User:AgustinGV
From WikiPathways
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== Research Interest == | == Research Interest == | ||
| - | I am | + | I am inserted in developing tools for analyzing Renal Genomic Data. |
| + | Genomic techniques produce large amounts of data which require new tools to analyze and interpret it. One way to visualize such data is the use of signaling pathways to plot gene-expression data and color-code significant changes. Also, by analyzing expression changes by a running algorithm on a gene list or pathway it is possible to find whether that particular gene set is enriched. | ||
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| + | Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity and don’t distinguish between different gene products, which limits their use in highly differentiated tissues. In addition, many of the available pathways have been created using purely bioinformatics techniques, which could be an issue given that the available data is disperse and sometimes incomplete. | ||
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| + | One way to address these issues is to create and manually curate Renal-Specific Pathways by crosslinking genomic and classical data to decide which nodes to include. This is of particular importance because creating a small number of nodes will limit the usefulness of the pathway while adding unnecessary nodes will dilute the specific characteristics of the tissue, as well as the power for detecting changes in genetic programs. This is focus of my contributions at Wikipathways. | ||
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| + | The [[Portal:RenalGenomics | Renal Genomics Portal at Wikipathways]] created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologist and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research. | ||
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| + | == Main Contributions == | ||
| + | ====[[Portal:RenalGenomics | Renal Genomics Portal]]==== | ||
* [[Pathway:WP3882|Thick Ascending Limb Transport (Rattus norvegicus)]] | * [[Pathway:WP3882|Thick Ascending Limb Transport (Rattus norvegicus)]] | ||
* [[Pathway:WP3887|Angiotensin signaling in thick ascending limbs (Rattus norvegicus)]] | * [[Pathway:WP3887|Angiotensin signaling in thick ascending limbs (Rattus norvegicus)]] | ||
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* [[Pathway:WP3901|Lipid Droplet Metabolism (Rattus norvegicus)]] | * [[Pathway:WP3901|Lipid Droplet Metabolism (Rattus norvegicus)]] | ||
* [[Pathway:WP3916|Hexoses metabolism in proximal tubules (Rattus norvegicus)]] | * [[Pathway:WP3916|Hexoses metabolism in proximal tubules (Rattus norvegicus)]] | ||
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== About Me == | == About Me == | ||
Revision as of 13:33, 15 June 2017
| iD | This user has the ORCID identifier: 0000-0002-3682-0815 |
I hereby elect to apply CC0 to all my contributions to WikiPathways.
Contents |
Research Interest
I am inserted in developing tools for analyzing Renal Genomic Data.
Genomic techniques produce large amounts of data which require new tools to analyze and interpret it. One way to visualize such data is the use of signaling pathways to plot gene-expression data and color-code significant changes. Also, by analyzing expression changes by a running algorithm on a gene list or pathway it is possible to find whether that particular gene set is enriched.
Many digital platforms have collections of curated pathways publicly available for analysis. However, most of these pathways lack tissue/cell specificity and don’t distinguish between different gene products, which limits their use in highly differentiated tissues. In addition, many of the available pathways have been created using purely bioinformatics techniques, which could be an issue given that the available data is disperse and sometimes incomplete.
One way to address these issues is to create and manually curate Renal-Specific Pathways by crosslinking genomic and classical data to decide which nodes to include. This is of particular importance because creating a small number of nodes will limit the usefulness of the pathway while adding unnecessary nodes will dilute the specific characteristics of the tissue, as well as the power for detecting changes in genetic programs. This is focus of my contributions at Wikipathways.
The Renal Genomics Portal at Wikipathways created to facilitate access of renal researchers to a collection of renal-related/specific pathways. Crowd contributions by renal physiologist and clinicians to further develop these pathways and to create similar ones would provide a powerful and freely-available tool to expand renal genomic research.
Main Contributions
Renal Genomics Portal
- Thick Ascending Limb Transport (Rattus norvegicus)
- Angiotensin signaling in thick ascending limbs (Rattus norvegicus)
- Proximal Tubule Transporters (Rattus norvegicus)
- Fructose metabolism in proximal tubules (Rattus norvegicus)
- Lipid Droplet Metabolism (Rattus norvegicus)
- Hexoses metabolism in proximal tubules (Rattus norvegicus)
About Me
- Real name: Agustin Gonzalez-Vicente
- Work: Case Western Reserve University
- Location: Cleveland OH
- Professional Interests: Renal Genomics, Epithelial Transport, Salt-sensitive Hypertension.
- Contact: [email protected]
