TNF-alpha NF-kB signaling pathway (Canis familiaris)

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MTPalmitoylationPlasma membraneCytoplasmDephosphorylationGOProteins in a complex interactionECMolecule in the pathwayAcetylationInhibitionDeubiquitinationDeacetylationCYNucleusPMCY ->NUUbiquitinationExtracellularMethylationCY ->NUSumoylationDemethylationLigandTranslocationRecruitmentReceptorEndosomeEndoplasmic reticulumControlReaction through unknown mechanisms/moleculesEnzyme complexMitochondrionCY ->NUPhosphorylationCY ->NUProteolytic cleavageCY ->NUENMolecular associationDAccession Number: NetPath 9; cellmap:9Glycosylation(Protein-protein interaction)DesumoylationAutophosphorylationNUGolgi apparatusActivationERFANCD2GenePSMD7YWHAHAZI2PIAS3POLR2LSUMO1FADDTNFRSF1BTNFRSF1ACAV1PSMB5BIRC3GNB2L1PKN1BCL3CRADDCASP2RPS11TNIP2TNFRSF11ACAPN3RPL6MCM5TRAF4RPS6KA5RPL30DDX3XPSMC2PSMD1RPL8EIF4A3MCCPSMD6PTPN11SMARCE1MAP3K7IP3IQGAP2SMARCC1NFKB2TRAF2MAP3K1PEBP1SMARCA4SMARCB1CHUKUNC5CLTANKBCL7ANFKBIZPSMD12NKIRAS1ACTL6AKPNA3TNFMAP3K3SMARCC2GSK3BRELACSNK2A1POLR1DIKBKGCD3EAPYWHABRELAPSMC1CHUKKTN1GAB1IKBKELOC480438ZFAND5PAPOLATRAF2IKBKGGeneRIPK3NFKBIALOC480907GTF2ITNIP1RPS6KB1RELNFKB1Gene SymbolSTAT1USP2KPNA6NFKBIAPOLR2HLOC475035CASP3TNFAIP3TRADDPRKACACUL1PRKCZNKIRAS2COPS3FAF1PTK2CASP10WDR68SRCRIPK2LOC486122RELCDC37MAP3K7IP1DAPTNFRSF1APOLR1ENR2C2PSMD13POLR1ACREBBPPDCD2DPF2NFKBIEGLG1FLNAMAP3K3PMLTRADDUBE2IAKAP8PSMC3RASAL2RELBCASP8AP2FBLBIRC2G3BP2UBE2D2SKP1LOC612286TNFNFKB1RIPK1BIRC3BAG4YWHAZALPLMAP3K14TRAF2TIFANALP4YWHAEGeneTNFRELATNFRSF1BRELACOMMD1TRPC4APLRPPRCHSPB1TRAF4TNFRPL4NFKBIBTXLNATBK1POLR1BNFKBIABIRC2RPS13POLR1CRIPK1AKT2CASP7HIST3H3TNFRSF1AUBCH5CBTRCTRAF3PSMD3RNF25MAP2K5GeneFBXW11TRAF6MAP3K2MAP3K8USP11YWHAQTBK1PPP2CACSNK2BRNF216CSNK2A2TNFRSF8CDC34PFDN2CASP8KPNA2FKBP5NR2C2AKT1HSP90AB1LOC487309CYLDMAP3K7IP2IKBKBNFKB1CFLARTNFRSF1BMCM7NSMAFMTIF2TNFMARK2TRAF1TRAF1PEG3RELBKCNQ1IKBKAPTRAIPTNFTRAF5YWHAG


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118009view11:31, 23 May 2021EweitzModified title
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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ZFAND5GeneProduct476324 (Entrez Gene)

Annotated Interactions

No annotated interactions
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