Thyroid hormones production and peripheral downstream signaling effects (Homo sapiens)

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ER104046404415296154611, 12421041411029332158103838489387401584840838153235427484, 308254727283225383440464081536434781631254848838279404814882442154224174093940382481983847273148371510353782242316481940581927237284835381829510333841281584338727251091554831910428403814401621261842481035817, 44BasalmembraneActivationThyroid follicular cellInhibitionGlutathione metabolismCell proliferationNucleusStimulationCell cycle arrestPreoptic areaCold or overfeedingInsulin secretionLipid dropletBloodmTORC1Cell differentiationERB cell maturationNucleusProduction of DIO1, DIO2 and DIO3CatalyzationFollicular lumenNeuronGlial cellData node for a gene product which mutation result in CHEndocytoseApical membraneGs stimulationNucleusCell survivalAdipose tissueAHNPVNGrowthDifferentiationTH productionARCCell growth, proliferationand protein synthesisConversionTo liverGq stimulationLegendNodesSympathetic nervous systemDownregulationphosphorylationLiverEdgesAnterior pituitaryHypothalamusGlucose transportData node for a pathwayMAPK signallingSpontaneous crosslinkingProteolytic cleavagePancreasFFANucleusLipolysisProliferative signallingGs stimulationData node for a gene or its productHeat productionin brown ATData node for a metaboliteT3DUOX2T3ZNF516MGLLBeta-3 ART3PKAmTORCASP9mTOR2O2GSK3BPCG-1TCA cycleMIT and DITTG bound MIT, DIT, T3 and T4IYDT3CREBFRS2Gene productBNPPFKFB2T3IodideATF2AQP7ACTL6BBADPIP3TSC2THRHypothalamicAMPKAdenylate cyclaseMAFADAGcGMPTTF2IP3ACRHEBRASPI3KMC4RPOMCGlycerolDIO1GRB2SLC5A5PRDM16AS160TGIP3RTriiodothyronine (T3)DUOXA2TRHATGLERKDownregulatedWnt signallingOxidative phosphorylationSLC16A10RAF1T4cAMPPKCSodiumPLINTGtRNAsecRPS6KB1RasPPARGTSC2ANPASK1Thyroxine (T4)SLCO1C1NOTCH signallingNP-RTPOFFATHRB1TSHp38NADPH ITGBS6NOTCHUCP1TTR bound T4SHHAKTNHSLRPS6KA6HypoxiaTTF1H2O2NorepinephrinePAX8TBG bound T4NADP+FOXO1JMJD1BCa2+MLST8SECISBP2LTREFGF21RAPTORSOSMDM2AGRPSIRT6CREBPRAS40P53KLBKDM1ATSC1SLC26A4FGFR1B-CateninAlbumin bound T4PKGInflammationTSHRRXRMEKRHEBPathwaySRCmTORMKK3T4WntIodideNPYITGAMetaboliteMCT8IodidePLCTG bound MIT and DITTG bound MIT, DIT, T3 and T4TBG bound T3Albumin bound T3TTR bound T3MCT8cAMPPKAphosphorylationDGMG1919FGF214040phosphorylation40phosphorylationphosphorylationUCP110MCT88MCT8DIO2T4T3DIO2MCT8MCT8T3T2SHHDIO3NucleusT3SLC16A10ITGB46ITGA202020T3THRA12622121145Glucose metabolismDAGPKCIP3IP3RCa2+PLC3838383838cAMP38PKA13, 38TRETHRRXRNucleusT3MCT8T4MCT8T4T3DIO2SodiumTRERXRT3THRB1IodideGene product


Description

Congenital hypothyroidism is a hormonal disorder of the thyroid hormone production which results in increased birth weight, impaired glucose metabolism and decreased body temperature. Above, an overview of thyroid hormones production occurring in thyroid gland and their relevant downstream signalling for congenital hypothyroidism is displayed. As the legend states, known prevalent gene mutations that lead to congenital hypothyroidism are colored red.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
135857view12:45, 19 November 2024EweitzModified description
135823view14:05, 12 November 2024EgonwFixed the ChEBI identifier of T4
128791view00:26, 22 February 2024EweitzOntology Term : 'thyroid follicular cell' added !
128790view00:25, 22 February 2024EweitzOntology Term : 'neuron' added !
128789view00:25, 22 February 2024EweitzOntology Term : 'glial cell' added !
128788view00:24, 22 February 2024EweitzStandardize case
127760view09:28, 3 December 2023EgonwChEBI id for Ca2+ instead of the "Ca" atom
123317view19:41, 15 July 2022EgonwMore metabolites typed as such
123315view11:34, 15 July 2022EgonwT4 is a metabolite
120402view09:12, 30 November 2021Fehrhartboxed pathway nodes
117846view15:16, 22 May 2021EweitzModified title
116407view09:04, 7 May 2021EweitzModified title
111628view06:17, 31 August 2020EgonwModified title
108781view13:57, 29 January 2020Rik-lahaije
108638view08:52, 14 January 2020Rik-lahaijechanged nodes
108396view20:35, 16 December 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
108391view13:22, 16 December 2019Rik-lahaijelines
108390view13:13, 16 December 2019Rik-lahaijeModified description
108389view12:57, 16 December 2019Rik-lahaijeannotations
108388view12:52, 16 December 2019Rik-lahaijechanged legend
108387view12:46, 16 December 2019Rik-lahaije
108378view10:24, 15 December 2019Marvin M2Connected lines and converted some into graphical lines
108263view14:56, 3 December 2019L DupuisConverted interactions to graphical lines in legend
108262view14:55, 3 December 2019L DupuisConnected unconnected lines
108096view12:55, 28 November 2019FehrhartOntology Term : 'congenital hypothyroidism' added !
108095view12:52, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
107964view09:26, 18 November 2019FehrhartOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
107960view09:14, 14 November 2019Rik-lahaijeModified description
107959view09:09, 14 November 2019Rik-lahaijeModified title
107958view09:09, 14 November 2019Rik-lahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2O2Metabolite
ACProteinA0A0K0K1K3 (Uniprot-TrEMBL)
ACTL6BGeneProductENSG00000077080 (Ensembl)
AGRPGeneProductENSG00000159723 (Ensembl)
AKTGeneProductENSG00000117020 (Ensembl)
ANPProteinA0A087X094 (Uniprot-TrEMBL)
AQP7GeneProductENSG00000165269 (Ensembl)
AS160GeneProductENSG00000136111 (Ensembl)
ASK1ProteinG3V4Q4 (Uniprot-TrEMBL)
ATF2GeneProductENSG00000115966 (Ensembl)
ATGLProteinQ96AD5 (Uniprot-TrEMBL)
Adenylate cyclaseProteinA0A0A0MSC1 (Uniprot-TrEMBL)
Albumin bound T3Complex
Albumin bound T4Complex
B-Catenin GeneProductENSG00000168036 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BNPProteinP16860 (Uniprot-TrEMBL)
Beta-3 ARProteinP13945 (Uniprot-TrEMBL)
CASP9GeneProductENSG00000132906 (Ensembl)
CREB GeneProductENSG00000107175 (Ensembl)
Ca2+Metabolite29108 (ChEBI)
DAGMetabolite
DGMetabolite
DIO1GeneProductENSG00000211452 (Ensembl)
DIO2GeneProductENSG00000211448 (Ensembl)
DIO3GeneProductENSG00000197406 (Ensembl)
DUOX2GeneProductENSG00000140279 (Ensembl)
DUOXA2GeneProductENSG00000140274 (Ensembl)
Downregulated Wnt signallingPathwaymap04310 (KEGG Pathway)
ERKProteinP28482 (Uniprot-TrEMBL)
FFAMetabolite
FGF21GeneProductENSG00000105550 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FRS2GeneProductENSG00000166225 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
Gene productGeneProduct
GlycerolMetabolite
H2O2Metabolite
Hypothalamic AMPKMetabolite
Hypoxia
IP3Metabolite
IP3RGeneProductENSG00000123104 (Ensembl)
ITGAGeneProductENSG00000138448 (Ensembl)
ITGBGeneProductENSG00000259207 (Ensembl)
IYDGeneProductENSG00000009765 (Ensembl)
InflammationPathwayWP453 (WikiPathways)
IodideMetabolite
IodideMetaboliteQ27259563 (Wikidata)
JMJD1BProteinQ7LBC6 (Uniprot-TrEMBL)
KDM1AGeneProductENSG00000004487 (Ensembl)
KLBGeneProductENSG00000134962 (Ensembl)
MAFAGeneProductENSG00000182759 (Ensembl)
MC4RGeneProductENSG00000166603 (Ensembl)
MCT8ProteinP36021 (Uniprot-TrEMBL)
MDM2GeneProductENSG00000135679 (Ensembl)
MEKProteinQ02750 (Uniprot-TrEMBL)
MGMetabolite
MGLLGeneProductENSG00000074416 (Ensembl)
MIT and DITMetabolite
MKK3 ProteinA0A024R2W7 (Uniprot-TrEMBL)
MLST8GeneProductENSG00000167965 (Ensembl)
MetaboliteMetabolite
NADP+Metabolite
NADPH Metabolite
NHSLGeneProductENSG00000135540 (Ensembl)
NOTCH signallingPathwaymap04330 (KEGG Pathway)
NOTCHGeneProductENSG00000148400 (Ensembl)
NP-RProteinP16066 (Uniprot-TrEMBL)
NPYGeneProductENSG00000122585 (Ensembl)
NorepinephrineMetabolite
Oxidative phosphorylationPathwaymap00190 (KEGG Pathway)
P53GeneProductENSG00000141510 (Ensembl)
PAX8ProteinA0A140TA56 (Uniprot-TrEMBL)
PCG-1 GeneProductENSG00000109819 (Ensembl)
PFKFB2GeneProductENSG00000123836 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIP3Metabolite
PKAProteinQ15136 (Uniprot-TrEMBL)
PKCProteinA0A087X0I9 (Uniprot-TrEMBL)
PKGGeneProduct
PLCProteinA0A087WT80 (Uniprot-TrEMBL)
PLINGeneProductENSG00000166819 (Ensembl)
POMCGeneProductENSG00000115138 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
PathwayPathway
RAF1GeneProductENSG00000132155 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPS6KA6GeneProductENSG00000072133 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RXRGeneProductENSG00000186350 (Ensembl)
RasGeneProductENSG00000174775 (Ensembl)
S6GeneProductENSG00000137154 (Ensembl)
SECISBP2LGeneProductENSG00000138593 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SIRT6GeneProductENSG00000077463 (Ensembl)
SLC16A10GeneProductENSG00000112394 (Ensembl)
SLC26A4GeneProductENSG00000091137 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLCO1C1GeneProductENSG00000139155 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
SodiumMetabolite
T2Metabolite
T3Metabolite
T4Metabolite
T4 Metabolite
TBG bound T3GeneProduct
TBG bound T4GeneProduct
TCA cycle Pathwaymap00020 (KEGG Pathway)
TGMetabolite
TG bound MIT and DITComplexE5RG33 (Uniprot-TrEMBL)
TG bound MIT, DIT, T3 and T4ComplexE5RG33 (Uniprot-TrEMBL)
TGProteinE5RG33 (Uniprot-TrEMBL)
THRA1GeneProductENSG00000126351 (Ensembl)
THRB1GeneProductENSG00000151090 (Ensembl)
THRProteinP10827 (Uniprot-TrEMBL)
TPOProteinE9PFM6 (Uniprot-TrEMBL)
TRE
TRHGeneProductENSG00000170893 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TSHGeneProductENSG00000134200 (Ensembl)
TSHRGeneProductENSG00000165409 (Ensembl)
TTF1GeneProductENSG00000125482 (Ensembl)
TTF2GeneProductENSG00000116830 (Ensembl)
TTR bound T3 Complex
TTR bound T4Complex
Thyroxine (T4)Metabolite
Triiodothyronine (T3)Metabolite
UCP1GeneProductENSG00000109424 (Ensembl)
WntGeneProductENSG00000162552 (Ensembl)
ZNF516GeneProductENSG00000101493 (Ensembl)
cAMPMetabolite
cGMPMetabolite
mTORGeneProductENSG00000198793 (Ensembl)
mTORPathwaymap04150 (KEGG Pathway)
p38ProteinQ16539 (Uniprot-TrEMBL)
tRNAsecGeneProduct

Annotated Interactions

No annotated interactions

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