Complement and coagulation cascades (Pan troglodytes)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Complement and coagulation cascades" Data-Source="WikiPathways" Version="WP558_Pt" Organism="Pan troglodytes"> <Comment Source="WikiPathways-description">Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Source: KEGG Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP558 CPTAC Assay Portal]</Comment> <Comment Source="ECO">ECO:0007481 - biological system reconstruction evidence based on orthology evidence used in automatic assertion</Comment> <Comment Source="HomologyMapper">This pathway was inferred from Homo sapiens pathway WP558.gpml (WP558_r119232) with a 90.0% conversion rate.</Comment> <BiopaxRef>c93</BiopaxRef> <Graphics BoardWidth="1158.6666666666665" BoardHeight="1148.185982592761" /> <DataNode TextLabel="C2" GraphId="a0d" Type="GeneProduct" GroupRef="dc09f"> <Comment Source="HomologyMapper">No homologues found for original id L:717</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C2 | complement component 2" /> <Graphics CenterX="423.3333333333333" CenterY="896.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="PLAT" GraphId="a2d" Type="GeneProduct" GroupRef="eb776"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5327</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLAT | plasminogen activator tissue" /> <Graphics CenterX="723.0" CenterY="476.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000020201" /> </DataNode> <DataNode TextLabel="CFD" GraphId="a62" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1675</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Adn" /> <Graphics CenterX="428.0" CenterY="781.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000023827" /> </DataNode> <DataNode TextLabel="F8" GraphId="a9d" Type="GeneProduct" GroupRef="ca272"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2157</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F8 | coagulation factor VIII procoagulant comp..." /> <Graphics CenterX="423.3333333333333" CenterY="280.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000022455" /> </DataNode> <DataNode TextLabel="SERPINA5" GraphId="aae" Type="GeneProduct" GroupRef="fd374"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5104</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SERPINA5 | serine (or cysteine) proteinase inhi..." /> <Graphics CenterX="373.3333333333333" CenterY="400.0" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000032490" /> </DataNode> <DataNode TextLabel="F9" GraphId="abe" Type="GeneProduct" GroupRef="ca272"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2158</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F9 | coagulation factor IX (plasma thromboplast..." /> <Graphics CenterX="423.3333333333333" CenterY="260.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000022330" /> </DataNode> <DataNode TextLabel="F2R" GraphId="ac8" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2149</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F2R | coagulation factor II (thrombin) receptor..." /> <Graphics CenterX="773.3333333333334" CenterY="83.33333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000017004" /> </DataNode> <DataNode TextLabel="CLU" GraphId="acc40" Type="GeneProduct"> <Comment>CLU</Comment> <Comment>Type your comment here</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1191</Comment> <Graphics CenterX="955.0" CenterY="748.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000020107" /> </DataNode> <DataNode TextLabel="SERPINA1" GraphId="aff" Type="GeneProduct" GroupRef="fd374"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5265</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SERPINA1 | serine (or cysteine) proteinase inhi..." /> <Graphics CenterX="373.3333333333333" CenterY="446.6666666666667" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000023666" /> </DataNode> <DataNode TextLabel="TFPI" GraphId="b0c" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7035</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="TFPI | tissue factor pathway inhibitor (lipopro..." /> <Graphics CenterX="560.0" CenterY="100.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000012723" /> </DataNode> <DataNode TextLabel="CRRY" GraphId="b10" Type="GeneProduct" GroupRef="f6da0"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Crry" /> <Graphics CenterX="640.0" CenterY="690.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CFH" GraphId="b3e" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3075</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CFH | complement factor H" /> <Graphics CenterX="326.6666666666667" CenterY="691.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000001799" /> </DataNode> <DataNode TextLabel="FGB" GraphId="b53" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2244</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="FGB | fibrinogen beta chain" /> <Graphics CenterX="744.6666666666666" CenterY="217.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000016534" /> </DataNode> <DataNode TextLabel="KLKB1" GraphId="b56" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3818</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="KLKB1 | kallikrein B plasma (Fletcher factor) ..." /> <Graphics CenterX="414.6666666666667" CenterY="591.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000048789" /> </DataNode> <DataNode TextLabel="MASP2" GraphId="b5e" Type="GeneProduct" GroupRef="f99fd"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:10747</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MASP2 | mannan-binding lectin serine protease 2..." /> <Graphics CenterX="306.6666666666667" CenterY="870.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000000137" /> </DataNode> <DataNode TextLabel="C5AR1" GraphId="b64" Type="GeneProduct" GroupRef="d4dcf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:728</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C5R1 | complement component 5 receptor 1 (C5a l..." /> <Graphics CenterX="848.0731364275667" CenterY="983.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000028958" /> </DataNode> <DataNode TextLabel="A2M" GraphId="b73" Type="GeneProduct" GroupRef="fd374"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="A2M | alpha-2-macroglobulin" /> <Graphics CenterX="373.3333333333333" CenterY="423.3333333333333" Width="66.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="CD46" GraphId="ba3" Type="GeneProduct" GroupRef="f6da0"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:4179</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="MCP | membrane cofactor protein (CD46 trophobl..." /> <Graphics CenterX="640.0" CenterY="756.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000001931" /> </DataNode> <DataNode TextLabel="F13B" GraphId="bc7" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2165</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F13B | coagulation factor XIII B polypeptide" /> <Graphics CenterX="706.6666666666666" CenterY="290.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000001806" /> </DataNode> <DataNode TextLabel="F10" GraphId="bd0" Type="GeneProduct" GroupRef="b87cb"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2159</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F10 | coagulation factor X" /> <Graphics CenterX="543.3333333333334" CenterY="220.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000045053" /> </DataNode> <DataNode TextLabel="F7" GraphId="bd9" Type="GeneProduct" GroupRef="a3390"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2155</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F7 | coagulation factor VII (serum prothrombin ..." /> <Graphics CenterX="422.3333333333333" CenterY="181.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000047424" /> </DataNode> <DataNode TextLabel="CR2" GraphId="bdf" Type="GeneProduct" GroupRef="e08a4"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1380</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="CR2 | complement component (3d/Epstein Barr vir..." /> <Graphics CenterX="848.0731364275667" CenterY="1030.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000041818" /> </DataNode> <DataNode TextLabel="F3" GraphId="bf4" Type="GeneProduct" GroupRef="a3390"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2152</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F3 | coagulation factor III (thromboplastin ti..." /> <Graphics CenterX="422.3333333333333" CenterY="161.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000000977" /> </DataNode> <DataNode TextLabel="CD59A" GraphId="c04" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cd59" /> <Graphics CenterX="801.8027210884355" CenterY="754.1156462585034" Width="58.244400000000006" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="SERPING1" GraphId="c27" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:710</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SERPING1 | serine (or cysteine) proteinase inhi..." /> <Graphics CenterX="285.9259259259262" CenterY="1035.3703703703704" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000046666" /> </DataNode> <DataNode TextLabel="C1S" GraphId="c35" Type="GeneProduct" GroupRef="fb858"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:716</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C1S | complement component 1 s subcomponent" /> <Graphics CenterX="316.6666666666667" CenterY="956.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000004605" /> </DataNode> <DataNode TextLabel="C1QC" GraphId="c3b" Type="GeneProduct" GroupRef="fb858"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:714</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C1QG | complement component 1 q subcomponent ..." /> <Graphics CenterX="256.6666666666667" CenterY="963.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000000319" /> </DataNode> <DataNode TextLabel="BDKRB1" GraphId="c42" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:623</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDKRB1 | bradykinin receptor B1" /> <Graphics CenterX="960.0" CenterY="640.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000030674" /> </DataNode> <DataNode TextLabel="C7" GraphId="c47" Type="GeneProduct" GroupRef="a2196"> <Comment Source="GenMAPP remarks">MGI:88235 LL:109828</Comment> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:730</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C7 | complement component 7" /> <Graphics CenterX="763.3333333333334" CenterY="823.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000016824" /> </DataNode> <DataNode TextLabel="F5" GraphId="c66" Type="GeneProduct" GroupRef="b87cb"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2153</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F5 | coagulation factor V (proaccelerin labile..." /> <Graphics CenterX="543.3333333333334" CenterY="240.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000001659" /> </DataNode> <DataNode TextLabel="VWF" GraphId="c86" Type="GeneProduct" GroupRef="ca272"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7450</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="VWF | von Willebrand factor" /> <Graphics CenterX="483.3333333333333" CenterY="280.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000004566" /> </DataNode> <DataNode TextLabel="PLAU" GraphId="cc7" Type="GeneProduct" GroupRef="eb776"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5328</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLAU | plasminogen activator urokinase" /> <Graphics CenterX="723.0" CenterY="500.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000002646" /> </DataNode> <DataNode TextLabel="SERPINF2" GraphId="cd5" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5345</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SERPINF2 | serine (or cysteine) proteinase inhi..." /> <Graphics CenterX="680.6666666666666" CenterY="619.0" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000008536" /> </DataNode> <DataNode TextLabel="C3AR1" GraphId="cd8" Type="GeneProduct" GroupRef="d4dcf"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:719</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C3AR1 | complement component 3a receptor 1" /> <Graphics CenterX="848.0731364275667" CenterY="960.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000004630" /> </DataNode> <DataNode TextLabel="THBD" GraphId="ce1" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:7056</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="THBD | thrombomodulin" /> <Graphics CenterX="640.0" CenterY="363.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000013317" /> </DataNode> <DataNode TextLabel="Fibrin monomer" GraphId="ced" Type="Metabolite"> <Graphics CenterX="843.0" CenterY="217.0" Width="84.0" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="9001-31-4" /> </DataNode> <DataNode TextLabel="CLTC" GraphId="d36" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1213</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C5" /> <Graphics CenterX="613.3333333333334" CenterY="863.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000009472" /> </DataNode> <DataNode TextLabel="CFI" GraphId="d3a" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:3426</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cfi" /> <Graphics CenterX="563.6666666666666" CenterY="740.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000031127" /> </DataNode> <DataNode TextLabel="Bradykinin" GraphId="d46" Type="Metabolite"> <Graphics CenterX="851.3333333333334" CenterY="640.6666666666666" Width="66.33333333333333" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> <Xref Database="CAS" ID="58-82-2" /> </DataNode> <DataNode TextLabel="F2" GraphId="d80" Type="GeneProduct" GroupRef="ae9d1"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:2147</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="F2 | coagulation factor II (thrombin)" /> <Graphics CenterX="640.3333333333334" CenterY="217.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000003552" /> </DataNode> <DataNode TextLabel="Daf2" GraphId="d90" Type="GeneProduct" GroupRef="f6da0"> <Graphics CenterX="640.0" CenterY="733.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="C1R" GraphId="d99" Type="GeneProduct" GroupRef="fb858"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:715</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C1R | complement component 1 r subcomponent" /> <Graphics CenterX="316.6666666666667" CenterY="936.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000004606" /> </DataNode> <DataNode TextLabel="PROC" GraphId="da2" Type="GeneProduct" GroupRef="c37d2"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5624</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PROC | protein C (inactivator of coagulation fa..." /> <Graphics CenterX="543.3333333333334" CenterY="431.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000012428" /> </DataNode> <DataNode TextLabel="CD55" GraphId="da8" Type="GeneProduct" GroupRef="f6da0"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:1604</Comment> <Graphics CenterX="640.0" CenterY="711.5412186379929" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000024008" /> </DataNode> <DataNode TextLabel="PROS1" GraphId="daf" Type="GeneProduct" GroupRef="c37d2"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5627</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PROS1 | protein S (alpha)" /> <Graphics CenterX="543.3333333333334" CenterY="451.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000015128" /> </DataNode> <DataNode TextLabel="PLAUR" GraphId="db8" Type="GeneProduct" GroupRef="dadf2"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5329</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="PLAUR | plasminogen activator urokinase recept..." /> <Graphics CenterX="815.0" CenterY="501.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000011091" /> </DataNode> <DataNode TextLabel="C1QB" GraphId="dc7" Type="GeneProduct" GroupRef="fb858"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:713</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="C1QB | complement component 1 q subcomponent ..." /> <Graphics CenterX="256.6666666666667" CenterY="943.3333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000043586" /> </DataNode> <DataNode TextLabel="SERPINE1" GraphId="dc8" Type="GeneProduct"> <Comment Source="HomologyMapper">Homology Mapping from Homo sapiens to Pan troglodytes: Original ID = L:5054</Comment> <Attribute Key="org.pathvisio.model.BackpageHead" Value="SERPINE1 | serine (or cysteine) proteinase inhi..." /> <Graphics CenterX="671.0" CenterY="441.6666666666667" Width="73.33333333333333" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSPTRG00000019519" /> </DataNode> <DataNode TextLabel="C6" GraphId="dd4" 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