Non-homologous end joining (Bos taurus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Non-homologous end joining" Last-Modified="2/22/2013" Organism="Bos taurus"> <Comment Source="WikiPathways-category">Cellular Process</Comment> <Comment Source="WikiPathways-description">(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP438_r80022 WP438(80022)] with a 91.0% conversion rate.</Comment> <Graphics BoardWidth="1016.5" BoardHeight="897.0" /> <DataNode TextLabel="PRKDC" GraphId="fd1" Type="GeneProduct" GroupRef="c3a60"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729</Comment> <Graphics CenterX="440.0" CenterY="689.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017019" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="ffe" Type="GeneProduct" GroupRef="c3a60"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="440.0" CenterY="709.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="bf6" Type="GeneProduct" GroupRef="c3a60"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="440.0" CenterY="729.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="ea1" Type="GeneProduct" GroupRef="d4ede"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="593.0" CenterY="730.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="b87" Type="GeneProduct" GroupRef="d4ede"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="593.0" CenterY="710.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="PRKDC" GraphId="f33" Type="GeneProduct" GroupRef="d4ede"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729</Comment> <Graphics CenterX="593.0" CenterY="690.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017019" /> </DataNode> <DataNode TextLabel="PRKDC" GraphId="b50" Type="GeneProduct" GroupRef="ba922"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729</Comment> <Graphics CenterX="407.0" CenterY="269.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017019" /> </DataNode> <DataNode TextLabel="XRCC4" GraphId="c06" Type="GeneProduct" GroupRef="d9568"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152422</Comment> <Graphics CenterX="270.0" CenterY="458.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000024275" /> </DataNode> <DataNode TextLabel="NHEJ1" GraphId="c69" Type="GeneProduct" GroupRef="d9568"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79840</Comment> <Graphics CenterX="270.0" CenterY="478.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000031041" /> </DataNode> <DataNode TextLabel="Ligase V" GraphId="a98" Type="GeneProduct"> <Graphics CenterX="516.0" CenterY="696.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="Ligase V" GraphId="edd" Type="GeneProduct"> <Graphics CenterX="516.0" CenterY="723.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="b29" Type="GeneProduct" GroupRef="d14cd"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="409.0" CenterY="129.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="be0" Type="GeneProduct" GroupRef="d14cd"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="409.0" CenterY="149.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="Nbs1 ?" GraphId="db7" Type="GeneProduct" GroupRef="cbcf5"> <Graphics CenterX="773.0" CenterY="451.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="" ID="" /> </DataNode> <DataNode TextLabel="RAD50" GraphId="f35" Type="GeneProduct" GroupRef="cbcf5"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113522</Comment> <Graphics CenterX="773.0" CenterY="471.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000011252" /> </DataNode> <DataNode TextLabel="MRE11A" GraphId="b8a" Type="GeneProduct" GroupRef="cbcf5"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000020922</Comment> <Graphics CenterX="773.0" CenterY="491.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000008925" /> </DataNode> <DataNode TextLabel="XRCC4" GraphId="ba5" Type="GeneProduct" GroupRef="f5a76"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152422</Comment> <Graphics CenterX="476.0" CenterY="600.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000024275" /> </DataNode> <DataNode TextLabel="NHEJ1" GraphId="f94" Type="GeneProduct" GroupRef="f5a76"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187736</Comment> <Graphics CenterX="476.0" CenterY="620.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000031041" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="ccc" Type="GeneProduct" GroupRef="e2d0c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="650.0" CenterY="129.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="b07" Type="GeneProduct" GroupRef="e2d0c"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="650.0" CenterY="149.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="a78" Type="GeneProduct" GroupRef="ba922"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="407.0" CenterY="289.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="a5b" Type="GeneProduct" GroupRef="ba922"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="407.0" CenterY="309.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="PRKDC" GraphId="d2b" Type="GeneProduct" GroupRef="e52a3"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729</Comment> <Graphics CenterX="649.0" CenterY="270.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017019" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="e14" Type="GeneProduct" GroupRef="e52a3"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079246</Comment> <Graphics CenterX="649.0" CenterY="290.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000010426" /> </DataNode> <DataNode TextLabel="XRCC6" GraphId="f19" Type="GeneProduct" GroupRef="e52a3"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196419</Comment> <Graphics CenterX="649.0" CenterY="310.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000006103" /> </DataNode> <DataNode TextLabel="PRKDC" GraphId="ba9" Type="GeneProduct" GroupRef="de744"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000253729</Comment> <Graphics CenterX="147.0" CenterY="451.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> <Xref Database="Ensembl" ID="ENSBTAG00000017019" /> </DataNode> <DataNode TextLabel="XRCC5" GraphId="a46" Type="GeneProduct" GroupRef="de744"> <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = 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