Cholesterol metabolism (Rattus norvegicus)

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1, 2Sterol regulatory elementSterol responsive genesApoc1Sc5dIDLLipcLdlrSqleLrp1Dhcr7CholesterolLanosterinHmgcs1HMG-CoAMevalonateMevalonate PyrophosphatVLDLCholesterolDimethylallylpyrophosphateCholesterol esterLplFatty Acid CoALDLLssDehydrocholesterolHDLSc4molNsdhlIdi1LathosterolSrebf1Fdft1Acetoacetyl-CoAMVKMvdSqualeneSoat1Acetyl-CoAFarnesyl pyrophosphateApoc2Apoe(S)-2,3-EpoxysqualeneHmgcrIsopentenyl pyrophosphateFdpsGeranyl pyrophosphateScarb1Nucleus


Description

Cholesterol is essential for life - it's a required for the regulation of membrane fluidity. Cholesterol also serves as a precursor for many other biochemical pathways.

Cholesterol is synthesized throughout the body but mainly in liver, intestines, adrenal glands and reproductive organs. Synthesis starts with the combination of Acetyl-CoA and Acetoacetyl-CoA. An important intemediary in the synthesis of cholesterol is mevalonate.

Synthesis of cholesterol is regulated by a homeostatic mechanism.

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Ontology Terms

 

Bibliography

  1. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB; ''Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins.''; EMBO J, 1997 PubMed Europe PMC Scholia
  2. Wassmann S, Nickenig G; ''Improvement of Endothelial Function by HMG-CoA Reductase Inhibitors.''; Drug News Perspect, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114498view07:34, 18 January 2021EgonwTranslocation
107002view13:46, 17 September 2019MaintBotHMDB identifier normalization
83034view02:57, 18 November 2015Mkutmonfixed issue with literature reference
83033view02:56, 18 November 2015Mkutmonfix outdated identifiers and improved layout
77527view17:45, 22 September 2014KhanspersOntology Term : 'arterial occlusive disease pathway' added !
72578view16:02, 23 November 2013EgonwReplace a revoked HMDB id with a ChEBI id.
69457view19:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
69093view18:11, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
67117view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol metabolic pathway' added !
58977view18:46, 21 February 2013MaintBotUpdated Ensembl data source
48279view23:30, 17 May 2012KhanspersUpdating PubChem xrefs
48268view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45002view15:52, 6 October 2011Mkutmonconnecting lines
41788view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
34153view19:37, 9 December 2009MaintBotAutomatic update of empty xrefs
33394view14:45, 30 November 2009MaintBotRemoved group label
29751view23:02, 1 June 2009KhanspersFixed literature references
29748view22:55, 1 June 2009KhanspersModified categories
28543view14:58, 11 February 2009I450472Specify description
28486view13:34, 11 February 2009I450472Periodical save, work in progress
28477view13:23, 11 February 2009I450472Periodical save, work in progress
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28242view14:42, 10 February 2009SusanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetaboliteHMDB0001188 (HMDB)
Acetoacetyl-CoAMetaboliteHMDB0001484 (HMDB)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Apoc1GeneProductENSRNOG00000018426 (Ensembl)
Apoc2GeneProductENSRNOG00000018402 (Ensembl)
ApoeGeneProductENSRNOG00000018454 (Ensembl)
Cholesterol esterMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteHMDB0000067 (HMDB)
DehydrocholesterolMetaboliteHMDB0000032 (HMDB)
Dhcr7GeneProductENSRNOG00000020776 (Ensembl)
DimethylallylpyrophosphateMetaboliteHMDB0001120 (HMDB)
Farnesyl pyrophosphateMetaboliteHMDB0000961 (HMDB)
Fatty Acid CoAMetabolite
Fdft1GeneProductENSRNOG00000021314 (Ensembl)
FdpsGeneProduct83791 (Entrez Gene)
Geranyl pyrophosphateMetaboliteHMDB0001285 (HMDB)
HDLMetabolite
HMG-CoAMetaboliteHMDB0001375 (HMDB)
HmgcrGeneProduct25675 (Entrez Gene)
Hmgcs1GeneProduct29637 (Entrez Gene)
IDLMetabolite
Idi1GeneProductENSRNOG00000016690 (Ensembl)
Isopentenyl pyrophosphateMetaboliteHMDB0001347 (HMDB)
LDLMetabolite
LanosterinMetaboliteHMDB0001251 (HMDB)
LathosterolMetaboliteHMDB0001170 (HMDB)
LdlrGeneProductENSRNOG00000009946 (Ensembl)
LipcGeneProductENSRNOG00000060338 (Ensembl)
LplGeneProductENSRNOG00000012181 (Ensembl)
Lrp1GeneProduct299858 (Entrez Gene)
LssGeneProductENSRNOG00000054549 (Ensembl)
MVKGeneProduct81727 (Entrez Gene)
Mevalonate PyrophosphatMetaboliteHMDB0001981 (HMDB)
MevalonateMetaboliteHMDB0000227 (HMDB)
MvdGeneProductENSRNOG00000013376 (Ensembl)
NsdhlGeneProductENSRNOG00000057814 (Ensembl)
Sc4molGeneProductENSRNOG00000032297 (Ensembl)
Sc5dGeneProductENSRNOG00000008305 (Ensembl)
Scarb1GeneProductENSRNOG00000000981 (Ensembl)
Soat1GeneProductENSRNOG00000004111 (Ensembl)
SqleGeneProductENSRNOG00000009550 (Ensembl)
SqualeneMetaboliteHMDB0000256 (HMDB)
Srebf1GeneProductENSRNOG00000003463 (Ensembl)
VLDLMetabolite

Annotated Interactions

No annotated interactions

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