Selenium micronutrient network (Mus musculus)

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PLASMAINTRACELULARNegative effect Influence on expression Unspecified interactions INORGANIC IONBindingGENERIC BINDING PROTEINPositive effect REACTIONTransportTransformation GENERIC ENZYMEMETABOLITEPGI2BC22:5 (n-6)EPA (n-3)ZincPGD2NADPLA (n-6)iPF2-alphaIECysteineXanthineGlutathioneGpx3Hypoxanthine Thromboxane A2BCopperLeukotriene D4Lipoic acidIEBFolic acidLeukotriene B4TLipoxin B4BXdhAscorbic acidBBBLeukotriene A4ALA (n-3)Lipoxin A415-HETETAA (n-6)BSODDHA (n-3)ALA (n-3)PGD2PGH3ROSLeukotriene E4RiboflavinTPtgisF2-IsoprostaneKmoNADPHBFads2TNADPTNFads1MthfrCOX2Methionine BGsrBH2OBEPA (n-3)BCysteinePtgesManganeseBTromboxane A2HemeTEndoperoxidaseLeukotriene F4SeleniumPnpoCOX1IronZincLA (n-6)TBTNVitamin B12CopperGlutathioneBTTRXR 2TSeleniumBPGE3HypoxanthineMethionineAA (n-6)PGG2T5-HPETEPtgdsC22:5 (n-6)Vitamin B12TRXR 1TryptophanLipoxin A4Leukotriene C4Leukotriene D4PGI2Folic acidNiacinMethionine sulfoxideRNSGpx2NADPHPGH2Gpx6BThromboxane B2BMtr15-HETEPGE2BBSepp1O2Leukotriene B4BUric acidPGE2Uric AcidAscorbic acidPGF2aa-TocopherolPGF2aIronFADSelRThioredoxinLeukotriene C4PGG3Homocysteineglutathione disulfideBLeukotrieneE4BBGpx4d4 desaturasePGFSFMNSelWPyridoxal 5'-phosphateHomocysteineTRXR 3DHA (n-3)Pyridoxal 5'-phosphateCatBa-tocopherolAlox5SelkGpx1H2O2Tbxas121


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP15(r29615) with a 55% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC Scholia
  2. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120916view06:28, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
117941view10:44, 23 May 2021EweitzModified title
114037view16:00, 17 December 2020Finterlyconnect lines
106850view13:33, 17 September 2019MaintBotHMDB identifier normalization
95973view10:21, 11 February 2018EgonwROS is not a protein.
87651view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
85064view11:29, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82692view18:05, 22 October 2015EgonwFixed a typo.
73551view18:26, 30 January 2014EgonwH2O not H20....
73506view23:16, 29 January 2014KhanspersModified title
73497view23:06, 29 January 2014KhanspersModified title
73495view23:05, 29 January 2014KhanspersModified title
69459view19:10, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
69087view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
69055view18:04, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68382view09:37, 4 July 2013EgonwUnmarked more "T"s and "B"s as metabolite.
68381view09:32, 4 July 2013EgonwMore clean up: unmarked things without identifier which do not look like a metabolite (like "T" and "B"), and added an ID for lopoic acid.
68380view09:27, 4 July 2013EgonwMarked a few things with gene identifiers as Protein (rather than GeneProduct, following custom in this pathway).
59028view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58514view19:52, 14 February 2013MaintBotModified title
56486view08:50, 8 January 2013EgonwConverted the Type of three DataNodes with an entrez gene ID into "Protein".
43804view22:24, 28 July 2011Samuel SklarSpecify description
43803view18:58, 28 July 2011Samuel SklarSpecify description
43802view18:34, 28 July 2011Samuel SklarPeriodical save, work in progress
43801view18:13, 28 July 2011Samuel SklarPeriodical save, work in progress
43800view18:03, 28 July 2011Samuel SklarPeriodical save, work in progress
41274view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
34380view22:46, 9 December 2009MaintBotAutomatic update of empty xrefs
33050view22:24, 7 October 2009MaintBotadded xrefs
31872view12:38, 14 August 2009MaintBotFixed group labels
30905view00:25, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0011134 (HMDB)
5-HPETEMetaboliteHMDB0001193 (HMDB)
AA (n-6)MetaboliteHMDB0001043 (HMDB)
ALA (n-3)MetaboliteHMDB0001388 (HMDB)
Alox5Protein11689 (Entrez Gene)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
B
C22:5 (n-6)MetaboliteHMDB0001976 (HMDB)
COX1Protein17708 (Entrez Gene)
COX2Protein17709 (Entrez Gene)
CatProtein12359 (Entrez Gene)
CopperMetaboliteHMDB0000657 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DHA (n-3)MetaboliteHMDB0002183 (HMDB)
EPA (n-3)MetaboliteHMDB0001999 (HMDB)
EndoperoxidaseProtein
F2-IsoprostaneMetaboliteHMDB0004659 (HMDB)
FADMetaboliteHMDB0001248 (HMDB)
FMNProtein342184 (Entrez Gene)
Fads1Protein76267 (Entrez Gene)
Fads2Protein56473 (Entrez Gene)
Folic acidMetaboliteHMDB0000121 (HMDB)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gpx1Protein14775 (Entrez Gene)
Gpx2Protein14776 (Entrez Gene)
Gpx3Protein14778 (Entrez Gene)
Gpx4Protein625249 (Entrez Gene)
Gpx6Protein75512 (Entrez Gene)
GsrProteinENSMUSG00000031584 (Ensembl)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Hypoxanthine MetaboliteHMDB0000157 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IE
IronMetaboliteHMDB0000692 (HMDB)
KmoProtein98256 (Entrez Gene)
LA (n-6)MetaboliteHMDB0000673 (HMDB)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
LeukotrieneE4MetaboliteHMDB0002200 (HMDB)
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine MetaboliteHMDB0000696 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
MthfrProtein17769 (Entrez Gene)
MtrProtein238505 (Entrez Gene)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NiacinMetaboliteHMDB0001406 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
PGD2MetaboliteHMDB0001403 (HMDB)
PGE2MetaboliteHMDB0001220 (HMDB)
PGE3MetaboliteHMDB0002664 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB0003235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB0001381 (HMDB)
PGH3Metabolite
PGI2MetaboliteHMDB0001335 (HMDB)
PnpoProtein103711 (Entrez Gene)
PtgdsProtein19215 (Entrez Gene)
PtgesProtein64292 (Entrez Gene)
PtgisProtein19223 (Entrez Gene)
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
RNSMetabolite
ROSMetaboliteCHEBI:26523 (ChEBI) http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB0000244 (HMDB)
SODProtein
SelRProtein51734 (Entrez Gene)
SelWProtein6415 (Entrez Gene)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelkProtein80795 (Entrez Gene)
Sepp1Protein20363 (Entrez Gene)
T
TGeneProduct0 (Entrez Gene)
TNMetabolite
TRXR 1Protein7296 (Entrez Gene)
TRXR 2Protein10587 (Entrez Gene)
TRXR 3Protein114112 (Entrez Gene)
Tbxas1Protein21391 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Tromboxane A2MetaboliteHMDB0001452 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric AcidMetaboliteHMDB0000289 (HMDB)
Uric acidMetaboliteHMDB0000289 (HMDB)
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
XdhProtein22436 (Entrez Gene)
ZincMetaboliteHMDB0001303 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
a-tocopherolMetaboliteHMDB0001893 (HMDB)
d4 desaturaseProtein
glutathione disulfideMetaboliteHMDB0000656 (HMDB)
iPF2-alphaMetaboliteHMDB0004659 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1272"
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