Alpha 6 beta 4 signaling pathway (Bos taurus)

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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Alpha 6 beta 4 signaling pathway" Organism="Bos taurus" License="Freely available under Creative Commons license">
  <Comment Source="WikiPathways-description">The integrin alpha6beta4 was discovered in the late 1980s by two different groups and was called either alphaEbeta4 or Ic-Ic binding protein (Ic-IcBP) (1,2). The alpha6beta4 integrin is a component of Hemidesmosomes (HDs) (3, 4,5). Increased expression of alphaEbeta4 and changes in its distribution is found to be correlated with increased aggressiveness of tumors and poor prognosis (6, 7). Although integrin alpha6beta4, can interact with different laminin isoforms, its preferred ligand in the epidermal BM is laminin-5 (8, 9). The beta4 integrin is a large protein and has a cytoplasmic domain of more than 1000 amino acids (10, 11). This domain contains a Na-Ca exchanger (CalX) motif followed by two pairs of type III fibronectin (FNIII) domains separated by a connecting segment (CS). It is found to associate with the intermediate filament system through plectin and BP230, which are components of hemidesmosomes (12,13,14). Interaction of intgrin beta4 with components of hemidesmosomes including plectin, BP230 and BP180 is found to be important in signaling events associated with cell growth, survival, and migration under physiological and pathological conditions.

Studies have shown that beta4 can regulate keratinocyte migration both positively and negatively (15,16,17,18). It is also found to regulate cell survival in keratinocytes in cell culture systems under stress in a PI3K/Akt pathway dependent manner (19,18). However, alpha6beta4 was not found to have any effect on keratinocyte survival in vivo (20, 18, 16). Apart from its effects on keratinocytes, evidence suggests that integrin alpha6beta4 is important in cancer cell invasion (21,22,23,24) and survival (25,26,27,28,16,29). The cancer cell invasion is regulated through a IRS/PI3K dependent process while the effect on carcinoma cell survival in a PI3K/Akt and dependent manner. Activation of the transcription factors NFkappaB and NF-IL6 in a p38Mapk dependent pathway and subsequent activation of IL6 gene expression was shown to be mechanism of alpha6beta4 induced survival of thymocytes and proliferation of thymic epithelial cells (27,30). Integrin alpha6beta4 is also known activate the Ras/Raf/MEK/ERK cascade which is found to be involved in the regulation of cell cycle (31,32,33,34).
NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org).  If you use this pathway, please cite the NetPath website until the pathway is published.</Comment>
  <Comment Source="WikiPathways-category">Cellular Process</Comment>
  <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://wikipathways.org/instance/WP244_r78506 WP244(78506)]  with a 98.0% conversion rate.</Comment>
  <BiopaxRef>cac</BiopaxRef>
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  <Attribute Key="org.pathvisio.model.WindowWidth" Value="15480.0"/>
  <Graphics BoardWidth="1198.0" BoardHeight="1221.79862136878"/>
  <DataNode TextLabel="ITGB4" GraphId="a070f" Type="Protein" GroupRef="d24ea">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="429.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000018169"/>
  </DataNode>
  <DataNode TextLabel="MAPK14" GraphId="a1368" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="429.33333333333326" CenterY="931.0" Width="60.4458" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000020783"/>
  </DataNode>
  <DataNode TextLabel="PTK2" GraphId="a5b24" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTK2"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="429.0000000000003" CenterY="625.0" Width="42.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000009578"/>
  </DataNode>
  <DataNode TextLabel="ITGB4" GraphId="a8a28" Type="Protein" GroupRef="aa170">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="689.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000018169"/>
  </DataNode>
  <DataNode TextLabel="MTOR" GraphId="ab383" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="NFKB1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000015325"/>
  </DataNode>
  <DataNode TextLabel="MAPK1" GraphId="ae4fa" Type="Protein" GroupRef="daa8b">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000010312"/>
  </DataNode>
  <DataNode TextLabel="IRS2" GraphId="ae51f" Type="Protein" GroupRef="cad82">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8660</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000012019"/>
  </DataNode>
  <DataNode TextLabel="ITGA6" GraphId="afd25" Type="Protein" GroupRef="d05a9">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6R"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="626.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000017266"/>
  </DataNode>
  <DataNode TextLabel="PRKCD" GraphId="b017f" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000008719"/>
  </DataNode>
  <DataNode TextLabel="MAPK3" GraphId="b11ca" Type="Protein" GroupRef="daa8b">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000016156"/>
  </DataNode>
  <DataNode TextLabel="GAB1" GraphId="b3311" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK9"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="382.1120448179271" CenterY="773.5658263305324" Width="42.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000002813"/>
  </DataNode>
  <DataNode TextLabel="LAMA2" GraphId="b38f0" Type="Protein" GroupRef="c37e3">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3908</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000010229"/>
  </DataNode>
  <DataNode TextLabel="LAMB1" GraphId="b43ea" Type="Protein" GroupRef="c37e3">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3912</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="174.5" CenterY="332.66666666666663" Width="51.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000011412"/>
  </DataNode>
  <DataNode TextLabel="LAMA2" GraphId="baa58" Type="Protein" GroupRef="fe369">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3908</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000010229"/>
  </DataNode>
  <DataNode TextLabel="ITGA6" GraphId="bad8b" Type="Protein" GroupRef="fe369">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6R"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="346.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000017266"/>
  </DataNode>
  <DataNode TextLabel="AKT1" GraphId="bd3e5" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="AKT1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="319.99999999999983" CenterY="773.6666666666665" Width="42.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000017636"/>
  </DataNode>
  <DataNode TextLabel="ITGB4" GraphId="bde20" Type="Protein" GroupRef="d7486">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="55.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000018169"/>
  </DataNode>
  <DataNode TextLabel="EIF4EBP1" GraphId="be9eb" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOCS3"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000027654"/>
  </DataNode>
  <DataNode TextLabel="LAMA5" GraphId="bf735" Type="Protein" GroupRef="d9717">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3911</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="715.5" CenterY="311.66666666666663" Width="53.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000003061"/>
  </DataNode>
  <DataNode TextLabel="LAMC1" GraphId="c10e7" Type="Protein" GroupRef="c37e3">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="Ensembl" ID="ENSBTAG00000011966"/>
  </DataNode>
  <DataNode TextLabel="PTPN11" GraphId="c244d" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PTPN11"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="375.0" CenterY="625.0" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000002048"/>
  </DataNode>
  <DataNode TextLabel="LAMC2" GraphId="c26f5" Type="Protein" GroupRef="d24ea">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3918</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="482.0" CenterY="332.66666666666663" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000000793"/>
  </DataNode>
  <DataNode TextLabel="PIK3R2" GraphId="c6979" Type="Protein" GroupRef="b41bd">
    <Comment Source="HomologyConvert">HomologyConvert: Multiple homologues found: En:ENSBTAG00000002350;En:ENSBTAG00000002350;</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PIK3R2"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Xref Database="" ID=""/>
  </DataNode>
  <DataNode TextLabel="LAMB1" GraphId="c8a2b" Type="Protein" GroupRef="d7486">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3912</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="57.0" CenterY="332.66666666666663" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000011412"/>
  </DataNode>
  <DataNode TextLabel="LAMC1" GraphId="cae06" Type="Protein" GroupRef="d7486">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="107.5" CenterY="332.66666666666663" Width="51.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000011966"/>
  </DataNode>
  <DataNode TextLabel="LAMA3" GraphId="cc0b3" Type="Protein" GroupRef="d24ea">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3909</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="457.5" CenterY="312.66666666666663" Width="53.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000027181"/>
  </DataNode>
  <DataNode TextLabel="LAMB1" GraphId="cce10" Type="Protein" GroupRef="d05a9">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3912</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="573.0" CenterY="332.66666666666663" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000011412"/>
  </DataNode>
  <DataNode TextLabel="ITGB4" GraphId="ce87a" Type="Protein" GroupRef="fe369">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6ST"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="291.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000018169"/>
  </DataNode>
  <DataNode TextLabel="SOS1" GraphId="d32d5" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115904</Comment>
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    <Xref Database="Ensembl" ID="ENSBTAG00000011643"/>
  </DataNode>
  <DataNode TextLabel="LAMC1" GraphId="d6fb1" Type="Protein" GroupRef="d9717">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3913</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="691.0" CenterY="332.66666666666663" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000022635"/>
  </DataNode>
  <DataNode TextLabel="LAMC1" GraphId="d7149" Type="Protein" GroupRef="fe369">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3913</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="CDK5R1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="293.0" CenterY="331.66666666666663" Width="50.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000022635"/>
  </DataNode>
  <DataNode TextLabel="IRS1" GraphId="d7a9c" Type="Protein" GroupRef="cad82">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3667</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="320.0000000000003" CenterY="625.6666666666665" Width="42.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000021308"/>
  </DataNode>
  <DataNode TextLabel="ITGA6" GraphId="db214" Type="Protein" GroupRef="c37e3">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL6R"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="228.0" CenterY="483.0" Width="54.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000017266"/>
  </DataNode>
  <DataNode TextLabel="GRB2" GraphId="db5db" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177885</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="482.05042016806703" CenterY="707.1428571428572" Width="42.0" Height="20.0" ZOrder="32768" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000004736"/>
  </DataNode>
  <DataNode TextLabel="RHOA" GraphId="dd415" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPT"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
    <Graphics CenterX="598.9999999999999" CenterY="625.0" Width="42.0" Height="20.0" ZOrder="32768" FillColor="00ffff" FontName="SansSerif" FontWeight="Bold" FontSize="12" Valign="Middle"/>
    <Xref Database="Ensembl" ID="ENSBTAG00000004279"/>
  </DataNode>
  <DataNode TextLabel="RAC1" GraphId="dd941" Type="Protein">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879</Comment>
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAC1"/>
    <Attribute Key="org.pathvisio.model.GenMAPP-Xref" Value=""/>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:284217</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3911</Comment>
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    <Comment> ITGB4 interacts with ITGA6 in PA-JEB keratinocytes, 804G cells,MDA-MB-435 cells and HUVECs.</Comment>
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915</Comment>
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  <DataNode TextLabel="ITGA6" GraphId="ee133" Type="Protein" GroupRef="d7486">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655</Comment>
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  <DataNode TextLabel="LAMB3" GraphId="f4087" Type="Protein" GroupRef="d24ea">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3914</Comment>
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  <DataNode TextLabel="ITGB4" GraphId="fb8b0" Type="Protein" GroupRef="c37e3">
    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265</Comment>
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    <Comment Source="HomologyConvert">HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578</Comment>
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    <Comment>Alpha 6 beta 4 ligation induces the activation of ERK1/2</Comment>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singh S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Khatri P</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Draghici S</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bader GD</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sander C</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leonard WJ</bp:AUTHORS>
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pandey A</bp:AUTHORS>
    </bp:PublicationXref>
  </Biopax>
</Pathway>