Type II interferon signaling (IFNG) (Gallus gallus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Type II interferon signaling (IFNG)" Organism="Gallus gallus"> <Comment Source="WikiPathways-description">Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]</Comment> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP619&amp;amp;oldid=28124 WP619(r28124)] with a 60% conversion rate.</Comment> <BiopaxRef>f74</BiopaxRef> <Graphics BoardWidth="1830.0" BoardHeight="969.0"/> <DataNode TextLabel="IFNG" GraphId="ad082" Type="GeneProduct" GroupRef="e2df7"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="207.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="396054"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="b506a" Type="GeneProduct" GroupRef="e2df7"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="227.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="396054"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="b739b" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="136.0" CenterY="342.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="396054"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="e6eda" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="346.0" CenterY="187.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="421685"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="c97af" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="346.0" CenterY="207.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="418502"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="d6a35" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="346.0" CenterY="227.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="395681"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="fa442" Type="GeneProduct" GroupRef="bf74f"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="346.0" CenterY="247.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="374199"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="dd317" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="344.0" CenterY="388.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="374199"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="f8b8c" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="344.0" CenterY="348.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="418502"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="e9f60" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="344.0" CenterY="328.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="421685"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="db588" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="344.0" CenterY="368.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="395681"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="a32aa" Type="GeneProduct" GroupRef="a1dfa"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="344.0" CenterY="408.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="396054"/> </DataNode> <DataNode TextLabel="JAK2" GraphId="ad68c" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK2"/> <Graphics CenterX="535.0" CenterY="252.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="374199"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="ddd82" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="535.0" CenterY="204.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="418502"/> </DataNode> <DataNode TextLabel="IFNGR1" GraphId="d35ca" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR1"/> <Graphics CenterX="535.0" CenterY="180.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="421685"/> </DataNode> <DataNode TextLabel="JAK1" GraphId="b9575" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="JAK1"/> <Graphics CenterX="535.0" CenterY="228.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="395681"/> </DataNode> <DataNode TextLabel="IFNGR2" GraphId="cc9ce" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNGR2"/> <Graphics CenterX="344.0" CenterY="559.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="418502"/> </DataNode> <DataNode TextLabel="IFNG" GraphId="e8714" Type="GeneProduct" GroupRef="a73e6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="IFNG"/> <Graphics CenterX="344.0" CenterY="619.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref 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