Neuroinflammation (Homo sapiens)

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1Proteolysis and IkB DegradationInflammatory Response GenesOxidative Stress, Inflammatory Cytokines, UVTranscriptionProteinsUbiquination and PhosphorylationInflammatory Gene ExpressionTranslationCytokinesNitrateL-citrullineL-argininep65TNF-αJNKMTORp50C-JUNTLR4Calmodulin[SAPK]H2ONOCa2+NADP+Nitrate reductase[NFκB]IL-1BIκBαCOX1AP-1NitriteIKKαAKTO2PI3KiNOSP38/MAPKCOX2NADPHNADPHNADP+O2JNKC-JUNp50p65p50p65IκBαIκBα


Description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Shabab T, Khanabdali R, Moghadamtousi SZ, Kadir HA, Mohan G; ''Neuroinflammation pathways: a general review.''; Int J Neurosci, 2017 PubMed Europe PMC Scholia
  2. Xing B, Bachstetter AD, Van Eldik LJ; ''Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.''; J Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Liu T, Zhang L, Joo D, Sun SC; ''NF-κB signaling in inflammation.''; Signal Transduct Target Ther, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128365view22:59, 2 February 2024EweitzStandardize case
125017view18:51, 13 January 2023EgonwCorrect data source
123490view04:49, 29 July 2022EgonwMade a pathway clickable
111814view19:06, 8 September 2020EgonwCorrected the format of the BRENDA identifier.
110412view10:17, 9 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110407view03:27, 9 May 2020Marvin M2Ontology Term : 'stress response pathway' added !
110386view15:59, 8 May 2020AnnabayaModified description
110382view15:35, 8 May 2020AnnabayaOntology Term : 'regulatory pathway pertinent to the brain' added !
110380view15:33, 8 May 2020AnnabayaOntology Term : 'PW:0000754' removed !
110379view15:33, 8 May 2020AnnabayaOntology Term : 'drug pathway' added !
110369view15:15, 8 May 2020AnnabayaEdit NFkB interactions
110366view12:19, 8 May 2020AnnabayaEdit interactions and fix gene IDs
110353view13:39, 7 May 2020AnnabayaNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProduct391 (HGNC)
AP-1GeneProductIPR002112 (InterPro)
C-JUNGeneProduct1679 (HomoloGene)
COX1GeneProductENSG00000198804 (Ensembl)
COX2GeneProductENSG00000198712 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
CalmodulinMetaboliteCHEBI:3324 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
IKKαGeneProductENSG00000213341 (Ensembl)
IL-1BGeneProduct481 (HomoloGene)
IκBαGeneProduct7863 (HomoloGene)
JNKGeneProduct6881 (HGNC)
L-arginineMetaboliteCHEBI:16467 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
MTORGeneProductENSG00000198793 (Ensembl)
NADP+MetaboliteCHEBI:7424 (ChEBI)
NADPHMetaboliteCHEBI:7425 (ChEBI)
NOMetaboliteCHEBI:16480 (ChEBI)
Nitrate reductaseGeneProductBRENDA:EC1.7.99.4 (BRENDA)
NitrateMetaboliteCHEBI:7580 (ChEBI)
NitriteMetaboliteCHEBI:7585 (ChEBI)
O2MetaboliteCHEBI:15379 (ChEBI)
P38/MAPKGeneProduct6873 (HGNC)
PI3KGeneProductIPR000403 (InterPro)
TLR4GeneProductENSG00000136869 (Ensembl)
TNF-αGeneProduct496 (HomoloGene)
[NFκB]GeneProduct
[SAPK]GeneProduct
iNOSGeneProductENSG00000007171 (Ensembl)
p50GeneProductENSG00000138303 (Ensembl)
p65GeneProduct32064 (HomoloGene)

Annotated Interactions

No annotated interactions

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