Neural crest cell migration during development (Homo sapiens)
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Description
During normal neuronal development, neural crest cells participate in migration and invasion processes. The growth factor, BDNF, binds to and activates NGFR (p75^NTR) in various contexts, invoking signaling pathways that lead to transcriptional activation in the nucleus.
Quality Tags
Ontology Terms
Bibliography
- Wislet S, Vandervelden G, Rogister B; ''From Neural Crest Development to Cancer and Vice Versa: How p75NTRand (Pro)neurotrophins Could Act on Cell Migration and Invasion?''; Front Mol Neurosci, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | 207 (Entrez Gene) | AKT |
AKT2 | GeneProduct | 208 (Entrez Gene) | AKT |
AKT3 | GeneProduct | 10000 (Entrez Gene) | AKT |
ARF1 | GeneProduct | 375 (Entrez Gene) | |
BDNF | GeneProduct | 627 (Entrez Gene) | BDNF |
CDH11 | GeneProduct | 1009 (Entrez Gene) | Cadherin |
EPHB1 | GeneProduct | 2047 (Entrez Gene) | MMP |
EPHB2 | GeneProduct | 2048 (Entrez Gene) | MMP |
EPHB3 | GeneProduct | 2049 (Entrez Gene) | MMP |
EPHB4 | GeneProduct | 2050 (Entrez Gene) | MMP |
EPHB6 | GeneProduct | 2051 (Entrez Gene) | MMP |
F2RL2 | GeneProduct | 2151 (Entrez Gene) | MMP |
FOS | GeneProduct | 2353 (Entrez Gene) | AP-1 |
JUN | GeneProduct | 3725 (Entrez Gene) | JUN/AP |
MMP2 | GeneProduct | 4313 (Entrez Gene) | MMP2 |
MMP8 | GeneProduct | 4317 (Entrez Gene) | MMP |
MMP9 | GeneProduct | 4318 (Entrez Gene) | MMP |
NGEF | GeneProduct | 25791 (Entrez Gene) | |
NGFR | GeneProduct | 4804 (Entrez Gene) | p75(NTR) |
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PAK2 | GeneProduct | 5062 (Entrez Gene) | |
PAK3 | GeneProduct | 5063 (Entrez Gene) | |
PAK4 | GeneProduct | 10298 (Entrez Gene) | |
PAK5 | GeneProduct | 57144 (Entrez Gene) | |
PAK6 | GeneProduct | 56924 (Entrez Gene) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | PI3K |
PIK3CB | GeneProduct | 5291 (Entrez Gene) | PI3K |
PIK3CD | GeneProduct | 5293 (Entrez Gene) | PI3K |
PIK3CG | GeneProduct | 5294 (Entrez Gene) | PI3K |
PIK3R3 | GeneProduct | 8503 (Entrez Gene) | PI3K |
PIK3R4 | GeneProduct | 30849 (Entrez Gene) | PI3K |
PIK3R5 | GeneProduct | 23533 (Entrez Gene) | PI3K |
PIK3R6 | GeneProduct | 146850 (Entrez Gene) | PI3K |
RAC1 | GeneProduct | 5879 (Entrez Gene) | |
RHOA | GeneProduct | 387 (Entrez Gene) | RhoA |
STAT3 | GeneProduct | 6774 (Entrez Gene) | STAT3 |
TIAM1 | GeneProduct | 7074 (Entrez Gene) | Tiam |
TRIO | GeneProduct | 7204 (Entrez Gene) | TRIO |
TWIST1 | GeneProduct | 7291 (Entrez Gene) | Twist1, |
Annotated Interactions
No annotated interactions