G-protein beta:gamma signaling (Homo sapiens)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="G-protein beta:gamma signaling" Organism="Homo sapiens"> <Comment Source="WikiPathways-description">The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha. View original pathway at [http://www.reactome.org/PathwayBrowser/#DIAGRAM=397795 Reactome].</Comment> <Comment Source="Reactome-Converter">Pathway is converted from Reactome ID: 397795</Comment> <Comment Source="Reactome-version">Reactome version: 75</Comment> <Comment Source="Reactome Author">Reactome Author: Jupe, Steve</Comment> <BiopaxRef>a93</BiopaxRef> <Attribute Key="reactome_id" Value="397795"/> <Graphics BoardWidth="1752.0" BoardHeight="1826.0"/> <DataNode TextLabel="PI(3,4,5)P3" GraphId="a0a7b" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="1243.0" CenterY="54.5" Width="82.0" Height="41.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16618"/> </DataNode> <DataNode TextLabel="GNG2 " GraphId="a12cb" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="240.0" CenterY="986.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P59768"/> </DataNode> <DataNode TextLabel="GNB4 " GraphId="a18de" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="421"/> <Graphics CenterX="800.0" CenterY="1326.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9HAV0"/> </DataNode> <DataNode TextLabel="GNG3 " GraphId="a1b46" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="31"/> <Graphics CenterX="800.0" CenterY="1046.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63215"/> </DataNode> <DataNode TextLabel="GNG4 " GraphId="a2fb4" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="61"/> <Graphics CenterX="800.0" CenterY="1066.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50150"/> </DataNode> <DataNode TextLabel="GNG5 " GraphId="a3cf4" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="97"/> <Graphics CenterX="940.0" CenterY="1126.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63218"/> </DataNode> <DataNode TextLabel="GNG11 " GraphId="a472b" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="241"/> <Graphics CenterX="800.0" CenterY="1186.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P61952"/> </DataNode> <DataNode TextLabel="GNB5 " GraphId="a4bb8" Type="Protein" GroupRef="b8650"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-167434"/> <Attribute Key="copies_num" Value="376"/> <Graphics CenterX="100.0" CenterY="1366.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14775"/> </DataNode> <DataNode TextLabel="PDK1:AKT:PIP3" GraphId="a4e32" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="1532.5" CenterY="48.5" Width="87.0" Height="39.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-198360"/> </DataNode> <DataNode TextLabel="PIK3CG " GraphId="a5542" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="391"/> <Graphics CenterX="240.0" CenterY="1326.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P48736"/> </DataNode> <DataNode TextLabel="PI(3,4,5)P3 " GraphId="a5a5e" Type="Metabolite" GroupRef="c9c98"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-202676"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="380.0" CenterY="1146.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16618"/> </DataNode> <DataNode TextLabel="GTP " GraphId="a5e73" Type="Metabolite" GroupRef="e1911"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="940.0" CenterY="986.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:15996"/> </DataNode> <DataNode TextLabel="BTK " GraphId="a60e2" Type="Protein" GroupRef="c5c73"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964249"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="520.0" CenterY="1106.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q06187"/> </DataNode> <DataNode TextLabel="GNG2 " GraphId="a6232" Type="Protein" GroupRef="dbbc0"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-9014577"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="1080.0" CenterY="1106.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref 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Database="Uniprot-TrEMBL" ID="Q01970"/> </DataNode> <DataNode TextLabel="GNB5 " GraphId="ceda4" Type="Protein" GroupRef="dbbc0"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-9014577"/> <Attribute Key="copies_num" Value="496"/> <Graphics CenterX="1080.0" CenterY="1426.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14775"/> </DataNode> <DataNode TextLabel="CDC42" GraphId="cf325" Type="Protein"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="651.5" CenterY="803.0" Width="65.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P60953"/> </DataNode> <DataNode TextLabel="GNB3 " GraphId="d0ad9" Type="Protein" GroupRef="a42e3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="352"/> <Graphics CenterX="380.0" CenterY="1586.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P16520"/> </DataNode> <DataNode TextLabel="AKT1 " GraphId="d1212" Type="Protein" GroupRef="a77c9"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-198360"/> <Attribute Key="copies_num" Value="2"/> <Graphics CenterX="380.0" CenterY="1006.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P31749"/> </DataNode> <DataNode TextLabel="ARHGEF6 " GraphId="d1321" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="800.0" CenterY="1006.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q15052"/> </DataNode> <DataNode TextLabel="GNB5 " GraphId="d1a4b" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="451"/> <Graphics CenterX="800.0" CenterY="1346.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O14775"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="d20f3" Type="Protein" GroupRef="c5c73"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964249"/> <Attribute Key="copies_num" Value="309"/> <Graphics CenterX="520.0" CenterY="1366.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNB2 " GraphId="d2aaa" Type="Protein" GroupRef="b8650"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-167434"/> <Attribute Key="copies_num" Value="301"/> <Graphics CenterX="100.0" CenterY="1306.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62879"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="d3328" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="287"/> <Graphics CenterX="240.0" CenterY="1226.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNG7 " GraphId="d3f12" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="105"/> <Graphics CenterX="240.0" CenterY="1066.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O60262"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="d50fa" Type="Protein" GroupRef="b8650"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-167434"/> <Attribute Key="copies_num" Value="276"/> <Graphics CenterX="100.0" CenterY="1286.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNG3 " GraphId="d517e" Type="Protein" GroupRef="b8650"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-167434"/> <Attribute Key="copies_num" Value="26"/> <Graphics CenterX="100.0" CenterY="1066.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63215"/> </DataNode> <DataNode TextLabel="GNG7 " GraphId="d558b" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="129"/> <Graphics CenterX="940.0" CenterY="1146.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="O60262"/> </DataNode> <DataNode TextLabel="PI(3,4,5)P3 " GraphId="d5b6e" Type="Metabolite" GroupRef="a77c9"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-198360"/> <Attribute Key="copies_num" Value="2"/> <Graphics CenterX="380.0" CenterY="986.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16618"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="d5f77" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="301"/> <Graphics CenterX="800.0" CenterY="1226.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="d6e9a" Type="Protein" GroupRef="dd4cb"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964267"/> <Attribute Key="copies_num" Value="291"/> <Graphics CenterX="660.0" CenterY="1226.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="d706a" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="321"/> <Graphics CenterX="940.0" CenterY="1266.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="G-protein&#10;beta-gamma:PI3K&#10;gamma" GraphId="d7660" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="519.5" CenterY="54.0" Width="113.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-392293"/> </DataNode> <DataNode TextLabel="GNB4 " GraphId="d7876" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="449"/> <Graphics CenterX="940.0" CenterY="1366.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9HAV0"/> </DataNode> <DataNode TextLabel="GNG10 " GraphId="d7b8a" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="211"/> <Graphics CenterX="800.0" CenterY="1166.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50151"/> </DataNode> <DataNode TextLabel="PLCB1 " GraphId="d905f" Type="Protein" GroupRef="fd953"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-425749"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="380.0" CenterY="1206.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9NQ66"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="d912d" Type="Protein" GroupRef="b2676"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964627"/> <Attribute Key="copies_num" Value="342"/> <Graphics CenterX="800.0" CenterY="1706.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNG12 " GraphId="d9179" Type="Protein" GroupRef="dd4cb"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964267"/> <Attribute Key="copies_num" Value="262"/> <Graphics CenterX="660.0" CenterY="1206.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9UBI6"/> </DataNode> <DataNode TextLabel="GNG5 " GraphId="d9ba4" Type="Protein" GroupRef="dbbc0"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-9014577"/> <Attribute Key="copies_num" Value="100"/> <Graphics CenterX="1080.0" CenterY="1166.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P63218"/> </DataNode> <DataNode TextLabel="AKT" GraphId="da1b2" Type="Complex"> <Comment Source="Reactome">This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis.</Comment> <Attribute Key="cellular_location" Value="cytosol"/> <Graphics CenterX="1322.5" CenterY="109.0" Width="33.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-202088"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="da331" Type="Protein" GroupRef="a42e3"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="271"/> <Graphics CenterX="380.0" CenterY="1506.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="PI(3,4,5)P3" GraphId="daa8a" Type="Metabolite"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="200.0" CenterY="462.5" Width="82.0" Height="41.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> <Xref Database="ChEBI" ID="CHEBI:16618"/> </DataNode> <DataNode TextLabel="GNG11 " GraphId="dab4b" Type="Protein" GroupRef="dbbc0"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-9014577"/> <Attribute Key="copies_num" Value="265"/> <Graphics CenterX="1080.0" CenterY="1266.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P61952"/> </DataNode> <DataNode TextLabel="GNB4 " GraphId="dba2d" Type="Protein" GroupRef="b8650"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-167434"/> <Attribute Key="copies_num" Value="351"/> <Graphics CenterX="100.0" CenterY="1346.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9HAV0"/> </DataNode> <DataNode TextLabel="GNG11 " GraphId="dbdb2" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="257"/> <Graphics CenterX="940.0" CenterY="1226.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P61952"/> </DataNode> <DataNode TextLabel="G-protein&#10;beta-gamma:PLC beta&#10;1/2/3" GraphId="dc22a" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="204.0" CenterY="320.0" Width="132.0" Height="50.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-398037"/> </DataNode> <DataNode TextLabel="GNG4 " GraphId="dcf37" Type="Protein" GroupRef="dd4cb"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964267"/> <Attribute Key="copies_num" Value="59"/> <Graphics CenterX="660.0" CenterY="1066.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50150"/> </DataNode> <DataNode TextLabel="GNG2 " GraphId="dd60f" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="800.0" CenterY="1026.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P59768"/> </DataNode> <DataNode TextLabel="GNB2 " GraphId="de285" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="313"/> <Graphics CenterX="240.0" CenterY="1246.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62879"/> </DataNode> <DataNode TextLabel="PIK3R5 " GraphId="de4f2" Type="Protein" GroupRef="dc3b3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-392293"/> <Attribute Key="copies_num" Value="391"/> <Graphics CenterX="240.0" CenterY="1346.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q8WYR1"/> </DataNode> <DataNode TextLabel="PLCB1 " GraphId="de8ec" Type="Protein" GroupRef="a42e3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="406"/> <Graphics CenterX="380.0" CenterY="1646.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9NQ66"/> </DataNode> <DataNode TextLabel="GNG13 " GraphId="dedb1" Type="Protein" GroupRef="dbbc0"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-9014577"/> <Attribute Key="copies_num" Value="331"/> <Graphics CenterX="1080.0" CenterY="1306.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9P2W3"/> </DataNode> <DataNode TextLabel="AKT2 " GraphId="def4b" Type="Protein" GroupRef="a77c9"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-198360"/> <Attribute Key="copies_num" Value="6"/> <Graphics CenterX="380.0" CenterY="1026.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P31751"/> </DataNode> <DataNode TextLabel="AKT3 " GraphId="df0e5" Type="Protein" GroupRef="ec91b"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-202088"/> <Attribute Key="copies_num" Value="2"/> <Graphics CenterX="520.0" CenterY="1006.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9Y243"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="e0669" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="331"/> <Graphics CenterX="800.0" CenterY="1266.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="PLCB3 " GraphId="e0b10" Type="Protein" GroupRef="a42e3"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-398037"/> <Attribute Key="copies_num" Value="406"/> <Graphics CenterX="380.0" CenterY="1686.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q01970"/> </DataNode> <DataNode TextLabel="GNG4 " GraphId="e0d33" Type="Protein" GroupRef="b2676"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964627"/> <Attribute Key="copies_num" Value="63"/> <Graphics CenterX="800.0" CenterY="1506.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P50150"/> </DataNode> <DataNode TextLabel="G-protein&#10;beta-gamma&#10;complex:PAK1:ARHGEF6:Active CDC42" GraphId="e1305" Type="Complex"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Graphics CenterX="989.0" CenterY="881.0" Width="112.0" Height="62.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="Hexagon" Color="a52a2a"/> <Xref Database="Reactome" ID="R-HSA-8964618"/> </DataNode> <DataNode TextLabel="GNB2 " GraphId="e1a44" Type="Protein" GroupRef="bb832"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964608"/> <Attribute Key="copies_num" Value="361"/> <Graphics CenterX="800.0" CenterY="1286.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62879"/> </DataNode> <DataNode TextLabel="GNB1 " GraphId="e24e7" Type="Protein" GroupRef="e1911"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-8964618"/> <Attribute Key="copies_num" Value="353"/> <Graphics CenterX="940.0" CenterY="1306.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="P62873"/> </DataNode> <DataNode TextLabel="GNG8 " GraphId="e27cd" Type="Protein" GroupRef="dd4cb"> <Attribute Key="cellular_location" Value="plasma membrane"/> <Attribute Key="complex_id" Value="R-HSA-8964267"/> <Attribute Key="copies_num" Value="146"/> <Graphics CenterX="660.0" CenterY="1126.0" Width="100.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Uniprot-TrEMBL" ID="Q9UK08"/> </DataNode> <DataNode TextLabel="PIK3R6 " GraphId="e2a5f" Type="Protein" GroupRef="d799c"> <Attribute Key="cellular_location" Value="cytosol"/> <Attribute Key="complex_id" Value="R-HSA-392291"/> <Attribute Key="copies_num" Value="1"/> <Graphics CenterX="100.0" 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Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. In the membrane, the G-protein beta-gamma complex binds to the catalytic domain of BTK and activates it. Active BTK is then released to the cytoplasm. 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Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, the GTPase Cell division control protein 42 homolog (CDC42) binds with this complex, following which ARHGEF6 activates CDC42. 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Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, ARHGEF6 activates Cell division control protein 42 homolog (CDC42) by acting as a GEF. Once active, CDC42 can facilitate the activation of PAK1. At this stage the whole complex dissociates to release the active CDC42 and active PAK1. CDC42 is known to be involved in epithelial cell polarization processes. 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Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, the GTPase Cell division control protein 42 homolog (CDC42) binds with this complex. Subsequently, ARHGEF6 acts as a GEF for CDC42 and facilitates the activation of CDC42. CDC42 is known to be involved in epithelial cell polarization processes.</Comment> <BiopaxRef>dd8</BiopaxRef> <Graphics ConnectorType="Segmented" ZOrder="12288" LineThickness="1.0"> <Point X="861.0" Y="877.0"/> <Point X="930.0" Y="878.0"/> <Anchor Position="0.0" Shape="None" GraphId="e3a8b"/> <Anchor Position="0.99" Shape="None" GraphId="bdd96"/> <Anchor Position="0.5" Shape="None" GraphId="d1818"/> </Graphics> <Xref Database="Reactome" ID="R-HSA-8964604"/> </Interaction> <Interaction GraphId="b82d2"> <Comment Source="Reactome">Phospholipase C (PLC) isozymes are a group of related proteins that cleave the polar head group from inositol phospholipids, typically in response to signals from cell surface receptors. They hydrolyze the highly phosphorylated lipid phosphatidylinositol 4,5-bisphosphate (PIP2) generating two products: inositol 1,4,5-trisphosphate (IP3), a universal calcium-mobilizing second messenger, and diacylglycerol (DAG), an activator of protein kinase C. PLC-beta isoforms are regulated by heterotrimeric GTP-binding proteins. PLC-beta 1 and 3 are widely expressed, with the highest concentrations found in (differing) specific regions of the brain. PLC-beta 2 is expressed at highest levels in cells of hematopoeitic origin; it is involved in leukocyte signaling and host defense. 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Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. Here, the G-protein beta-gamma complex activates BTK. Once active, BTK dissociates from PIP3 and G-protein beta-gamma complex and is released to the cytoplasm to phosphorylate downstream substrates. 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