Hippo-Merlin signaling dysregulation (Homo sapiens)

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1CadherinCDH5PRKAR1BCDH17CDH16PRKACBCDH11PRKAR2ACDH15CDH22CDH10CDH1PRKACGCDH8CDH19CDH20CDH13PRKAR2BCDH18CDH6PRKACACDH3CDH24PRKAR1ACDH7CDH9CDH4CDH12CDH2NucleusLATS2STK3LATS1YY1AP1NF2TAZMST1TEAD1YY1AP1TAZTEAD2TEAD3TEAD4FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKRTKFLT3NTRK1NTRK2PKA


Description

Fig 1 - under construction

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sekido Y; ''Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma.''; Cancers (Basel), 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128259view00:23, 30 January 2024EweitzStandardize case
127212view19:44, 17 August 2023Khanspersupdated YAP/TAZ and added phosphosites
116745view16:33, 11 May 2021AlexanderPicoReverted to version '04:01, 11 May 2021' by AlexanderPico
116744view16:29, 11 May 2021AlexanderPicoReverted to version '02:44, 1 March 2019' by AlexanderPico
116738view11:01, 11 May 2021EweitzOntology Term : 'DOID:1790' removed !
116737view11:00, 11 May 2021EweitzOntology Term : 'PW:0000003' removed !
116736view11:00, 11 May 2021EweitzOntology Term : 'PW:0001515' removed !
116735view11:00, 11 May 2021EweitzOntology Term : 'PW:0000013' removed !
116734view10:59, 11 May 2021EweitzModified title
103434view09:44, 1 March 2019Marvin M2Connected last unconnected line
103355view00:00, 23 February 2019AlexanderPicoOntology Term : 'signaling pathway' added !
103354view00:00, 23 February 2019AlexanderPicoOntology Term : 'disease pathway' added !
103353view23:59, 22 February 2019AlexanderPicoOntology Term : 'altered Hippo signaling pathway' added !
103352view23:59, 22 February 2019AlexanderPicoOntology Term : 'Hippo signaling pathway' added !
103351view23:59, 22 February 2019AlexanderPicoOntology Term : 'malignant mesothelioma' added !
103350view23:59, 22 February 2019AlexanderPicoModified description
103349view23:51, 22 February 2019AlexanderPicofixed curved line paths
103348view23:48, 22 February 2019AlexanderPicocompleted model
103315view01:15, 22 February 2019AlexanderPicoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CDH10GeneProduct1008 (Entrez Gene) Cadherin
CDH11GeneProduct1009 (Entrez Gene) Cadherin
CDH12GeneProduct1010 (Entrez Gene) Cadherin
CDH13GeneProduct1012 (Entrez Gene) Cadherin
CDH15GeneProduct1013 (Entrez Gene) Cadherin
CDH16GeneProduct1014 (Entrez Gene) Cadherin
CDH17GeneProduct1015 (Entrez Gene) Cadherin
CDH18GeneProduct1016 (Entrez Gene) Cadherin
CDH19GeneProduct28513 (Entrez Gene) Cadherin
CDH1GeneProduct999 (Entrez Gene) Cadherin
CDH20GeneProduct28316 (Entrez Gene) Cadherin
CDH2GeneProduct1000 (Entrez Gene) Cadherin
CDH22GeneProduct64405 (Entrez Gene) Cadherin
CDH24GeneProduct64403 (Entrez Gene) Cadherin
CDH3GeneProduct1001 (Entrez Gene) Cadherin
CDH4GeneProduct1002 (Entrez Gene) Cadherin
CDH5GeneProduct1003 (Entrez Gene) Cadherin
CDH6GeneProduct1004 (Entrez Gene) Cadherin
CDH7GeneProduct1005 (Entrez Gene) Cadherin
CDH8GeneProduct1006 (Entrez Gene) Cadherin
CDH9GeneProduct1007 (Entrez Gene) Cadherin
CSF1RGeneProductENSG00000182578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
EGFRGeneProductENSG00000146648 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
EPHA2GeneProductENSG00000142627 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
FGFR1GeneProductENSG00000077782 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
FGFR2GeneProductENSG00000066468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
FGFR3GeneProductENSG00000068078 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
FGFR4GeneProductENSG00000160867 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1GeneProductENSG00000102755 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT3GeneProductENSG00000122025 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
FLT4GeneProductENSG00000037280 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
IGF1RGeneProductENSG00000140443 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
INSRGeneProductENSG00000171105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
KDRGeneProductENSG00000128052 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
KITGeneProductENSG00000157404 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
LATS1GeneProduct9113 (Entrez Gene) LATS1/2
LATS2GeneProduct26524 (Entrez Gene) LATS1/2
METGeneProductENSG00000105976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
MST1GeneProduct4485 (Entrez Gene) MST1/2
NF2GeneProduct4771 (Entrez Gene) Nf2
NGFRGeneProductENSG00000064300 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
NTRK1GeneProductENSG00000198400 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2GeneProductENSG00000148053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
PDGFRAGeneProductENSG00000134853 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRBGeneProductENSG00000113721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
PRKACAGeneProduct5566 (Entrez Gene) PKA
PRKACBGeneProduct5567 (Entrez Gene) PKA
PRKACGGeneProduct5568 (Entrez Gene) PKA
PRKAR1AGeneProduct5573 (Entrez Gene) PKA
PRKAR1BGeneProduct5575 (Entrez Gene) PKA
PRKAR2AGeneProduct5576 (Entrez Gene) PKA
PRKAR2BGeneProduct5577 (Entrez Gene) PKA
STK3GeneProduct6788 (Entrez Gene) MST1/2
TAZGeneProduct6901 (Entrez Gene) YAP/TAZ
TEAD1GeneProductENSG00000187079 (Ensembl)
TEAD2GeneProductENSG00000074219 (Ensembl)
TEAD3GeneProductENSG00000007866 (Ensembl)
TEAD4GeneProductENSG00000197905 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
YY1AP1GeneProduct55249 (Entrez Gene) YAP/TAZ

Annotated Interactions

No annotated interactions

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