SARS-CoV-2 and COVID-19 pathway (Homo sapiens)

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Description

Collaborative project for curation biological processes involved in the COVID-19 disease after SARS-Cov-2 infection.

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Bibliography

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  1. ''From SARS and MERS CoVs to SARS-CoV-2: moving toward more biased codon usage in viral structural and non-structural genes.''; J Med Virol, 2020 PubMed Europe PMC Scholia
  2. ''A potential role for integrins in host cell entry by SARS-CoV-2.''; Antiviral Res, 2020 PubMed Europe PMC Scholia
  3. ''Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system''; https://doi.org/10.1101/2020.06.07.137802, 2020
  4. ''Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles.''; mBio, 2013 PubMed Europe PMC Scholia
  5. ''Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?''; Elife, 2020 PubMed Europe PMC Scholia
  6. ''Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.''; Antiviral Res, 2020 PubMed Europe PMC Scholia
  7. ''The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.''; J Virol, 2020 PubMed Europe PMC Scholia
  8. ''Simultaneous Treatment of COVID-19 With Serine Protease Inhibitor Camostat and/or Cathepsin L Inhibitor?''; J Clin Med Res, 2020 PubMed Europe PMC Scholia
  9. ''Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2.''; Science, 2020 PubMed Europe PMC Scholia
  10. ''Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.''; J Biol Chem, 2020 PubMed Europe PMC Scholia
  11. ''Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load.''; PeerJ, 2020 PubMed Europe PMC Scholia
  12. ''Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.''; iScience, 2020 PubMed Europe PMC Scholia
  13. ''HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.''; Nat Metab, 2020 PubMed Europe PMC Scholia
  14. ''The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine.''; bioRxiv, 2020 PubMed Europe PMC Scholia
  15. ''Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species.''; Infect Genet Evol, 2020 PubMed Europe PMC Scholia
  16. ''Identification of novel mutations in themethyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2.''; Biochem Biophys Rep, 2020 PubMed Europe PMC Scholia
  17. ''Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions.''; Antiviral Res, 2020 PubMed Europe PMC Scholia
  18. ''Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.''; Intensive Care Med, 2020 PubMed Europe PMC Scholia
  19. ''Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.''; Science, 2020 PubMed Europe PMC Scholia
  20. ''Presence of Genetic Variants Among Young Men With Severe COVID-19.''; JAMA, 2020 PubMed Europe PMC Scholia
  21. ''TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.''; Sci Immunol, 2020 PubMed Europe PMC Scholia
  22. ''Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant.''; J Transl Med, 2020 PubMed Europe PMC Scholia
  23. ''Cell entry mechanisms of SARS-CoV-2.''; Proc Natl Acad Sci U S A, 2020 PubMed Europe PMC Scholia
  24. ''SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.''; Cell, 2020 PubMed Europe PMC Scholia
  25. ''Structure of replicating SARS-CoV-2 polymerase.''; Nature, 2020 PubMed Europe PMC Scholia
  26. ''''; https://www.youtube.com/watch?v=e2Qi-hAXdJo,
  27. ''Presence of Genetic Variants Among Young Men With Severe COVID-19.''; JAMA, 2020 PubMed Europe PMC Scholia
  28. ''Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.''; EMBO J, 2020 PubMed Europe PMC Scholia
  29. ''Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.''; Science, 2020 PubMed Europe PMC Scholia
  30. ''Preprint: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-1 CoV-2 in human airway epithelial cells and provide promising drug targets''; 10.1101/2020.04.15.042085v1, 2020
  31. ''The crystal structure of Nsp9 replicase protein of COVID-19''; https://www.ebi.ac.uk/pdbe/entry/pdb/6w4b, 2020
  32. ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
  33. ''SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.''; Cell, 2020 PubMed Europe PMC Scholia
  34. ''Chemistry and Biology of SARS-CoV-2.''; Chem, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124663view13:52, 18 November 2022NhungPupdate viral proteins shapes, colors and labels
124656view13:28, 18 November 2022Mkutmonupdate virus protein style
124588view05:55, 13 November 2022EgonwAdded missing datasources
124587view05:54, 13 November 2022EgonwAdded missing identifiers
122702view14:57, 3 May 2022NhungPImprove layout
122701view14:54, 3 May 2022NhungPIncrease font and adjust layout to improve readability
120585view19:04, 17 December 2021EweitzFix case
120249view15:50, 20 November 2021EgonwAdded a missing identifier
118977view06:25, 6 June 2021EgonwTyped an interaction
118845view09:23, 2 June 2021EweitzOntology Term : 'COVID-19' added !
118844view09:23, 2 June 2021EweitzOntology Term : 'DOID:2945' removed !
118843view09:22, 2 June 2021EweitzModified title
115843view15:10, 18 March 2021Fehrhartadded S2 identifiers
115453view20:45, 19 February 2021EgonwFixed some references
115447view11:56, 19 February 2021EgonwAnnotated a number of interactions has translocations
115428view09:49, 19 February 2021EgonwAdded more references on interactions
115282view16:49, 9 February 2021FehrhartAdded peer reviewed paper to preprint version of reference
114429view19:16, 10 January 2021EgonwCholesterol depletion results in inhibition of membrane fusion.
114428view18:14, 10 January 2021EgonwAdded an alternative uptake mechanism.
114246view13:22, 29 December 2020EgonwTwo more articles
114234view06:23, 28 December 2020EgonwAdded a reported role of nsp14
113854view20:14, 1 December 2020EgonwAdded a role suggested for sphingosine.
113819view10:11, 28 November 2020EgonwAdded citation for nsp9 crystal structure and added heparan sulfate binding
113702view08:59, 17 November 2020Fehrhartsmall graphical updates
111980view19:27, 13 September 2020EgonwMore literature references linked to interactions.
111364view05:28, 3 August 2020EgonwConverted two interacting Label's to DataNode's.
111358view11:24, 2 August 2020EgonwAnother preprint is published now.
111357view11:18, 2 August 2020EgonwReplaced a DOI by the PubMed ID.
111348view04:56, 30 July 2020EgonwCompleted the TLR7 route, now with PubMed ID.
111317view09:38, 28 July 2020EgonwAdded new recent insight
111242view09:19, 27 July 2020EgonwAdded another reference.
111228view16:08, 26 July 2020EgonwRemoved another bit of info backed by the removed preprint.
111227view16:02, 26 July 2020EgonwRemoved a preprint marked for image duplication: https://pubpeer.com/publications/E7FD45D01851101DF958911F6F0F45
111226view15:59, 26 July 2020EgonwAdded another complex, and a nice YouTube video.
110895view09:40, 18 June 2020EgonwAdded another article about the role of FURIN
110894view06:59, 18 June 2020EgonwRestructured the map.
110893view06:49, 18 June 2020EgonwAdded NRP1
110890view20:54, 17 June 2020EgonwAdded the polymerase cmoplex.
110889view20:06, 17 June 2020EgonwA bit more literature
110886view17:44, 17 June 2020EgonwAdded another reference
110832view13:05, 11 June 2020Egonw
110811view22:26, 9 June 2020Mkutmonfix unconnected line
110668view18:35, 27 May 2020EgonwMade a few pathway nodes have a shape
110650view05:27, 25 May 2020EgonwAdded the missing protein identifier
110619view16:04, 21 May 2020EgonwOkay, it's getting complex :/
110618view15:42, 21 May 2020EgonwAdded two more recent papers (HT Chem2W)
110617view15:05, 21 May 2020EgonwAdded a new protein reported by UniProt.
110616view10:32, 21 May 2020EgonwAdded the Wikidata identifier for nsp1
110615view10:13, 21 May 2020EgonwLinked the preprint also to the inhibition interaction.
110614view10:12, 21 May 2020EgonwAdded the ECO code

External references

DataNodes

No datanodes

Annotated Interactions

No annotated interactions

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