Leptin and adiponectin (Homo sapiens)
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ArcPathVisio
Brace
Ellipse
EndoplasmicReticulum
GolgiApparatus
HexagonPathVisio
MimDegradation
Mitochondria
Octagon
PentagonPathVisio
Rectangle
RoundedRectangle
SarcoplasmicReticulum
TriangleEquilateralEast
TrianglePathVisio
none
beta-oxidation
Mitochondrion
ADIPOR1
Fatty acid
LEP
Fatty acid
ADIPOR2
ACACA
Acetyl-CoA
LEPR
CPT1A
ADIPOQ
Malonyl-CoA
PRKAA1
PRKAB1
PRKAG1
Name: Leptin and adiponectin
Organism: Homo sapiens
Description
Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in
Dyck et al.
.
Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway "Leptin and adiponectin", WP683 revision 71946, with a 100.0% conversion rate.
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Quality Tags
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Ontology Terms
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Pathway Ontology
:
Disease
:
Cell Type
:
Bibliography
Dyck DJ, Heigenhauser GJ, Bruce CR; ''The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.''; Acta Physiol (Oxf), 2006
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
138699
view
19:23, 29 April 2025
Khanspers
Update cell shape, increase label font size, updated layout
137956
view
20:54, 10 March 2025
Khanspers
Modified description
107151
view
14:23, 17 September 2019
MaintBot
ChEBI identifier normalization
106628
view
20:54, 12 September 2019
Khanspers
Modified description
105634
view
05:05, 10 August 2019
Khanspers
Modified description
90768
view
01:17, 14 December 2016
Khanspers
Ontology Term : 'glucose metabolism disease' added !
90767
view
01:16, 14 December 2016
Khanspers
Ontology Term : 'leptin system pathway' added !
90766
view
01:16, 14 December 2016
Khanspers
Ontology Term : 'adiponectin signaling pathway' added !
90765
view
01:16, 14 December 2016
Khanspers
updated source pathway information
90764
view
01:15, 14 December 2016
Khanspers
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACACA
GeneProduct
ENSG00000278540 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107476
ADIPOQ
GeneProduct
ENSG00000181092 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ADIPOR1
GeneProduct
ENSG00000159346 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72674
ADIPOR2
GeneProduct
ENSG00000006831 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68465
Acetyl-CoA
Metabolite
CHEBI:15351 (ChEBI)
CPT1A
GeneProduct
ENSG00000110090 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
Fatty acid
Metabolite
CHEBI:35366 (ChEBI)
LEP
GeneProduct
ENSG00000174697 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16846
LEPR
GeneProduct
ENSG00000116678 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
Malonyl-CoA
Metabolite
CHEBI:15531 (ChEBI)
PRKAA1
GeneProduct
ENSG00000132356 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAB1
GeneProduct
ENSG00000111725 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19079
PRKAG1
GeneProduct
ENSG00000181929 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19082
Annotated Interactions
No annotated interactions
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