MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Troponin CCalcium selective/non-selectivecation channelIncrease cell motilityActivated JUN forms transcription complex with cofactorIncrease traction forceTroponin C interacts with F-actinTranscription of Troponin COvarian Cancer CellExtracellular calcium sourceCofactorPJUNTroponin CPCREB1IP3MFAP5TNNC1RYR3DAGPLCG1PIP2FAKPRKCQITPR3Ca2+Ca2+Ca2+Ca2+Ca2+ERK2ERK1ITGB3ITGAVCancer-associated stromal fibroblasts(CAFs)Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationPFAKPPRKCQPPLCG1CofactorPCREB1Transcription of JunCREB1PERK2PERK1JUNName: MFAP5-mediated ovarian cancer cell motility and invasivenessOrganism: Homo sapiens


Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in Leung et al.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137085
Approved
view22:01, 27 February 2025KhanspersModified description
127230view20:08, 25 August 2023Khanspersadded lit ref and updated description
127188view22:11, 9 August 2023Khanspersupdated phosphosites
126996view19:27, 14 July 2023Khanspersclarify interactions, updated labels, some reactions
120029
CPTAC
view23:19, 15 October 2021Khanspersupdated phosphosites
108104view10:16, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteHMDB0007098 (HMDB)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
TNNC1GeneProductENSG00000114854 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

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