miR-1 in cardiac development (Mus musculus)

From WikiPathways

You do not have permission to edit pages, for the following reasons:

• You do not have permission to edit pages in the Pathway namespace.
• You are not allowed to execute the action you have requested.

You can view and copy the source of this page:

<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="miR-1 in cardiac development" Organism="Mus musculus"> <Comment Source="WikiPathways-description">This pathway is an adaptation from figure 2.a in Stefani et al. (2008). miR-1 regulates cardiac morphogenesis by optimizing the level of the HAND2 transcription factor. Electric conduction is abnormal in mice that lack miR-1 as a consequence of de-inhibition of IRX5, a homeodomain-containing transcription factor that represses the expression of the KCND2 potassium channel.</Comment> <Comment Source="WikiPathways-category">Physiological Process</Comment> <BiopaxRef>f12</BiopaxRef> <Graphics BoardWidth="578.0" BoardHeight="329.0"/> <DataNode TextLabel="mmu-mir-1-1" GraphId="bdc06" Type="Rna" GroupRef="c8d9f"> <Graphics CenterX="254.0" CenterY="87.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase Sequence" ID="MI0000139"/> </DataNode> <DataNode TextLabel="mmu-mir-1-2" GraphId="a18de" Type="Rna" GroupRef="c8d9f"> <Graphics CenterX="254.0" CenterY="109.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="miRBase Sequence" ID="MI0000652"/> </DataNode> <DataNode TextLabel="Hand2" GraphId="f3a5a" Type="GeneProduct"> <Graphics CenterX="193.0" CenterY="197.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="15111"/> </DataNode> <DataNode TextLabel="Irx5" GraphId="e352b" Type="GeneProduct"> <Graphics CenterX="325.0" CenterY="197.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="54352"/> </DataNode> <DataNode TextLabel="Kcnd2" GraphId="d7557" Type="GeneProduct"> <Graphics CenterX="325.0" CenterY="286.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="16508"/> </DataNode> <Interaction GraphId="b555f"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="254.0" Y="127.0" GraphRef="a267a" RelX="0.0" RelY="1.0"/> <Point X="325.0" Y="187.0" GraphRef="e352b" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="d0a62"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="230.0" Y="127.0" GraphRef="a267a" RelX="-0.5" RelY="1.0"/> <Point X="193.0" Y="187.0" GraphRef="f3a5a" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="df4ac"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="193.0" Y="207.0" GraphRef="f3a5a" RelX="0.0" RelY="1.0"/> <Point X="193.5" Y="279.0" GraphRef="fd757" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="c5eb9"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="325.0" Y="207.0" GraphRef="e352b" RelX="0.0" RelY="1.0"/> <Point X="325.0" Y="276.0" GraphRef="d7557" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Interaction GraphId="df705"> <Graphics ZOrder="12288" LineThickness="1.0"> <Point X="365.0" Y="286.0" GraphRef="d7557" RelX="1.0" RelY="0.0"/> <Point X="438.0" Y="286.0" GraphRef="e1558" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> </Graphics> <Xref Database="" ID=""/> </Interaction> <Label TextLabel="miR-1" GraphId="b566a" GroupRef="c8d9f"> <Graphics CenterX="254.0" CenterY="65.0" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontName="Dialog" FontWeight="Bold" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="Electric conduction" GraphId="e1558"> <Graphics CenterX="493.0" CenterY="286.0" Width="110.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Label TextLabel="Heart morphogenesis" GraphId="fd757"> <Graphics CenterX="193.5" CenterY="289.0" Width="119.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle"/> </Label> <Group GroupId="c8d9f" GraphId="a267a" Style="Group"/> <InfoBox CenterX="0.0" CenterY="0.0"/> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">microRNA pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000808</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> <bp:PublicationXref xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" rdf:id="f12"> <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18270516</bp:ID> <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Small non-coding RNAs in animal development.</bp:TITLE> <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Rev Mol Cell Biol</bp:SOURCE> <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stefani G</bp:AUTHORS> <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Slack FJ</bp:AUTHORS> </bp:PublicationXref> </Biopax> </Pathway>

Return to miR-1 in cardiac development (Mus musculus).