MAPK Cascade (Gallus gallus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="MAPK Cascade" Last-Modified="5/1/2013" Organism="Gallus gallus"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP422&amp;amp;oldid=21570 WP422(r21570)] with a 63% conversion rate.</Comment> <Graphics BoardWidth="820.0" BoardHeight="736.1666666666666" /> <DataNode TextLabel="MAPK14" GraphId="a66" Type="GeneProduct" GroupRef="e7ebd"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14" /> <Graphics CenterX="613.0" CenterY="494.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="421183" /> </DataNode> <DataNode TextLabel="JUN" GraphId="a80" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JUN" /> <Graphics CenterX="416.6666666666667" CenterY="650.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="424673" /> </DataNode> <DataNode TextLabel="NRAS" GraphId="aa7" Type="GeneProduct" GroupRef="db21b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="NRAS" /> <Graphics CenterX="293.3333333333333" CenterY="199.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="419885" /> </DataNode> <DataNode TextLabel="RAF1" GraphId="b3e" Type="GeneProduct" GroupRef="b3e68"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1" /> <Graphics CenterX="293.3333333333333" CenterY="288.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="396245" /> </DataNode> <DataNode TextLabel="MAP2K7" GraphId="b61" Type="GeneProduct" GroupRef="c173d"> <Graphics CenterX="463.0" CenterY="444.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAP3K3" GraphId="b86" Type="GeneProduct" GroupRef="ac569"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K3" /> <Graphics CenterX="458.0" CenterY="327.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="419954" /> </DataNode> <DataNode TextLabel="GTP" GraphId="b92" Type="Metabolite"> <Graphics CenterX="36.666666666666664" CenterY="133.33333333333334" Width="32.333333333333336" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAP3K1" GraphId="c37" Type="GeneProduct" GroupRef="ac569"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K1" /> <Graphics CenterX="458.0" CenterY="287.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="427144" /> </DataNode> <DataNode TextLabel="MAPK3" GraphId="c44" Type="GeneProduct" GroupRef="b377f"> <Graphics CenterX="293.3333333333333" CenterY="457.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="ELK1" GraphId="c75" Type="GeneProduct" GroupRef="b1a21"> <Graphics CenterX="293.3333333333333" CenterY="563.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAP2" GraphId="c80" Type="GeneProduct" GroupRef="b1a21"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2" /> <Graphics CenterX="293.3333333333333" CenterY="543.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="424001" /> </DataNode> <DataNode TextLabel="MAP2K4" GraphId="c82" Type="GeneProduct" GroupRef="b5796"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K4" /> <Graphics CenterX="740.3333333333334" CenterY="562.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="417312" /> </DataNode> <DataNode TextLabel="HRAS" GraphId="c98" Type="GeneProduct" GroupRef="db21b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="HRAS" /> <Graphics CenterX="293.3333333333333" CenterY="179.0" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="396229" /> </DataNode> <DataNode TextLabel="MAP3K12" GraphId="c9d" Type="GeneProduct" GroupRef="ac569"> <Graphics CenterX="458.0" CenterY="347.6666666666667" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAPK10" GraphId="d09" Type="GeneProduct" GroupRef="c173d"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10" /> <Graphics CenterX="463.0" CenterY="544.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="422592" /> </DataNode> <DataNode TextLabel="MAP2K2" GraphId="d26" Type="GeneProduct" GroupRef="cd181"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2" /> <Graphics CenterX="293.3333333333333" CenterY="403.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="396349" /> </DataNode> <DataNode TextLabel="MBP" GraphId="d43" Type="GeneProduct" GroupRef="b1a21"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MBP" /> <Graphics CenterX="293.3333333333333" CenterY="523.3333333333334" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="396217" /> </DataNode> <DataNode TextLabel="MAPK12" GraphId="d6e" Type="GeneProduct" GroupRef="e7ebd"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK12" /> <Graphics CenterX="613.0" CenterY="514.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="769763" /> </DataNode> <DataNode TextLabel="GDP" GraphId="d8a" Type="Metabolite"> <Graphics CenterX="148.66666666666666" CenterY="252.0" Width="33.333333333333336" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="MAP2K6" GraphId="e5d" Type="GeneProduct" GroupRef="c173d"> <Graphics CenterX="613.0" CenterY="444.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="SIPA1" GraphId="e79" Type="GeneProduct"> <Comment Source="GenMAPP remarks">not confirmed SwissProt ID - mu: SPA1 MOUSE</Comment> <Graphics 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