Portal:AOP/Mission
From WikiPathways
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The proposed list of the first set of AOPs to be created: | The proposed list of the first set of AOPs to be created: | ||
| - | * Inhibition of β-oxidation leads to liver steatosis | + | *Inhibition of β-oxidation leads to liver steatosis |
| - | * HDAC inhibition | + | *HDAC inhibition leads to teratogenicity |
| - | * Oxidative stress leads to hepatotoxicity | + | *ROS formation leads to teratogenicity |
| - | * Oxidative stress leads to nephrotoxicity | + | *Oxidative stress leads to hepatotoxicity |
| - | * Disturbance of the respiratory chain leads to mitotoxicity | + | *Oxidative stress leads to nephrotoxicity |
| - | * PPAR activation leads to hepatoxicity | + | *Disturbance of the respiratory chain leads to mitotoxicity |
| - | * OAT overactivation leads to nephrotoxicity | + | *PPAR activation leads to hepatoxicity |
| - | * PXR activation leads to liver steatosis | + | *OAT overactivation leads to nephrotoxicity |
| - | * NAPQI production causes hepatotoxicity | + | *PXR activation leads to liver steatosis |
| - | * MTP impairment leads to hepatotoxicity | + | *NAPQI production causes hepatotoxicity |
| - | * CYP51 inhibition causes embryotoxicity | + | *MTP impairment leads to hepatotoxicity |
| - | * Epithelial damage leads to popcorn lung | + | *CYP51 inhibition causes embryotoxicity |
| + | *Epithelial damage leads to popcorn lung | ||
| + | |||
Revision as of 13:20, 6 April 2017
The purpose of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the EU-ToxRisk program, in which Open PHACTS Foundation (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.
The proposed list of the first set of AOPs to be created:
- Inhibition of β-oxidation leads to liver steatosis
- HDAC inhibition leads to teratogenicity
- ROS formation leads to teratogenicity
- Oxidative stress leads to hepatotoxicity
- Oxidative stress leads to nephrotoxicity
- Disturbance of the respiratory chain leads to mitotoxicity
- PPAR activation leads to hepatoxicity
- OAT overactivation leads to nephrotoxicity
- PXR activation leads to liver steatosis
- NAPQI production causes hepatotoxicity
- MTP impairment leads to hepatotoxicity
- CYP51 inhibition causes embryotoxicity
- Epithelial damage leads to popcorn lung
Basic strategies and principles for general AOPs are described in this paper:
Villeneuve et al. (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Toxicological Sciences PubMed
