Tyrobp causal network in microglia (Mus musculus)

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1, 2Gpx1Fkbp15Slc7a7PycardNpc2Tcirg1HlxCd4Nckap1lAbcc4Bin2TyrobpCxcl16Lgals9cIgsf6Samsn1DpydSlc1a5Gimap2ItgamPpp1r18Il13ra1Rbm47Apbb1ipC1qcItgb2Adap2Tmem106aCapgStat5aElf4Rps6ka1Spp1Creb3l2Zfp36l2Runx3PlekNrrosLyl1Loxl3C3Ncf2GaptCd37Tgfbr1Gal3st4Cd84ItgaxRnase6Hcls1Il10raSh2b3Cytl1Tnfrsf1bRgs1Il18Kcne3Sft2d2MafLhfpl2


Description

The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells. Manually translated from human model from Zhang (Cell 2013) to mouse: Gimap2 and Lgals9 (light gray) have no mouse ortholog.

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Ontology Terms

 

Bibliography

  1. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V; ''Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.''; Cell, 2013 PubMed Europe PMC Scholia
  2. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K; ''Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.''; Nat Immunol, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116680view13:22, 9 May 2021EweitzModified title
101909view17:04, 16 November 2018EgonwRemoved "undefined" as data source.
99013view22:55, 22 October 2018KhanspersAdded new lit ref
98919view23:33, 15 October 2018AlexanderPicoModified description
90841view19:39, 14 December 2016KhanspersOntology Term : 'Alzheimer disease pathway' added !
90840view19:38, 14 December 2016KhanspersOntology Term : 'DOID:10652' removed !
85694view17:54, 5 June 2016AlexanderPicoOntology Term : 'microglial cell' added !
85693view17:53, 5 June 2016AlexanderPicoOntology Term : 'innate immune response pathway' added !
85692view17:53, 5 June 2016AlexanderPicoOntology Term : 'Alzheimer's disease' added !
85688view17:47, 5 June 2016AlexanderPicoModified description
85687view17:46, 5 June 2016AlexanderPicoQuick edit to datanode annotation or property
85686view17:45, 5 June 2016AlexanderPicoaltered color indicators for uncoverted datanodes
85685view17:44, 5 June 2016AlexanderPicoQuick edit to datanode annotation or property
85683view02:58, 5 June 2016KhanspersModified description
85682view02:57, 5 June 2016KhanspersModified description
84842view00:01, 26 March 2016AlexanderPicoQuick edit to datanode annotation or property
84841view21:28, 25 March 2016AlexanderPicochanged mim-conversions to arrows
84813view00:21, 23 March 2016KhanspersModified description
84812view00:12, 23 March 2016Khanspersupdated xrefs
84811view00:12, 23 March 2016Khanspersupdated xrefs
84810view00:09, 23 March 2016Khanspersdraft complete
84809view23:53, 22 March 2016KhanspersPeriodical save, work in progress
84808view23:43, 22 March 2016KhanspersPeriodical save, work in progress
84807view23:33, 22 March 2016KhanspersPeriodical save, work in progress
84801view22:07, 22 March 2016Khansperscompleted layout and lit ref
84800view22:03, 22 March 2016KhanspersPeriodical save, work in progress
84799view21:52, 22 March 2016Khanspersfirst draft
84798view21:09, 22 March 2016Khanspersfirst draft
84797view21:00, 22 March 2016KhanspersPeriodical save, work in progress
84796view20:50, 22 March 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abcc4GeneProductENSMUSG00000032849 (Ensembl)
Adap2GeneProductENSMUSG00000020709 (Ensembl)
Apbb1ipGeneProductENSMUSG00000026786 (Ensembl)
Bin2GeneProductENSMUSG00000098112 (Ensembl)
C1qcGeneProductENSMUSG00000036896 (Ensembl)
C3GeneProductENSMUSG00000024164 (Ensembl)
CapgGeneProductENSMUSG00000056737 (Ensembl)
Cd37GeneProductENSMUSG00000030798 (Ensembl)
Cd4GeneProductENSMUSG00000023274 (Ensembl)
Cd84GeneProductENSMUSG00000038147 (Ensembl)
Creb3l2GeneProductENSMUSG00000038648 (Ensembl)
Cxcl16GeneProductENSMUSG00000018920 (Ensembl)
Cytl1GeneProductENSMUSG00000062329 (Ensembl)
DpydGeneProductENSMUSG00000033308 (Ensembl)
Elf4GeneProductENSMUSG00000031103 (Ensembl)
Fkbp15GeneProductENSMUSG00000066151 (Ensembl)
Gal3st4GeneProductENSMUSG00000075593 (Ensembl)
GaptGeneProductENSMUSG00000046006 (Ensembl)
Gimap2GeneProduct
Gpx1GeneProductENSMUSG00000063856 (Ensembl)
Hcls1GeneProductENSMUSG00000022831 (Ensembl)
HlxGeneProductENSMUSG00000039377 (Ensembl)
Igsf6GeneProductENSMUSG00000035004 (Ensembl)
Il10raGeneProductENSMUSG00000032089 (Ensembl)
Il13ra1GeneProductENSMUSG00000017057 (Ensembl)
Il18GeneProductENSMUSG00000039217 (Ensembl)
ItgamGeneProductENSMUSG00000030786 (Ensembl)
ItgaxGeneProductENSMUSG00000030789 (Ensembl)
Itgb2GeneProductENSMUSG00000000290 (Ensembl)
Kcne3GeneProductENSMUSG00000035165 (Ensembl)
Lgals9cGeneProduct
Lhfpl2GeneProductENSMUSG00000045312 (Ensembl)
Loxl3GeneProductENSMUSG00000000693 (Ensembl)
Lyl1GeneProductENSMUSG00000034041 (Ensembl)
MafGeneProductENSMUSG00000055435 (Ensembl)
Ncf2GeneProductENSMUSG00000026480 (Ensembl)
Nckap1lGeneProductENSMUSG00000022488 (Ensembl)
Npc2GeneProductENSMUSG00000021242 (Ensembl)
NrrosGeneProductENSMUSG00000052384 (Ensembl)
PlekGeneProductENSMUSG00000020120 (Ensembl)
Ppp1r18GeneProductENSMUSG00000034595 (Ensembl)
PycardGeneProductENSMUSG00000030793 (Ensembl)
Rbm47GeneProductENSMUSG00000070780 (Ensembl)
Rgs1GeneProductENSMUSG00000026358 (Ensembl)
Rnase6GeneProductENSMUSG00000021880 (Ensembl)
Rps6ka1GeneProductENSMUSG00000003644 (Ensembl)
Runx3GeneProductENSMUSG00000070691 (Ensembl)
Samsn1GeneProductENSMUSG00000022876 (Ensembl)
Sft2d2GeneProductENSMUSG00000040848 (Ensembl)
Sh2b3GeneProductENSMUSG00000042594 (Ensembl)
Slc1a5GeneProductENSMUSG00000001918 (Ensembl)
Slc7a7GeneProductENSMUSG00000000958 (Ensembl)
Spp1GeneProductENSMUSG00000029304 (Ensembl)
Stat5aGeneProductENSMUSG00000004043 (Ensembl)
Tcirg1GeneProductENSMUSG00000001750 (Ensembl)
Tgfbr1GeneProductENSMUSG00000007613 (Ensembl)
Tmem106aGeneProductENSMUSG00000034947 (Ensembl)
Tnfrsf1bGeneProductENSMUSG00000028599 (Ensembl)
TyrobpGeneProductENSMUSG00000030579 (Ensembl)
Zfp36l2GeneProductENSMUSG00000045817 (Ensembl)

Annotated Interactions

No annotated interactions

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