Ethanol metabolism resulting in production of ROS by CYP2E1 (Rattus norvegicus)

From WikiPathways

Revision as of 13:45, 17 September 2019 by MaintBot (Talk | contribs)
Jump to: navigation, search
12-Difluoromethoxy-2,2-difluoroacetic acidPKCζ siRNAARENucleusROSPPSISP600125PromoterStressors converted by CYP2E1siRNAStaurosporineFluorideTrifluoroacetic acidMafg6-HydroxychlorzoxazoneVitamin CHalothaneSp1EthanolNfe2l2ChlorzoxazoneIsofluraneDiallyl sulfideNAPQIMapk8acetaldehydeMaffEnfluraneU0126MafkMethoxyfluraneAcetaminophenCyp2e1Map2k2Map2k1Protein kinase CSevofluranePSp1Nfe2l2SubstrateOutcome metaboliteFluorideFluorideCyp2e1Cyp2e1


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for human and mouse.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129195view16:39, 15 March 2024EgonwOntology Term : 'ethanol oxidation pathway' added !
106992view13:45, 17 September 2019MaintBotHMDB identifier normalization
104896view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98052view05:54, 13 July 2018Fehrhartlayout
98051view05:52, 13 July 2018Fehrhartsome layout work
97871view12:02, 12 June 2018Marvin M2Modified description
97141view11:53, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-HydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
AcetaminophenMetaboliteCHEBI:46195 (ChEBI)
ChlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
EthanolMetaboliteCHEBI:16236 (ChEBI)
FluorideMetaboliteCHEBI:17051 (ChEBI)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsofluraneMetaboliteCHEBI:6015 (ChEBI)
MaffGeneProductENSRNOG00000012886 (Ensembl)
MafgGeneProductENSRNOG00000036697 (Ensembl)
MafkGeneProductENSRNOG00000001277 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Map2k2GeneProductENSRNOG00000020005 (Ensembl)
Mapk8GeneProductENSRNOG00000020155 (Ensembl)
MethoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSRNOG00000001548 (Ensembl)
Protein kinase CProteinA0A0G2K5Q0 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSRNOG00000014084 (Ensembl)
StaurosporineMetaboliteCHEBI:57491 (ChEBI)
Trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)
U0126MetaboliteCHEBI:90693 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)

Annotated Interactions

No annotated interactions

Personal tools