User:AgustinGV

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== Research Interest ==
== Research Interest ==
I am inserted in developing tools for analyzing Renal Genomic Data.
I am inserted in developing tools for analyzing Renal Genomic Data.
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Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity which limits their usefulness in highly differentiated tissues.  
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Genomic techniques produce large amounts of data which require new tools to analyze and interpret it. One way to visualize such data is the use of signaling pathways to plot gene-expression data and color-code significant changes. Also, analyzing expression changes on a gene list or pathway with running algorithms allows to find whether that particular gene set is enriched.
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The [[Portal:RenalGenomics | Renal Genomics Portal at Wikipathways]] was created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologists and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research.
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Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity and don’t distinguish between different gene products, which limits their use in highly differentiated tissues. In addition, many of the available pathways have been created using purely bioinformatics techniques, which could be an issue given that the available data is disperse and sometimes incomplete.
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One way to address these issues is to create and manually curate Renal-Specific Pathways by crosslinking genomic and classical data to decide which nodes to include. This is of particular importance because creating a small number of nodes will limit the usefulness of the pathway while adding unnecessary nodes will dilute the specific characteristics of the tissue, as well as the power for detecting changes in genetic programs. This is the focus of my contributions at Wikipathways.
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The [[Portal:RenalGenomics | Renal Genomics Portal at Wikipathways]] was created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologist and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research.
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== Main Contributions ==
== Main Contributions ==

Revision as of 18:41, 27 July 2017

iD This user has the ORCID identifier:
0000-0002-3682-0815

I hereby elect to apply CC0 to all my contributions to WikiPathways.

Contents

Research Interest

I am inserted in developing tools for analyzing Renal Genomic Data. Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity which limits their usefulness in highly differentiated tissues. The Renal Genomics Portal at Wikipathways was created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologists and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research.

Main Contributions

Renal Genomics Portal


About Me

  • Name: Agustin Gonzalez-Vicente
  • Work: Case Western Reserve University
  • Location: Cleveland OH
  • Professional Interests: Renal Genomics, Epithelial Transport, Salt-sensitive Hypertension.
  • Contact: [email protected]
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