MTF1 activates gene expression (Homo sapiens)

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Bibliography

1. Grzywacz A, Gdula-Argasińska J, Muszyńska B, Tyszka-Czochara M, Librowski T, Opoka W.; ''Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level.''; PubMed Europe PMC Scholia
2. Laity JH, Andrews GK.; ''Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1).''; PubMed Europe PMC Scholia
3. Hardyman JE, Tyson J, Jackson KA, Aldridge C, Cockell SJ, Wakeling LA, Valentine RA, Ford D.; ''Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc.''; PubMed Europe PMC Scholia
4. Lavedan C, Leroy E, Torres R, Dehejia A, Dutra A, Buchholtz S, Nussbaum RL, Polymeropoulos MH.; ''Genomic organization and expression of the human beta-synuclein gene (SNCB).''; PubMed Europe PMC Scholia
5. Wang X, Lee G, Liebhaber SA, Cooke NE.; ''Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc.''; PubMed Europe PMC Scholia
6. Günther V, Lindert U, Schaffner W.; ''The taste of heavy metals: gene regulation by MTF-1.''; PubMed Europe PMC Scholia
7. Wang Y, Lorenzi I, Georgiev O, Schaffner W.; ''Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration.''; PubMed Europe PMC Scholia
8. Dong G, Chen H, Qi M, Dou Y, Wang Q.; ''Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review).''; PubMed Europe PMC Scholia
9. Günther V, Davis AM, Georgiev O, Schaffner W.; ''A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1).''; PubMed Europe PMC Scholia
10. Jakes R, Spillantini MG, Goedert M.; ''Identification of two distinct synucleins from human brain.''; PubMed Europe PMC Scholia
11. Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D.; ''Mechanisms of mammalian zinc-regulated gene expression.''; PubMed Europe PMC Scholia
12. McHugh PC, Wright JA, Brown DR.; ''Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
CSRP1 gene	Protein	ENSG00000159176 (Ensembl)
CSRP1 gene	GeneProduct	ENSG00000159176 (Ensembl)
CSRP1	Protein	P21291 (Uniprot-TrEMBL)
MTF1 dimer:12Zn2+:CSRP1 gene	Complex	R-HSA-5660435 (Reactome)
MTF1 dimer:12Zn2+:SNCB gene	Complex	R-HSA-5660451 (Reactome)
MTF1	Protein	Q14872 (Uniprot-TrEMBL)
MTF1 dimer:12Zn2+	Complex	R-HSA-5660456 (Reactome)
SNCB gene	Protein	ENSG00000074317 (Ensembl)
SNCB gene	GeneProduct	ENSG00000074317 (Ensembl)
SNCB	Protein	Q16143 (Uniprot-TrEMBL)
Zn2+	Metabolite	CHEBI:29105 (ChEBI)

Annotated Interactions

Source	Target	Type	Database reference	Comment
CSRP1 gene			R-HSA-5660503 (Reactome)
CSRP1 gene			R-HSA-5660514 (Reactome)
	CSRP1	Arrow	R-HSA-5660503 (Reactome)
MTF1 dimer:12Zn2+:CSRP1 gene		Arrow	R-HSA-5660503 (Reactome)
	MTF1 dimer:12Zn2+:CSRP1 gene	Arrow	R-HSA-5660514 (Reactome)
	MTF1 dimer:12Zn2+:SNCB gene	Arrow	R-HSA-5660479 (Reactome)
MTF1 dimer:12Zn2+:SNCB gene		Arrow	R-HSA-5660530 (Reactome)
MTF1 dimer:12Zn2+			R-HSA-5660479 (Reactome)
MTF1 dimer:12Zn2+			R-HSA-5660514 (Reactome)
			R-HSA-5660479 (Reactome)	The MTF1:zinc complex binds a metal response element in the promoter of the beta-synuclein (SNCB) gene and activates transcription in response to zinc (McHugh et al. 2011).
			R-HSA-5660503 (Reactome)	The CSRP1 gene is transcribed to yield mRNA which is translated to yield protein. Expression of CSRP1 is activated by zinc via MTF1 (Hardyman et al. 2016). As inferred from the mouse homolog, expression of CSRP1 is activated by cadmium via MTF1.
			R-HSA-5660514 (Reactome)	As inferred from the mouse homolog, the promoter of the CSRP1 gene contains 3 consensus metal response elements, at least one of which binds MTF1. Expression of CSRP1 is activated by cadmium via MTF1.
			R-HSA-5660530 (Reactome)	The SNCB (beta-synuclein) gene is transcribed to yield mRNA which is translated to yield protein (Lavedan et al. 1998). Transcription of SNCB is up-regulated by copper via a metal response binding element in the 5' promoter that binds MTF1 (McHugh et al. 2011).
SNCB gene			R-HSA-5660479 (Reactome)
SNCB gene			R-HSA-5660530 (Reactome)
	SNCB	Arrow	R-HSA-5660530 (Reactome)