PTF1A related regulatory pathway (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="PTF1A related regulatory pathway" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">By summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated together to generate a whole sight in early mouse development centered around Ptf1a, although there are some hypothetical relationships and the distinct development of dorsal and ventral pancreas in very early stage is neglected.</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway [http://wikipathways.org/instance/WP201_r69113 WP201 (rev 69113)] with a 81.0% conversion rate.</Comment> <Graphics BoardWidth="811.0" BoardHeight="818.0"/> <DataNode TextLabel="PDX1" GraphId="ab186" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029644</Comment> <Graphics CenterX="745.0" CenterY="438.0" Width="64.0333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000139515"/> </DataNode> <DataNode TextLabel="RBPJ" GraphId="d2c31" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039191</Comment> <Graphics CenterX="85.5" CenterY="232.0" Width="64.0333333333333" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000168214"/> </DataNode> <DataNode TextLabel="miR-495" GraphId="f7c58" Type="Rna"> <Comment Source="HomologyMapper">No homologues found for original id Mb:MI0004639</Comment> <Graphics CenterX="495.48333333333335" CenterY="121.0" Width="64.03333333333336" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="NKX6-1" GraphId="df375" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035187</Comment> <Graphics CenterX="226.48333333333332" CenterY="532.4833333333333" Width="64.0333333333333" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000163623"/> </DataNode> <DataNode TextLabel="CTNNB1" GraphId="ae0b5" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006932</Comment> <Graphics CenterX="161.0" CenterY="121.0" Width="64.03333333333332" Height="20.0" ZOrder="32778" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000168036"/> </DataNode> <DataNode TextLabel="HES1" GraphId="f5efd" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104853</Comment> <Graphics CenterX="745.0" CenterY="121.0" Width="64.0333333333333" Height="20.0" ZOrder="32782" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000114315"/> </DataNode> <DataNode TextLabel="PROX1" GraphId="ebb5b" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010175</Comment> <Graphics CenterX="294.4833333333333" CenterY="532.4833333333333" Width="64.0333333333333" Height="20.0" ZOrder="32784" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000117707"/> </DataNode> <DataNode TextLabel="RBPJ" GraphId="a9ec0" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039191</Comment> <Graphics CenterX="646.9833333333333" CenterY="232.0" Width="64.0333333333333" Height="20.0" ZOrder="32786" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000168214"/> </DataNode> <DataNode TextLabel="NOTCH1" GraphId="f722a" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026923</Comment> <Graphics CenterX="617.9833333333333" CenterY="121.0" Width="64.0333333333333" Height="20.0" ZOrder="32792" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000148400"/> </DataNode> <DataNode TextLabel="PDX1" GraphId="bc304" Type="Protein"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029644</Comment> <Graphics CenterX="85.5" CenterY="370.0" Width="64.0333333333333" Height="20.0" ZOrder="32794" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000139515"/> </DataNode> <DataNode TextLabel="FGF10" GraphId="efb35" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021732</Comment> <Graphics CenterX="238.98333333333332" CenterY="121.0" Width="64.03333333333333" Height="20.0" ZOrder="32798" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000070193"/> </DataNode> <DataNode TextLabel="KAT2B" GraphId="d8015" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000708</Comment> <Graphics CenterX="85.5" CenterY="121.0" Width="64.03333333333333" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000114166"/> </DataNode> <DataNode TextLabel="miR-145" GraphId="c4eae" Type="Rna"> <Comment Source="HomologyMapper">No homologues found for original id Mb:MI0000169</Comment> <Graphics CenterX="409.98333333333335" CenterY="121.0" Width="64.03333333333336" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="RBPJL" GraphId="ad08f" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000017007</Comment> <Graphics CenterX="647.0" CenterY="370.0" Width="64.0333333333333" Height="20.0" ZOrder="32806" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="Ensembl" ID="ENSG00000124232"/> </DataNode> <DataNode TextLabel="miR-18a" GraphId="ee0b7" Type="Rna"> <Comment Source="HomologyMapper">No homologues found for original id Mb:MI0000567</Comment> <Graphics CenterX="323.48333333333335" CenterY="121.0" Width="64.03333333333336" Height="20.0" ZOrder="32808" FontSize="10" Valign="Middle" Color="0000cc"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="PTF1A" GraphId="ba07e" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026735</Comment> <Graphics 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