IL18 signaling (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Rex DAB, Agarwal N, Prasad TSK, Kandasamy RK, Subbannayya Y, Pinto SM; ''A comprehensive pathway map of IL-18-mediated signalling.''; J Cell Commun Signal, 2019 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	129677	view	00:45, 22 May 2024	Eweitz	Modified title
	126321	view	05:20, 21 April 2023	Egonw	License is CCZero
	115147	view	06:57, 29 January 2021	Rex D A B	Modified title
	110011	view	18:31, 12 April 2020	Egonw	Fixed the data source for NCBI Protein identifiers.
	108627	view	18:33, 13 January 2020	Khanspers	converted interactions to graphical lines in legend
	108624	view	11:00, 13 January 2020	Subbannayya	added literature reference
	108623	view	10:57, 13 January 2020	Subbannayya	Modified description
	108059	view	10:24, 27 November 2019	Subbannayya	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
AARS	Rna	16 (Entrez Gene)
ABCF1	Rna	23 (Entrez Gene)
ABHD16A	Rna	7920 (Entrez Gene)
ACACB	GeneProduct	32 (Entrez Gene)
ACADS	Rna	35 (Entrez Gene)
ACOD1	Rna	730249 (Entrez Gene)
ACTA1	Rna	58 (Entrez Gene)
ACTA2	Rna	59 (Entrez Gene)
ADAMTS5	Rna	11096 (Entrez Gene)
ADIPOQ	Rna	9370 (Entrez Gene)
AKT1	GeneProduct	NP_005154.2 (Entrez Gene)
ALS2	Rna	57679 (Entrez Gene)
AMPK1	GeneProduct	5562 (Entrez Gene)
ANP32A	Rna	8125 (Entrez Gene)
APBA2	Rna	321 (Entrez Gene)
ARF6	Rna	382 (Entrez Gene)
ARFGAP1	Rna	55738 (Entrez Gene)
ARFGAP2	Rna	84364 (Entrez Gene)
ARG1	Rna	383 (Entrez Gene)
ARL4D	Rna	379 (Entrez Gene)
ATF2	Rna	467 (Entrez Gene)
ATF3	Rna	467 (Entrez Gene)
B2M	Rna	567 (Entrez Gene)
BAD	Rna	572 (Entrez Gene)
BAX	GeneProduct	581 (Entrez Gene)
BAZ1B	Rna	9031 (Entrez Gene)
BCL2	Rna	596 (Entrez Gene)
BCL2L1	Rna	598 (Entrez Gene)
BID	GeneProduct	637 (Entrez Gene)
BIN1	Rna	274 (Entrez Gene)
BIRC3	Rna	330 (Entrez Gene)
BMP2	Rna	650 (Entrez Gene)
BPGM	Rna	669 (Entrez Gene)
BSG	Rna	682 (Entrez Gene)
BTG2	Rna	7832 (Entrez Gene)
CA11	Rna	770 (Entrez Gene)
CASP3	GeneProduct	836 (Entrez Gene)
CASP8	GeneProduct	841 (Entrez Gene)
CCDC9	Rna	26093 (Entrez Gene)
CCL1	Rna	6346 (Entrez Gene)
CCL18	Rna	6362 (Entrez Gene)
CCL19	Rna	6363 (Entrez Gene)
CCL20	Rna	6364 (Entrez Gene)
CCL2	Rna	6347 (Entrez Gene)
CCL3	Rna	6348 (Entrez Gene)
CCL4	Rna	6351 (Entrez Gene)
CCL5	Rna	6352 (Entrez Gene)
CCN4	Rna	8840 (Entrez Gene)
CCNA2	Rna	890 (Entrez Gene)
CCNB2	Rna	9133 (Entrez Gene)
CD36	Rna	948 (Entrez Gene)
CD81	Rna	975 (Entrez Gene)
CD83	Rna	9308 (Entrez Gene)
CDK5R2	Rna	8941 (Entrez Gene)
CEBPB	GeneProduct	1051 (Entrez Gene)
CENPB	Rna	1059 (Entrez Gene)
CETP	Rna	1071 (Entrez Gene)
CFLAR	GeneProduct	8837 (Entrez Gene)
CHUK	GeneProduct	1147 (Entrez Gene)
CLDN12	Rna	9069 (Entrez Gene)
CLDN15	Rna	24146 (Entrez Gene)
CLDN1	Rna	9076 (Entrez Gene)
CLDN3	Rna	1365 (Entrez Gene)
CLDN4	Rna	1364 (Entrez Gene)
CNTN2	Rna	6900 (Entrez Gene)
COL1A1	Rna	1277 (Entrez Gene)
COL1A2	Rna	1278 (Entrez Gene)
COL3A1	Rna	1281 (Entrez Gene)
COX17	Rna	10063 (Entrez Gene)
CPT1A	Rna	1374 (Entrez Gene)
CREB1	GeneProduct	NP_604391.1 (Entrez Gene)
CRYGC	Rna	1420 (Entrez Gene)
CSN2	GeneProduct	1447 (Entrez Gene)
CTNNB1	GeneProduct	1499 (Entrez Gene)
CXCL16	Rna	58191 (Entrez Gene)
CXCL2	Rna	2920 (Entrez Gene)
CXCL3	Rna	2921 (Entrez Gene)
CXCL8	Rna	3576 (Entrez Gene)
CYCS	GeneProduct	54205 (Entrez Gene)
DEK	Rna	7913 (Entrez Gene)
DES	Rna	1674 (Entrez Gene)
ECH1	Rna	1891 (Entrez Gene)
EEF2	Rna	1938 (Entrez Gene)
ELAVL1	GeneProduct	1994 (Entrez Gene)
ELK1	GeneProduct	NP_001107595.1 (Entrez Gene)
ENO1	Rna	2023 (Entrez Gene)
EPB41	Rna	2035 (Entrez Gene)
EPS8	Rna	2059 (Entrez Gene)
FADD	Rna	8772 (Entrez Gene)
FAM110A	Rna	83541 (Entrez Gene)
FAM186B	Rna	84070 (Entrez Gene)
FAS	GeneProduct	355 (Entrez Gene)
FASLG	GeneProduct	356 (Entrez Gene)
FBXW7	Rna	55294 (Entrez Gene)
FN1	Rna	2335 (Entrez Gene)
FOS	Rna	2353 (Entrez Gene)
FOXN3	Rna	1112 (Entrez Gene)
FUT1	Rna	2523 (Entrez Gene)
GATA1	GeneProduct	2623 (Entrez Gene)
GPAT4	Rna	137964 (Entrez Gene)
GRIN2B	GeneProduct	2904 (Entrez Gene)
GRM7	Rna	2917 (Entrez Gene)
GRN	Rna	2896 (Entrez Gene)
GSK3A	GeneProduct	NP_002084.2 (Entrez Gene)
GSK3B	GeneProduct	2932 (Entrez Gene)
HADH	Rna	3033 (Entrez Gene)
HCAR2	Rna	338442 (Entrez Gene)
HDAC3	Rna	8841 (Entrez Gene)
HDGF	Rna	3068 (Entrez Gene)
HMOX1	Rna	3162 (Entrez Gene)
HOXD8	Rna	3234 (Entrez Gene)
HPS1	Rna	3257 (Entrez Gene)
HSPB1	GeneProduct	3315 (Entrez Gene)
HSPB8	Rna	26353 (Entrez Gene)
ICAM1	Rna	3383 (Entrez Gene)
IER3	Rna	8870 (Entrez Gene)
IFNG	Rna	3458 (Entrez Gene)
IKBKB	GeneProduct	3551 (Entrez Gene)
IL-18BP	GeneProduct	10068 (NCBI Protein)
IL10	Rna	3586 (Entrez Gene)
IL12B	Rna	3593 (Entrez Gene)
IL13	Rna	3596 (Entrez Gene)
IL17RC	Rna	84818 (Entrez Gene)
IL18	Rna	3606 (Entrez Gene)
IL18BP	Rna	10068 (Entrez Gene)
IL18R1	Rna	8809 (Entrez Gene)
IL18RAP	Rna	8807 (Entrez Gene)
IL1B	Rna	3553 (Entrez Gene)
IL2RA	Rna	3559 (Entrez Gene)
IL37	Protein	27178 (Entrez Gene)
IL6	Rna	3569 (Entrez Gene)
IL9	Rna	3578 (Entrez Gene)
IMP3	GeneProduct	55272 (Entrez Gene)
IRAK1	Protein	3654 (Entrez Gene)
IRAK4	GeneProduct	12682231 (Entrez Gene)
IRF1	GeneProduct	3659 (Entrez Gene)
IRF6	Rna	3664 (Entrez Gene)
ITGA2B	Rna	3674 (Entrez Gene)
ITM2C	Rna	81618 (Entrez Gene)
JUN	Rna	3725 (Entrez Gene)
JUN	GeneProduct	NP_002219.1 (Entrez Gene)
KCNH2	Rna	3757 (Entrez Gene)
KIFC3	Rna	3801 (Entrez Gene)
KITLG	Rna	4254 (Entrez Gene)
KLC1	Rna	3831 (Entrez Gene)
KLF2	Rna	10365 (Entrez Gene)
KRT31	Rna	3881 (Entrez Gene)
LARS2	Rna	23395 (Entrez Gene)
LCK	GeneProduct	3932 (Entrez Gene)
LMNB2	Rna	84823 (Entrez Gene)
LONP2	Rna	83752 (Entrez Gene)
LRRFIP1	Rna	9208 (Entrez Gene)
LTB	Rna	4050 (Entrez Gene)
MAP2K7	GeneProduct	5609 (Entrez Gene)
MAP3K7	GeneProduct	6885 (Entrez Gene)
MAPK14	GeneProduct	NP_001306.1 (Entrez Gene)
MAPK1	GeneProduct	5594 (Entrez Gene)
MAPK3	GeneProduct	5595 (Entrez Gene)
MAPK8	GeneProduct	NP_620637.1 (Entrez Gene)
MAPK9	GeneProduct	5601 (Entrez Gene)
MBTPS1	Rna	8720 (Entrez Gene)
MEF2A	GeneProduct	4205 (Entrez Gene)
MEPCE	Rna	56257 (Entrez Gene)
MMP13	Rna	4322 (Entrez Gene)
MMP1	Rna	4312 (Entrez Gene)
MMP14	Rna	4323 (Entrez Gene)
MMP2	Rna	4313 (Entrez Gene)
MMP3	Rna	4314 (Entrez Gene)
MMP8	Rna	4317 (Entrez Gene)
MMP9	Rna	4318 (Entrez Gene)
MTCH1	Rna	23787 (Entrez Gene)
MYD88	Rna	4615 (Entrez Gene)
MYD88	Protein	4615 (Entrez Gene)
MYH6	Rna	4624 (Entrez Gene)
MYH7	Rna	4625 (Entrez Gene)
NACA	Rna	4666 (Entrez Gene)
NCAPH2	Rna	29781 (Entrez Gene)
NCF1	GeneProduct	653361 (Entrez Gene)
NCF2	GeneProduct	4688 (Entrez Gene)
NDUFC1	Rna	4717 (Entrez Gene)
NFATC4	GeneProduct	4776 (Entrez Gene)
NFKB1	GeneProduct	4790 (Entrez Gene)
NFKB2	Rna	4791 (Entrez Gene)
NFKBIA	Rna	4792 (Entrez Gene)
NFKBIA	GeneProduct	4792 (Entrez Gene)
NFKBIE	Rna	4794 (Entrez Gene)
NFKBIZ	Rna	64332 (Entrez Gene)
NOS2	Rna	4843 (Entrez Gene)
NOX1	GeneProduct	27035 (Entrez Gene)
NPPA	Rna	4878 (Entrez Gene)
NPPB	Rna	4879 (Entrez Gene)
NR0B2	Rna	8431 (Entrez Gene)
NR1H3	Rna	10062 (Entrez Gene)
NR4A1	Rna	3164 (Entrez Gene)
NRN1	Rna	51299 (Entrez Gene)
NSMF	Rna	26012 (Entrez Gene)
PARP1	GeneProduct	142 (Entrez Gene)
PHF20	Rna	51230 (Entrez Gene)
PIGT	Rna	51604 (Entrez Gene)
PIK3R1	GeneProduct	5295 (Entrez Gene)
PKN1	Rna	5585 (Entrez Gene)
PLA2G7	Rna	7941 (Entrez Gene)
PLCG1	Rna	5335 (Entrez Gene)
PLD1	Rna	5337 (Entrez Gene)
PLOD3	Rna	8985 (Entrez Gene)
PPP1R13L	Rna	10848 (Entrez Gene)
PPT2	Rna	9374 (Entrez Gene)
PRCC	Rna	5546 (Entrez Gene)
PRKCA	GeneProduct	5578 (Entrez Gene)
PRKCB	GeneProduct	5579 (Entrez Gene)
PRKCD	GeneProduct	5580 (Entrez Gene)
PRM1	Rna	5619 (Entrez Gene)
PTEN	GeneProduct	5728 (Entrez Gene)
PTGS2	Rna	5743 (Entrez Gene)
PTMS	Rna	5763 (Entrez Gene)
PTPN7	Rna	5778 (Entrez Gene)
PTPRZ1	Rna	5803 (Entrez Gene)
PTX3	Rna	5806 (Entrez Gene)
PWWP3A	Rna	84939 (Entrez Gene)
PYGB	Rna	5834 (Entrez Gene)
Protein	GeneProduct	11 (Entrez Gene)
RAE1	Rna	8480 (Entrez Gene)
RAF1	GeneProduct	NP_001341618.1 (Entrez Gene)
RANGAP1	Rna	5905 (Entrez Gene)
RASA3	Rna	22821 (Entrez Gene)
REL	Rna	5966 (Entrez Gene)
RELA	Rna	5970 (Entrez Gene)
RELA	GeneProduct	5970 (Entrez Gene)
RELB	Rna	5966 (Entrez Gene)
RFX5	Rna	5993 (Entrez Gene)
RGS16	Rna	6004 (Entrez Gene)
RND2	Rna	8153 (Entrez Gene)
RPS11	Rna	6205 (Entrez Gene)
RPS6KB1	GeneProduct	6198 (Entrez Gene)
RPS6	GeneProduct	NP_001001.2 (Entrez Gene)
RPTOR	Rna	57521 (Entrez Gene)
RUNX2	Rna	860 (Entrez Gene)
RUSC1	Rna	23623 (Entrez Gene)
RXRB	Rna	6257 (Entrez Gene)
S1PR4	Rna	8698 (Entrez Gene)
SDC4	Rna	6385 (Entrez Gene)
SEMA6C	Rna	10500 (Entrez Gene)
SEMA6D	Rna	80031 (Entrez Gene)
SLC12A3	GeneProduct	6559 (Entrez Gene)
SLC4A7	Rna	9497 (Entrez Gene)
SNTB1	Rna	6641 (Entrez Gene)
SOCS3	Rna	9021 (Entrez Gene)
SP1	GeneProduct	6667 (Entrez Gene)
SPON1	Rna	10418 (Entrez Gene)
SPP1	Rna	6696 (Entrez Gene)
SRC	GeneProduct	NP_005408.1 (Entrez Gene)
STAT3	GeneProduct	NP_644805.1 (Entrez Gene)
STK40	Rna	83931 (Entrez Gene)
STMN1	Rna	3925 (Entrez Gene)
STOML1	Rna	9399 (Entrez Gene)
SYT10	Rna	341359 (Entrez Gene)
TACR1	Rna	6869 (Entrez Gene)
TBX21	Rna	30009 (Entrez Gene)
TF	Rna	7018 (Entrez Gene)
TGM2	Rna	7052 (Entrez Gene)
TICAM2	GeneProduct	353376 (Entrez Gene)
TIMP1	Rna	7076 (Entrez Gene)
TIMP3	Rna	7078 (Entrez Gene)
TMEM165	Rna	55858 (Entrez Gene)
TMSB4X	Rna	7114 (Entrez Gene)
TNF	GeneProduct	7124 (Entrez Gene)
TNFAIP2	Rna	7127 (Entrez Gene)
TNFAIP3	Rna	7128 (Entrez Gene)
TNFRSF11B	Rna	4982 (Entrez Gene)
TNFRSF1A	GeneProduct	7132 (Entrez Gene)
TNFSF11	Rna	8600 (Entrez Gene)
TNIP3	Rna	79931 (Entrez Gene)
TOMM40	Rna	10452 (Entrez Gene)
TP53	GeneProduct	7157 (Entrez Gene)
TRAF1	Rna	7185 (Entrez Gene)
TRAF6	Protein	7189 (Entrez Gene)
TRPC2	Rna	7221 (Entrez Gene)
TRPC4AP	Rna	26133 (Entrez Gene)
TRPM7	Rna	54822 (Entrez Gene)
TSHZ1	Rna	10194 (Entrez Gene)
UCK1	Rna	83549 (Entrez Gene)
UGGT1	Rna	56886 (Entrez Gene)
UGT2B10	Rna	7365 (Entrez Gene)
ULBP2	Rna	80328 (Entrez Gene)
USP5	Rna	8078 (Entrez Gene)
VEGFA	Rna	7422 (Entrez Gene)
ZBTB7A	Rna	51341 (Entrez Gene)
ZC3H12A	Rna	80149 (Entrez Gene)
ZDHHC7	Rna	55625 (Entrez Gene)
ZNF143	Rna	7702 (Entrez Gene)
ZNF219	Rna	51222 (Entrez Gene)
ZNF444	Rna	55311 (Entrez Gene)

Annotated Interactions

No annotated interactions