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1 Degradation Chemotaxis NO induction MAP2K1 GNAI2 SHC3 Ccl2 GNG11 GNG8 NCF1 PTK2 CXCR5 Gm12844 NFKB1 STAT5B ADCY3 Ubiquitin mediated proteolysis GNB3 GRK1 ADCY4 CCL28 Leukocyte transendothelial migration ADCY8 Gm11787 PIK3R2 CXCL12 ADCY6 CCL19 PREX1 PLCB4 CSK Gm5741 HRAS ROCK1 AKT3 PRKACB Diacylglycerol PIK3R3 CCL4 JAK2 CCL21 Cxcl15 c-C motif chemokine 12-like Phosphatidylinositol-3,4,5-trisphosphate CCL15 CCR1 PXN CXCR2 Cytokine-cytokine receptor interaction PRKCZ RAC1 ROCK2 Gm3785 D-myo-Inositol 1,4,5-trisphosphate CRKL PTK2B XCR1 CCR1 GNG3 CXCL9 GNG12 KRAS Regulation of actin cytoskeleton RASGRP2 CCL22 MAPK signaling pathway XCL1 CCL15 BCAR1 AKT1 CCL3 CCL24 TIAM1 GNG10 Rhoa CRK CCR3 JAK3 CCR7 IKBKG CX3CR1 CXCL11 CCL25 CCR10 CXCR4 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like CCR8 GNG7 PIK3CD NFKBIB PIK3R1 GNB1 GNG4 CCL21 ADCY5 CHUK CCR4 CXCL14 VAV3 VAV1 ELMO1 RAP1A CXCR2 GNB5 GNAI1 ADCY9 PLCB2 HCK CDC42 SOS1 GRK4 RELA Jak-STAT signaling pathway CCR2 DOCK2 WASL 3',5'-Cyclic AMP PRKCB NRAS CCL27 SOS2 Calcium PLCB1 PRKCD Gm4356 ADCY2 MAPK1 GNG13 ARRB2 PIK3CG CCL5 RAP1B CXCL3 CCL1 STAT3 CCR9 GNB2 RAF1 CCL19 STAT1 CCL27 ITK GRK6 GNG5 PIK3CA ADCY1 CXCL16 IKBKB GRB2 PAK1 LYN CXCR3 CCR2 GNAI3 PARD3 AKT2 CXCR6 AC006486.9 CCL17 PRKACG FOXO3 PRKCZ CCL7 RAC2 STAT2 GNB4 PLCB3 GSK3B FGR BRAF PIK3CB VAV2 PIK3R5 SHC2 PPBP GNG2 Ccl8 SHC1 CCR6 CXCL13 GRK2 CXCL10 GNG5 NFKBIA ADCY7 CCL11 SHC4 GRK5 CXCL3 MAPK3 PRKX CCL26 WAS ARRB1 CX3CL1 PF4 CCL20 CCL7 GNGT1 GNGT2 TIAM2 CXCL5 ROS production Receptor internalization Migration Chemotaxis Cellular shape changes Metestasis Degranulation ROS production Cytokine production Cellular growth and differentiation Cell survival Migration Apoptosis
Description
Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as chemoattractants in guiding migration of cells. Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization.
This pathway was adapted from KEGG
Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
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