" Y="1122.0" GraphRef="e206e" RelX="1.6900000000000546" RelY="4.7000000000000455" /> <Point X="1705.0" Y="1117.0" GraphRef="b0b40" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950365" /> </Interaction> <Interaction GraphId="db1a9"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1066.0" Y="968.0" GraphRef="a5f15" RelX="-1.0" RelY="0.0" /> <Point X="725.0" Y="757.0" GraphRef="ff013" RelX="286.0" RelY="25.5" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950415" /> </Interaction> <Interaction GraphId="db886"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).Among the up-regulated proteins is :BolA-like protein 2(BOLA2).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1431.0" Y="931.0" /> <Point X="1700.0" Y="1261.0" /> <Anchor Position="0.0" Shape="None" GraphId="c0a38" /> <Anchor Position="0.99" Shape="None" GraphId="b283b" /> <Anchor Position="0.5" Shape="None" GraphId="b7247" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950344" /> </Interaction> <Interaction GraphId="dbdcc"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1422.0" Y="961.0" GraphRef="d383c" RelX="1.0" RelY="-0.015384615384615385" /> <Point X="1431.0" Y="931.0" GraphRef="c0a38" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950344" /> </Interaction> <Interaction GraphId="dc192"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1312.0" Y="1524.0" GraphRef="dac2c" RelX="0.9775280898876404" RelY="-0.015384615384615385" /> <Point X="1322.0" Y="1494.0" GraphRef="cea14" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950681" /> </Interaction> <Interaction GraphId="dc26a"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1122.0" Y="945.0" GraphRef="a5f15" RelX="-0.008849557522123894" RelY="-1.0" /> <Point X="1331.0" Y="604.0" GraphRef="dc9b4" RelX="120.5" RelY="213.0" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9006431" /> </Interaction> <Interaction GraphId="dc378"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Cell division control protein 42 homolog(CDC42).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="733.0" Y="961.0" /> <Point X="302.0" Y="925.0" /> <Anchor Position="0.0" Shape="None" GraphId="bf40b" /> <Anchor Position="0.99" Shape="None" GraphId="c9567" /> <Anchor Position="0.5" Shape="None" GraphId="bb22a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950637" /> </Interaction> <Interaction GraphId="dc861"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="670.0" Y="725.0" GraphRef="b4973" RelX="0.9775280898876404" RelY="-0.015384615384615385" /> <Point X="680.0" Y="695.0" GraphRef="a04f2" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950426" /> </Interaction> <Interaction GraphId="dcd2b"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1136.0" Y="374.0" GraphRef="dc9e5" RelX="0.2300000000000182" RelY="-1.509999999999991" /> <Point X="1122.0" Y="370.0" GraphRef="adace" RelX="0.0" RelY="0.9459459459459459" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950533" /> </Interaction> <Interaction GraphId="dd9e1"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1066.0" Y="968.0" GraphRef="a5f15" RelX="-1.0" RelY="0.0" /> <Point X="703.0" Y="1250.0" GraphRef="a9ab8" RelX="120.0" RelY="-6.5" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950175" /> </Interaction> <Interaction GraphId="ddf40"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1066.0" Y="968.0" GraphRef="a5f15" RelX="-1.0" RelY="0.0" /> <Point X="761.0" Y="1607.0" GraphRef="b0817" RelX="151.5" RelY="-2.0" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950634" /> </Interaction> <Interaction GraphId="de2bd"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1456.0" Y="763.0" GraphRef="c7e35" RelX="0.9775280898876404" RelY="-0.015384615384615385" /> <Point X="1466.0" Y="733.0" GraphRef="cf308" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950718" /> </Interaction> <Interaction GraphId="de54e"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :Heterogeneous nuclear ribonucleoproteins A2/B1(HNRNPA2B1).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1164.0" Y="770.0" /> <Point X="1678.0" Y="130.0" /> <Anchor Position="0.0" Shape="None" GraphId="af250" /> <Anchor Position="0.99" Shape="None" GraphId="fd051" /> <Anchor Position="0.5" Shape="None" GraphId="a13d0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950292" /> </Interaction> <Interaction GraphId="def57"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :ADP-ribosylation factor 1(ARF1).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="743.0" Y="1535.0" /> <Point X="456.0" Y="1494.0" /> <Anchor Position="0.0" Shape="None" GraphId="e2d0f" /> <Anchor Position="0.99" Shape="None" GraphId="cdc29" /> <Anchor Position="0.5" Shape="None" GraphId="c5e3a" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950173" /> </Interaction> <Interaction GraphId="df330"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Programmed cell death protein 4(PDCD4).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1346.0" Y="834.0" /> <Point X="1701.0" Y="1228.0" /> <Anchor Position="0.0" Shape="None" GraphId="d76f7" /> <Anchor Position="0.99" Shape="None" GraphId="e8fa3" /> <Anchor Position="0.5" Shape="None" GraphId="ea5ce" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950721" /> </Interaction> <Interaction GraphId="df718"> <Comment Source="Reactome">The most important and most analysed IL-12-induced protein is Interferon-gamma (IFNG). In response to IL-12 normal T cells produce interferon-gamma (IFNG) (van de Vosse et al 2005). In PBMCs from subjects that lack the interleukin-12 receptor beta 2 subunit (IL12RB2) no interferon gamma is produced in response to IL-12, while in healthy subjects it is (de Jong et al 1998). To identify genes induced by IL-12, microarray analysis of over 33.000 genes was conducted using human PBMC enriched for CD3 + T cells after stimulation for 6 h with IL-12. Approximately 90 genes were differentially induced by IL-12 stimulation, of which IFNG was upregulated 24-fold (Watford et al 2008). Expression of IL-12 induced genes was also analysed by a microarray containing 6000 human genes, in differentiated Th1 cells. In these cells IL-12 induced a 53-fold upregulation of IFNG (Rogge et al 2000) Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). </Comment> <BiopaxRef>af7</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1215.0" Y="554.0" /> <Point X="1206.0" Y="228.0" /> <Anchor Position="0.0" Shape="None" GraphId="ee7bb" /> <Anchor Position="0.99" Shape="None" GraphId="ed185" /> <Anchor Position="0.5" Shape="None" GraphId="dc9b4" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-9006431" /> </Interaction> <Interaction GraphId="e00f2"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1697.0" Y="1193.0" GraphRef="afdda" RelX="1.8599999999999" RelY="3.8899999999998727" /> <Point X="1700.0" Y="1189.0" GraphRef="a3602" RelX="-1.0" RelY="-0.037037037037037035" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950684" /> </Interaction> <Interaction GraphId="e0326"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1103.0" Y="555.0" GraphRef="e8fd1" RelX="0.9775280898876404" RelY="-0.015384615384615385" /> <Point X="1113.0" Y="525.0" GraphRef="e2bdb" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950533" /> </Interaction> <Interaction GraphId="e1850"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="733.0" Y="1565.0" GraphRef="df488" RelX="0.9775280898876404" RelY="-0.015384615384615385" /> <Point X="743.0" Y="1535.0" GraphRef="e2d0f" RelX="0.0" RelY="0.0" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950173" /> </Interaction> <Interaction GraphId="e1890"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1066.0" Y="968.0" GraphRef="a5f15" RelX="-1.0" RelY="0.0" /> <Point X="732.0" Y="1413.0" GraphRef="d2ca3" RelX="135.0" RelY="-6.5" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950190" /> </Interaction> <Interaction GraphId="e3275"> <Comment Source="Reactome">In response to IL-12 normal T cells produce interleukin-10 (IL10) (van de Vosse et al 2005).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="975.0" Y="581.0" /> <Point X="973.0" Y="462.0" /> <Anchor Position="0.0" Shape="None" GraphId="c8f6b" /> <Anchor Position="0.99" Shape="None" GraphId="e94d6" /> <Anchor Position="0.5" Shape="None" GraphId="f88e8" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8981073" /> </Interaction> <Interaction GraphId="e393c"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the up-regulated proteins is :Peptidyl-prolyl cis-trans isomerase A(PPIA). This protein is found in four spots, which probably represent four different isoforms.</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1228.0" Y="639.0" /> <Point X="1452.0" Y="124.0" /> <Anchor Position="0.0" Shape="None" GraphId="ac644" /> <Anchor Position="0.99" Shape="None" GraphId="aa8fc" /> <Anchor Position="0.5" Shape="None" GraphId="dc026" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950328" /> </Interaction> <Interaction GraphId="e497e"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1122.0" Y="945.0" GraphRef="a5f15" RelX="-0.008849557522123894" RelY="-1.0" /> <Point X="1396.0" Y="693.0" GraphRef="a13d0" RelX="-25.0" RelY="243.0" ArrowHead="TBar" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950292" /> </Interaction> <Interaction GraphId="e521f"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). Among the down-regulated proteins is :U2 small nuclear ribonucleoprotein A' (SNRPA1).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1370.0" Y="1647.0" /> <Point X="1440.0" Y="1648.0" /> <Anchor Position="0.0" Shape="None" GraphId="d616e" /> <Anchor Position="0.99" Shape="None" GraphId="ad2be" /> <Anchor Position="0.5" Shape="None" GraphId="c34da" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950608" /> </Interaction> <Interaction GraphId="e5b0f"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 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Among the up-regulated proteins is :Ras-related protein Ral-A(RALA).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1113.0" Y="525.0" /> <Point X="1136.0" Y="374.0" /> <Anchor Position="0.0" Shape="None" GraphId="e2bdb" /> <Anchor Position="0.99" Shape="None" GraphId="dc9e5" /> <Anchor Position="0.5" Shape="None" GraphId="a41f3" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950533" /> </Interaction> <Interaction GraphId="ee878"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 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Among the down-regulated proteins is :Ras-related protein Rap-1b(RAP1B).</Comment> <BiopaxRef>c44</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="727.0" Y="862.0" /> <Point X="302.0" Y="791.0" /> <Anchor Position="0.0" Shape="None" GraphId="b2a85" /> <Anchor Position="0.99" Shape="None" GraphId="f5125" /> <Anchor Position="0.5" Shape="None" GraphId="d1248" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8950225" /> </Interaction> <Interaction GraphId="f60ad"> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="1122.0" Y="945.0" GraphRef="a5f15" RelX="-0.008849557522123894" RelY="-1.0" /> <Point X="977.0" Y="532.0" GraphRef="f88e8" RelX="3.0" RelY="10.5" ArrowHead="Arrow" /> </Graphics> <Xref Database="Reactome" ID="R-HSA-8981073" /> </Interaction> <Interaction GraphId="f67d7"> <Comment Source="Reactome">Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005). 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