Extracellular vesicle-mediated signaling in recipient cells (Homo sapiens)

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1RTKPackaging of proteinsEGFRvIIIRTK ligandMultivesicular bodiesRecipient cellHost cellExosomeRAF1FrizzledCD133TGFB1SMAD3TGFB3MFGE8APCTGFAPI3KEGFRMAPKSMAD4TGFBR3CTNNB1WNT3AWNT5AMTORHGFRERBB2DKK4AXIN1AKT1TGFBR1TGFB2NRASHRASWNTSMAD2TGFBR2TGFB1KRASTSPAN8HGFMutant KRASPPExosome mediatedsignal transductionAKT1


Description

Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells. This pathway is part the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

  1. Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S; ''Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?''; Proteomics, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129825view22:57, 22 May 2024EweitzRefine node types for RTK, PI3K
129824view22:53, 22 May 2024EweitzPoint PI3K to gene family
129820view22:29, 22 May 2024EweitzPoint RTK to gene family
106411view21:57, 28 August 2019KhanspersModified description
105591view04:46, 10 August 2019KhanspersModified description
88052view13:46, 25 July 2016SusanOntology Term : 'signaling pathway' added !
79555view12:46, 25 March 2015ZariAdded ID for NRAS and TGFBR2 genes
78078view23:48, 30 November 2014Khanspersconnected interaction
78004view19:34, 5 November 2014AlexanderPicoclarified exsome zoom
77982view18:01, 4 November 2014KhanspersOntology Term : 'nervous system disease' added !
77981view18:00, 4 November 2014KhanspersModified description
77980view17:55, 4 November 2014KhanspersAdded lit ref
77953view19:31, 30 October 2014KhanspersOntology Term : 'cancer' added !
77952view19:30, 30 October 2014Khanspersminor edit
77951view19:28, 30 October 2014KhanspersModified description
77950view19:27, 30 October 2014KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CD133GeneProduct8842 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DKK4GeneProduct27121 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
FrizzledGeneProduct
HGFGeneProduct3082 (Entrez Gene)
HGFRGeneProduct4233 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAPKGeneProduct
MFGE8GeneProduct4240 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
NRASProtein4893 (Entrez Gene)
PI3K GeneProduct23533 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TGFAGeneProduct7039 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2Protein7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TSPAN8GeneProduct7103 (Entrez Gene)
WNTGeneProduct
WNT3AGeneProduct89780 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)

Annotated Interactions

No annotated interactions

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