Tamoxifen metabolism (Pan troglodytes)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Tamoxifen metabolism" Last-Modified="2/20/2013" Organism="Pan troglodytes"> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP691&amp;amp;oldid=29331 WP691(r29331)] with a 85% conversion rate.</Comment> <Comment Source="WikiPathways-category">Metabolic Process</Comment> <BiopaxRef>f3d</BiopaxRef> <BiopaxRef>fe9</BiopaxRef> <BiopaxRef>fe6</BiopaxRef> <BiopaxRef>c03</BiopaxRef> <BiopaxRef>a43</BiopaxRef> <Graphics BoardWidth="1319.0" BoardHeight="921.0" /> <DataNode TextLabel="Tamoxifen-N-oxide" GraphId="a0d35" Type="Metabolite"> <Graphics CenterX="663.0" CenterY="166.0" Width="96.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CP2D6_PANTR" GraphId="a2108" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CP2D6_PANTR" /> <Graphics CenterX="727.0" CenterY="419.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000034370" /> </DataNode> <DataNode TextLabel="cis-4-hydroxytamoxifen" GraphId="a30e1" Type="Metabolite"> <Graphics CenterX="208.5" CenterY="582.0" Width="121.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="SSRI" GraphId="a425a" Type="Metabolite"> <Graphics CenterX="623.0" CenterY="419.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="trans-4-hydroxytamoxifen-N-glucuronide" GraphId="a9b00" Type="Metabolite"> <Graphics CenterX="483.0" CenterY="491.0" Width="192.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="alpha-hydroxy-N-desmethyltamoxifen" GraphId="aac9c" Type="Metabolite"> <Graphics CenterX="1031.0" CenterY="185.0" Width="184.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PAP" GraphId="ac585" Type="Metabolite"> <Graphics CenterX="163.0" CenterY="799.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000061" /> </DataNode> <DataNode TextLabel="PAP" GraphId="b02b8" Type="Metabolite"> <Graphics CenterX="517.0" CenterY="799.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="HMDB" ID="HMDB0000061" /> </DataNode> <DataNode TextLabel="CYP2A6" GraphId="b13e3" Type="GeneProduct" GroupRef="b3930"> <Graphics CenterX="446.0" CenterY="254.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="cis-4-hydroxy-N-desmethyltamoxifen" GraphId="b1653" Type="Metabolite"> <Graphics CenterX="1121.5" CenterY="582.0" Width="197.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="SULT2A1" GraphId="b2b8f" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SULT2A1" /> <Graphics CenterX="1027.0" CenterY="146.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000011219" /> </DataNode> <DataNode TextLabel="CYP2C9" GraphId="b3994" Type="GeneProduct" GroupRef="e6f12"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYP2C9" /> <Graphics CenterX="294.0" CenterY="399.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000002780" /> </DataNode> <DataNode TextLabel="trans-tamoxifen-N-glucuronide" GraphId="b4a2c" Type="Metabolite"> 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Value="B1NL93_PANTR" /> <Graphics CenterX="546.0" CenterY="144.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000019460" /> </DataNode> <DataNode TextLabel="PAPS" GraphId="b84ae" Type="Metabolite"> <Graphics CenterX="65.0" CenterY="800.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="10214" /> </DataNode> <DataNode TextLabel="B1NL93_PANTR" GraphId="b9a4f" Type="GeneProduct" GroupRef="a6451"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="B1NL93_PANTR" /> <Graphics CenterX="624.0" CenterY="362.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000019460" /> </DataNode> <DataNode TextLabel="UGT1A10" GraphId="ba3eb" Type="GeneProduct" GroupRef="ee405"> <Graphics CenterX="501.0" CenterY="677.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="B1NL93_PANTR" GraphId="baacf" Type="GeneProduct" GroupRef="e4ee6"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="B1NL93_PANTR" /> <Graphics CenterX="730.0" CenterY="492.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000019460" /> </DataNode> <DataNode TextLabel="trans-4-Sulfoxytamoxifen" GraphId="bb2d8" Type="Metabolite"> <Graphics CenterX="578.5" CenterY="760.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="SULT2A1" GraphId="be683" Type="GeneProduct" GroupRef="ccd31"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SULT2A1" /> <Graphics CenterX="117.0" CenterY="881.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000011219" /> </DataNode> <DataNode TextLabel="SULT2A1" 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GraphId="c68bd" Type="GeneProduct" GroupRef="ee405"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="UGT2B7" /> <Graphics CenterX="501.0" CenterY="637.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Entrez Gene" ID="471218" /> </DataNode> <DataNode TextLabel="PAPS" GraphId="c6e0c" Type="Metabolite"> <Graphics CenterX="419.0" CenterY="800.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="10214" /> </DataNode> <DataNode TextLabel="CP2D6_PANTR" GraphId="c9707" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CP2D6_PANTR" /> <Graphics CenterX="516.0" CenterY="419.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000034370" /> </DataNode> <DataNode TextLabel="trans-4-hydroxy-N-desmethyltamoxifen" GraphId="cad7a" Type="Metabolite"> <Graphics CenterX="871.5" 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</DataNode> <DataNode TextLabel="deaminohydroxytamoxifen" GraphId="dbce9" Type="Metabolite"> <Graphics CenterX="1062.0" CenterY="528.0" Width="138.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="3033897" /> </DataNode> <DataNode TextLabel="alpha-hydroxytamoxifen" GraphId="dcade" Type="Metabolite"> <Graphics CenterX="908.5" CenterY="109.0" Width="123.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CYP2C19" GraphId="dcd33" Type="GeneProduct" GroupRef="a0231"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYP2C19" /> <Graphics CenterX="290.0" CenterY="517.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000002779" /> </DataNode> <DataNode TextLabel="UGT1A4" GraphId="dde2c" Type="GeneProduct"> <Graphics CenterX="506.0" CenterY="531.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CYP1B1" GraphId="de482" Type="GeneProduct" GroupRef="a0231"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CYP1B1" /> <Graphics CenterX="290.0" CenterY="498.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000011843" /> </DataNode> <DataNode TextLabel="trans-4-Sulfoxytamoxifen" GraphId="df4c1" Type="Metabolite"> <Graphics CenterX="224.5" CenterY="760.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="N,N-didesmethyltamoxifen" GraphId="dfcb7" Type="Metabolite"> <Graphics CenterX="1062.0" CenterY="319.0" Width="130.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="PubChem-compound" ID="3036172" /> </DataNode> <DataNode TextLabel="UGT1A4" 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