Mitochondrial immune response to SARS-CoV-2 (Homo sapiens)

From WikiPathways

Revision as of 16:23, 12 January 2021 by GabrielCouillaud (Talk | contribs)
Jump to: navigation, search
5, 8435623756IRF3Innate Immune ResponseInterleukin-1 Induced Activation of NF-kappa-BIKBKEMitochondrial CIII assemblyElectron Transport Chain (OXPHOS) AutophagyTOMM70orf9bHSP90TBK1NLRX1IFN-IMAVSIRF3P1orf9c33


Description

SARS-CoV-2 mitochondrial immune response

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Suhail S, Zajac J, Fossum C, Lowater H, McCracken C, Severson N, Laatsch B, Narkiewicz-Jodko A, Johnson B, Liebau J, Bhattacharyya S, Hati S; ''Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.''; Protein J, 2020 PubMed Europe PMC Scholia
  2. Offringa A, Montijn R, Singh S, Paul M, Pinto YM, Pinto-Sietsma SJ; ''''; , PubMed Europe PMC Scholia
  3. Dominguez Andres A, Feng Y, Campos AR, Yin J, Yang CC, James B, Murad R, Kim H, Deshpande AJ, Gordon DE, Krogan N, Pippa R, Ronai ZA; ''SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells.''; bioRxiv, 2020 PubMed Europe PMC Scholia
  4. Arnoult D, Soares F, Tattoli I, Castanier C, Philpott DJ, Girardin SE; ''An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
  5. Kreimendahl S, Rassow J; ''The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  6. Lei Y, Wen H, Ting JP; ''The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy.''; Autophagy, 2013 PubMed Europe PMC Scholia
  7. Berthelot JM, Drouet L, Lioté F; ''Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
  8. Schmoldt A, Benthe HF, Haberland G, Suzuki T, Uchiyama M; ''Inhibitory effect of parathion on the photosynthetic electron transport system in isolated spinach chloroplasts.''; Bull Environ Contam Toxicol, 1975 PubMed Europe PMC Scholia
  9. Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Kaushal Baid, Michael R. D’Agostino, Jann Catherine Ang, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman; ''Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses''; https://doi.org/10.1101/2020.06.18.158154, 2020 PubMed Europe PMC Scholia
  10. Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP; ''NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.''; Immunity, 2011 PubMed Europe PMC Scholia
  11. Burtscher J, Cappellano G, Omori A, Koshiba T, Millet GP; ''Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.''; iScience, 2020 PubMed Europe PMC Scholia
  12. V'kovski P, Kratzel A, Steiner S, Stalder H, Thiel V; ''''; , PubMed Europe PMC Scholia
  13. Zhao RZ, Jiang S, Zhang L, Yu ZB; ''Mitochondrial electron transport chain, ROS generation and uncoupling (Review).''; Int J Mol Med, 2019 PubMed Europe PMC Scholia
  14. Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey E, Cohen NA, Weiss SR; ''SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes.''; bioRxiv, 2020 PubMed Europe PMC Scholia
  15. Frieman M, Heise M, Baric R; ''SARS coronavirus and innate immunity.''; Virus Res, 2008 PubMed Europe PMC Scholia
  16. Robinson EL, Alkass K, Bergmann O, Maguire JJ, Roderick HL, Davenport AP; ''Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.''; J Mol Cell Cardiol, 2020 PubMed Europe PMC Scholia
  17. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
  18. Morgan MJ, Liu ZG; ''Crosstalk of reactive oxygen species and NF-κB signaling.''; Cell Res, 2011 PubMed Europe PMC Scholia
  19. Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC; ''SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia
  20. Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
  21. Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I; ''Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.''; Nature, 2020 PubMed Europe PMC Scholia
  22. Davies JP, Almasy KM, McDonald EF, Plate L; ''Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies.''; bioRxiv, 2020 PubMed Europe PMC Scholia
  23. West AP, Shadel GS, Ghosh S; ''Mitochondria in innate immune responses.''; Nat Rev Immunol, 2011 PubMed Europe PMC Scholia
  24. Tong Meng, Hao Cao, Hao Zhang, Zijian Kang, Da Xu, Haiyi Gong, Jing Wang, Zifu Li, Xingang Cui, Huji Xu, Haifeng Wei, Xiuwu Pan, Rongrong Zhu, Jianru Xiao, Wang Zhou, Liming Cheng, Jianmin Liu; ''The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS''; https://doi.org/10.1101/2020.02.08.926006, 2020 DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
134348view15:25, 20 July 2024EgonwRemoved template comments
129286view18:45, 19 March 2024EgonwRemoved duplicate XML elements
129285view18:43, 19 March 2024EgonwLinked to two other pathways for fusion and endocytosis
124641view12:51, 18 November 2022NhungPmodify viral proteins shapes and labels
121595view18:00, 21 February 2022KJTLUCUpdated Senescence label
121521view22:38, 20 February 2022KJTLUCAdded Senescence
119236view19:04, 22 June 2021FinterlyAdded DOI to PublicationXref
119097view09:38, 17 June 2021FinterlyAdded PMID
118886view12:11, 3 June 2021EweitzOntology Term : 'immune response pathway' added !
118885view12:11, 3 June 2021EweitzModified title
118882view12:09, 3 June 2021EweitzOntology Term : 'COVID-19' added !
115837view14:43, 18 March 2021FehrhartUpdated S1/S2 identifiers
115236view07:51, 6 February 2021EgonwNot a conversion
115235view07:48, 6 February 2021EgonwFixed three interaction type to binding
115172view16:57, 2 February 2021FehrhartCorrected some graphical standards (metabolite = blue) and IDs
115148view08:11, 29 January 2021EgonwReplaced a DOI with the corresponding PubMed ID.
114614view15:59, 25 January 2021Clairebillingsleyupdated identifyers
114610view14:51, 25 January 2021Fehrhart
114608view14:33, 25 January 2021GabrielCouillaud
114607view14:29, 25 January 2021GabrielCouillaud
114605view13:39, 25 January 2021GabrielCouillaud
114604view13:38, 25 January 2021GabrielCouillaudadded edge from angiotensin II to ROS
114603view13:28, 25 January 2021GabrielCouillaudAdded orf9c identifer
114602view13:15, 25 January 2021GabrielCouillaudChaged ORF6 interaction to IRF3
114601view12:53, 25 January 2021GabrielCouillaud
114600view12:45, 25 January 2021Clairebillingsleyupdated identifyers
114599view12:31, 25 January 2021GabrielCouillaudChanged IKBKE interaction type
114575view16:26, 22 January 2021ClairebillingsleyangII / ROS link added
114574view15:44, 22 January 2021ClairebillingsleyAdded receptors and interactions in RAS
114569view06:59, 22 January 2021GabrielCouillaud
114568view06:34, 22 January 2021GabrielCouillaudAdded new refernces to ORF9C/BCS1L interaction and nsp2/PHB/PHB2 interactions
114558view14:11, 21 January 2021GabrielCouillaudAdded IRF7 protein to pathway
114555view17:47, 20 January 2021GabrielCouillaudAdded reference to IKBKE interaction
114545view11:02, 20 January 2021GabrielCouillaudChanged TOMM70 ID to ensembl
114544view10:32, 20 January 2021GabrielCouillaudAdded missing refernces
114543view10:13, 20 January 2021GabrielCouillaudDeleted PLpro interaction with STING1 and added references for its IRF3 repression
114542view09:02, 20 January 2021GabrielCouillaudChanged uncertain interactions of ORF9B with MAVS
114535view18:13, 19 January 2021ClairebillingsleyAdded mitochondiral interactions involving DRP1, MFN2, PHB1/2, Nsp2
114528view15:46, 19 January 2021ClairebillingsleyStructural edits for clarity
114525view14:58, 19 January 2021ClairebillingsleyAdditions to STING and MAVS, and additional Orf's and Nsp interactions
114521view09:36, 19 January 2021GabrielCouillaudAdded genes related to OXPHOS ETC
114518view06:18, 19 January 2021EgonwOntology Term : 'severe acute respiratory syndrome' added !
114517view06:18, 19 January 2021EgonwOntology Term : 'disease pathway' added !
114508view17:03, 18 January 2021ClairebillingsleyAdded dsRNA interactions interacting with MAVS
114507view16:14, 18 January 2021GabrielCouillaud
114506view15:17, 18 January 2021GabrielCouillaudAdded references to orf9b/TOMM70 interaction edge
114503view14:16, 18 January 2021GabrielCouillaudAdded SARS-CoV-2 protein interactions
114489view10:27, 17 January 2021GabrielCouillaudAdded annotation for NFKB genes
114486view12:28, 16 January 2021GabrielCouillaud
114485view12:03, 16 January 2021GabrielCouillaudAdded some missing identifiers

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AutophagyPathway
Electron Transport Chain (OXPHOS) PathwayWP111 (WikiPathways)
HSP90Protein
IFN-IGeneProduct
IKBKEGeneProductENSG00000263528 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
Innate Immune ResponsePathway
Interleukin-1 Induced Activation of NF-kappa-BPathwayWP3656 (WikiPathways)
MAVSGeneProductENSG00000088888 (Ensembl)
Mitochondrial CIII assemblyPathwayWP4921 (WikiPathways)
NLRX1GeneProductENSG00000160703 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TOMM70ProteinO94826 (Uniprot-TrEMBL)
orf9bProtein
orf9cProtein

Annotated Interactions

No annotated interactions

Personal tools