User:AgustinGV

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== Research Interest ==
== Research Interest ==
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I am inserted in developing tools for analyzing Renal Genomic Data.
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I am interested in Systems Biology, particularly in Genomics and Proteomics of the kidney and in metabolic diseases.
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Genomic techniques produce large amounts of data which require new tools to analyze and interpret it. One way to visualize such data is the use of signaling pathways to plot gene-expression data and color-code significant changes. Also, analyzing expression changes on a gene list or pathway with running algorithms allows to find whether that particular gene set is enriched.
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== Main Contributions ==
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[[Portal:RenalGenomics | Renal Genomics Portal]]
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Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity and don’t distinguish between different gene products, which limits their use in highly differentiated tissues. In addition, many of the available pathways have been created using purely bioinformatics techniques, which could be an issue given that the available data is disperse and sometimes incomplete.
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Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity which limits their usefulness in highly differentiated tissues.  
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One way to address these issues is to create and manually curate Renal-Specific Pathways by crosslinking genomic and classical data to decide which nodes to include. This is of particular importance because creating a small number of nodes will limit the usefulness of the pathway while adding unnecessary nodes will dilute the specific characteristics of the tissue, as well as the power for detecting changes in genetic programs. This is the focus of my contributions at Wikipathways.
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The [[Portal:RenalGenomics | Renal Genomics Portal at Wikipathways]] created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologist and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research.
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== Main Contributions ==
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====[[Portal:RenalGenomics | Renal Genomics Portal]]====
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* [[Pathway:WP3882|Thick Ascending Limb Transport (Rattus norvegicus)]]
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* [[Pathway:WP3887|Angiotensin signaling in thick ascending limbs (Rattus norvegicus)]]
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* [[Pathway:WP3881|Proximal Tubule Transporters (Rattus norvegicus)]]
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* [[Pathway:WP3894|Fructose metabolism in proximal tubules (Rattus norvegicus)]]
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* [[Pathway:WP3901|Lipid Droplet Metabolism (Rattus norvegicus)]]
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* [[Pathway:WP3916|Hexoses metabolism in proximal tubules (Rattus norvegicus)]]
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The [[Portal:RenalGenomics | Renal Genomics Portal at Wikipathways]] was created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologists and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal "omics" field.
== About Me ==
== About Me ==
* ''Name'': Agustin Gonzalez-Vicente
* ''Name'': Agustin Gonzalez-Vicente
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* ''Work'': Case Western Reserve University
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* ''Work'': Cleveland Clinic, Lerner Research Institute
* ''Location'': Cleveland OH
* ''Location'': Cleveland OH
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* ''Professional Interests'': Renal Genomics, Epithelial Transport, Salt-sensitive Hypertension.
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* ''Professional Interests'': Systems Biology, Genomics, Proteomics, Genetics.
* ''Contact'': [email protected]
* ''Contact'': [email protected]

Current revision

iD This user has the ORCID identifier:
0000-0002-3682-0815

I hereby elect to apply CC0 to all my contributions to WikiPathways.

Research Interest

I am interested in Systems Biology, particularly in Genomics and Proteomics of the kidney and in metabolic diseases.

Main Contributions

Renal Genomics Portal

Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity which limits their usefulness in highly differentiated tissues.

The Renal Genomics Portal at Wikipathways was created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologists and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal "omics" field.

About Me

  • Name: Agustin Gonzalez-Vicente
  • Work: Cleveland Clinic, Lerner Research Institute
  • Location: Cleveland OH
  • Professional Interests: Systems Biology, Genomics, Proteomics, Genetics.
  • Contact: [email protected]
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