Portal:AOP/Mission

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The proposed list of the first set of AOPs to be created:
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The proposed list of the first set of AOPs to be created (to be defined soon):
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*Inhibition of β-oxidation leads to liver steatosis
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*HDAC inhibition leads to teratogenicity
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*ROS formation leads to teratogenicity
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*Oxidative stress leads to hepatotoxicity
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*Oxidative stress leads to nephrotoxicity
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*Disturbance of the respiratory chain leads to mitotoxicity
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*PPAR activation leads to hepatoxicity
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*OAT overactivation leads to nephrotoxicity
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*PXR activation leads to liver steatosis
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*NAPQI production causes hepatotoxicity
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*MTP impairment leads to hepatotoxicity
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*CYP51 inhibition causes embryotoxicity
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*Epithelial damage leads to popcorn lung
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Revision as of 11:17, 18 May 2017

The purpose of this portal is to create a collection of AOPs on the molecular level for the AOPs that are, or will be created for the EU-ToxRisk program, in which Open PHACTS Foundation (OPF) is responsible for AOP creation. The subjects of the first AOPs are linked to the use cases of the EU-ToxRisk program, and there will be a team of experts involved in the creation of each AOP.


The proposed list of the first set of AOPs to be created (to be defined soon):


Basic strategies and principles for general AOPs are described in this paper:

Villeneuve et al. (2014). Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Toxicological Sciences PubMed

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