Mitochondrial immune response to SARS-CoV-2 (Homo sapiens)
From WikiPathways
Description
SARS-CoV-2 mitochondrial immune response
Quality Tags
Ontology Terms
Bibliography
View all... |
- Suhail S, Zajac J, Fossum C, Lowater H, McCracken C, Severson N, Laatsch B, Narkiewicz-Jodko A, Johnson B, Liebau J, Bhattacharyya S, Hati S; ''Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review.''; Protein J, 2020 PubMed Europe PMC Scholia
- Offringa A, Montijn R, Singh S, Paul M, Pinto YM, Pinto-Sietsma SJ; ''''; , PubMed Europe PMC Scholia
- Dominguez Andres A, Feng Y, Campos AR, Yin J, Yang CC, James B, Murad R, Kim H, Deshpande AJ, Gordon DE, Krogan N, Pippa R, Ronai ZA; ''SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in Cells.''; bioRxiv, 2020 PubMed Europe PMC Scholia
- Arnoult D, Soares F, Tattoli I, Castanier C, Philpott DJ, Girardin SE; ''An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix.''; J Cell Sci, 2009 PubMed Europe PMC Scholia
- Kreimendahl S, Rassow J; ''The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
- Lei Y, Wen H, Ting JP; ''The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy.''; Autophagy, 2013 PubMed Europe PMC Scholia
- Berthelot JM, Drouet L, Lioté F; ''Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia
- Schmoldt A, Benthe HF, Haberland G, Suzuki T, Uchiyama M; ''Inhibitory effect of parathion on the photosynthetic electron transport system in isolated spinach chloroplasts.''; Bull Environ Contam Toxicol, 1975 PubMed Europe PMC Scholia
- Arinjay Banerjee, Nader El-Sayes, Patrick Budylowski, Daniel Richard, Hassaan Maan, Jennifer A. Aguiar, Kaushal Baid, Michael R. D’Agostino, Jann Catherine Ang, Benjamin J.-M. Tremblay, Sam Afkhami, Mehran Karimzadeh, Aaron T. Irving, Lily Yip, Mario Ostrowski, Jeremy A. Hirota, Robert Kozak, Terence D. Capellini, Matthew S. Miller, Bo Wang, Samira Mubareka, Allison J. McGeer, Andrew G. McArthur, Andrew C. Doxey, Karen Mossman; ''Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses''; https://doi.org/10.1101/2020.06.18.158154, 2020 PubMed Europe PMC Scholia
- Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP; ''NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.''; Immunity, 2011 PubMed Europe PMC Scholia
- Burtscher J, Cappellano G, Omori A, Koshiba T, Millet GP; ''Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity.''; iScience, 2020 PubMed Europe PMC Scholia
- V'kovski P, Kratzel A, Steiner S, Stalder H, Thiel V; ''''; , PubMed Europe PMC Scholia
- Zhao RZ, Jiang S, Zhang L, Yu ZB; ''Mitochondrial electron transport chain, ROS generation and uncoupling (Review).''; Int J Mol Med, 2019 PubMed Europe PMC Scholia
- Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey E, Cohen NA, Weiss SR; ''SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes.''; bioRxiv, 2020 PubMed Europe PMC Scholia
- Frieman M, Heise M, Baric R; ''SARS coronavirus and innate immunity.''; Virus Res, 2008 PubMed Europe PMC Scholia
- Robinson EL, Alkass K, Bergmann O, Maguire JJ, Roderick HL, Davenport AP; ''Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.''; J Mol Cell Cardiol, 2020 PubMed Europe PMC Scholia
- Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
- Morgan MJ, Liu ZG; ''Crosstalk of reactive oxygen species and NF-κB signaling.''; Cell Res, 2011 PubMed Europe PMC Scholia
- Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC; ''SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia
- Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
- Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I; ''Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.''; Nature, 2020 PubMed Europe PMC Scholia
- Davies JP, Almasy KM, McDonald EF, Plate L; ''Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies.''; bioRxiv, 2020 PubMed Europe PMC Scholia
- West AP, Shadel GS, Ghosh S; ''Mitochondria in innate immune responses.''; Nat Rev Immunol, 2011 PubMed Europe PMC Scholia
- Tong Meng, Hao Cao, Hao Zhang, Zijian Kang, Da Xu, Haiyi Gong, Jing Wang, Zifu Li, Xingang Cui, Huji Xu, Haifeng Wei, Xiuwu Pan, Rongrong Zhu, Jianru Xiao, Wang Zhou, Liming Cheng, Jianmin Liu; ''The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS''; https://doi.org/10.1101/2020.02.08.926006, 2020 DOI Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
Autophagy | Pathway | ||
Electron Transport Chain (OXPHOS) | Pathway | WP111 (WikiPathways) | |
HSP90 | Protein | ||
IFN-I | GeneProduct | ||
IKBKE | GeneProduct | ENSG00000263528 (Ensembl) | |
IRF3 | GeneProduct | ENSG00000126456 (Ensembl) | |
Innate Immune Response | Pathway | ||
Interleukin-1 Induced Activation of NF-kappa-B | Pathway | WP3656 (WikiPathways) | |
MAVS | GeneProduct | ENSG00000088888 (Ensembl) | |
Mitochondrial CIII assembly | Pathway | WP4921 (WikiPathways) | |
NLRX1 | GeneProduct | ENSG00000160703 (Ensembl) | |
TBK1 | GeneProduct | ENSG00000183735 (Ensembl) | |
TOMM70 | Protein | O94826 (Uniprot-TrEMBL) | |
orf9b | Protein | ||
orf9c | Protein |
Annotated Interactions
No annotated interactions